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Fine-scale evolutionary genetic insights into Anopheles gambiae X-chromosome

Journal of Biomedical Science and Engineering 2009年第5期2卷 304-311页

作者： Hemlata Srivastava Jyotsana dixit Aditya P. Dash Aparup Das Evolutionary Genomics and Bioinformatics Laboratory National Institute of Malaria Research Sector 8 Dwarka New Delhi-110 077 India Present address: World Health Organization Southeast Asian Regional Office New Delhi India

Understanding the genetic architecture of indi-vidual taxa of medical importance is the first step for designing disease preventive strategies. To understand the genetic details and evolu-tionary perspective of the model malaria vector, Anopheles gambiae and to use the information in other species of local importance, we scanned the published X-chromosome se-quence for detail characterization and obtain evolutionary status of different genes. The te-locentric X-chromosome contains 106 genes of known functions and 982 novel genes. Majori-ties of both the known and novel genes are with introns. The known genes are strictly biased towards less number of introns;about half of the total known genes have only one or two in-trons. The extreme sized (either long or short) genes were found to be most prevalent (58% short and 23% large). Statistically significant positive correlations between gene length and intron length as well as with intron number and intron length were obtained signifying the role of introns in contributing to the overall size of the known genes of X-chromosome in An. gam-biae. We compared each individual gene of An. gambiae with 33 other taxa having whole ge-nome sequence information. In general, the mosquito Aedes aegypti was found to be ge-netically closest and the yeast Saccharomyces cerevisiae as most distant taxa to An. gambiae. Further, only about a quarter of the known genes of X-chromosome were unique to An. gambiae and majorities have orthologs in dif-ferent taxa. A phylogenetic tree was constructed based on a single gene found to be highly orthologous across all the 34 taxa. Evolutionary relationships among 13 different taxa were in-ferred which corroborate the previous and pre-sent findings on genetic relationships across various taxa.

关键词： Anopheles gambiae Comparative Genomics Evolution Malaria Orthologous Genes X-chromosome

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Association of cannabis use disorder with atrial fibrillation in young men without concomitant tobacco use:Insights from nationwide propensity matched analysis

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World Journal of Experimental Medicine 2024年第3期14卷 64-71页

作者： Bhavin Patel Sumanth Khadke Kshitij Mahajan Avleen Dhingra Rishika Trivedi Samrath Singh Brar Sakshi dixit Vaibhav Periwal Shaylika Chauhan Rupak Desai Department of Internal Medicine Trinity Health Oakland HospitalPontiacMI 48341United States Lahey Hospital and Medical Center Division of Cardiovascular MedicineDepartment of MedicineBurlingtonMA 01805United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Department of Medicine Dayanand Medical College and HospitalLudhiana 141001PunjabIndia Department of Internal Medicine DHR HealthEdinburgTX 78539United States Department of Medicine Government Medical CollegePatiala 147001PunjabIndia Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States Independent Researcher Outcomes ResearchAtlantaGA 30079United States

BACKGROUND Recent data are inconclusive regarding the risk of arrhythmias among young cannabis ***,many young adults use both cannabis and tobacco,which could add a residual confounding effect on ***,we studied young men who have cannabis use disorder(CUD)excluding tobacco use disorder(TUD)to understand their independent association with atrial fibrillation(AF)and related *** To study the association of CUD with AF and related *** We used weighted discharge records from National Inpatient Sample(2019)to assess the baseline characteristics and mortality rates for AF-related hospitalizations in young(18-44 years)men in 1:1 propensity-matched CUD+vs CUD-cohorts without *** Propensity matched CUD+and CUD-cohorts consisted of 108495 young men in each *** analysis showed an increased incidence of AF in black population with *** addition,the CUD+cohort had lower rates of hyperlipidemia(6.4%vs 6.9%),hypertension(5.3%vs 6.3%),obesity(9.1%vs 10.9%),alcohol abuse(15.5%vs 16.9%),but had higher rates of anxiety(24.3%vs 18.4%)and chronic obstructive pulmonary disease(COPD)(9.8%vs 9.4%)compared to *** adjustment with covariates including other substance abuse,a non-significant association was found between CUD+cohort and AF related hospitalizations(odd ratio:1.27,95%confidence interval:0.91-1.78,P=0.15).CONCLUSION Among hospitalized young men,the CUD+cohort had a higher prevalence of anxiety and COPD,and slightly higher proportion of black *** there were higher odds of AF hospitalizations in CUD+cohort without TUD,the association was statistically *** subgroup analysis showed higher rates of AF in black ***-scale prospective studies are required to evaluate long-term effects of CUD on AF risk and prognosis without TUD and concomitant substance abuse.

