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Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

World Journal of Clinical Cases 2024年第28期12卷 6159-6164页

作者： Ippokratis Messaritakis Georgios Vougiouklakis Asimina Koulouridi aris p.agouridis Nikolaos Spernovasilis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus School of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome's role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis precision oncology

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Is there a role of lipid-lowering therapies in the management of fatty liver disease?

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World Journal of Hepatology 2022年第1期14卷 119-139页

作者： Ismini Tzanaki aris p.agouridis Michael S Kostapanos School of Medicine European University CyprusNicosiaCyprusNicosia 2404Cyprus School of Medicine European University CyprusNicosia 2404Cyprus General Medicine Addenbrooke's HospitalCambridge University HospitalsCambridge CB20QQUnited Kingdom

Atherogenic dyslipidemia is characterized by increased triglyceride-rich lipoproteins and low high-density lipoprotein cholesterol *** is highly prevalent in non-alcoholic fatty liver disease(NAFLD)and contributes to the increased cardiovascular risk associated with this *** insulin resistance it plays an important pathogenetic role in NAFLD/non-alcoholic steatohepatitis(NASH)development and *** has been shown that cholesterol-lowering reduces cardiovascular risk more in NAFLD vs non-NAFLD high-risk *** evidence highlights the importance of effective lipid modulation in *** this narrative review the effects of the most commonly used lipid-lowering therapies on liver outcomes alongside their therapeutic implications in NAFLD/NASH are critically *** and clinical evidence suggests that statins reduce hepatic steatosis,inflammation and fibrosis in patients with NAFLD/*** data are derived from observational and small prospective clinical studies using changes in liver enzyme activities,steatosis/fibrosis scores,and imaging evidence of steatosis as ***,relevant histologic benefits were noted in small biopsy *** and rosuvastatin showed greater benefits,whereas data for other statins are scarce and sometimes *** studies to those of statins showed efficacy of ezetimibe against hepatic ***,no significant anti-inflammatory and anti-fibrotic actions of ezetimibe have been *** studies showed that fibrates through peroxisome proliferator-activated receptor(ppAR)αactivation may have a role in NAFLD prevention and ***,no relevant benefits have been noted in human ***-related differences in ppARαexpression and its activation responsiveness may help explain this ***-3 fatty acids reduced hepatic steatosis in numerous heterogeneous studies,but their benefits on hepatic inflammation and

关键词： Non-alcoholic fatty liver Non-alcoholic steatohepatitis Statin Ezetimibe Fibrates ω-3 fatty acids Bile acid resins

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In vitro study on the transmission of multidrug-resistant bacteria from textiles to pig skin

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World Journal of Experimental Medicine 2023年第5期13卷 134-141页

作者： pavlina Lena Spyridon Karageorgos Maria Liatsou aris p.agouridis Nikolaos Spernovasilis Demetris Lamnisos panagiotis papageorgis Constantinos Tsioutis Mpn Unilab Clinical Laboratory Nicosia 1066Cyprus Department of Health Sciences School of SciencesEuropean University CyprusNicosia 2404Cyprus First Department of pediatrics “Aghia Sophia”Children’s HospitalNational and Kapodistrian University of AthensAthens 11527Greece School of Medicine European University CyprusNicosia 2404Cyprus Infectious Diseases German Oncology CenterLimassol 4108Cyprus Department of Life Sciences School of SciencesEuropean University CyprusNicosia 2404Cyprus

BACKGROUND The survival of microorganisms on textiles and specifically on healthcare profes-sionals’(HCp)attire has been demonstrated in several *** ability of microorganisms to adhere and remain on textiles for up to hours or days raises questions as to their possible role in transmission from textile to skin via HCp to *** To evaluate the presence,survival and transmission of different multidrug-resistant bacteria(MDRB)from HCp attire onto *** Three MDRB[methicillin-resistant Staphylococcus aureus(MRSA);vancomycin-resistant Enterococcus faecium(VRE);carbapenem-resistant Klebsiella pneumoniae,(CRKp)]were inoculated on textiles from scrubs(60%cotton-40%polyester)and white coat(100%cotton)at concentrations of 108 colony-forming units(CFU),105 CFU,and 103 CFU per *** inoculation of swatches was divided in time intervals of 1 min,5 min,15 min,30 min,1 h,2 h,3 h,4 h,5 h,and 6 *** the end of each period,textiles were imprinted onto pig skins and each skin square was inverted onto three different selective chromogenic *** from the pig skin squares was recorded for the 3 MDRB at the three above concentrations,for the whole length of the 6-h *** MRSA was recovered from pig skins at all concentrations for the whole duration of the 6-h *** was recovered from the concentration of 108 CFU/mL for 6 h and from 105 CFU/mL for up to 3 h,while showing no growth at 103 CFU/*** was recovered from 108 CFU/mL for 6 h,up to 30 min from 105 CFU/mL and for 1 min from the concentration of 103 CFU/*** Evidence from the current study shows that MRSA can persist on textiles and transmit to skin for 6 h even at low *** fact that all MDRB can be sustained and transferred to skin even at lower concentrations,supports that textiles are implicated as vectors of bacterial spread.

