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Microglia lactylation in relation to central nervous system diseases

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHATIR T.CUONG-le School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng le Wang Wenwu Zhang Gang Li Xing Cheng peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 467-500页

作者： Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine learning Models Duc-Dam Nguyen Nguyen Viet Tiep Quynh-Anh Thi Bui Hiep Van le Indra Prakash Romulus Costache Manish Pandey Binh Thai Pham Faculty of Civil Engineering University of Transport TechnologyThanh XuanHa Noi100000Vietnam Faculty of Hydraulic Engineering Hanoi University of Civil EngineeringHa Noi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India Research Institute of the University of Bucharest Bucharest050663Romania National Institute of Hydrology and Water Management Bucharest013686Romania Department of Civil Engineering Transilvania University of BrasovBrasov500152Romania Danube Delta National Institute for Research and Development Tulcea820112Romania Marwadi University Research Center(MURC) Marwadi UniversityRajkotGujaratBharat360003India Department of Civil Engineering Faculty of Engineering&TechnologyMarwadi UniversityRajkotGujaratBharat360003India

This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and ***,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer perceptron Neural Network(MLP),were employed for comparison and *** models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to *** factors were instrumental in predicting the output variable,which was the probability of landslide *** analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other *** AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of *** results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.

关键词： Landslide susceptibility map spatial analysis ensemble modelling information values(IV)

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Direct observation of photonic Landau levels and helical edge states in strained honeycomb lattices

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Light(Science & Applications) 2020年第1期9卷 627-636页

作者： Omar Jamadi Elena Rozas Grazia Salerno Marijana Milicevic Tomoki Ozawa Isabelle Sagnes aristide.le.aitre Luc le Gratiet Abdelmounaim Harouri Iacopo Carusotto Jacqueline Bloch Alberto Amo Universite de Lille CNRSUMR 8523—PhLAM—Physique des Lasers Atomes et Molecules59000 LilleFrance Depto.de Fisica de Materiales e Instituto Nicolas Cabrera Universidad Autonoma de Madrid(UAM)28049 MadridSpain Center for Nonlinear Phenomena and Complex Systems Universite Libre de BruxellesCP 231Campus PlaineB-1050 BrusselsBelgium Universite Paris-Saclay CNRSCentre de Nanosciences et de Nanotechnologies91120 PalaiseauFrance Interdisciplinary Theoretical and Mathematical Sciences Program(iTHEMS) RIKENWakoSaitama 351-0198Japan INO-CNR BEC Center and Dipartimento di Fisica Universita di Trento38123 PovoItaly

We report the realization of a synthetic magnetic field for photons and polaritons in a honeycomb lattice of coupled semiconductor micropillars.A strong synthetic field is induced in both the s and p orbital bands by engineering a uniaxial hopping gradient in the lattice,giving rise to the formation of Landau levels at the Dirac *** provide direct evidence of the sublattice symmetry breaking of the lowest-order Landau level wavefunction,a distinctive feature of synthetic magnetic *** realization implements helical edge states in the gap between n=0 and n=±1 Landau levels,experimentally demonstrating a novel way of engineering propagating edge states in photonic *** light of recent advances in the enhancement of polariton–polariton nonlinearities,the Landau levels reported here are promising for the study of the interplay between pseudomagnetism and interactions in a photonic system.

关键词： Landau helical realization

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Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期 118-133页

作者： Ze-le Chen Qiang-Qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

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基于4G技术的工程结构无线振动测试系统节点设计

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太原学院学报（自然科学版） 2025年第1期43卷 38-46页

作者：秦乐余沛信阳学院土木工程学院河南信阳464000

结构振动测试是大型土木工程结构健康监测的有效保障,传统振动测试存在布线困难、低频率信号拾取困难、通信速率底、易受到测试现场条件限制等问题。以4G技术为研究对象,提出了一种基于4G技术的工程结构无线振动测试系统节点设计方案,... 详细信息

