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Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

Grappling with COVID-19 by imposing and lifting nonpharmaceutical interventions in Sri Lanka: A modeling perspective

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Infectious Disease Modelling 2021年第1期6卷 820-831页

作者： Mahesh Jayaweera Chamath Dannangoda Dilum Dilshan Janith Dissanayake hasini Perera Jagath Manatunge Buddhika Gunawardana Department of Civil Engineering University of MoratuwaSri Lanka Department of Physics and Astronomy University of Texas at Rio Grande ValleyBrownsvilleTX78520USA Department of Civil&Environmental Engineering College of EngineeringSeoul National University1Gwanak-roGwanak-guSeoul08826Republic of Korea Department of Forestry and Environmental Science University of Sri JayewardenepuraSri Lanka

The imposition and lifting of non-pharmaceutical interventions(NPIs)to avert the COVID-19 pandemic have gained popularity worldwide and will continue to be enforced until herd immunity is *** developed a linear regression model to ascertain the nexus between the time-varying reproduction number averaged over a time window of six days(R_(ts))and seven NPIs:contact tracing,quarantine efforts,social distancing and health checks,hand hygiene,wearing of facemasks,lockdown and isolation,and health-related *** analysis suggests that the second wave that emerged in Sri Lanka in early October 2020 continued despite numerous *** model indicates that the most effective single NPI was lockdown and ***,the least effective individual NPIs were hand hygiene and wearing of *** model also demonstrates that to mitigate the second wave to a satisfactory level(R_(ts)<1),the best single NPI was the contact tracing with stringent imposition(%of improvement of R_(ts) was 69.43 against the base case).By contrast,the best combination of two NPIs was the lockdown&isolation with health-related supports(%of improvement was 31.92 against the base case).As such,many health authorities worldwide can use this model to successfully strategize the imposition and lifting of NPIs for averting the COVID-19 pandemic.

关键词： Contact tracing Isolation Lockdown Modeling Reproduction number

Patients’ Experiences and Opinions on Pulmonary Rehabilitation and Use of It as a Tool of Palliative Care on Idiopathic Pulmonary Fibrosis (IPF)

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Open Journal of Respiratory Diseases 2021年第2期11卷 61-75页

作者： Sameera Peumal Senanayake Kalpani Abhayasinghe Rathugamage Sithija Priyankara Fernando Heeraluge Erandie hasini Perera Ridmi Shashiprabha Maddumage Athuraliya Gamacharige Kasuni Neranja Kathaluwa Liyana Kankanamge Tharini Dilanka Sandharenu Faculty of Allied Health Sciences General Sir John Kotelawala Defence University Ratmalana Sri Lanka School of Sports Sciences Swansea University Swansea Wales UK Institute for Research and Development in Health and Social Care Colombo Sri Lanka

Background: Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and life-limiting condition. It has no cure hence it is vital to establish effective methods of improving the quality of remaining life in these patients. One of the key components of improving quality of life is pulmonary rehabilitation. However little research has been conducted to understand the perspectives and lived experience of people with IPF on pulmonary rehabilitation. Hence, we aim to fill this gap in the existing literature. Methods: We sought to understand how patients coped with pulmonary rehabilitation. A patient-centred approach was used to explore the physical and psychological impact of pulmonary rehabilitation. Semi-structured interviews were conducted by experienced academics. Interviews used a topic guide but mostly led by the participants. An inductive thematic approach was used to analyse data, allowing us to identify common themes in the participants’ experiences. Results: Of fifty invited participants, ten took part in the study (aged 53 - 81 years). Inductive analysis of interviews identified seven second-order themes and eleven first-order themes, represented by two General Dimensions: “motivation

Perceived Improvements of Quality of Life (QoL) among Patients with Idiopathic Pulmonary Fibrosis (IPF) in Response to a 6-Week Rehabilitation Program

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Open Journal of Respiratory Diseases 2021年第2期11卷 27-36页

作者： Sameera Peumal Senanayake Rathugamage Sithija Priyankara Fernando Heeraluge Erandie hasini Perera Ridmi Shashiprabha Maddumage Athuraliya Gamacharige Kasuni Neranja Kathaluwa Liyana Kankanamge Tharini Dilanka Sandharenu Faculty of Allied Health Sciences General Sir John Kotelawala Defence University Werahara Sri Lanka School of Sports Sciences Swansea University Wales United Kingdom

Idiopathic pulmonary fibrosis (IPF) is a chronic, life-limiting with an average life expectancy of 05 years following the onset of the disease, with no curative treatments. These patients need palliative care and rehabilitation is one of the methods that can be used to improve quality of life (QoL) among these patients. Yet the research conducted to assess benefits of pulmonary rehabilitation (PR) in terms of improving physical activity and QoL in IPF patients remains limited. Hence this study aims to evaluate the effect of a bespoke pulmonary rehabilitation programme, on the physical, physiological and psychological parameters and improvements of QoL among IPF patients. Eleven (11) subjects with IPF received 6 weeks of pulmonary rehabilitation. An interviewer administered quality of life questionnaire, six-minute walking test (6MWT), Incremental bicycle exercise tests were performed, and cardiac and respiratory parameters were assessed pre- and post-rehabilitation. The 6MWT was significantly increased following training (Pre 312.55 ± 89.99;Post, 380.73 ± 59.60). A significant improvement was observed in overall QoL (2.226 ± 0.026), dyspnoea (-0.455 ± 0.004) anxiety (-2.070 ± 0.038), depression (-2.217 ± 0.027) scores. No significant changes were found in the VO2 max and other cardiopulmonary parameters, while non-significant improvement was seen in SpO2 at peak exercise from 85.8 - 86.5. Bespoke pulmonary rehabilitation program is beneficial in short term improvement of the functional exercise capacity, dyspnoea and QoL among IPF patients.

