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Insights into induction of the immune response by the hepatitis B vaccine

World j.urnal of Gastroenterology 2022年第31期28卷 4249-4262页

作者： Federico Alej.ndro Di Lello Alfredo Pedro martínez Diego martín Flichman Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina Consej. Nacional de Investigaciones Científicas y Técnicas Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been *** countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at *** of these actions have significantly contributed to reducing both the incidence of HBV infection and its related ***,there are still many drawbacks to *** main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal ***,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency *** developed and approved novel vaccine formulations using more potent adj.vants or multiple antigens have shown better performance,particularly in difficult *** advances re-launch the expectations of achieving the World Health Organization’s obj.ctive of completing hepatitis control by 2030.

关键词： Hepatitis B virus Vaccine Immune response Antibodies Neutralizing

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Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm:A potential therapeutic opportunity?

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Genes & Diseases 2023年第3期10卷 639-642页

作者： Lídia Puertas-Umbert Saray Varona Carme Ballester-Servera j.dith Alonso Silvia Aguiló Mar Orriols Ernesto martínez-martínez Antonio Rodríguez-Sinovas j.sémartínez-González Cristina Rodríguez Institut de Recerca Hospital de la Santa Creu i Sant Pau(IRHSCSP) Barcelona 08025Spain Instituto de Investigación Biomédica Sant Pau Barcelona 08036Spain CIBER de Enfermedades Cardiovasculares ISCIIIMadrid 28029Spain Instituto de Investigaciones Biomédicas de Barcelona-Consej. Superior de Investigaciones Científicas(IIBB-CSIC) Barcelona 08036Spain Facultad de Medicina Universidad Complutense de MadridInstituto de Investigación Sanitaria Gregorio MarañónMadrid 28040Spain Cardiovascular Diseases Research Group Vall d’Hebron Institut de RecercaVall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain

Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease with a prevalence up to 8% in males over 60 years of age.1 This is a complex disorder characterized by permanent and focal dilation of abdominal aorta that exceeds at least 50% of the normal diameter. In these patients, the aortic diameter progressively expands boosted by smoking and aging as maj.r risk factors. Unfortunately, aneurysm growth increases the risk of aortic rupture, a life-threatening emergency that carries a mortality rate of 80%. Despite the increasing effort of the scientific community to identify therapeutic strategies for AAA, there are currently no pharmacological tools that ameliorate aneurysm expansion, while the underlying mechanisms involved in this disease are not completely understood.

关键词： aneurysm aortic therapeutic

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Plant Cover and Soil Biochemical Properties in a Mine Tailing Pond Five Years After Application of Marble Wastes and Organic Amendments

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Pedosphere 2012年第1期22卷 22-32页

作者： R.ZORNOZA A.FAZ D.M.CARMONA S.KABAS S.martínez-martíInez j.A.ACOSTA Sustainable Use Managementand Reclamation of Soil and Water Research Group.Department of Agrarian Science and Technology.Technical University of Cartagena.Paseo Alfonso XIII5230203 Cartagena.Murcia(Spain) Universidad Pontificia Bolivariana.Environmental Research Group.Circular 1a No.70-01.Medelín(Colombia)

Tailing ponds pose environmental hazards, such as toxic metals which can contaminate the surroundings through wind and water erosions and leaching. Various chemical and biochemical properties, together with extractable and soluble metals were measured five years after reclamation of a polluted soil affected by former mining activities. This abandoned mine site contains large amounts of Fe-oxyhydroxides, sulphates, and heavy metals. As a consequence, soils remain bare and the soil organic matter content is low （〈 3 g kg-1）. Marble waste, pig manure and sewage sludge were applied in 2004. Plant cover and richness, and soil chemical, biochemical and biological parameters were analysed five years later. Results showed that all soil biochemical properties as well as vegetation cover and richness were higher in treated soils than in the untreated contaminated plots （control）, although organic matter, pH values and extractable metals concentrations were similar among treatments. Soluble cadmium and zinc were lower in the amended plots than in control.

关键词： hydrolase activities metal pollution microbial biomass organic amendments remediation

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Interpolation of Ideal Measures by Abstract K and j.Spaces

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Acta Mathematica Sinica,English Series 2007年第8期23卷 1357-1374页

作者： Luz M.FERNNDEZ-CABRERA Antón martínez Sección Departamental de Matemática Aplicada Escuela de EstadísticaUniversidad Complutense de Madrid28040 MadridSpain Departamento de Matemática Aplicada I E.T.S.Ingenieros IndustrialesUniversidad de Vigo36200

We work with the abstract K and j.interpolation method generated by a sequence lattice Г. We investigate the deviation of an interpolated operator from a given operator ideal by establishing formulae for the ideal measure of the interpolated operator in terms of the ideal measures of restrictions of the operator. Formulae are given in terms of the norms of the shift operators on Г.