关键词： Cannabis Marijuana Atrial fibrillation Tobacco use disorder Original research Smoking

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The Role of Prophylactic Antibiotics for Percutaneous Procedures in Orthopaedic Surgery

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Surgical Science 2011年第6期2卷 348-352页

作者： A. Gulati A. dixit D. M. Williamson Great Western Hospital Swindon and Marlborough NHS Trust UK

Introduction This study investigates the current practice of surgeons in the United Kingdom with regards to their usage of prophylactic antibiotics for percutaneous orthopaedic procedures. Methods An electronic survey of 10 questions was devised and sent to all members of the British Orthopaedic Association. Three hundred and three replies were obtained (172 consultants, 131 trainees). Results Only half the numbers of orthopaedic surgeons would routinely use antibiotics for percutaneous K-wire fixation. Of the other half, 28% would never prescribe antibiotics and 22% would use them in special circumstances only. These ‘special circumstances’ were also not standardised. 92% of those who did prescribe antibiotics would administer single dose only and the majority (90%) would administer them during induction. There was no significant difference between trainees and consultants or between different orthopaedic procedures with regards to whether prophylactic antibiotics were prescribed or not. Discussion This survey highlights the split of opinion amongst practising orthopaedic surgeons as to the necessity or otherwise of antibiotic prophylaxis in percutaneous orthopaedic procedures. There are no reliable guidelines and further work should be carried out to investigate this subject.

关键词： Prophylactic Antibiotics Percutaneous Procedures K-Wires

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法律缺失与经济学

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作者： (dixit Avinash K.)迪克西特

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仙茅:对健康有众多益处的黑金(英文)

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中西医结合学报 2010年第7期8卷 613-623页

作者： Nagendra Singh Chauhan Vikas Sharma Mayank Thakur Vinod Kumar dixit Department of Pharmaceutical Sciences Dr.Hari Singh Gour University

仙茅(石蒜科)是一种濒临灭绝的多年生草本植物,是印度本土药,作为强有力的适应原和春药在印度传统药物中占有重要位置。它也是多种印度传统药物处方的重要组成部分,被认为具有促进性欲、刺激免疫、保护肝脏、抗氧化、抗癌和治疗糖尿病... 详细信息

仙茅(石蒜科)是一种濒临灭绝的多年生草本植物,是印度本土药,作为强有力的适应原和春药在印度传统药物中占有重要位置。它也是多种印度传统药物处方的重要组成部分,被认为具有促进性欲、刺激免疫、保护肝脏、抗氧化、抗癌和治疗糖尿病等作用。已有报道,从仙茅中提取出多种化学成分,如植物黏胶,酚苷、皂苷和脂肪族化合物等。仙茅也是中医和日本汉方医学中各种草药处方的重要成分。本文对仙茅的多种生物活性和其不同化学成分的作用进行了综述。

关键词：仙茅催欲药医学,印度传统提取物

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提高认知能力的印度传统草药土丁桂(英文)

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中西医结合学报 2009年第11期7卷 1001-1022页

作者： Neeraj Kumar SETHIYA Alok NAHATA Sri Hari MISHRA Vinod Kumar dixit Herbal Drug Technology Labaratory Department of Pharmacy the Maharaja Sayajirao University of Baroda Vadodara Department of Pharmaceutical Sciences Dr. Hari Singh Gour Vishwavidyalaya Herbal Drug Technology Labaratory Department of Pharmacy the Maharaja Sayajirao Uniersity of Baroda

土丁桂属草药是作用于中枢神经系统的印度传统药物,特别是对促进记忆和改善智力有较好疗效。从印度传统医学和梵语文献中提取的大量信息提示,冠以土丁桂属草药名称的植物类别共4种:旋花科田旋花、旋花科土丁桂、蝶形花科蝴蝶花豆和龙胆... 详细信息

土丁桂属草药是作用于中枢神经系统的印度传统药物,特别是对促进记忆和改善智力有较好疗效。从印度传统医学和梵语文献中提取的大量信息提示,冠以土丁桂属草药名称的植物类别共4种:旋花科田旋花、旋花科土丁桂、蝶形花科蝴蝶花豆和龙胆科穿心草。这些草药名称均在古代文献中有所记载,可单独使用或与其他药材组合成各种草药处方。本文就现有的科学信息,如土丁桂属不同植物来源物种的生药学特征、化学成分、药理作用、临床前及临床应用等方面进行述评,以期为科学地应用土丁桂提供依据。此外,还可根据不同植物来源土丁桂属草药的不同功效进行鉴别应用。

关键词：旋花科田旋花旋花科土丁桂蝶形花科蝴蝶花豆龙胆科穿心草医学印度传统认知障碍

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An Expert System for the Prediction of Surface Finish in Turning Process

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厦门大学学报（自然科学版） 2002年第S1期41卷 191-页

作者： U S dixit K Acharyya A D Sahasrabudhe Department of Mechanical Engineering Indian Institute of TechnologyDepartment of Mechanical Engineering Indian Institute of TechnologyDepartment of Mechanical Engineering Indian Institute of Technology Guwahati IndiaGuwahati IndiaGuwahati India

Prediction of surface finish in turning process is a difficult but important task. Artificial Neural Networks (ANN) can reliably pred ict the surface finish but require a lot of training data. To overcome this prob lem, an expert system approach is proposed, wherein it will be possible to predi ct the surface finish from limited experiments. The expert system contains a kno wledge base prepared from machining data handbooks and number of experiments con ducted by turning steel rods, over a wide range of cutting parameters. With this knowledge base, the expert system predicts surface finish for different tool-w ork-piece combinations, by carrying out few experiments for each case. The prop osed expert system model is validated by carrying out a number of experiments.

