Association of cannabis use disorder with atrial fibrillation in young men without concomitant tobacco use:Insights from nationwide propensity matched analysis

作     者：Bhavin Patel Sumanth Khadke Kshitij Mahajan Avleen Dhingra Rishika Trivedi Samrath Singh Brar Sakshi Dixit Vaibhav Periwal Shaylika Chauhan Rupak Desai 

作者机构：Department of Internal MedicineTrinity Health Oakland HospitalPontiacMI 48341United States Lahey Hospital and Medical CenterDivision of Cardiovascular MedicineDepartment of MedicineBurlingtonMA 01805United States Department of Internal MedicineTrinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Department of MedicineDayanand Medical College and HospitalLudhiana 141001PunjabIndia Department of Internal MedicineDHR HealthEdinburgTX 78539United States Department of MedicineGovernment Medical CollegePatiala 147001PunjabIndia Department of Internal MedicineGeisinger Health SystemWikes-BarrePA 18702United States Independent ResearcherOutcomes ResearchAtlantaGA 30079United States 

出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)

年 卷 期：2024年第14卷第3期

页      面：64-71页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Cannabis Marijuana Atrial fibrillation Tobacco use disorder Original research Smoking 

摘      要：BACKGROUND Recent data are inconclusive regarding the risk of arrhythmias among young cannabis ***,many young adults use both cannabis and tobacco,which could add a residual confounding effect on ***,we studied young men who have cannabis use disorder(CUD)excluding tobacco use disorder(TUD)to understand their independent association with atrial fibrillation(AF)and related *** To study the association of CUD with AF and related *** We used weighted discharge records from National Inpatient Sample(2019)to assess the baseline characteristics and mortality rates for AF-related hospitalizations in young(18-44 years)men in 1:1 propensity-matched CUD+vs CUD-cohorts without *** Propensity matched CUD+and CUD-cohorts consisted of 108495 young men in each *** analysis showed an increased incidence of AF in black population with *** addition,the CUD+cohort had lower rates of hyperlipidemia(6.4%vs 6.9%),hypertension(5.3%vs 6.3%),obesity(9.1%vs 10.9%),alcohol abuse(15.5%vs 16.9%),but had higher rates of anxiety(24.3%vs 18.4%)and chronic obstructive pulmonary disease(COPD)(9.8%vs 9.4%)compared to *** adjustment with covariates including other substance abuse,a non-significant association was found between CUD+cohort and AF related hospitalizations(odd ratio:1.27,95%confidence interval:0.91-1.78,P=0.15).CONCLUSION Among hospitalized young men,the CUD+cohort had a higher prevalence of anxiety and COPD,and slightly higher proportion of black *** there were higher odds of AF hospitalizations in CUD+cohort without TUD,the association was statistically *** subgroup analysis showed higher rates of AF in black ***-scale prospective studies are required to evaluate long-term effects of CUD on AF risk and prognosis without TUD and concomitant substance abuse.