关键词： real interpolation ideal measures operator ideals shift operators

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Ecological perspectives on variable retention forestry

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Ecological Processes 2020年第1期9卷 139-144页

作者： Guillermo j.martínez Pastur Ilkka Vanha-Maj.maa j.rry F.Franklin Centro Austral de Investigaciones Científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Natural Resources Institute Finland(Luke) Latokartanonkaari 9FI-00790 HelsinkiFinland School of Environmental and Forest Science University of WashingtonSeattleWA 98195USA

Forest management globally affects the ecosystem services,especially those related to ecosystem functioning and biodiversity conservation,by altering forest structure and *** degree of alteration was related to the intensity and type of harvesting;therefore,the maj.r silvicultural challenge is to develop alternatives to mitigate climate change and maintain forest functions and biodiversity while also providing acceptable levels of timber *** retention forestry(VRF)is a highly flexible concept,with continuity of forest cover,structure,function,and species composition,thereby supporting multiple economic,environmental,and cultural *** special issue provides an overview of the concepts and applications related to VRF implementation around the *** shows that VRF has been applied globally for several decades,with varying levels and retention types,depending on local conditions and the economic importance of *** challenges of VRF seem to differ to some extent on different continents,yet the general aims have been accepted in most of the *** has been successful in mitigating many effects of intensive harvesting,though in some forests of the world,the retention levels are too low to maintain acceptable levels of biodiversity and ecosystem *** conclude that an active collaboration between scientists and forest practitioners is needed to realize all of the opportunities provided by VRF in solving global forestry-related issues.

关键词： Sustainable forestry Biodiversity conservation Timber production Aggregated retention Dispersed retention Forest certification Prescribed burning Synergies and trade-offs

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： marta García-j.an Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Premature losses of leaf area in response to drought and insect herbivory through a leaf lifespan gradient

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j.urnal of Forestry Research 2022年第1期33卷 39-50页

作者： Sonia Mediavilla Montserrat martínez-Ortega Santiago Andrés j.vier Bobo Alfonso Escudero Departamento de Ecología Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain Departamento de Botánica y Fisiología Vegetal Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain

Implications of the differences in leaf life span are still subj.ct to debate in the field of *** leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate *** study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic *** of leaf area may be an important determinant of total leaf carbon *** Mediterranean tree species,distributed on four sites with different climates were *** species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit *** leaf area losses were estimated in response to insect herbivory and summer drought over two *** results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer *** respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.

关键词： Accelerated senescence Insect herbivory Leaf life span Leaf structural reinforcement Summer drought

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Reuse of port industrial heritage in tourist cities:Shipyards as case studies

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Frontiers of Architectural Research 2024年第1期13卷 164-183页

作者： María j.Andrade Eduardo j.ménez-Morales Rachel Rodríguez-Ramos Pablo martínez-Ramírez Department of Art and Architecture School of ArchitectureMalaga UniversityMalaga 29013Spain

The progressive deindustrialisation of many western cities since the 1980s has led to many industrial zones linked to port activities being abandoned or falling into *** such as Barcelona,Naples,Lisbon,Amsterdam,and Hamburg have port industrial complexes of high tangible and intangible heritage value that could totally or partially disappear,resulting in an irreparable loss of their scientific,architectural,social,technological,and historical *** that in mind,Adaptive Reuse(AR)of the built heritage allows the industrial memory of the ports to be preserved by turning them into new functional centres within the existing urban *** occurs in the context of the contemporary challenges of those cities,such as touristification,the circular economy and climate change,while guaranteeing the life cycle of those *** article analyses two case studies—the Nederlandsche Scheepsbouw Maatschappij.NDSM)and the Rotterdamsche Droogdok Maatschappij.RDM)shipyards,both in the Netherlands—in order to contribute to the knowledge of AR of Port Industrial *** are two examples of good practices in port industrial heritage interventions,where the factors behind their acclaim can be easily highlighted.A multi-scale methodology is therefore used and tailored to the case of port industrial heritage,based on analysing previous studies of the heritage in different spheres and on different scales.A relationship matrix tool is thus *** enables a comparative study to be conducted,using key variables and indicators,and considering qualitative and quantitative *** provides extensive output information for each case study,which is summarised in the most favourable factors for the success of the AR of this port industrial heritage.