关键词： Textiles Attire Multidrug-resistant bacteria Methicillin-resistant Staphylococcus aureus Vancomycin-resistant Enterococcus faecium Extended-spectrum b-lactamase pig skin Skin Transmission

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Epicardial adipose tissue deposition in patients with diabetes and renal impairment: Analysis of the literature

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World Journal of Diabetes 2020年第2期11卷 33-41页

作者： Zoi Kleinaki aris p.agouridis Maria Zafeiri Theodoros Xanthos Constantinos Tsioutis School of Medicine European University Cyprus Diabetes and Obesity Center Konstantopouleio Hospital

Diabetes mellitus(DM)is defined as a chronic disease of disordered metabolism with an ongoing increase in prevalence and incidence *** disease in patients with diabetes is associated with increased morbidity and premature mortality,particularly attributed to their very high cardiovascular *** this group of patients frequently lacks specific symptomatology prior to the adverse events,a screening tool for the identification of high-risk patients is *** epicardial adipose tissue(EAT)is a biologically active organ having properties similar to visceral adipose tissue and has been associated with metabolic diseases and coronary artery *** to conventional cardiovascular risk factors and anthropometric measures,including body mass index and waist circumference,the EAT can early predict the development of coronary artery *** of EAT can be performed by twodimensional echocardiography,magnetic resonance imaging or computer ***,its role and significance in patients with DM and nephropathy has not been thoroughly *** aim of the current editorial is to evaluate all available evidence regarding EAT in patients with DM and renal *** search of the literature revealed that patients with DM and nephropathy have increased EAT measurements,uncontrolled underlying disease,high body mass index and raised cardiovascular risk *** the practical implications of this test,EAT assessment could serve as a novel and non-invasive biomarker to identify high-risk patients for cardiovascular adverse events.

关键词： Epicardial adipose tissue Epicardial fat Diabetes mellitus Renal impairment Diabetic nephropathy Cardiovascular risk

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Cytopathologic diagnosis of fine needle aspiration biopsies of thyroid nodules

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World Journal of Clinical Cases 2016年第2期4卷 38-48页

作者： Evangelos p Misiakos Niki Margari Christos Meristoudis Nickolas Machairas Dimitrios Schizas Konstantinos petropoulos aris Spathis petros Karakitsos Anastasios Machairas 3rd Department of Surgery Attikon University Hospital University of Athens School of Medicine Department of Cytopathology Attikon University HospitalUniversity of Athens School of Medicine 2nd Department of propedeutic Surgery Laiko HospitalUniversity of Athens School of Medicine

Fine-needle aspiration(FNA) cytology is an important diagnostic tool in patients with thyroid *** systems have been proposed for the cyropathologic diagnosis of the thyroid *** cases with indeterminate cytological findings still remain a matter of *** this review we analyze all literature regarding Thyroid Cytopathology Reporting systems trying to identify the most suitable methodology to use in clinical practice for the preoperative diagnosis of thyroid nodules.A review of the English literature was conducted,and data were analyzed and summarized and integrated from the authors' *** main purpose of thyroid FNA is to identify patients with higher risk for malignancy,and to prevent unnecessary surgeries for benign *** Bethesda System for Reporting Thyroid Cytopathology is the most widely used system for the diagnosis of thyroid FNA *** system also contains guidelines for the diagnosis and treatment of indeterminate or suspicious for malignancy *** conclusion,patients who require repeated FNAs for indeterminate diagnoses will be resolved by repeat FNA in a percentage of 72%-80%.

关键词： Thyroid Cytopathology Nodule papillary cancer Fine needle Biopsy

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A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study

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Oncology Research 2023年第2期31卷 207-220页

作者： GUSTAVO MARTÍN VILLOLDO MARÍA TERESA pOMBO MARIANA aris JOAQUÍN CHEMI pABLO MANDÓ SUpRIYA NAGARAJU JUAN CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA AMAT JOSÉLEÓN MELLADO JOSÉMORDOH ALBERTO VILLARONGA MARÍA MARCELA BARRIO Urology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immunohistochemistry Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Centro de Investigaciones Oncológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Department MD Anderson Cancer CenterHoustonTX77030USA pathology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive *** induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor *** searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment ***-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by *** polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EpX+*** addition,pD-1/pD-L1 staining was *** results correlated with BCG *** most non-responders,Th1/Th2 markers were compared in pre-and post-BCG *** was 65.6%in the study *** responders had a higher G/T ratio and a greater number of degranulated EpX+*** combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower ***-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of ***-L1/pD-1 expression was not associated with the response to *** results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity.