结构振动测试是大型土木工程结构健康监测的有效保障,传统振动测试存在布线困难、低频率信号拾取困难、通信速率底、易受到测试现场条件限制等问题。以4G技术为研究对象,提出了一种基于4G技术的工程结构无线振动测试系统节点设计方案,通过节点工作原理介绍及各个模块的功能特性分析,研究了标准振动台性能对比测试和基于有线及无线的结构振动对比试验。结果表明:节点传感器的线性度误差为0.29%,且在短距离以及超远距离测试条件下,试验结构的各阶频率测试结果均与有线加速度传感器的测试结果一致,表明节点在测试精度和数据高速率传输等方面具有较大优势,解决了中远及超远距离中工程数据传输问题,具有一定的工程实用性,在土木工程健康监测和工程强震观测领域具有广泛的应用前景。

关键词： 4G通信技术无线振动测试节点灵敏度脉动自由衰减

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level excursion analysis of probabilistic quasibrittle fracture

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Science China(Technological Sciences) 2020年第7期63卷 1141-1153页

作者： le Jia-Liang Department of Civil Environmentaland Geo-EngineeringUniversity of MinnesotaMinneapolis 55455USA

It has widely been acknowledged that no structures can be designed to be risk free, and therefore reliability analysis plays an essential role in the design of engineering structures. The recent focus has been placed on structures made of brittle heterogenous(a.k.a. quasibrittle) materials, such as ceramics, composites, concrete, rock, cold asphalt mixture, and many more at the microscale. This paper presents a level excursion model for the analysis of probabilistic failure of quasibrittle structures, in which the failure statistics is calculated as a first passage probability. The model captures both the spatial randomness of local material resistance and the random stress field induced by microstructures(e.g. randomly distributed flaws). The model represents a generalization of the classical weakest-link model at the continuum limit and it recovers the classical Weibull distribution as an asymptotic distribution function. The paper discusses two applications of the model. The model is first applied to the strength distribution of polycrystalline silicon(poly-Si) MEMS specimens. It is shown that the model agrees well with the experimentally measured strength distributions of poly-Si MEMS specimens of different sizes. The model predicts a complete size effect curve of the mean structural strength transitioning from a vanishing size effect at the small-size limit to the classical Weibull size effect at the large-size limit. The second application is concerned with the left tail of strength distribution of quasibrittle *** taking into account both random stress and strength fields, the model is used to investigate the origin of the power-law tail distribution of structural strength.

关键词： quasibrittle materials strength distribution first passage analysis Weibull statistics size effect

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Finite Morse Index Solutions of a Nonlinear Schr?dinger Equation

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Acta Mathematica Sinica,English Series 2023年第3期39卷 513-522页

作者： Phuong le Faculty of Economic Mathematics University of Economics and LawHo Chi Minh CityVietnam Vietnam National University Ho Chi Minh CityVietnam

We prove Liouville type theorems for stable and finite Morse index H_(loc)^(1)∩L_(loc)^(∞)solutions of the nonlinear Schrodinger equation -Δu+λ|x|^(a)u=|x|b|^(u)|^(p-1)u in R^(N),where N≥2,λ>0,a,b>-2 and p>1,Our analysis reveals that all stable solutions of the equation must be zero for all p>1,Furthermore,finite Morse index solutions must be zero if N≥3 an p≥(N+2+2b)/(N-2).The main tools we use are integral estimates,a Pohozaev type identity and a monotonicity formula.

关键词： Schrodinger equation Liouville type theorems stable solutions finite Morse index solutions monotonicity formula

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CLASSIFICATION OF SOLUTIONS TO HIGHER FRACTIONAL ORDER SYSTEMS

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Acta Mathematica Scientia 2021年第4期41卷 1302-1320页

作者： Phuong le Faculty of Economic Mathematics University of Economics and LawHo Chi Minh CityVietnam VietnamNational UniversityHo Chi Minh CityVietnam

let 00 for all s,t≥*** main technique we use is the method of moving spheres in integral *** our assumptions are more general than those in the previous literature,some new ideas are introduced to overcome this diffi... 详细信息

let 0lent integral *** classify all such solutions when f(s,t)is nondecreasing in s and increasing in t,g(s,t)is increasing in s and nondecreasing in i,and f(μ^(n-α)s,μ^(n-β)t)/μ^(n-α),g(μ^(n-α)s,μ^(n-β)t)/μ^(n-β)are nonincreasing in μ>0 for all s,t≥*** main technique we use is the method of moving spheres in integral *** our assumptions are more general than those in the previous literature,some new ideas are introduced to overcome this difficulty.

关键词： Higher fractional order system integral system general nonlinearity method of moving spheres classification of solutions

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