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Biologics in the management of pediatric inflammatory bowel disease:When and what to choose

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World Journal of Clinical Pediatrics 2025年第1期14卷 21-45页

作者： Arghya samanta Anshu Srivastava Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

Pediatric inflammatory bowel disease(PIBD)is a chronic inflammatory disorder of the gastrointestinal tract,with rising global incidence and *** the past two decades,biologics have added to the therapeutic armamentarium and revolutionized the approach to treatment of inflammatory bowel *** available biologics include monoclonal antibodies which target inflammatory cytokines(anti-tumor necrosis factor alpha,anti-interleukin 12/23)or recruitment of leucocytes to the gastrointestinal tract(anti-alpha4beta7 integrin)and small molecules(Janus kinase inhibitors,sphingosine 1-phosphate-inhibitors)which modify the proinflammatory *** their potential disease-modifying ability,recent pediatric guidelines from the West have advocated upfront use of biologics in appropriate clinical scenarios as a top-down approach rather than the conventional step-up *** real-world studies are available regarding the clinical efficacy of biologics in PIBD,there is paucity of long-term outcome and safety data in ***,little information is available about the best approach in the newly industrialized-developing countries where PIBD is rising but at the same time,infections are prevalent and resources are *** this review,we summarize the efficacy and safety profile of biologics and small molecule drugs and discuss the challenges in the management of PIBD,especially in the developing world,and future directions.

关键词： Biologics Children Inflammatory bowel disease Therapeutic drug monitoring Dual biologic

Responses of non-marine deposits to fluctuating base level and their implications in the Precambrian sequence building:Late Neoproterozoic Girbhakar Sandstone,Rajasthan,India

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Journal of Palaeogeography 2025年第01期14卷 66-90页

作者： Pradip samanta Soumik Mukhopadhyay Arunava Sen Madhurya Roy Department of Geology University of North Bengal Department of Geological Sciences Jadavpur University

The distinctive sedimentation patterns of the late Neoproterozoic Girbhakar Sandstone were investigated within the context of a Precambrian sedimentation system devoid of vegetation. This comprehensive study utilized an integrated approach, incorporating facies analysis, fluvial architectural elements analysis, and palaeocurrent analysis, to offer detailed insights into the controlling factors of sedimentology and depositional settings within the studied interval. Process-based facies analysis revealed thirteen distinct facies types organized into five associations, uncovering a diverse range of depositional palaeoenvironments —from alluvial fan and braided fluvial to transitional marine settings. An alluvial fan, dominated by debris flow and multiple ephemeral channels at the basin margin, emerged initially. The stratigraphic architecture of this alluvial fan and the associated ephemeral fluvial system was primarily influenced by water table fluctuations in arid to semiarid climatic conditions. A transition to a semi-perennial to perennial braided fluvial system occurred as the depositional slope decreased. However, the stratigraphic architecture of these fluvial systems exhibited distinctive variations in response to fluctuating base level rise. Notably, the basal segment, characterized by an unconformity below and a granular lag succeeded by wave-agitated sandstone above, represented the lowstand systems tract(LST). During the early LST, channel belts prograded at the northern distal end of upstream aggradational semi-perennial braided systems in response to the transgression of Girbhakar Sea from the north, aligning with the late Neoproterozoic Indian plate configuration. The coarsening upward deposits suggest a potential classification as a braid-delta, formed by a gradual rise in base level, low epeiric gradient, and episodic flashy discharges, which facilitate the downstream development of this deposit. During the late LST, the evolution of perennial fluvial

关键词： Late Neoproterozoic Marwar Basin Girbhakar Sandstone Alluvial fan Braid-delta Braid-plain Allogenic and autogenic control Lowstand systems tract Fluvial sequence stratigraphy

Hybrid bidirectional quantum communication with different levels of control with simulation

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Communications in Theoretical Physics 2025年第1期77卷 65-91页

作者： Plaban Saha Manoj Kumar Mandal Binayak S Choudhury Soumen samanta Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah—711103West BengalIndia Department of Applied Science and Humanities Haldia Institute of TechnologyHatiberiaHaldiaPurba Medinipur—721657West BengalIndia

In this paper,we develop a quantum communication protocol for the simultaneous preparation of a two-qubit and a three-qubit state at the positions of two different parties situated spatially *** one party,Alice,it is a remote state preparation of a known two-qubit state while for the other party,Bob,it is a joint remote state preparation with the help of a third party,*** protocol is executed in a hybrid form bi-directionally in the presence of two controllers,Charlie and *** is a hierarchy in the process through different levels of control under which the actions by Alice and Bob are *** is a need for a ten-qubit entangled channel connecting the five *** generation of this channel through a circuit is *** protocol is executed on the IBM Quantum *** also study the effect of noise on our ***,amplitude-damping,bit-flip and phase-flip noisy environments are considered and the corresponding variations of fidelity are theoretically and numerically analyzed.

关键词： remote state preparation joint remote state preparation hierarchy entangled state quantum circuit controlled protocol

Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta samanta Gabriele Capurso Ivo Boskoski Cristiano Spada Jorge D Machicado Stefano Francesco Crinò Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Department of Gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy Department of Gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy Department of Gastroenterology University of Michigan HealthAnn ArborMI 48107United States Department of Endoscopy University of VeronaVerona 37121VenetoItaly Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

GaAs-based resonant tunneling diode:Device aspects from design,manufacturing,characterization and applications

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Journal of Semiconductors 2023年第10期44卷 26-35页

作者： Swagata samanta Department of Electronics and Communication Engineering SRM University-APAndhra PradeshIndia

This review article discusses the development of gallium arsenide(GaAs)-based resonant tunneling diodes(RTD)since the *** the best of my knowledge,this article is the first review of GaAs RTD technology which covers different epitaxialstructure design,fabrication techniques,and characterizations for various application *** is expected that the details presented here will help the readers to gain a perspective on the previous accomplishments,as well as have an outlook on the current trends and future developments in GaAs RTD research.

