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Moderate anxiety in pregnant women does not compromise gestational immune-endocrine status and outcome, but renders mothers to be susceptible for diseased states development: A preliminary report

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Advances in Bioscience and Biotechnology 2012年第1期3卷 101-106页

作者： Tania Romo-González Beda Y. Retureta Elly N. Sánchez-Rodríguez armando j. martínez Anahi Chavarría Gabriel Gutiérrez-Ospina Grupo de Biología y Salud Integral Instituto de Investigaciones Biológicas Universidad Veracruzana Xalapa Veracruz México Instituto de Neuroetología Universidad Veracruzana Xalapa Veracruz México Laboratorio de Biología de Sistemas Departamento de Biología Celular Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Ciudad de México México Laboratorio de Neuroinmunología Departamento de Medicina Experimental Facultad de Medicina Universidad Nacional Autónoma de México Ciudad de México México Reproduction Development and Sexual Function Department of Anatomy and Cell Biology Queen’s University Kingston Canada

High anxiety levels during pregnancy commonly lead to clinical complications that affect the mother/child’s prenatal and perinatal health. Such complications are thought to result from combining deficiencies of the endocrine milieu and decreased immune tolerance that support pregnancy. It is yet unclear whether pregnant women subj.cted to moderate anxiety develop a similar state of endocrine deficits and compromised immune tolerance. Here, we evaluated this issue by monitoring endocrine and immune parameters during pregnancy in a sample of women suffering of moderate anxiety. The health of mothers and children, as well as the outcome of the pregnancies were also revised and recorded. Moderately anxious pregnant women present increments of state anxiety, serum cortisol and progesterone, but not of estradiol, as pregnancy progressed. No variations of leukocyte anti- and pro-inflammatory cytokine mRNA expression were found along pregnancy. However, these pregnant women did show an increased frequency of gestational and perinatal complications, conditions that had no maj.r consequences for their health and that of their children at birth. Hence, moderate anxiety renders the mother to be susceptible to develop diseased states during or by the end of pregnancy, while keeping the endocrine milieu and immune tolerance reasonably in place.

关键词： Gestation Pregnancy Anxiety Progesterone Estradiol Pro-Inflammatory Cytokines Anti-Inflammatory Cytokines Immune Tolerance Endocrine Deficiency

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Luj.n Alej.ndro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko j.remic Lydia j.ménez-Díaz j.an D.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(j.remic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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5DGWO-GAN:A Novel Five-Dimensional Gray Wolf Optimizer for Generative Adversarial Network-Enabled Intrusion Detection in IoT Systems

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Computers, Materials & Continua 2025年第1期82卷 881-911页

作者： Sarvenaz Sadat Khatami Mehrdad Shoeibi Anita Ershadi Oskouei Diego martín Maral Keramat Dashliboroun Department of Data Science Engineering University of HoustonHoustonTX 77204USA The WPI Business School Worcester Polytechnic InstituteWorcesterMA 01609USA School of Systems and Enterprises Stevens Institute of TechnologyHobokenNJ 07030USA Department of Computer Science Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain Ernest G.Welch School of Art&Design Georgia State UniversityAtlantaGA 30303USA

The Internet of Things(IoT)is integral to modern infrastructure,enabling connectivity among a wide range of devices from home automation to industrial control *** the exponential increase in data generated by these interconnected devices,robust anomaly detection mechanisms are *** detection in this dynamic environment necessitates methods that can accurately distinguish between normal and anomalous behavior by learning intricate *** paper presents a novel approach utilizing generative adversarial networks(GANs)for anomaly detection in IoT ***,optimizing GANs involves tuning hyper-parameters such as learning rate,batch size,and optimization algorithms,which can be challenging due to the non-convex nature of GAN loss *** address this,we propose a five-dimensional Gray wolf optimizer(5DGWO)to optimize GAN *** 5DGWO introduces two new types of wolves:gamma(γ)for improved exploitation and convergence,and theta(θ)for enhanced exploration and escaping local *** proposed system framework comprises four key stages:1)preprocessing,2)generative model training,3)autoencoder(AE)training,and 4)predictive model *** generative models are utilized to assist the AE training,and the final predictive models(including convolutional neural network(CNN),deep belief network(DBN),recurrent neural network(RNN),random forest(RF),and extreme gradient boosting(XGBoost))are trained using the generated data and AE-encoded *** evaluated the system on three benchmark datasets:NSL-KDD,UNSW-NB15,and *** conducted on diverse IoT datasets show that our method outperforms existing anomaly detection strategies and significantly reduces false *** 5DGWO-GAN-CNNAE exhibits superior performance in various metrics,including accuracy,recall,precision,root mean square error(RMSE),and convergence *** proposed 5DGWO-GAN-CNNAE achieved the lowest RMSE values across the NSL-KDD,UNSW-NB15,and