关键词： Non-muscle invasive bladder cancer BCG predictive biomarkers Lymphocyte polarization

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Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 375-381页

作者： Nadia Artha Dewi Aulanni'am Aulanni 'am Hidayat Sujuti Muhammad aris Widodo Ojoko Wahono Soeatmadji Department of Ophthalmology Vitreoretinal Subdivision Faculty of Medicine Brawijaya University Malang 65111 Indonesia Department of Biochemistry Faculty of Sciences Brawijaya University Malang 65111 Indonesia Department of Biochemistry Faculty of Medicine Brawijaya University Malang 65111 Indonesia Department of pharmacology Faculty of Medicine Brawijaya University Malang 65111 Indonesia Department of Endocrinology Faculty of Medicine Brawijaya University Malang 65111 Indonesia

AIM： To investigate the mechanism of pericyte migration through Angiopoietin-2 （Ang-2）/Tie-2 signaling pathway. METHODS： We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/pKB inhibitor, and DMSO intravitreal. Retinal digest preparation was done to examine the retinal vasculature including pericyte： endothelial ratio, and morphology of pericyte migration. Tie-2, ERKI/2 and Akt/pKB phosporylation were analyzed by confocal laser scanning microscopy. RESULTS： There was a correlation between pericyte migration with increasing Ang-2 （p〈0.05）. pericyte number reduced by 40% （1：2.4） after 5wk diabetes on diabetic rats. The pericyte： endothelial ratio on group with Tie-2 inhibitor were 1：1.8. The same result shows on group with Akt/pKB inhibition. ERK1/2 inhibitor group shows the best results of pericyte： endothelial ratio （1：1,7）, Inhibition on Tie-2 receptor decreased the phosphorylation activity of Tie-2, ERK1/2 and Akt/pKB pathway. ERK1/2 inhibition also decreasing the phosphorylation of Tie-2 and Akt/pKB. But on Akt/pKB inhibition, the phosphorylation of Tie-2 and ERK1/2 were relative the same. CONCLUSION： Ang-2 has a role for pericyte migration on diabetic rats through Tie-2 receptor, ERKII2 and Akt/pKB pathways. ERK1/2 is a dominant pathway based on the ability to supress another pathway activity and decreasing pericyte migration on diabetic rats.

关键词： pericyte Angiopoietin/Tie-2 diabetes cellmigration rat

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Last glacial geomorphologic records in Mt Chelmos, North peloponnesus, Greece

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Journal of Mountain Science 2018年第5期15卷 948-965页

作者： Kosmas pAVLOpOULOS aris LEONTARITIS Constantin D. ATHANASSAS Chara pETRAKOU Dimitris VANDARAKIS Kosnstantinos NIKOLAKOpOILOS Leonidas STAMATOpOULOS Katherina THEODORAKOpOULOU paris Sorbonne University Abu Dhabi P.O. 38044 Abu Dhabi United Arab Emirates Harokopio University 70 El. Venizelou sir. 17671 Athens Greece Department of Geological Sciences School of Mining and Metallurgical Engineering National Technical University of Athens (NTUA) Zografos Athens 15780 Greece Hellenic Centre for Marine Research 46.7 Ion Athens-Sounio av. P.O. Box 712 Greece University of patrus Geology Department University Campus 26504 Rio Achaia Greece National and Kapodistrian University of Athens Panepistimioupolis 15784 Ilissia Athens Greece

This study deals with the analysis of the glacial processes that have affected the relief of Mt Chelmos in northern peloponnesus, Greece during middle and Late pleistocene. The goal was to compile a combined geomorphological-geological map of the study area which would enable the chronological stratification of the glacial landforms cropping up on Mt. Chelmos. Chronological stratification was further aided by optically stimulated luminescence(OSL)dating. The map served as the basis upon which the reconstruction and discussion on the phases of the Middle-Late Quaternary paleoclimatic history of *** have been made. A sophisticated semiautomated method was first used to analyze the Digital Elevation Model(DEM), combined with Aster,Quickbird and ALOS imagery in order to identify glacial and periglacial, as well as karstic ***, these features along with other nonrecognizable features from the remote-sensing images were documented in the field. In this way, several glacial landforms were identified, such as moraines and cirques, indicating extended glaciation phases during the middle and Late pleistocene. Additionally,a ground moraine located at an altitude of 1900-2050 m, within the Spanolakos glacial valley, was dated using the OSL-dating method. The resulting ages indicate a phase of glacier advance/stabilization during MIS-5 b(89-86 ka), which is in consistence with pollenrecord evidence from Greece and the *** above the floors of the highest cirques on Mount Tymphi(Hughes 2004). These glacial landforms postdate the youngest moraines on Mount Tymphi(Tymphian Stage MIS 5 d-2), and it has been argued that they might be Younger Dryas in age(Woodward and Hughes 2011) although this has not been confirmed by radiometric dating(Hughes et al. 2006 d).Recent field observations throughout the mountains of central Greece(Leontartitis and pavlopoulos, unpublished data) demonstrate that the glaciation extent has been underestimated in several

