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Diagnosis of neurocysticercosis among patients with seizures in northern coastal districts of Andhra Pradesh, India

Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 903-908页

作者： Bala Chandra Sekhar Pappala Jyothi Padmaja Indugula Sateesh kumar Talabhatula Ramalakshmi Suryakarani Kolli arpit kumar shrivastava Priyadarshi Soumyaranjan Sahu Department of Microbiology Andhra Medical College Great Eastern Medical School and Hospital Department of Neurology Andhra Medical College Department of Microbiology Rangaraya Medical College Department of Biotechnology School of Biotechnology and Kalinga Institute of Medical Sciences KIIT University Division of Pathology School of Medicine International Medical University

Objective: To report cases of neurocysticercosis(NCC) from three neighboring districts of Andhra Pradesh state in India where NCC burden was never explored ***: A total of 160 patients presenting with recent onset seizures were recruited from neurology, general medicine, and pediatric outpatient clinics of a local major tertiary care teaching hospital serving above districts during the period 2011–2014. Brain imaging was performed in all the above cases. A commercial immunoglobulin G-ELISA kit(sensitivity = 85%; specificity = 94%) was employed for the serological diagnosis of ***: The recruited patients presented with generalized, simple partial, and complex partial seizures(55%, 31.25% and 13.75% respectively). NCC was diagnosed in 44 of160(27.5%) seizure cases based on imaging characteristics, and a positive serum antibody ELISA. No association was detected between seropositivity with the number and location of the lesion(s) in the ***: The possible potentiality of NCC could be identified as an underlying cause of the recent onset of seizures in this region as explored in the present study. It is recommended that NCC should be suspected as one of the major differential in every recent onset seizure with or without a radio imaging supportive diagnosis, especially in areas endemic for taeniasis/cysticercosis.

关键词： Neurocysticercosis Cysticercosis Seizures Andhra Pradesh

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Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

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Image smog restoration using oblique gradient profile prior and energy minimization

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Frontiers of Computer Science 2021年第6期15卷 147-153页

作者： Ashok kumar arpit JAIN College of Computing Science and Information Technogy TeerthankerMahaveer UniversityMoradabad 244001India

Removing the smog from digital images is a challenging pre-processing tool in various imaging ***,many smog removal(i.e.,desmogging)models are proposed so far to remove the effect of smog from *** desmogging models are based upon a physical model,it means it requires efficient estimation of transmission map and atmospheric veil from a single smoggy ***,many prior based restoration models are proposed in the literature to estimate the transmission map and an atmospheric ***,these models utilized computationally extensive minimization of an energy ***,the existing restoration models suffer from various issues such as distortion of texture,edges,and ***,in this paper,a convolutional neural network(CNN)is used to estimate the physical attributes of smoggy *** gradient channel prior(OGCP)is utilized to restore the smoggy ***,a dataset of smoggy and sunny images are ***,we have trained CNN to estimate the smog gradient from smoggy ***,based upon the computed smog gradient,OGCP is utilized to restore the still smoggy *** analyses reveal that the proposed CNN-OGCP based desmogging model outperforms the existing desmogging models in terms of various performance metrics.

关键词： convolutional neural networks desmogging smog oblique gradient channel prior

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Liquefaction proneness of stratified sand-silt layers based on cyclic triaxial tests

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1826-1845页

作者： arpit Jain Satyendra Mittal Sanjay kumar Shukla Department of Civil Engineering Indian Institute of TechnologyRoorkeeUttarakhandIndia School of Engineering Edith Cowan UniversityJoondalupPerthAustralia Department of Civil Engineering Indian Institute of Technology MadrasChennaiIndia Department of Civil Engineering BIT SindriIndia

Most studies on liquefaction have addressed homogeneous soil strata using sand or sand with fine content without considering soil *** this study,cyclic triaxial tests were conducted on the stratified sand specimens embedded with the silt layers to investigate the liquefaction failures and void-redistribution at confining stress of 100 kPa under stress-controlled *** loosening of underlying sand mass and hindrance to pore-water flow caused localized bulging at the sand-silt *** is observed that at a silt thickness of 0.2H(H is the height of the specimen),nearly 187 load cycles were required to attain liquefaction,which was the highest among all the silt thicknesses with a single silt ***,0.2H is assumed as the optimum silt thickness(t_(opt)).The silt was placed at the top,middle and bottom of the specimen to understand the effect of silt layer *** to the increase in depth of the silt layer from the top position(capped soil state)to the bottom,the cycles to reach liquefaction(N_(cyc,L))increased 2.18 ***,when the number of silt layers increased from single to triple,there was an increase of about 880%in N_(cyc,L).The micro-characterization analysis of the soil specimens indicated silty materials transported in upper sections of the specimen due to the dissipated pore *** main parameters,including thickness(t),location(z),cyclic stress ratio(CSR),number of silt layers(n)and modified relative density(D_(r,m)),performed significantly in governing the lique-faction *** this,a multilinear regression model is developed based on critical parameters for prediction of N_(cyc,L).Furthermore,the developed constitutive model has been validated using the data from the present study and earlier findings.

