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Depressive Symptom Endorsement among Alzheimer’s Disease, Vascular Dementia and Mild Cognitive Impairment

Open Journal of Medical Psychology 2012年第3期1卷 32-37页

作者： James R. Hall Leigh Johnson april wiechmann Robert C. Barber Sid O’Bryant Department of Psychiatry Behavioral Health and Clinical Neuroscience University of North Texas Health Sciences Center Fort Worth USA Department of Psychiatry Behavioral Health and Clinical Neuroscience University of North Texas Health Sciences Center Fort Worth USADepartment of Internal Medicine University of North Texas Health Science Center Fort Worth USA Institute of Aging and Alzheimer’s Disease Research University of North Texas Health Science Center Fort Worth USADepartment of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth USA Institute of Aging and Alzheimer’s Disease Research University of North Texas Health Science Center Fort Worth USADepartment of Psychiatry Behavioral Health and Clinical Neuroscience University of North Texas Health Sciences Center Fort Worth USA

Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore differences in the presentation of depressive symptoms in various types of cognitive impairment. Method: Retrospective chart review was conducted on 254 consecutive cases of community dwelling elderly newly diagnosed with mild Alzheimer’s Dementia (AD) n = 122, mild Vascular Dementia (VaD) n = 71 or Amnestic Mild Cognitive Impairment (aMCI) n = 32 and Non-Amnestic MCI (nMCI) n = 29. Results: Analysis revealed no significant differences (p 05). No statistically significant differences were found between VaD and nMCI or between the MCI groups. Conclusions: Support is provided for the use of GDS subscales in a wide range of cognitively impaired elderly. This study suggests in mild dementia the number and type of depressive symptoms vary significantly between AD and VaD. There are indications that aMCI patients are similar in their symptom endorsement to AD and nMCI are similar to VaD which is consistent with some of the notions regarding likely trajectories of the respective MCI groups.

关键词： Depression Cognitive Impairment Alzheimer’s Vascular Dementia Mild Cognitive Impairment

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让46万人抢着买会员，老乡鸡凭啥？

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销售与市场 2024年第19期 100-103页

作者： april

老乡鸡的会员运营堪称行业标杆，但老乡鸡能走到今天，绝不是因此而已。这几天，老乡鸡又出圈了！原因是，老乡鸡最近办“超级会员节”，为了感谢会员们长期以来的陪伴，老乡鸡给999名持有超级会员身份时间最长的超级老乡邮寄了专属大...

老乡鸡的会员运营堪称行业标杆，但老乡鸡能走到今天，绝不是因此而已。这几天，老乡鸡又出圈了！原因是，老乡鸡最近办“超级会员节”，为了感谢会员们长期以来的陪伴，老乡鸡给999名持有超级会员身份时间最长的超级老乡邮寄了专属大礼包—“超会包”。会员们惊喜之余，将“超会包”晒到网上，引起了不少网友的羡慕。“超会包”里不仅有定制的扇子、钥匙扣、大鸡腿抱枕等常规周边，还有定制的88元会员卡、刮刮乐和超级会员定制手提袋。就连手提袋上的字“我超会的”，“超会”两个字都是超级会员的缩写，象征着老乡鸡超级会员身份的专属手提袋，可以说是相当有心了。

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Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining-another cause for diagnostic overlap:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3200-3205页

作者： Maria Bernadette Che-Ying Chow Lucas Bushrow Irmeen Siddiqui april Chiu Mirza Hamirani Anjali A Satoskar Department of Pathology The Ohio State University Medical CenterColumbusOH 43210United States Department of Pathology North District HospitalSheung ShuiHong KongChina Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine S.Joseph's HospitalParkersburgWV 26101United States

BACKGROUND Glomerulopathy with fibrillary deposits is not uncommon in routine nephropathology practice,with amyloidosis and fibrillary glomerulonephritis being the two most frequently encountered *** amyloid heavy and light chain(AHL)is relatively uncommon and its biopsy diagnosis is usually limited to cases that show strong equivalent staining for a single immunoglobulin(Ig)heavy chain and a single light chain,further supported by mass spectrometry(MS)and serum studies for monoclonal *** polyclonal light chain staining can pose a *** SUMMARY Herein we present a challenging case of renal AHL with polyclonal and polytypic Ig gamma(IgG)staining pattern by *** patient is a 62-yearold Caucasian male who presented to an outside institution with a serum creatinine of up to 8.1 mg/dL and nephrotic range *** the finding of a polyclonal and polytypic staining pattern on immunofluorescence,ultrastructural study of the renal biopsy demonstrated the presence of fibrils with a mean diameter of 10 *** red was positive while DNAJB9 was *** suggested a diagnosis of amyloid AHL type with IgG and lambda,but kappa light chains were also present supporting the immunofluorescence staining *** immunofixation studies demonstrated IgG lambda monoclonal *** patient was started on *** chronic renal injury however was quite advanced and he ended up needing dialysis shortly *** Tissue diagnosis of AHL amyloid can be *** confirmation using other available diagnostic techniques is recommended in such cases.

