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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Modeling slow deformation of polygonal particles using DeM

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Particuology 2008年第6期6卷 506-514页

作者： Andrés A. pea pedro G. Lind Hans j. Herrmann Institute for Computational Physics Universitt Stuttgart Computational Physics IfB HIF E12 ETH Hnggerberg CH-8093 Zrich Switzerland Departamento de Física Universidade Federal do Ceará

We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete element Method （DeM） when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time.

关键词： Granular media Discrete element method Slow deformation Contact forces

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A Sophisticated Network of Signaling Pathways Regulates Stomatal Defenses to Bacterial Pathogens

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Molecular Plant 2015年第4期8卷 566-581页

作者： Dominique arnaud Ildoo Hwang Department of Life Sciences POSTECH Biotech Center Pohang University of Science and Technology Pohang /90-/84 Korea

Guard cells are specialized cells forming stomatal pores at the leaf surface for gas exchanges between the plant and the atmosphere. Stomata have been shown to playan important role in plant defense as a part of the innate immune response. Plants actively close their stomata upon contact with microbes, thereby preventing pathogen entry into the leaves and the subsequent colonization of host tissues. In this review, we present current knowledge of molecular mechanisms and signaling pathways implicated in stomatal defenses, with particular emphasis on plant-bacteria interactions. Stomatal defense responses begin from the perception of pathogen-associated molecular patterns （PAMPs） and activate a signaling cascade involving the production of secondary messengers such as reactive oxygen species, nitric oxide, and calcium for the regulation of plasma membrane ion channels. The analyses on downstream molecular mechanisms implicated in PAMP-triggered stomatal closure have revealed extensive interplays among the components regulating hormonal signaling pathways. We also discuss the strategies deployed by pathogenic bacteria to counteract stomatal immunity through the example of the phytotoxin coronatine.

关键词： stomata immunity hydrogen peroxide nitric oxide calcium hormones

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Nanovolcano microelectrode arrays: toward long- term on-demand registration of transmembrane action potentials by controlled electroporation

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Microsystems & Nanoengineering 2020年第1期6卷 578-589页

作者： Benoit X.e.Desbiolles etienne de Coulon Nicolas Maino arnaud Bertsch Stephan Rohr Philippe Renaud Laboratory of Microsystems LMIS4 Ecole Polytechnique Federale de LausanneLausanneSwitzerland Department of Physiology Laboratory of Cellular Optics IIUniversity of BernBernSwitzerland

Volcano-shaped microelectrodes(nanovolcanoes)functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular *** nanovolcanoes exhibit recording characteristics similar to those of state-of-the-art micro-nanoelectrode arrays that use electroporation as an insertion *** this study,we investigated whether the use of electroporation improves the performance of nanovolcano arrays in terms of action potential amplitudes,recording durations,and *** with neonatal rat cardiomyocyte monolayers grown on nanovolcano arrays demonstrated that electroporation pulses with characteristics derived from analytical models increased the efficiency of nanovolcano recordings,as they enabled multiple on-demand registration of intracellular action potentials with amplitudes as high as 62 mV and parallel recordings in up to~76%of the available *** performance of nanovolcanoes showed no dependence on the presence of functionalized nanopatterns,indicating that the tip geometry itself is instrumental for establishing a tight seal at the cell–electrode interface,which ultimately determines the quality of ***,the use of electroporation permitted the recording of attenuated cardiomyocyte action potentials during consecutive days at identical sites,indicating that nanovolcano recordings are nondestructive and permit long-term on-demand recordings from excitable cardiac *** from demonstrating that less complex manufacturing processes can be used for next-generation nanovolcano arrays,the finding that the devices are suitable for performing on-demand recordings of electrical activity from multiple sites of excitable cardiac tissues over extended periods of time opens the possibility of using the devices not only in basic research but also in the context of comprehensive drug testing.