关键词： Cyclic triaxial tests Soil stratification Soil liquefaction Regression model

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Secondary Silicates as a Barrier to Carbon Capture and Storage in Deccan Basalt

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 861-876页

作者： Amit kumar J.P. shrivastava Department of Geology University of DelhiDelhi 110007India

Investigating the immobilization of CO2,previous basalt-water-CO2 interaction studies revealed the formation of carbonates over a short period,but with the extensive formation of secondary silicates(SS).The mechanisms involved in these processes remain unresolved,so the present study was undertaken to understand secondary mineral formation *** and Rietveld refinement data for neo-formed minerals show a drastic decrease in the Ca-O bond length,with the calcite structure degenerating after 80 h(hours).However,SEM images and EDS data revealed that a longer interaction time resulted in the formation of chlorite and smectite,adjacent to basalt grains which prevent basaltwater-CO2 interaction to form carbonates,thus restricting carbonate *** a result of this,the CO2 mineralization rate is initially high(till 80 h),but it later reduces *** is evident that,for such temperature-controlled transformations,low temperature is conducive to minimizing SS surface coating at the time of mineral carbonation.

关键词： basalt-water-CO2 interaction carbon capture and storage CO2 mineralization leachate chemistry normalized mass loss secondary silicates

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Performance Analysis of AODV Routing forWireless Sensor Network in FPGA Hardware

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Computer Systems Science & Engineering 2022年第3期40卷 1073-1084页

作者： Namit Gupta Kunwar Singh Vaisla arpit Jain Adesh kumar Rajeev kumar Department of Computer Science&Engineering Uttarakhand Technical UniversityDehradun248007India Department of Computer Science B T Kumaon Institute of Technology DwarahatIndia Faculty of Engineering&CS Teerthanker Mahaveer UniversityMoradabadIndia Department of Electrical&Electronics Engineering School of EngineeringUniversity of Petroleum and Energy StudiesDehradun248007India

Wireless sensor network(WSN)is a group of interconnected sensor nodes that work wirelessly to capture the information of *** routing of the network is a challenging *** routing of WSN is classified as proactive,reactive,and *** on-demand distance vector(AODV)routing is an example of reactive routing based on the demand route formations among different nodes in the *** research article emphasizes the design and simulation of the AODV routing hardware chip using very-high-speed integrated circuit hardware description language(VHDL)programming in Xilinx integrated synthesis environment(ISE)14.7 *** performance of the chip is studied based on the field-programmable gate array(FPGA)hardware parameters such as slices,lookup table(LUTs),input/output block(IOB),flipflops,and memory for the different configurations of the network(N=10,20….100).The delay and frequency are also estimated on the Virtex-5 *** performance of the WSN with AODV routing is also analyzed based on the packet delivery ratio,throughput,delay,and control *** simulation test cases verified the 8-bit,64-bit,and 128-bit data communication within the nodes.

关键词： Wireless sensor network FPGA synthesis AODVrouting simulation and synthesis VHDL simulation

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Pichia as yeast cell factory for production of industrially important bio-products:Current trends,challenges,and future prospects

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Journal of Bioresources and Bioproducts 2023年第2期8卷 108-124页

作者： Akansha shrivastava Mamta Pal Rakesh kumar Sharma Department of Biosciences Manipal University JaipurJaipur 303007India Sardar Swaran Singh National Institute of Bio-Energy Jalandhar 144601India

Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and *** a variety of biotechnological production hosts,a few specific genera of yeast have proven *** developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these *** this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia ***-edge solutions involving genetic and process engineering have also been ***,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like *** processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关键词： Natural product Pichia Non-conventional yeast Biosynthesis System biology Synthetic biology

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Trace elemental signatures and mineral chemistry of clays associated with the alteration halos of the Paleoproterozoic U mineralization in Bijawars of the Sonrai Basin,Central India

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Acta Geochimica 2020年第3期39卷 365-386页

作者： Surendra kumar Jha Rashmi Sharma Jaya Prakash shrivastava University of Delhi DelhiIndia Department of Cement Technology A.K.S.UniversitySatnaMPIndia