关键词： Heavy and light chain amyloid Fibrillary glomerulonephritis DNAJB9 Serum immunofixation Protein electrophoresis Mass spectrometry Congo red Case report

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CONCURRENT PRODUCT PORTFOLIO PLANNING AND MIXED PRODUCT ASSEMBLY LINE BALANCING

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Chinese Journal of Mechanical Engineering 2007年第1期20卷 96-99页

作者： BRYAN april HU S Jack KOREN Yoram Department of Mechanical Engineering University of Michigan Ann Arbor USA

Reconfigurable products and manufacturing systems have enabled manufacturers to provide ＂cost effective＂ variety to the market. In spite of these new technologies, the expense of manufacturing makes it infeasible to supply all the possible variants to the market for some industries. Therefore, the determination of the right number of product variantsto offer in the product portfolios becomes an important consideration. The product portfolio planning problem had been independently well studied from marketing and engineering perspectives. However, advantages can be gained from using a concurrent marketing and engineering approach. Concurrent product development strategies specifically for reconfigurable products and manufacturing systems can allow manufacturers to select best product portfolios from marketing, product design and manufacturing perspectives. A methodology for the concurrent design of a product portfolio and assembly system is presented. The objective of the concurrent product portfolio planning and assembly system design problem is to obtain the product variants that will make up the product portfolio such that oversupply of optional modules is minimized and the assembly line efficiency is maximized. Explicit design of the assembly system is obtained during the solution of the problem. It is assumed that the demand for optional modules and the assembly times for these modules are known a priori. A genetic algorithm is used in the solution of the problem. The basic premise of this methodology is that the selected product portfolio has a significant impact on the solution of the assembly line balancing problem. An example is used to validate this hypothesis. The example is then further developed to demonstrate how the methodology can be used to obtain the optimal product portfolio. This approach is intended for use by manufacturers during the early design stages of product family design.

关键词： Product portfolio Assembly system design Assembly line balancing Concurrent design and manufacturing Optimization

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Inactivation, reactivation and regrowth of indigenous bacteria in reclaimed water after chlorine disinfection of a municipal wastewater treatment plant

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Journal of Environmental Sciences 2013年第7期25卷 1319-1325页

作者： Dan Li Siyu Zeng april Z. Gu Miao He Hanchang Shi Environmental Simulation and Pollution Control State Key Joint Laboratory School of Environment Tsinghua University Department of Civil and Environmental Engineering Northeastern University

Disinfection of reclaimed water prior to reuse is important to prevent the transmission of pathogens. Chlorine is a widely utilized disinfectant and as such is a leading contender for disinfection of reclaimed water. To understand the risks of chlorination resulting from the potential selection of pathogenic bacteria, the inactivation, reactivation and regrowth rates of indigenous bacteria were investigated in reclaimed water after chlorine disinfection. Inactivation of total coliforms, Enterococcus and Salmonella showed linear correlations, with constants of 0.1384, 0.1624 and 0.057 L/（mg·min） and R 2 of 0.7617, 0.8316 and 0.845, respectively. However, inactivation of total viable cells by measurement of metabolic activity typically showed a linear correlation at lower chlorine dose （0-22 （mg·min）/L）, and a trailing region with chlorine dose increasing from 22 to 69 （mg·min）/L. Reactivation and regrowth of bacteria were most likely to occur after exposure to lower chlorine doses, and extents of reactivation decreased gradually with increasing chlorine dose. In contrast to total coliforms and Enterococcus, Salmonella had a high level of regrowth and reactivation, and still had 2% regrowth even after chlorination of 69 （mg·min）/L and 24 hr storage. The bacterial compositions were also significantly altered by chlorination and storage of reclaimed water, and the ratio of Salmonella was significantly increased from 0.001% to 0.045% after chlorination of 69 （mg·min）/L and 24 hr storage. These trends indicated that chlorination contributes to the selection of chlorine-resistant pathogenic bacteria, and regrowth of pathogenic bacteria after chlorination in reclaimed water with a long retention time could threaten public health security during wastewater reuse.