关键词： Industrial heritage Port-city Adaptive reuse Best practices Circular economy HUL Touristification

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Machine learning insights concerning inflammatory and liver-related risk comorbidities in non-communicable and viral diseases

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World j.urnal of Gastroenterology 2022年第44期28卷 6230-6248页

作者： j.Alfredo martínez marta Alonso-Bernáldez Diego martínez-Urbistondo j.an A Vargas-Nuñez Ana Ramírezde Molina Alberto Dávalos Omar Ramos-Lopez Precision Nutrition and Cardiometabolic Health Madrid Institute of Advanced Studies-Food InstituteMadrid 28049Spain Department of Internal Medicine Hospital Universitario HM SanchinarroMadrid 28050Spain Servicio de Medicina Interna Hospital Universitario Puerta de Hierro MajadahondaMadrid 28222MajadahondaSpain Molecular Oncology and Nutritional Genomics of Cancer Madrid Institute of Advanced Studies-Food InstituteMadrid 28049Spain Laboratory of Epigenetics of Lipid Metabolism Madrid Institute of Advanced Studies-Food InstituteMadrid 28049Spain Medicine and Psychology School Autonomous University of Baja CaliforniaTijuana 22390Baja CaliforniaMexico

The liver is a key organ involved in a wide range of functions,whose damage can lead to chronic liver disease(CLD).CLD accounts for more than two million deaths worldwide,becoming a social and economic burden for most *** the different factors that can cause CLD,alcohol abuse,viruses,drug treatments,and unhealthy dietary patterns top the *** conditions prompt and perpetuate an inflammatory environment and oxidative stress imbalance that favor the development of hepatic *** stages of fibrosis can eventually lead to cirrhosis or hepatocellular carcinoma(HCC).Despite the advances achieved in this field,new approaches are needed for the prevention,diagnosis,treatment,and prognosis of *** this context,the scientific community is using machine learning(ML)algorithms to integrate and process vast amounts of data with unprecedented *** techniques allow the integration of anthropometric,genetic,clinical,biochemical,dietary,lifestyle and omics data,giving new insights to tackle CLD and bringing personalized medicine a step *** review summarizes the investigations where ML techniques have been applied to study new approaches that could be used in inflammatoryrelated,hepatitis viruses-induced,and coronavirus disease 2019-induced liver damage and enlighten the factors involved in CLD development.

关键词： Machine learning Liver inflammation Liver disease Viral diseases Comorbidity

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Importance of Quercus *** diversity and biomass of vascular epiphytes in a managed pine-oak forest in Southern Mexico

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Forest Ecosystems 2022年第3期9卷 366-377页

作者： Nayely martínez-Meléndez Neptalí Ramírez-Marcial j.sé G. García-Franco Manuel j.sús Cach-Pérez Pablo martínez-Zurimendi Departamento de Conservacion de la Biodiversidad El Colegio de la Frontera Sur(ECOSUR)San Cristobal de Las Casas29290ChiapasMexico Red de Ecología Functional Instituto de EcologíaA.C.Xalapa91073VeracruzMexico Departamento de Agricultura Sociedad y AmbienteEl Colegio de la Frontera Sur(ECOSUR)Villahermosa86280TabascoMexico

Background:Forestry management modifies the diversity,structure,and functioning of intervened *** extraction reduces tree density and basal area,leading to changes in the communities of vascular *** obj.ctive of this study was to evaluate the diversity and biomass of vascular epiphytes in Quercus trees remaining in two pine-oak forest stands that have been subj.cted to two stages of the Silvicultural Development Method(release cutting,and thinning)in comparison with an unharvested old-secondary forest in southern *** each treatment,richness of epiphytes present on 60 oak trees was recorded and their dry biomass *** calculated the true diversity(Hill numbers)and beta diversity using the j.ccard coefficient of similarity,and generated rank abundance curves per taxonomic epiphyte group(bromeliads,orchids,ferns and others).For each treatment,the relationships between overall diversity and epiphyte biomass to the host trees basal area were analyzed using log linear ***:We recorded a total of 67 species of epiphytes species belonging to 10 families hosted by five species of *** greatest species richness(^(0)D)was recorded in the old-secondary *** common(^(1)D)and dominant(^(2)D)species were recorded in the release cutting than in the other *** diversity and biomass were both slightly related to host tree basal *** of epiphytes was similar(60%)among treatments,although orchids,bromeliads,and other families were more diverse in the old-secondary *** bromeliad species were shared across all treatments,although orchids presented the most exclusive species in the unharvested *** bromeliad Tillandsia seleriana provided the greatest contribution to biomass in all treatments,followed by the orchid Camaridium *** linear models indicated that epiphyte diversity was significantly related to treatment,and epiphyte biomass to basal area of host ***:Alt

关键词： Bromeliads Chiapas Ferns Orchids Richness Sierra Madre Silvicultural development method(SDM)

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