Paleoproterozoic Bijawars of the Sonrai basin consists of(a) Sonrai(mostly carbonate carbonaceous shale and phosphatic breccia) and(b) Solda Formations(commonly chloritic and ferruginous shale) with well-developed clay-organo-rich facies,often marked with hydrothermal *** studies revealed abundance order of kaolinite> chlorite> illite> smectite;and kaolinite> illite> chlorite in clay(0.2-2.0 μm) fractions separated from the Sonrai and Solda Formations,*** understand atomic substitutions and trace elemental concentrations,clay minerals were analyzed by fusion ICPMS and *** normalized data plots show U,Th,Rb,Ba,Pb Sr,and large-ion lithophiles enrichment,whereas,Bandai sandstone and Rohini carbonate clays show HREE enrichment with asymmetrical patterns,similar to those reported from the well-established McArthur River,Cigar Lake,and Sue UTUD of *** Rohni carbonate,chondrite-normalized REE data plots revealed M shape REE patterns,ascribed to Gd-Tb-Dy-Ho tetrad effect and anomalous Y,Zr,and Hf *** to HREE incorporation in the clay inter-layers,linear and flattened REE trends were *** REE patterns associated with the highly altered chlorite and illite represent negative Eu anomaly related to the dilational nature of the uraninite structure and is suggestive of anoxic conditions.

关键词： Bijawars Sonrai basin Clays REE patterns Uranium mineralization

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Design and Simulation of Ring Network-on-Chip for Different Configured Nodes

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Computers, Materials & Continua 2022年第5期71卷 4085-4100页

作者： arpit Jain Rakesh kumar Dwivedi Hammam Alshazly Adesh kumar Sami Bourouis Manjit Kaur Faculty of Engineering&Computer Sciences Teerthanker Mahaveer UniversityMoradabadUttar Pradesh244001India Faculty of Computers and Information South Valley UniversityQena83523Egypt Department of Electrical and Electronics Engineering School of EngineeringUniversity of Petroleum and Energy StudiesDehradun248007India Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia School of Engineering and Applied Sciences Bennett UniversityGreater Noida201310India

The network-on-chip(NoC)technology is frequently referred to as a front-end solution to a back-end *** physical substructure that transfers data on the chip and ensures the quality of service begins to collapse when the size of semiconductor transistor dimensions shrinks and growing numbers of intellectual property(IP)blocks working together are integrated into a *** system on chip(SoC)architecture of today is so complex that not utilizing the crossbar and traditional hierarchical bus *** connectivity reduces the amount of hardware required for routing and functions,allowing SoCs with NoC interconnect fabrics to operate at higher ***(Octagons)is a direct NoC that is specifically used to solve the scalability problem by expanding each node in the shape of an *** paper discusses the ring NoC design concept and its simulation in Xilinx ISE 14.7,as well as the communication of functional *** the field-programmable gate array(FPGA)synthesis,the performance of NoC is evaluated in terms of hardware and timing *** design allows 64 to 256 node communication in a single chip with‘N’bit data transfer in the ring *** performance of the NoC is evaluated with variable nodes from 2 to 256 in Digilent manufactured Virtex-5 FPGA hardware.

关键词： Ring NoC FPGA synthesis nodes communication SoC design integrated synthesis environment

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Feeder and post Deccan Trap dyke activities in the northern slope of the Satpura Mountain： Evidence from new 40Ar-39Ar ages

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Geoscience Frontiers 2017年第3期8卷 483-492页

作者： J.P.shrivastava R.kumar N.Rani Department of Geology University of Delhi

We present new 40Ar-39Ar plagioclase crystallization ages from the dykes exposed at the northern slope of the Satpura Mountain range near Betul-Jabalpur-Pachmarhi area, - 800 km NE of the Western Ghats escarpment. Among the two plateau ages, the first age of 66.56 ± 0.42 Ma from a dyke near Mohpani village represents its crystallization age which is either slightly older or contemporaneous with the nearby Mandla lava flows （63-65 Ma）. We suggest that the Mohpani dyke might be one of the feeders for the surrounding lava flows as these lavas are significantly younger than the majority of the main Deccan lavas of the Western Ghats （66.38-65.54 Ma）. The second age of 56.95 -- 1.08 Ma comes from a younger dyke near Olini village which cuts across the lava flows of the area. The age correlates well with the Mandla lavas which are chemically similar to the uppermost Poladpur, Ambenali and Mahabaleshwar Formation lavas of SW Deccan. Our study shows that the dyke activities occurred in two phases, with the second one representing the terminal stage.

关键词： 40Aro39Ar ages Deccan dykes Betul-Jabalpur-Pachmarhi area Narmada-Tapi dyke system

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