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SARS-CoV-2 infection of monocytes:balancing acts of antibodies and inflammasomes

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2668-2669页

作者： R.Camille Brewer William H.Robinson Tobias V.lanz Division of Immunology and Rheumatology Department of MedicineStanford University School of Medicine269 Campus DriveStanfordCA 94305USA Geriatric Research Educationand Clinical Centers(GRECC)VA Palo Alto Health Care System3801 Miranda AvePalo AltoCA 94304USA

In a recent study in Nature,Junqueira et *** evidence that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infects human monocytes and lung macrophages.1 The infection is antibody-mediated via Fc-receptors(FcγRs),and activates NLRP3 and AIM2 inflammasomes,which in turn induce pyroptosis and halt viral *** monocytes secrete the proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,which contribute to systemic inflammation and severe coronavirus disease 19(COVID-19)(Fig.1).

关键词： NLRP3 monocytes infection

Domestic Violence and Alcohol and Illegal Drugs Consumption in Mexican Youth

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Journal of Health Science 2014年第10期2卷 476-486页

作者： Patricia Martinez lanz Centro Anahuac de lnvestigacion en Psicologla Universidad Anahuac Mexico Norte Avenida Universidad Anahuac 46 LomasAnahuac 52786 Estado de Mexico Mexico

The objective of this research was to analyze the differences between domestic violence and different levels of alcohol and illegal drug use in young people. A nonrandom sample of 509 young people were selected, with an age range of 12-25 years （M = 15.46）, 44.2% men and 55.8% women. A scale that assessed domestic violence, composed by 4 areas and 16 tested reagents was used： verbal aggression, physical aggression, humiliation and respect （ct = 0.72）; substance use was assessed using 13 indicators on frequency and quantity. The results showed that 40.7% of participants had consumed alcohol at some time in their life and 19.4% illegal drugs. An indicator of substance use was designed, combining presence-absence of consumption and in the case of illegal drugs, considering the number of drugs, which resulted in five categories that ranged from not consumption, consume of alcohol only and illegal drugs. The analysis of the differences between domestic violence by consumption category, showed significant differences, where young people who not consumed alcohol or illegal drugs, were those who scored lower on domestic violence compared to those who reported using any substance.

关键词： Alcohol illegal drugs family violence youth.

Target-oriented robust optimization of a microgrid system investment model

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Frontiers in Energy 2018年第3期12卷 440-455页

作者： lanz UY Patric UY Jhoenson SIY Anthony Shun Fung CHIU Charlle SY Department of Industrial Engineering De La Salle University Manila1004 the Philippines

An emerging alternative solution to address energy shortage is the construction of a microgrid system. This paper develops a mixed-integer linear programming microgrid investment model considering multi-period and multi-objective investment setups. It further investigates the effects of uncertain demand by using a target-oriented robust optimization （TORO） approach. The model was validated and analyzed by subjecting it in different scenarios. As a result, it is seen that there are four factors that affect the decision of the model： cost, budget, carbon emissions, and useful life. Since the objective of the model is to maximize the net present value （NPV） of the system, the model would choose to prioritize the least cost among the different distribution energy resources （DER）. The effects of load uncertainty was observed through the use of Monte Carlo simulation. As a result, the deterministic model shows a solution that might be too optimistic and might not be achievable in real life situations. Through the application of TORO, a profile of solutions is generated to serve as a guide to the investors in their decisions considering uncertain demand. The results show that pessimistic investors would have lower NPV targets since they would invest more in storage facilities, incurring more electricity stock out costs. On the contrary, an optimistic investor would tend to be aggressive in buying electricity generating equipment to meet most of the demand, however risking more storage stock out costs.

