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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson s.dos Reis Diana Pinto sabrina F.lütke Eder C.lima luis F.O.silva Irineu A.s.de Brum Guilherme l.Dotto department of Forest Biomaterials and Technology Biomass Technology Centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad de la Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of Chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

Chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).Chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin *** aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex *** complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths sustainable material Chitin powder Chitin porous aerogel Yttrium adsorption and recovery

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jesús lópez-Gambero Juan Antonio Navarro Carlos sanjuan Elena Baixeras Juan decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra s.l.Calle Johannes Kepler MálagaSpain departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar science 2024年第1期35卷 63-77页

作者： Paula BONA Juliana sTERlI Marcelo saúl de la FUENTE Eduardo olivERO Marta s.FERNÁNdeZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian sea and final dismemberment of southern *** this context,Eocene marine vertebrates from seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of south *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the la Meseta and submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles dermochelyidae Paleogene la Meseta Formation submeseta Formation leticia Formation

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linking sedimentary provenance,climate and tectonics in the Neoproterozoic seridóBelt,Borborema Province(NE Brazil)

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Geoscience Frontiers 2023年第6期14卷 414-431页

作者： Carlos V.A.Ribeiro Marcos C.C.sales armando l.s.de oliv.ira Ricardo sallet Programa de Pós-graduação em Geologia Instituto de GeociênciasUniversidade de Brasília(UnB)CEP 70910-900 BrasíliaDFBrazil Programa de Pós-Graduação em Geociências Universidade Federal de PernambucoDepartamento de GeologiaCentro de Tecnologia e GeociênciasAv.da ArquiteturaCEP 50740-530 RecifePEBrazil departamento de Geologia Universidade Federal do Rio Grande do NorteCEP 59078-970 NatalRNBrazil

The seridóBelt,at the extreme northeast of Brazil,is one of the several Neoproterozoic mobile belts related to the Brasiliano/Pan-African Orogeny in Western *** lithostratigraphy of the seridóBelt comprises basal quartzites and metaconglomerates(Equador Formation)overlain by hornblende-bearing paragneisses,calc-silicate rocks and marbles(Jucurutu Formation)and biotiteschists(seridóFormation).We investigated the sedimentary provenance of these rocks based on an integration of compiled whole-rock geochemistry,sm-Nd isotopes,U-Pb detrital zircon ages and a new set of whole-rock trace elements *** Formation quartzites have major and trace elements patterns that resemble cratonic sandstones,with a typical felsic provenance consistent with the isotopic composition of plutonic Archean to Paleoproterozoic basement *** proxies suggest that these rocks were deposited in fresh waters under anoxic conditions and moderate to intense weathering conditions(CIA=58–79).A shift in provenance led to an increase in intermediate-mafic sources during the deposition of the Jucurutu and seridó*** elements from rock types in these units are nearly identical,yet they differ on the contents of some high field-strength elements(e.g.,sc,V and Ni),which are higher in the seridóFormation than average *** proxies show similar depositional environments,with brackish to marine conditions for the Jucurutu and seridóformations under anoxic to euxinic *** conditions are consistently lower in the Jucurutu Formation(CIA=58–66)in comparison with the seridóFormation(CIA=60–88).Compiled U-Pb data suggest maximum depositional ages of 633±11 Ma and 633±6 Ma for Jucurutu and seridóformations,respectively,suggesting deposition following the ca.645–635 Ma Marinoan *** compared the geochemistry of the seridóFormation schists with currently exposed basement rocks and showed a strong affinity with Neoproterozoic arc-related

关键词： Whole-rock geochemistry Marinoan Glaciation U-Pb detrital zircon Brasiliano Orogeny

Endophytic Occupation in Nodules of Rhynchosia Plants from semiarid Regions of Argentina

