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Pancreatic stellate cell: Pandora's box for pancreatic disease biology

World Journal of Gastroenterology 2017年第3期23卷 382-405页

作者： Ratnakar R Bynigeri aparna jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar Institute of Basic Sciences Asian Healthcare FoundationHyderabad 500082India Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Surgical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India

Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma.

关键词： Pancreatic stellate cells Pancreatic fibrosis Pancreatic cancer stroma Physiological functions Pancreatic stellate cells-cancer-stromal interactions Therapeutic targets

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Assessing Policy Measures Safeguarding Workers from Artificial Intelligence in the United States

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Journal of Computer and Communications 2023年第11期11卷 149-166页

作者： Yining Zhao Karthik jakkampudi The Village School Houston USA

With the proliferation of artificial intelligence (AI) technology, the profound impact it has had on the economy cannot be ignored. With each passing day, AI advancements grow increasingly significant, demanding the close attention of both corporations and governments. It is imperative for all stakeholders to grasp the ramifications of AI on the workforce and societal inequality. While past research has predominantly revolved around the potential of AI-driven automation and the specter of job displacement, a crucial aspect often overlooked has been policy evaluation that considers those directly impacted—employers and employees within the workplace. Through a comprehensive survey encompassing the perspectives of over 5000 individuals and 2000 firms, we endeavor to unravel the intricate web of AI implementation within professional settings and, by proxy, potential policy solutions to combat the various aspects of AI. The revelations stemming from our study are telling Training emerges as an indispensable catalyst in the assimilation of AI, rendering it more effective and, notably, enhancing the perceptions of AI among the workforces. Furthermore, consultations surrounding AI integration within organizations prove to be a positive force, facilitating its harmonious coexistence with human labor. However, it is the vital nexus of communication between employers and employees that stands as the linchpin to the successful incorporation of AI into the modern workplace. Furthermore, examples of federal and regulatory policy are provided that could be used to combat concerns that will arise in accompaniment with AI. In essence, our findings implore a balanced and nuanced approach—One that empowers rather than alienates employees. Only through such an approach can we hope to foster coexistence between AI and the invaluable human workforce.

关键词： Artificial Intelligence US Workplace Automation Tasks

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