SARS-CoV-2 infection of monocytes:balancing acts of antibodies and inflammasomes

作     者：R.Camille Brewer William H.Robinson Tobias V.Lanz 

作者机构：Division of Immunology and RheumatologyDepartment of MedicineStanford University School of Medicine269 Campus DriveStanfordCA 94305USA Geriatric ResearchEducationand Clinical Centers(GRECC)VA Palo Alto Health Care System3801 Miranda AvePalo AltoCA 94304USA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第8期

页      面：2668-2669页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：NLRP3 monocytes infection 

摘      要：In a recent study in Nature,Junqueira et *** evidence that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infects human monocytes and lung macrophages.1 The infection is antibody-mediated via Fc-receptors(FcγRs),and activates NLRP3 and AIM2 inflammasomes,which in turn induce pyroptosis and halt viral *** monocytes secrete the proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,which contribute to systemic inflammation and severe coronavirus disease 19(COVID-19)(Fig.1).