关键词： microgrid renewable resources robust optimization target-oriented robust optimization

Principal Component Analysis of Male Criminal Behavior

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Health 2021年第10期13卷 1112-1128页

作者： Patricia Martínez-lanz Carlos Cuevas-Covarrubias Patricia Hernández-Valdez Interdisciplinary Research Center Universidad Anáhuac México Mexico City Mexico Research Center of Statistics and Applied Mathematics Universidad Anáhuac México Mexico City Mexico

The present study was conducted in order to establish factors that can potentially facilitate crime, as well as the status of the emotional wellbeing presented in the prison population. The sample was composed of 358 inmates of the Federal Center for Social Rehabilitation number 7 in Mexico. A questionnaire was specifically developed;it evaluated sociodemographic factors and Likert scales of substance intake, domestic violence, and depressive symptoms. Validity and reliability (Cronbach’s Alpha = 0.703) of the instrument showed appropriate relations between the reagents of the scales;results showed—through Chi-Square analysis—statistically significant differences in the correlations between sociodemographic factors, domestic violence, addictions, and depressive symptoms. Although results showed a connection between domestic violence and substance abuse with criminal behavior, low socioeconomic conditions exhibited a higher degree of correlation with criminal activity. On the other hand, high depression symptoms are present in one out of every five inmates.

关键词： Delinquency Addictions Violence Depression Crime Criminal Behavior Prison Population Wellbeing

Microstructure Evolution of a Nickel-Base Alloy Resistant to High Temperature during Aging

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Journal of Minerals and Materials Characterization and Engineering 2016年第1期4卷 48-61页

作者： Alberto Carlos Picasso César Armando lanz Matías Sosa Lissarrague Aldo Daniel Garófoli Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CICPBA) Universidad Nacional del Sur Bahía Blanca Argentina

In the present study, the microstructural evolution during aging at 1023, 1073, 1123 and 1173 K of a 35Cr-45Ni heat resistant alloy, produced in the form of centrifugally cast tubes, was characterized by means of light optical microscopy, scanning electron microscopy (SEM) with secondary and backscattered electron imaging, energy-dispersive X-ray spectroscopy (EDS) and Vickers hardness tests. The evolution of the Vickers hardness at 1023 K for aged samples shows that the microstructure is stable during the analyzed aging period. At 1073 K, the rate of increase in hardness is lower than 1023 K and this behavior would be associated with morphological changes observed in primary interdendritic carbides and secondary carbides in the matrix. At 1123 K and 1173 K, an atypical behavior in Vickers hardness curve is presented;where it can be seen that at certain aging times, the hardness decreases significantly. A microstructural analysis of these samples indicates that they have a region free of precipitates (near interdendritic edges) where the hardness is lower. Probably, these regions are areas poor in chromium.

关键词： Microstructural Characterization 35Cr-45Ni Alloy Aging Precipitation Depleted Zones

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沉睡的鸽子

琴童 2020年第11期 6-9页

作者： David lanz(曲) 不详

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克隆：保护濒危物种的诺亚方舟

科学（中文版） 2001年第2期 52-57页

作者： lanz.,RP 谢新耀等 ACT医疗与科技开发部

Relevance of Family in Academic Success on Children

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Health 2017年第2期9卷 279-288页

作者： Patricia Martínez lanz Ana Cristina Losada Fernández Fabiola Pecchioni Fernández Martha Patricia Hernández Valdez Universidad Aná huac Mé xico M&eacute xico City M&eacute xico

The purpose of this study was to analyze the relationship between academic success and functional and dysfunctional families. A non-experimental, cross-sectional, descriptive correlational design was used. A convenience sample of 200 children between 6 and 13 years old, primary and junior high school students was conducted (32.3% were female and 67.7% were male). To assess the relationship, a study case of 21 reagents was designed to empty the obtained information from medical review records from a psychopedagogic clinic. Academic success was measured as from the revision of informal tests and standardized tests. Results showed that the population levels of academic success were average. However, a significant relationship between the age of the parents and the level of academic success was found, indicating that these variables are associated with this problem. Besides that, it was found that there is a tendency in children with cognitive, emotional and sensory problems reflected in low academic success. The findings provide information that could be considered for the development of programs of psychopedagogic intervention to treat children with learning disabilities and low academic success.

关键词： Academic Success Low Academic Success Functional Family Dysfunctional Family Children

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导电性变化的分析作为乳中乳酸菌的生长指标

农业科技译丛（湛江） 1995年第A1期7卷 1-4页

作者： lanz.,M 郭晋杰

分析导电性变化是评价乳中服酸菌生长和活力的一种有效方法，该技术可监测纯菌株，控制混合培养的菌种稳定性，导电仪方法特别适用于乳品工业中控制乳酸菌引酵物的稳定性。

关键词：导电性乳酸菌活力乳