关键词： inactivation regrowth reactivation indigenous bacteria reclaimed water

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Efficient training of ANN potentials by including atomic forces via Taylor expansion and application to water and a transition-metal oxide

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npj Computational Materials 2020年第1期6卷 1205-1218页

作者： april M.Cooper Johannes Kästner Alexander Urban Nongnuch Artrith School of Chemistry University of St AndrewsSt AndrewsUK Institute for Theoretical Chemistry University of StuttgartStuttgartGermany Department of Chemical Engineering Columbia UniversityNew YorkNYUSA

Artificial neural network(ANN)potentials enable the efficient large-scale atomistic modeling of complex materials with near firstprinciples *** molecular dynamics simulations,accurate energies and interatomic forces are a prerequisite,but training ANN potentials simultaneously on energies and forces from electronic structure calculations is computationally ***,we introduce an efficient alternative method for the training of ANN potentials on energy and force information,based on an extrapolation of the total energy via a Taylor *** translating the force information to approximate energies,the quadratic scaling with the number of atoms exhibited by conventional force-training methods can be avoided,which enables the training on reference datasets containing complex atomic structures.

关键词： forces enable atomic

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Evaluation of the infectivity,gene and antigenicity persistence of rotaviruses by free chlorine disinfection

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Journal of Environmental Sciences 2011年第10期23卷 1691-1698页

作者： Dan Li april Z. Gu Siyu Zeng Wan Yang Miao He Hanchang Shi Environmental Simulation and Pollution Control （ESPC） State Key Joint Laboratory School of Environment Tsinghua University Beijing 100084 China Department of Civil and Environmental Engineering Northeastern University Boston MA 02115 USA

The effects of free chlorine disinfection of tap water and wastewater effluents on the infectivity, gene integrity and surface antigens of rotaviruses were evaluated by a bench-scale chlorine disinfection experiments. Plaque assays, integrated cell culture-quantitative RT- PCR （ICC-RT-qPCR）, RT-qPCR, and enzyme-linked immunosorbent assays （ELISA）, respectively, were used to assess the influence of the disinfectant on virus infectivity as well as genetic and antigenic integrity of simian rotavirus SA11 as a surrogate for human rotaviruses. The ICC-RT-qPCR was able to detect rotaviruses survival from chlorine disinfection at chlorine dose up to 20 mg/L （60 min contact）, which suggested a required chlorine dose of 5 folds （from 1 to 5 mg/L） higher than that indicated by the plaque assay to achieve 1.8 log10 reductions in tap water with 60 rain exposing. The VP7 gene was more resistant than the infectivity and existed at chlorine dose up to 20 mg/L （60 min contact）, while the antigencity was undetectable with chlorine dose more than 5 mg/L （60 min contact）. The water quality also impacted the inactivation efficiencies, and rotaviruses have a relatively higher resistant in secondary effluents than in the tap water under the same chlorine disinfection treatments. This study indicated that rotaviruses have a higher infectivity, gene and antigencity resistance to chlorine than that previously indicated by plaque assay only, which seemed to underestimate the resistance of rotaviruses to chlorine and the risk of rotaviruses in environments. Present results also suggested that re-evaluation of resistance of other waterborne viruses after disinfections by more sensitive infectivity detection method （such as ICC-RT-qPCR） may be necessary, to determine the adequate disinfectant doses required for the inactivation of waterborne viruses.

关键词： rotaviruses free chlorine disinfection infectivity genes antigenicity ICC-RT-qPCR

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Blue Electrogenerated Chemiluminescence from Halide Perovskite Nanocrystals

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Journal of Analysis and Testing 2019年第2期3卷 125-133页

作者： Yiliyasi Wusimanjiang Jeetika Yadav Victoria Arau april ESteen Nathan IHammer Shanlin Pan Department of Chemistry and Biochemistry The University of AlabamaTuscaloosaAL 35487USA Chemistry and Biochemistry The University of MississippiOxfordMS 38677USA

Electrogenerated chemiluminescence(ECL)has been extensively used in ultrasensitive electroanalysis because it can be generated electrochemically without using expensive optics and light *** ECL emission can be obtained with a reasonable quantum yield and *** ECL is rare and often suffers from stability and poor quantum *** ECL emission at 473 nm from organometallic halide perovskite nanocrystals(PNCs),CH_(3)NH_(3)PbCl_(1.08)Br_(1.92),is reported here for the first time using tripropylamine(TPrA)as *** blue ECL emission peak resembles its photoluminescence peak *** addition to this blue emission peak,the ECL spectra of CH_(3)NH_(3)PbCl_(1.08)Br_(1.92) PNCs also showed a broad ECL peak at 745 *** of the second ECL peak at 745 nm from CH_(3)NH_(3)PbCl_(1.08)Br_(1.92) PNCs was can be explained by the existence of surface trap states on as-synthesized PNC due to incomplete surface *** anion tunability of ECL emission from CH3NH3PbX3(X:Cl,Br,I)PNCs is also *** fluorescence microscopy image of single PNC and stability of selected single PNCs are presented in this with simultaneous acquisition of fluorescence spectra using 405-nm laser *** photoluminescence(PL)decay was described by PL lifetime(τ)of 1.2 *** effect of the addition of surfactants(oleic acid and n-octylamine)on the fluorescence intensity and stability of CH_(3)NH_(3)PbCl_(1.08)Br_(1.92) PNCs is also discussed.

