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Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Journal of Pharmaceutical Analysis 2020年第4期10卷 277-290页

作者： armel jackson seukep Victor Kuete Lutfun Nahar Satyajit DSarker Mingquan Guo Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanChina Sino-Africa Joint Research Center Chinese Academy of SciencesWuhanChina Unit of Research in Microbiology and Antimicrobial Substances/Laboratory of Cancer Research Faculty of ScienceDepartment of BiochemistryUniversity of DschangDschangCameroon Laboratory of Growth Regulators Institute of Experimental Botany ASCR&PalackýUniversitySlechtitelu 2778371OlomoucCzech Republic Centre for Natural Products Discovery School of Pharmacy and Biomolecular SciencesLiverpool John Moores UniversityLiverpoolL33AFUnited Kingdom

The upsurge of multiple drug resistance(MDR)bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic *** major factor in MDR is efflux pump-mediated resistance.A unique pump can make bacteria withstand a wide range of structurally diverse ***,their inhibition is a promising route to eliminate resistance phenomenon in *** are excellent alternatives as resistance-modifying *** can directly kill bacteria or interact with the crucial events of pathogenicity,thereby decreasing the ability of bacteria to develop *** botanicals display noteworthy efflux pumps inhibitory *** plants are of growing ***,some plant families would be excellent sources of efflux pump inhibitors(EPIs)including Apocynaceae,Berberidaceae,Convolvulaceae,Cucurbitaceae,Fabaceae,Lamiaceae,and *** applicable methods for screening plant-derived EPIs include checkerboard synergy test,berberine uptake assay and ethidium bromide *** silico highthroughput virtual detection can be evaluated as a criterion of excluding compounds with efflux substrate-like characteristics,thereby improving the selection process and extending the identification of *** ascertain the efflux activity inhibition,real-time PCR and quantitative mass spectrometry can be *** review emphasizes on efflux pumps and their roles in transmitting bacterial resistance and an update plant-derived EPIs and strategies for identification.

关键词： Multidrug-resistant bacteria Efflux pump inhibitors Plant secondary metabolites Edible plants Efflux activity assays

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Prevalence, Risk Factors, and Awareness of Chronic Kidney Disease among Diabetes Mellitus and Hypertensive Individuals at the Buea Regional Hospital, Cameroon

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Journal of Biosciences and Medicines 2023年第4期11卷 260-277页

作者： Patience Nformi Ndapkwi Elisabeth Zeuko’o Menkem Oteh Njockawoh Mpey Eleonore Ngounou Woquan Sama Luma Watching Djakissam Erastus Nembo Nembu jackson seukep armel Francis Désiré Bomba Taksinkou Denis Teuwafeu Fabrice Fekam Boyom Department of Biomedical Sciences Faculty of Health Sciences University of Buea Buea Cameroon Antimicrobial and Biocontrol Agent Unit Laboratory for Phytobiochemistry and Medicinal Plants Studies Department of Biochemistry Faculty of Sciences University of Yaoundé 1 Yaoundé Cameroon Department of Medical Laboratory Sciences Faculty of Health Sciences University of Buea Buea Cameroon Department of Internal Medicine and Pediatrics Faculty of Health Sciences University of Buea Buea Cameroon

Background: Kidney failure, cardiovascular disease, and early mortality are just a few of the major negative effects of chronic renal disease, a serious global health issue. The considerable financial and public health burden associated with chronic kidney disease can be lessened by raising awareness and adopting better practices for its impact, prevention, and early identification. Objective: In this study, individuals with hypertension and diabetes were evaluated for their knowledge of chronic kidney disease, its prevalence, and its risk factors. Method: It was a hospital-based cross-sectional study conducted on adult (>18 years) patients with diabetes mellitus and hypertension. Each participant provided written informed consent before having their data collected through interviews, medical information, and blood samples for CKD screening. The CKD epidemiology collaboration (CKD-EPI) equation was used to calculate the glomerular filtration rate (GFR) from serum creatinine, and CKD was determined using the estimated GFR (e-GFR). To find independent CKD factors, multivariate logistic regression was employed, with a p-value of 0.05 being regarded as statistically significant. This was accomplished using SPSS (Statistical Program for Social Sciences) version 22.0, IBM Corp., Armonk, NY. Result: A total of 156 participants took part in the study among which 95 (60.9%) were male, most of the participants 82 (52.6%) were aged between 51 - 70 years (mean 59.42 ± 11.007), 76 (48.7%) were unemployed and 97 (62.2%) were single. Overall, the knowledge score of participants on CKD was 65.4% for good knowledge and 34.6% for poor or inadequate knowledge of CKD. More than half of the participants (60%) had chronic kidney disease. Among these, the greatest proportion of CKD patients were those who were hypertensive (88.2%) followed by those who were both hypertensive and diabetic (70.7%). Conclusion: There is poor management of CKD in the South West Region of Cameroon which has co

关键词： Chronic Kidney Disease Prevalence Risk Factors Hypertension Diabetes Mellitus

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