关键词： arrays recording action

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Transaction fees optimization in the ethereum blockchain

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Blockchain(Research and Applications) 2022年第3期3卷 12-22页

作者： arnaud Laurent Luce Brotcorne Bernard Fortz INRIA Lille Nord-europe 40 Avenue HalleyLille59000France Universitélibre de Bruxelles Bruxelles1050Belgium

In blockchains,transaction fees are fixed by the *** probability for a transaction to be processed quickly increases with the fee *** this paper,we study the transaction fee optimization problem in the ethereum *** problem consists of determining the minimum price a user should pay so that its transaction is processed with a given probability in a given amount of *** reach this goal,we define a new solution method based on a Monte Carlo approach to predict the probability that a transaction will be mined within a given time *** results on real data highlight the quality of the results.

关键词： Pricing Blockchain ethereum Optimization Gasprice ether Monte-Carlo

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Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients

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World journal of Gastroenterology 2011年第25期17卷 3069-3072页

作者： Timothée Noterdaeme Luc Longrée Christian Bataille arnaud Deroover Anne Lamproye jean Delwaide Yves Beguin Pierre Honoré Olivier Detry Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège Department of Medicine Division of Hematology and OncologyCHC LiègeUniversity of Liège Department of Internal Medicine CHR HuyUniversity of Liège Department of Hepatogastroenterology CHU de LiègeUniversity of Liège Department of Medicine Division of HematologyCHU LiègeUniversity of Liège

Hepatitis B （HBV） reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases. Chemotherapy-induced HBV reacti- vation may ultimately lead to terminal acute liver failure. Liver transplantation （LT） currently remains the only definitive treatment option for such cases, but is generally denied to patients suffering from malignancy. Here, the authors describe 2 cases of cancer-free and HBV graft renfection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma. These 2 cases, and some other reports in the literature, may suggest that patients suffering from hematologic malignan- cies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good.

关键词： Liver transplantation Contraindication Cancer Liver failure Chemotherapy Hepatitis 13 virus

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Dissipation and amplification management in an electrical model of microtubules: Hybrid behavior network

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Chinese Physics B 2023年第11期32卷 392-400页

作者： Sedric Ndoungalah Guy Roger Deffo arnaud Djine Serge Bruno Yamgoue Department of Physics Faculty of ScienceUniversity of BamendaP.O.Box 39 BamendaCameroon Research Unit of Automation and Applied Computers(UR-AIA) Department of Electrical EngineeringIUT-FV of BandjounUniversity of DschangBP 134BandjounCameroon Department of Physics Higher Teacher Training College BambiliThe University of BamendaP.O.Box 39 BamendaCameroon

The control of dissipation and amplification of solitary waves in an electrical model of a microtubule is *** model consists of a shunt nonlinear resistance–capacitance(j(V)–C(V)) circuit and a series resistance–inductance(R–L) circuit. Through linear dispersion analysis, two features of the network are found, that is, low bandpass and bandpass filter characteristics. The effects of the conductance’s parameter λ on the linear dispersion curve are also analyzed. It appears that an increase of λ induces a decrease(an increase) of the width of the bandpass filter for positive(negative) values of λ. By applying the reductive perturbation method, we derive the equation governing the dynamics of the modulated waves in the system. This equation is the well-known nonlinear Schr?dinger equation extended by a linear term proportional to a hybrid parameter σ, i.e., a dissipation or amplification coefficient. Based on this parameter, we successfully demonstrate the hybrid behavior(dissipation and amplification) of the system. The exact and approximate solitary wave solutions of the obtained equation are derived, and the effects of the coefficient σ on the characteristic parameters of these waves are investigated. Using the analytical solutions found, we show numerically that the waves that are propagated throughout the system can be dissipated, amplified, or remain stable depending on the network parameters. These results are not only in agreement with the analytical predictions, but also with the existing experimental results in the literature.

