Depressive Symptom Endorsement among Alzheimer’s Disease, Vascular Dementia and Mild Cognitive Impairment

作     者：James R. Hall Leigh Johnson April Wiechmann Robert C. Barber Sid O’Bryant 

作者机构：Department of Psychiatry Behavioral Health and Clinical Neuroscience University of North Texas Health Sciences Center Fort Worth USA Department of Psychiatry Behavioral Health and Clinical Neuroscience University of North Texas Health Sciences Center Fort Worth USADepartment of Internal Medicine University of North Texas Health Science Center Fort Worth USA Institute of Aging and Alzheimer’s Disease Research University of North Texas Health Science Center Fort Worth USADepartment of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth USA Institute of Aging and Alzheimer’s Disease Research University of North Texas Health Science Center Fort Worth USADepartment of Psychiatry Behavioral Health and Clinical Neuroscience University of North Texas Health Sciences Center Fort Worth USA 

出 版 物：《Open Journal of Medical Psychology》 (医学心理学（英文）)

年 卷 期：2012年第1卷第3期

页      面：32-37页

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Depression Cognitive Impairment Alzheimer’s Vascular Dementia Mild Cognitive Impairment 

摘      要：Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore differences in the presentation of depressive symptoms in various types of cognitive impairment. Method: Retrospective chart review was conducted on 254 consecutive cases of community dwelling elderly newly diagnosed with mild Alzheimer’s Dementia (AD) n = 122, mild Vascular Dementia (VaD) n = 71 or Amnestic Mild Cognitive Impairment (aMCI) n = 32 and Non-Amnestic MCI (nMCI) n = 29. Results: Analysis revealed no significant differences (p 05). No statistically significant differences were found between VaD and nMCI or between the MCI groups. Conclusions: Support is provided for the use of GDS subscales in a wide range of cognitively impaired elderly. This study suggests in mild dementia the number and type of depressive symptoms vary significantly between AD and VaD. There are indications that aMCI patients are similar in their symptom endorsement to AD and nMCI are similar to VaD which is consistent with some of the notions regarding likely trajectories of the respective MCI groups.