关键词： Semi-automated geomorphologicalmapping Glacial geomorphology Mediterranean OSL dating

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Anti-diabetic potential of Urena lobata leaf extract through inhibition of dipeptidyl peptidase IV activity

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Asian pacific Journal of Tropical Biomedicine 2015年第8期5卷 630-634页

作者： Yudi purnomo Djoko Wahono Soeatmadji Sutiman Bambang Sumitro Mochammad aris Widodo School of Medicine Brawijaya University pharmacology Department School of Medicine Malang Islamic University Internal Department School of Medicine Brawijaya University Biology Department Faculty of Science Brawijaya University pharmacology Department School of Medicine Brawijaya University

Objective: To evaluate the anti-diabetic potential of leaf extract from Urena lobata(U. lobata) through dipeptidyl peptidase IV(Dpp-IV) inhibitory ***: U. lobata leaf was extracted in hot water and ethanol. The activity of DppIV inhibitor was tested by in vitro study using gly-pro-p-nitroanilide as substrat of DppIV and vildagliptin, as standard reference. A product of the reactions between gly-pro-pnitroanilide and Dpp-IV, was observed by microplate readers with λ = 405 nm. All data were expressed as mean ± SD and the IC50 value was determined by non linear regression curve fit. Active substances in leaf extract of U. lobata was analyzed by liquid chromatography-mass spectrometry. Dpp-IV inhibitory activity of active compounds was evaluated in silico using docking server. Results: The ethanolic extract of U. lobata showed stronger Dpp-IV inhibitor activity than water extract with the IC50 values of 1 654.64 and 6 489.88 μg/mL, respectively. Vildagliptin, based on standard reference for Dpp-IV inhibitor activity, has IC50 value of 57.44 μg/mL. Based on in silico analysis, mangiferin, stigmasterol and β-sitosterol in U. lobata extract have a strong inhibitory activity on Dpp-IV. Conclusions: The results showed that Dpp-IV inhibitory activity of U. lobata is related to its active compounds such as mangiferin, stigmasterol and β-sitosterol.

关键词： Anti-diabetic Dipeptidyl peptidase IV In silico In vitro Urena lobata

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Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1568-1577页

作者： Seskoati prayitnaningsih Hidayat Sujuti Maksum Effendi Aulia Abdullah Nanda Wahyu Anandita Febriani Yohana Nur permatasari Mohamad aris Widodo Department of Ophthalmology Faculty of MedicineBrawijaya University pharmacology Laboratory Faculty of MedicineBrawijaya University

AIM： To evaluate effect of hypertension on retinal ganglion cell（RGC） apoptosis, intraocular pressure（IOp）,and the activation of endothelin-1（ET-1） signaling pathway in central retinal artery（CRA） in ***： The experimental study was performed on20 male Sprague Dawley rats that were divided into control group, and hypertension groups. The hypertension was induced by subcutaneous deoxycorticoacetate（DOCA）10 mg/kg twice a week and administered 0.9% Na Cl solution daily for 2, 6, and 10 wk. Blood pressure（Bp） was measured using animal Bp analyzer. IOp was measured by handheld tonometry. Retinal tissue preparations by paraffin blocks were made after enucleation. The expression of ET-1, e NOS, ET-1 receptor A（ETRA）, ET-1receptor B（ETRB）, and phosphorylated myosin light chain kinase（MLCK）, and caldesmon（Ca D） in CRA and RGC apoptosis were evaluated through immunofluorescent staining method then observed using laser scanning confocal microscopy. RESULTS： Bp significantly increased in all of the hypertension groups compared to control（p =0.001）.peak IOp elevation（7.78±4.14 mm Hg） and RGC apoptosis（576.15±33.28 Au） occurred on 2wk of hypertension. ET-1expression（1238.6±55.1 Au） and e NOS expression（2814.2±70.7 Au） were found highest in 2wk of hypertension,although the ratio of ET-1/e NOS decreased since *** peak expression in 10 wk of hypertension（1219.4 ±6.3 Au）, while ETRBsignificantly increased only in 2 weeks group（1069.2 ±9.6 Au）. The highest MLCK expression（1190.09±58.32 Au）, Ca D（1670.28±18.36 Au）were also found in 2wk of ***： Hypertension effects to activation of ET-1 signaling pathway significantly in CRA, elevation of IOp, and RGC apoptosis. The highest value was achieved at 2wk, which is the development phase of hypertension.

关键词： hypertension central retinal artery endothelin- 1 signaling pathway rats

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