关键词： microtubule dissipation and amplification hybrid behavior solitary wave solutions

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The electrode tortuosity factor:why the conventional tortuosity factor is not well suited for quantifying transport in porous Li-ion battery electrodes and what to use instead

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npj Computational Materials 2020年第1期6卷 633-644页

作者： Tuan-Tu Nguyen arnaud Demortière Benoit Fleutot Bruno Delobel Charles Delacourt Samuel j.Cooper Laboratoire de Réactivitéet Chimie des Solides(LRCS) CNRS UMR 7314Universitéde Picardie Jules VerneHub de l’EnergieRue Baudelocque80039 Amiens CedexFrance Renault Technocentre 78084 GuyancourtFrance Réseau sur le Stockage electrochimique de l’energie(RS2e) CNRS FR 3459Hub de l’EnergieRue Baudelocque80039 Amiens CedexFrance ALISTORe-european Research Institute CNRS FR 3104Hub de l’EnergieRue Baudelocque80039 Amiens CedexFrance Dyson School of Design engineering Imperial College LondonLondon SW72DBUK

The tortuosity factor of porous battery electrodes is an important parameter used to correlate electrode microstructure with performance through numerical ***,having an appropriate method for the accurate determination of tortuosity factors is *** paper presents a numerical approach,based on simulations performed on numerically-generated microstructural images,which enables a comparison between two common experimental methods.

关键词： methods electrode porous

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Self-supervised image quality assessment for X-ray tomographic images of Li-ion battery

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npj Computational Materials 2022年第1期8卷 1848-1856页

作者： Kai Zhang Tuan-Tu Nguyen Zeliang Su arnaud Demortière Laboratoire de Réactivitéet Chimie des Solides(LRCS) CNRS UMR 7314UPJVHub de l’Energie15 rue Baudelocque80039Amiens CedexFrance eNSTA Paris 91120PalaiseauFrance Renault Technocentre 78084GuyancourtFrance Réseau sur le Stockage electrochimique de l’energie(RS2e) CNRS FR 3459Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance ALISTORe-european Research Institute CNRS FR 3104Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance

Image perception plays a fundamental role in the tomography-based approaches for microstructure characterization and has a deep impact on all subsequent stages of image processing,such as segmentation and 3D *** enhancement of image perception,however,frequently involves observer-dependence,which reflects user-to-user dispersion and uncertainties in the calculated *** work presents an objective quantitative method,which uses convolutional neural networks (CNN) for the quality assessment of the X-ray tomographic *** only dozens of annotations,our method allows to evaluate directly and precisely the quality of tomographic *** metrics were employed to evaluate the correlation between our predicted scores and subjective human *** evaluation results demonstrate that our method can be a direct tool to guide the enhancement process in order to produce reliable segmentation *** processing of the tomographic image can thus evolve into a robust observer-independent procedure and advance towards the development of an efficient self-supervised approach.

关键词： image networks battery

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Global perspectives on the ecological,cultural and socioeconomic relevance of wild edible fungi

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Studies in Fungi 2021年第1期6卷 408-424页

作者： Pérez-Moreno j Mortimer pe Xu j Karunarathna SC Li H Centre for Mountain Futures Kunming Institute of BotanyChinese Academy of SciencesKunmingChina edafología Campus MontecilloColegio de PostgraduadosTexcocoMéxico CIFOR-ICRAF China Program World Agroforestry(ICRAF)KunmingChina

Wild edible fungi(WeF),including mushrooms and truffles,comprise a natural source of nutritious and healthy *** consumption of WeF began at least 18,700 years ago during the Stone *** data from over 100 countries indicates the existence of more than 2,100 edible species,a figure that is continually growing,as vast regions and many cultures remain ***,only around 30 species of WeF are grown commercially at a *** also play a key ecological role in the structure and functioning of natural ecosystems and have significantly contributed in shaping all life on the *** as food,medicine or both,they are important for the survival,cultures,and economies of hundreds of ethnic groups around the *** the last 15 years,there has been a noteworthy increase in the international trade of WeF,which is currently estimated at billions(USD)*** 2017,the WeF global trade,of either fresh or processed products,exceeded 1,230,000 *** to their ecological,sociocultural and economic importance,the international WeF trade has a role to play in the post-pandemic recovery *** main challenge of this period will be maintaining natural ecosystems while simultaneously improving human *** elements of this challenge include ensuring food security,enhancing rural development,creating sustainable jobs,mitigating hunger,and slowing the loss of traditional knowledge generated over *** review analyzes the ways in which sustainable use of WeF could contribute to achieving these goals.

关键词： Biocultural importance edible Wild Mushrooms Global Sustainable Development Socioeconomic value Traditional knowledge

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