关键词： Internet of things intrusion detection generative adversarial networks five-dimensional binary gray wolf optimizer deep learning

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria j.ménez Carretero IrisÁlvarez-Merz j.rge Hernández-Campano Sergei A.Kirov j.sús M.Hernández-Guij. Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Caj.l Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of j.st four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain inj.ry in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain inj.ry.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Tongluo j.edu as an adj.vant therapy for oral cancer

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World j.urnal of Clinical Cases 2025年第5期13卷 52-57页

作者： Sarah Monserrat Lomelímartínez Melissa martínez Nieto Ana Esther Mercado González Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Department of Well-being and Sustainable Development Centro Universitario del NorteUniversidad de GuadalajaraColotlan 46200Mexico Independent Researcher Guadalajara 44340Mexico Antiguo Hospital Civil de Guadalaj.ra“Fray Antonio Alcalde” Universidad de GuadalajaraGuadalajara 44280Mexico

Oral cancer is one of the malignant neoplasms that present maj.r global health *** is the sixth most prevalent type of cancer in the world,with a high incidence and mortality *** letter is a review of the study by Yin et al which was published in the World j.urnal of Clinical Cases(2024).The study evaluated the effect of Tongluo j.edu as an adj.vant treatment for oral *** the years,there has been a continuous search for effective and less invasive treatments for oral *** article emphasizes and discusses various therapeutic options currently available,and it highlights that early intervention and multidisciplinary management are crucial for improving *** Chinese medicine,particularly Tongluo j.edu,presents potential complementary approach to co-nventional oral cancer *** research on Tongluo j.edu should be focused on validation of its efficacy and safety through large,well-designed clinical trials,as well as better understanding of the molecular mechanisms in-volved,and optimization of therapeutic ***,continuous education of health professionals is key to the effective and safe integration of this traditional medicine into clinical *** research is essential for optimization of therapeutic strategies and for addressing the challenges presented by this neoplasm.

关键词： Oral cancer Tongluo j.edu Traditional Chinese medicine Chinese herbal medicine Herbal drugs Dentistry

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Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters

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j.urnal of Environmental Sciences 2015年第7期27卷 254-260页

作者： M.martínez-Sales F.García-Ximénez F.j.Espinós Aquaculture and Environmental Research Group (ACUMA) Polytechnic University of Valencia

Organic contaminants can be detected at low concentrations in drinking water, raising concerns for human health, particularly in reproduction. In this respect, we attempted to use the zebrafish as a bioindicator to detect the possible presence of these substances in drinking water, aiming to define the most relevant parameters to detect these substances, which particularly affect the development and reproduction of zebrafish. To this end, batches of30 embryos with the chorion intact were cultured in drinking waters from different sources,throughout their full life-cycle up to 5 months, in 20 L tanks. Six replicates were performed in all water groups, with a total of 24 aquariums. Two generations（F0 and F1） were studied and the following parameters were tested： in the F0 generation, survival and abnormality rates evaluated at 5 dpf（days post-fertilization） and at 5 mpf（months post-fertilization）,the onset of spawning and the fertility rate from 3 mpf to 5 mpf, and the sex ratio and underdeveloped specimens at 5 mpf. Furthermore, in the F0 offspring（F1）, survival and abnormality rates were evaluated at 5 dpf and the hatching rate at 72 hpf. These results revealed that the hatching rate is the most sensitive parameter to distinguish different levels of effects between waters during the early life stages, whereas the rate of underdeveloped specimens is more suitable at later life stages. Regarding adult reproduction, fertility rate was the most sensitive parameter. The possible reversibility or accumulative nature of such effects will be studied in future work.

