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Effects of albendazole,artesunate,praziquantel and miltefosine,on Opisthorchis viverrini cercariae and mature metacercariae

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 120-126页

作者： Phornphitcha Pechdee Monticha Chaiyasaeng Chanisala Sereewong Jukkrid Chaiyos apiporn suwannatrai Sutee Wongmaneeprateep Smarn Tesana Food-Borne Parasite Research Group Department of ParasitologyFaculty of MedicineKhon Kaen University Department of Fisheries Faculty of AgricultureKhon Kaen University

Objective:To explore larvicidal effects of anthelmintic drugs on Opisthorchis viverrini(***) for alternative approach to interrupting its cycle for developing a field-based control ***:The larvicidal activities of albendazole(A1),artesunate(Ar),praziquantel(Pzq) and miltefosine(Mf) on *** cercariae and mature metacercariae were *** concentrations(LC_(50) and LC_(95)) of these drugs were *** metacercariae previously exposed to various concentrations of the drugs were administered to *** were harvested 30 d post infection and worm recovery rates ***,Ar,Pzq and Mf produced morphological degeneration and induced shedding tails of cercariae after 24 h ***:The LC_(50) and LC_(95) of Al,Ar,Pzq and Mf on cercariae were 0.720 and 1.139,0.350 and 0.861,0.017 and 0.693,and 0.530 and 1.134 ppm,***_(50) and LC_(95) of Ar on mature metacercariae were 303.643 and 446.237 ppm and of Mf were 289.711 and 631.781 ppm,respectively but no lethal effect in Pzq-and Al-treated groups(up to 1 ppt).No worms were found in hamsters administered Pzq-treated *** adult worms from Al-treated metacercariae were significantly bigger in size compared to the control group(P<0.05).Fecundity and body width were greater in adults from Mf-treated metacercariae compared to the control group(P<0.05).Conclusions:The larvicidal effects of these drugs were high efficacy to *** cercariae but lesser efficacy to *** should be further studied with the eventual aim of developing a field-based control program.

关键词： Albendazole Artesunate Praziquantel Miltefosine Opisthorchis viverrini Cercariae

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Repeated praziquantel treatment and Opisthorchis viverrini infection:a population-based cross-sectional study in northeast Thailand

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Infectious Diseases of Poverty 2019年第2期8卷 34-42页

作者： Kavin Thinkhamrop Narong Khuntikeo Paiboon Sithithaworn Wilaiphorn Thinkhamrop Kinley Wangdi Matthew J.Kelly apiporn T.suwannatrai Darren J.Gray Cholangiocarcinoma Screening and Care Program(CASCAP) Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Data Management and Statistical Analysis Center(DAMASAC) Faculty of Public HealthKhon Kaen UniversityKhon Kaen 40002Thailand Department of Surgery Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Parasitology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Global Health Research School of Population HealthAustralian National UniversityCanberraACT 2601Australia

Background:Opisthorchis viverrini infection is highly prevalent in northeast *** liver fluke is classified as a carcinogen due to its causal links with cholangiocarcinoma(CCA)*** treatment with praziquantel(PZQ)effectively cures *** infection,the prevalence remains high due to the traditional consumption of raw ***,re-infection is common in the endemic community,leading to severe hepatobiliary morbidities including the fatal *** this study,we evaluate the association between the frequency of previous PZQ treatment and current *** infections among Thai adults living in the endemic area of northeast ***:This study includes all participants who were screened for *** infection in the Cholangiocarcinoma Screening and Care Program(CASCAP),northeast *** of PZQ treatment was recorded using a health *** infections were diagnosed using urine antigen *** between PZQ and *** were determined by adjusted odds ratio(aOR)and 95%confidence interval(CI)using multiple logistic ***:Among participants,27.7%had previously been treated once with PZQ,8.2%twice,2.8%three times,and 3.5%more than three *** *** prevalence was 17%(n=524).Compared with participants who never used PZQ,the aOR for infection among those who used the drug once was 1.09(95%CI:0.88-1.37),twice was 1.19(95%CI:0.85-1.68),three times was 1.28(95%C/:0.74-2.21),and more than three times was 1.86(95%C/:1.18-2.93;P=0.007).Conclusions:The population with a frequent history of PZQ use and still continued raw fish consumption showed high levels of repeated reinfection with *** were infected,treated and re-infected *** findings suggest that certain participants continue raw fish consumption even after previous *** is a particular problem in highly endemic areas for *** and increases the risk of CCA.

关键词： Praziquantel Opisthorchis viverrini Screening Urine Thailand

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Correction to:Repeated praziquantel treatment and Opisthorchis viverrini infection:a population-based crosssectional study in northeast Thailand

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Infectious Diseases of Poverty 2019年第3期8卷 108-108页

作者： Kavin Thinkhamrop Narong Khuntikeo Paiboon Sithithaworn Wilaiphorn Thinkhamrop Kinley Wangdi Matthew J.Kelly apiporn T.suwannatrai Darren J.Gray Cholangiocarcinom a Screening and Care Program(CASCAP) Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Data Managem ent and Statistical Analysis Center(DAMASAC) Faculty of Public HealthKhon Kaen UniversityKhon Kaen 40002Thailand Department of Surgery Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Parasitology Faculty of MedicineKhon KaenUniversityKhon Kaen 40002Thailand Department of Global Health Research School of Population HealthAustralian National UniversityCanberra ACT 2601Australia

In the original publication of this article[1],there is an error in the section of‘Ethics approval and consent to participate’at the end of the article,the correct Ethics reference number should be HE551404 rather t... 详细信息

关键词： approval treatment northeast

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