关键词： expert system Artificial Neural Network surface finish turning

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Solution of the Generalized Abel Integral Equation by Using Almost Bernstein Operational Matrix

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American Journal of Computational Mathematics 2011年第4期1卷 226-234页

作者： Sandeep dixit Rajesh K. Pandey Sunil Kumar Om P. Singh 不详

A direct almost Bernstein operational matrix of integration is used to propose a stable algorithm for numerical inversion of the generalized Abel integral equation. The applicability of the earlier proposed methods was restricted to the numerical inversion of a part of the generalized Abel integral equation. The method is quite accurate and stable as illustrated by applying it to intensity data with and without random noise to invert and compare it with the known analytical inverse. Thus it is a good method for applying to experimental intensities distorted by noise.

关键词： Abel Inversion Bernstein Polynomials Almost Bernstein Operational Matrix Of Integration Noise Resistance

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钒技术在难减排行业和能源转型中的作用评估

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钢铁钒钛 2024年第4期45卷 84-94页

作者： David A Santos Manish K dixit Pranav Pradeep Kumar Sarbajit Banerjee 无德克萨斯农工大学化学系德克萨斯州77843-3255美国德克萨斯农工大学材料科学和工程系德克萨斯州77843-3255美国德克萨斯农工大学建筑科学系德克萨斯州77843-3255美国德克萨斯农工大学土木与环境工程学院德克萨斯州77843-3255美国顶点翻译公司

重工业的减碳和可再生能源技术的出现皆与获得矿物资源有着密不可分的联系。因此,迫切需要对关键元素在减少温室气体排放方面的作用进行基准评估。考察了钒作为微合金元素在建筑碳减排以及作为电网储能用液流电池的主要成分在能源转型... 详细信息

重工业的减碳和可再生能源技术的出现皆与获得矿物资源有着密不可分的联系。因此,迫切需要对关键元素在减少温室气体排放方面的作用进行基准评估。考察了钒作为微合金元素在建筑碳减排以及作为电网储能用液流电池的主要成分在能源转型中的作用。研究结果表明,钒可使每年减少总计1.85亿t碳排放。其中,中国和欧盟的减排幅度分别为各自排放量的1.15%和0.18%。研究结果强调了关键金属在发展低碳基础设施中的作用,同时指出了进行全面评估并施加政策干预减轻供应链风险的必要性。

关键词：钒微合金化液流电池碳减排

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Development of a Core Set from a Large Rice Collection using a Modified Heuristic Algorithm to Retain Maximum Diversity

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Journal of Integrative Plant Biology 2009年第12期51卷 1116-1125页

作者： Hun-Ki Chung Kyu-Won Kim Jong-Wook Chung Jung-Ro Lee Sok-Young Lee Anupam dixit Hee-Kyoung Kang Weiguo Zhao Kenneth L. McNally Ruraidh S. Hamilton Jae-Gyun Gwag Yong-Jin Park National Agrobiodiversity Center National Academy of Agricultural Science Suwon 441-707 Korea Department of Plant Resources College of Industrial Sciences Kongju National University Yesan 340-802 Korea Rice DNA and Quality Testing Laboratory Basmati Export Development Foundation SVBP University of Agriculture and Technology Meerut 250110 India Department of Horticultural Science College of Industrial Science Kongju National University Yesan 340-802 Korea jiangsu University of Science and Technology Seficultural Research Institute Chinese Academy of Agricultural Sciences Zhenjiang 212018 China Genetic Resources Center International Rice Research Institute Metro Manila 1301 Philippines

A new heuristic approach was undertaken for the establishment of a core set for the diversity research of rice. As a result, 107 entries were selected from the 10 368 characterized accessions. The core set derived using this new approach provided a good representation of the characterized accessions present in the entire collection. No significant differences for the mean, range, standard deviation and coefficient of variation of each trait were observed between the core and existing collections. We also compared the diversity of core sets established using this Heuristic Core Collection （HCC） approach with those of core sets established using the conventional clustering methods. This modified heuristic algorithm can also be used to select genotype data with allelic richness and reduced redundancy, and to facilitate management and use of large collections of plant genetic resources in a more efficient way.

关键词： core collection genetic diversity heuristic core collection Oryza sativa sampling strategy.

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