关键词： ECL(electrogenerated chemiluminescence) Photoluminescence(PL) Perovskite nanocrystals(PNCs) Blue light emission Photoluminescence quantum yield(PLQY) Surfactants

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Risk of ischaemic and haemorrhagic stroke in Chinese undergoing percutaneous coronary intervention treated with potent P2Y12 inhibitor versus clopidogrel

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Stroke & Vascular Neurology 2022年第4期7卷 310-318,I0015-I0019页

作者： Andrew Kei-Yan Ng Pauline Yeung Ng april Ip Kui Kai Lau Chung-Wah Siu Cardiac Medical Unit Grantham HospitalHong KongHong Kong Department of Adult Intensive Care Queen Mary HospitalHong KongHong Kong Department of Medicine The University of Hong KongHong KongHong Kong The State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong KongHong Kong

Background Stroke after acute coronary syndrome(ACS)can be *** is uncertain whether the risks of ischaemic stroke or intracranial haemorrhage(ICH)are associated with different choices of P2Y12 inhibitors(potent P2Y12 inhibitors such as ticagrelor and prasugrel vs clopidogrel).Even though East Asians are known to have different thrombotic and haemorrhagic profiles from Caucasians,data on Chinese patients are *** This was a retrospective cohort study conducting in Chinese patients with ACS who underwent first-ever percutaneous coronary intervention from 14 hospitals in Hong Kong between 2010 and *** primary efficacy endpoint was ischaemic *** secondary efficacy endpoint was a composite outcome of thrombotic events including all-cause mortality,non-fatal myocardial infarction and ischaemic *** primary safety endpoint was *** secondary safety endpoint was a composite of major bleeding *** After adjustment of baseline characteristics by 1:1 propensity score matching,a total of 6220 patients(3110 on each group)were *** with clopidogrel,potent P2Y12 inhibitors were associated with a lower risk of ischaemic stroke(HR 0.57;95%CI 0.37 to 0.87;p=0.008)and a lower risk of thrombotic events(HR 0.77;95%CI 0.66 to 0.90;p=0.001).Potent P2Y12 inhibitor was associated with similar risk of ICH(HR 0.65;95%CI 0.34 to 1.25,p=0.20)and major bleeding(HR 0.83;95%CI 0.68 to 1.01,p=0.069).Conclusions Potent P2Y12 inhibitors were associated with a lower adjusted risk of ischaemic stroke and thrombotic events,compared with *** risks of ICH and major bleeding were similar.

关键词： P2Y12 coronary haemorrhagic

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In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering

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Bioactive Materials 2018年第1期3卷 19-27页

作者： Chuying Ma Ethan Gerhard Qiaoling Lin Silun Xia april Dawn Armstrong Jian Yang Department of Biomedical Engineering Materials Research InstituteThe Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA CATS College CanterburyKent CT13LQUK Department of Orthopaedics and Rehabilitation College of MedicineThe Pennsylvania State UniversityHersheyPA 17033USA

Citrate based polymer poly(octamethylene citrate)(POC)has shown promise when formulated into composite material containing up to 65 wt%hydroxylapatite(HA)for orthopedic *** significant research into POC,insufficient information about the biocompatibility of the monomers 1,8-Octanediol and Citrate used in its synthesis is ***,we investigated the acute cytotoxicity,immune response,and long-term functionality of both *** results showed a cell-type dependent cytotoxicity of the two monomers:1,8-Octanediol induced less acute toxicity to 3T3 fibroblasts than Citrate while presenting comparable cytotoxicity to MG63 osteoblast-like cells;however,Citrate demonstrated enhanced compatibility with hMSCs compared to 1,*** critical cytotoxic concentration values EC30 and EC50,standard for comparing cytotoxicity of chemicals,were also ***,Citrate showed slower and less inhibitory effects on long-term hMSC cell proliferation compared with 1,***,osteogenic differentiation of hMSCs exposure to Citrate resulted in less inhibitory effect on alkaline phosphatase(ALP)*** monomer triggered undesired pro-inflammatory *** combination with diffusion model analysis of monomer release from cylindrical implants,based on which the maximum concentration of monomers in contact with bone tissue was estimated to be 2.2104 mmol/L,far lower than the critical cytotoxic concentrations as well as the 1,8-Octanediol concentration(0.4 mg/mL or 2.7 mmol/L)affecting hMSCs differentiation,we provide strong evidence for the cytocompatibility of the two monomers degraded from citrate-based composites in the orthopedic setting.

关键词： Biodegradable Poly(octamethylene citrate) Citrate 1,8-Octanediol Cytocompatibility Osteogenic differentiation Surface erosion

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