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1081-1099页

作者： Cinthia T.lucero María de los Á.Ruíz Fabiola Pagliero Carolina Castaño Mariela l.Ambrosino Graciela s.lorda Facultad de Ciencias Exactas y Naturales Universidad Nacional de La PampaRuta Nacional 35km 330Santa RosaLa PampaCP6300Argentina INTA EEA Anguil“Ing.Agr.Guillermo Covas”Ruta Nacional 5 km 580AnguilLa PampaCC116326Argentina

Beneﬁcial microbes can improve soil health by promoting soil structure,nutrient cycling,and disease *** addition,a wide array of rhizospheric microbes are responsible for producing metabolically active compounds including various types of plant growth ***,microbial biodiversity studies could contribute to the improvement of agricultural practices in deprived areas,such as the Pampean semiarid *** vast majority of studies conducted on endophytic microorganisms have focused on intensive crop legume *** contrast,little attention has been paid to microorganisms of native legumes,whose ecology is not directly affected by human *** this study,endophytic microorganisms isolated from root nodules of a selected native legume of the genus Rhynchosia were *** isolates were studied with a focus on their plant growth-pro-moting rhizobacteria(PGPR)*** the edaphic characteristics of the Pampean semiarid region,the isolates obtained were evaluated for their ability to grow under three salt stress conditions(50,100,and 200 mM NaCl)and four different pH values(6,7,8,and 9).Based on their PGPR activities,the selected strains were phylogenetically grouped using *** results showed great variability among the isolates in terms of the characteristics *** legumes manifested a wide endophytic variability and remarkable perfor-mance in PGPR *** conclude that they could be used as potential bioinoculants for legume cultivation,an excellent alternative to the use of chemical fertilizers that currently pollute the environment.

关键词： Native strains endophytes PGPR native legumes stress

Experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar sánchez-lópez Ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain departamento de Física Aplicada Universidad Miguel HernándezElche 03202Spain departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.l silva l.A.O.Nunes s.M.lima l.H.C.Andrade Optical and Photothermal spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of são Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

Weighted Probability density Estimator with Updated Bandwidths

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Journal of systems science & Complexity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKAsA RAO B l s school of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000China school of Big Data and statistics Anhui UniversityHefei 230601China CR Rao Advanced Institute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this paper,the authors study a class of weighted version of probability density *** is shown that the weighted estimator contains some existing estimators of probability density,no matter they are recursive or *** statistical results including weak consistency,strong consistency,rate of strong consistency,and asymptotic normality are established under some mild ***,the random weighted estimator is also *** numerical simulations and a real data analysis are presented to study the numerical performances of the estimators.

关键词： Asymptotic normality consistency numerical simulation probability density real data analysis updated bandwidths weighted estimator

Model Change Active learning in Graph-Based semi-supervised learning

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1270-1298页

作者： Kevin s.Miller Andrea l.Bertozzi department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLos AngelesCA 90095USA

Active learning in semi-supervised classification involves introducing additional labels for unlabelled data to improve the accuracy of the underlying classifier.A challenge is to identify which points to label to best improve performance while limiting the number of new labels."Model Change"active learning quantifies the resulting change incurred in the classifier by introducing the additional label(s).We pair this idea with graph-based semi-supervised learning(ssl)methods,that use the spectrum of the graph laplacian matrix,which can be truncated to avoid prohibitively large computational and storage *** consider a family of convex loss functions for which the acquisition function can be efficiently approximated using the laplace approximation of the posterior *** show a variety of multiclass examples that illustrate improved performance over prior state-of-art.

关键词： Active learning Graph-based methods semi-supervised learning(ssl) Graph laplacian

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen schrama Hans van Eenennaam saskia J.santegoets Timo Oosenbrug Annemarthe van der Veen Joris l.Vos Charlotte l.Zuur Noel F.C.C.de Miranda Heinz Jacobs sjoerd H.van der Burg Jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOs B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology leiden University Medical Center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTl)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the sTING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTl anticancer *** cooperation with CD40 ligand(l),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTl response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTls locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTl priming Tumor control