关键词： gallium arsenide microfabrication resonant tunneling devices

Maximization of Acoustic Levitating Force for a Single-Axis Acoustic Levitation System Using the Finite Element Method

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Chinese Physics Letters 2019年第3期36卷 49-52页

作者： Saurabh Yadav arpan Gupta Acoustic and Vibration Laboratory School of Engineering Indian Institute of Technology Mandi

We investigate single-axis acoustic levitation using standing waves to levitate particles freely in a medium bounded by a driver and a reflector. The acoustic pressure at the pressure antinode of the standing wave counteracts the downward gravitational force of the levitating object. The optimal relationship between the air gap and the driving frequency leads to resonance and hence maximization of the levitating force. Slight deviation from the exact resonance condition causes a reduction in acoustic pressure at the pressure antinodes. This results in a significant reduction of the levitating force. The driving frequency is kept constant while the air gap is varied for different conditions. The optimal air gap for maximizing the levitation force is studied for first three resonance modes. Furthermore, a levitating particle is introduced between the driver and the reflector. The dependence of the resonance condition on the size of the levitating particle as well as the position of the particle between the driver and the reflector has also been studied. As the size of the levitating particle increases, the resonance condition also gets modified. Finite element results show a good agreement with the validated results available in the literature. Furthermore, the finite element approach is also used to study the variation of acoustic pressure at the pressure antinode with respect to the size of the reflector. The optimum diameter of the reflector is calculated for maximizing the levitating force for three resonance modes.

关键词： Maximization Levitating Acoustic Levitation Method

Hybrid Approach to Document Anomaly Detection:An Application to Facilitate RPA in Title Insurance

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International Journal of Automation and computing 2021年第1期18卷 55-72页

作者： Abhijit Guha Debabrata samanta Data Science Department CHRIST(Deemed to be University)Bangalore 560029India First American India Private Ltd. Bangalore 560038India Computer Science Department CHRIST(Deemed to be University)Bangalore 560029India

Anomaly detection(AD)is an important aspect of various domains and title insurance(TI)is no *** process automation(RPA)is taking over manual tasks in TI business processes,but it has its limitations without the support of artificial intelligence(AI)and machine learning(ML).With increasing data dimensionality and in composite population scenarios,the complexity of detecting anomalies increases and AD in automated document management systems(ADMS)is the least explored *** learning,being the fastest maturing technology can be combined along with traditional anomaly detectors to facilitate and improve the RPAs in *** present a hybrid model for AD,using autoencoders(AE)and a one-class support vector machine(OSVM).In the present study,OSVM receives input features representing real-time documents from the TI business,orchestrated and with dimensions reduced by *** results obtained from multiple experiments are comparable with traditional methods and within a business acceptable range,regarding accuracy and performance.

关键词： Anomaly detection title insurance autoencoder one-class support vector machine(OSVM) term frequency-inverse document frequency(TF-IDF) robotic process automation dimensionality reduction

A strategic way of high-performance energy storage device development with environmentally viable “Water-in-salt” electrolytes

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Journal of Energy Chemistry 2023年第3期78卷 350-373,I0010页

作者： Prakas samanta Souvik Ghosh Aniruddha Kundu Pranab samanta Naresh Chandra Murmu Tapas Kuila Surface Engineering&Tribology Division Council of Scientific and Industrial Research Central Mechanical Engineering Research InstituteMahatma Gandhi AvenueDurgapur-713209West BengalIndia Academy of Scientific and Innovative Research(AcSIR) CSIR-Human Resource Development Centre(CSIR-HRDC)CampusPostal Staff College AreaSector 19Kamla Nehru NagarGhaziabad-201002Uttar PradeshIndia

Development of cost-effective and environmental friendly energy storage devices(ESDs) has attracted widespread attention in recent scenario of energy ***,the environmentally viable "water-in-salt"(WiS) electrolytes has received significant interest for the development of advanced high performance *** WiS electrolyte exhibits wide electrochemical stability window(ESW),highsafety,non-flammability and superior electrochemical performance compared to the conventional "salt-in-water" *** review aims to provide a comprehensive discussion on WiS electrolyte based on theoretical,electrochemical and physicochemical characteristics.A strategic way for the usage of WiS electrolyte in rechargeable metal-ion batteries and supercapacitors with potentially improved electrochemical performance has been reviewed *** review also discussed the unique advantages of WiS electrolytes as well as the future scope and challenges.

关键词： Water-in-salt electrolyte Solid electrolyte interphase High energy density Aqueous batteries Aqueous supercapacitors

Study of an epidemic model with Z-type control

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International Journal of Biomathematics 2018年第7期11卷 37-57页

作者： Sudip samanta Department of Mathematics Faculty of Science and Arts --Rabigh King Abdulaziz University Rabigh 25732Saudi Arabia

In the present paper,an epidemic model with Z-type control mechanism has been pro- posed and analyzed to explore the disease control strategy on an infectious disease *** uncontrolled model can have a disease-free equilibrium and an endemic *** expression of the basic reproduction number and the conditions for the stability of the equilibria are *** is also observed that the disease-free equilibrium is globally asymptotically stable if R0*** model is further improved by considering Z-control mechanism and *** can be controlled by using Z-control while the basic reproduction of the uncontrolled system is greater than *** positivity conditions of the solutions are derived and the basin of attraction for successful implementation of Z-control mechanism is also *** verify the analytical findings,extensive numerical simulations on the model are carried out.

关键词： SI model basic reproduction number global stability Z-type control basin of attraction disease control