关键词： Organic pollutants Bioindicator Development and reproduction parameters Drinking water Zebrafish

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Proteomic profile of human monocytic cells infected with dengue virus

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Asian Pacific j.urnal of Tropical Biomedicine 2016年第11期6卷 914-923页

作者： Viviana martínez-Betancur Marleín martínez-Gutierrez Programa de Estudio y Control de Enfermedades Tropicales-PECET Universidad de Antioquia Grupo de Investigación en Ciencias Animales-GRICA Facultad de Medicina Veterinaria y Zootecnia Universidad Cooperativa de Colombia

Obj.ctive: To identify the changes in the proteome of U937 cells infected with dengue virus(DENV).Methods: In this study, differentiated U937 cultures were infected with two DENV-2strains, one of which was associated with dengue(DENV-2/NG) and the other one with severe dengue(DENV-2/16681), with the aim of determining the cellular proteomic profiles under different infection conditions. Cellular proteins were extracted and separated by two-dimensional electrophoresis, and those proteins with differential expression profiles were identified by mass spectrometry. The obtained results were correlated with cellular viability, the number of infectious viral particles, and the viral DNA/protein ***: In comparison with non-infected cultures, in the cells infected with the DENV-2/NG strain, nine proteins were expressed differentially(five were upregulated and four were downregulated); in those cultures infected with the DENV-2/16681 strain, six proteins were differentially expressed(two were downregulated and four were upregulated). The downregulated proteins included fatty acid-binding protein, heterogeneous nuclear ribonucleoprotein 1, protein disulfide isomerase, enolase 1, heat shock 70 k Da protein 9, phosphotyrosyl phosphatase, and annexin IV. The upregulated proteins included heat shock 90 k Da protein AA1, tubulin beta, enolase 1, pyruvate kinase,transaldolase and phospholipase ***: Because the monocyte/macrophage lineage is critical for disease pathogenicity, additional studies on these proteins could provide a better understanding of the cellular response to DENV infection and could help identify new therapeutic targets against infection.

关键词： Dengue virus Proteomic Macrophages Monocytes U937 cells

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Adaptive phase field modelling of crack propagation in orthotropic functionally graded materials

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Defence Technology（防务技术） 2021年第1期17卷 185-195页

作者： Hirshikesh Emilio martínez-Paneda Sundararaj.n Nataraj.n Department of Mechanical Engineering Indian Institute of Technology MadrasChennai600036India Department of Civil and Environmental Engineering Imperial College LondonLondonSW72AZUK

In this work,we extend the recently proposed adaptive phase field method to model fracture in orthotropic functionally graded materials(FGMs).A recovery type error indicator combined with quadtree decomposition is employed for adaptive mesh *** proposed approach is capable of capturing the fracture process with a localized mesh refinement that provides notable gains in computational *** implementation is validated against experimental data and other numerical experiments on orthotropic materials with different material *** results reveal an increase in the stiffness and the maximum force with increasing material orientation *** study is then extended to the analysis of orthotropic *** is observed that,if the gradation in fracture properties is neglected,the material gradient plays a secondary role,with the fracture behaviour being dominated by the orthotropy of the ***,when the toughness increases along the crack propagation path,a substantial gain in fracture resistance is observed.

关键词： Functionally graded materials Phase field fracture Polygonal finite element method Orthotropic materials Recovery based error indicator

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Neural Regeneration Research 2021年第1期16卷 123-124页

作者： Carlos Bueno Salvador martínez Instituto de Neurociencias de Alicante(UMH-CSIC) San JuanAlicanteSpain

Human neurological disorders and spinal cord inj.ries are caused by a loss of neurons and glial cells in the brain or spinal *** proof-ofprinciple of cell therapy is that replacing damaged cells with new healthy ones will restore the lost *** and manipulating autologous neural stem cells(NSCs)could provide an ideal source of cells for use in cell replacement and the transfer of genes to a diseased central nervous *** are immature cells present,not only during embryonic development,but also in the adult brain of all mammalian species,including *** presence of NSCs in the adult mammalian brain has been described in two neurogenic niches,the ventricular-subventricular zone(V-SVZ)of the anterolateral ventricle wall and the subgranular zone of the hippocampal dentate ***,NSCs are defined as self-renewing multipotent cells that can generate neurons,astrocytes and *** maj.r barrier to isolating adult NSCs in humans is the inaccessibility of living *** this reason,an enormous effort has been made to derive neurons from human adult stem cells isolated from various tissue sources.

关键词： inj.ries ventricular adult

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