关键词： IPF 6MWT Pulmonary Rehabilitation QoL Oxygen Uptake VO2

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Book reviews

Fungal Diversity 2016年第2期77卷 381-402页

作者： Dhanushka N.Wanasinghe Sutakorn Kamolhan Dinushani Anupama Daranagama W.K.M.C.Dayarathne Asha J.Dissanayake Ishani D.Goonasekara K.K.Hapuarachchi Nimali Indiwaree de Silva hasini ek.nayak. Subashini C.Jayasiri Samantha C.Karunarathna Rekhani H.Perera Chayanard Phukhamsakda Indunil C.Senanayake Qiuju Shang Thilini K.Wickremasinghe Jing Yang YuanPin Xiao Center of Excellence in Fungal Research School of ScienceMae Fah Luang University333 Moo 1ThasudMuangChiang Rai 57100Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand

Rating system Exceptional/brilliant Excellent Good Has merit Not worth reading Acanthamoeba:Biology and Pathogenesis(2nd edition)By Naveed Ahmed Khan The American Phytopathological Society Hardcover;334 pages;including 88 figures and 26 tables;ISBN:978-1-908230-50-8(hardcover)ISBN:978-1-908230-51-5(eBook)Acanthamoeba is an opportunistic protist pathogen,causing a blinding keratitis and fatal granulomatous *** Acanthamoeba has gained increasing attention during the last few decades from the scientific communities,with cellular microbiology,environmental biology,physiology,cellular interactions,molecular biology,biochemistry and the evolutionary studies.

关键词： tables gained brilliant

Gastrointestinal bleeding in a patient with a continuous-flow biventricular assist device

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World Journal of Radiology 2016年第4期8卷 428-433页

作者： Raymond V Mirasol Jason J Tholany hasini Reddy Billie S Fyfe-Kirschner Christina L Cheng Issam F Moubarak John L Nosher Department of Internal Medicine Jersey Shore University Medical Center Department of Radiology Rutgers Robert Wood Johnson Medical School Department of Pathology Robert Wood Johnson University Hospital Department of Surgery Robert Wood Johnson University Hospital

The association between continuous-flow left ventricular assist devices(CF-LVADs)and gastrointestinal(GI)bleeding from angiodysplasia is well ***,the association between continuous-flow biventricular assist devices(CF-BIVADs)and bleeding angiodysplasia is less *** report a case of GI bleeding from a patient with a *** location of GI bleeding was identified by nuclear red blood cell bleeding *** vascular malformation leading to the bleed was identified and localized on angiography and then by *** intensity of bleeding,reflected by number of units of packed red blood cells needed for normalization of hemoglobin,as well as the time to onset of bleeding after transplantation,are similar to that seen in the literature for CF-LVADs and pulsatile *** angiography only detected a dilated late draining vein,pathology demonstrated the presence of both arterial and venous dilation in the submucosa,vascular abnormalities characteristic of a late arteriovenous malformation.

关键词： Continuous-flow ventricular assist devices Angiodysplasia Gastrointestinal bleeding Angiography Heart failure

乌鲁木齐市公交车司机职业紧张、抑郁症状与焦虑症状分析

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中国职业医学 2022年第6期49卷 678-682页

作者：蔡利君杨颖赵海莉赛依旦·亚力买买提叶力哈尔·哈斯尼宁丽新疆医科大学公共卫生学院新疆乌鲁木齐830054

目的分析乌鲁木齐市公交车司机职业紧张、抑郁症状和焦虑症状及相关影响因素。方法采用判断抽样法,选择乌鲁木齐市709名公交车司机为研究对象。采用《付出-回报失衡问卷》《Zung氏抑郁自评量表》《Zung氏焦虑自评表》分别调查公交车司... 详细信息

目的分析乌鲁木齐市公交车司机职业紧张、抑郁症状和焦虑症状及相关影响因素。方法采用判断抽样法,选择乌鲁木齐市709名公交车司机为研究对象。采用《付出-回报失衡问卷》《Zung氏抑郁自评量表》《Zung氏焦虑自评表》分别调查公交车司机的付出-回报失衡(ERI)模式职业紧张、抑郁症状和焦虑症状现况。结果研究对象ERI模式职业紧张、抑郁症状、焦虑症状检出率分别为62.2%(441/709)、30.2%(214/709)和18.2%(129/709)。二元logistic回归分析结果显示,文化程度、工龄、体育锻炼与饮酒均是研究对象ERI模式职业紧张的独立影响因素(P值均<0.05);个人月收入和体育锻炼均是其抑郁症状的影响因素(P值均<0.05);体育锻炼是其焦虑症状的影响因素(P<0.05)。结论乌鲁木齐市公交车司机的职业紧张、抑郁症状和焦虑症状情况不容乐观。应重点关注高学历、长工龄、低个人月收入、无体育锻炼习惯及存在饮酒行为的人群,以预防其职业紧张与心理健康问题的发生。

关键词：司机职业紧张抑郁症状焦虑症状影响因素

Fungal diversity notes 491–602: taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2017年第2期83卷 1-261页

作者： Saowaluck Tibpromma Kevin D.Hyde Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Jian-Kui Liu D.Jayarama Bhat E.B.Gareth Jones Eric H.C.McKenzie Erio Camporesi Timur S.Bulgakov Mingkwan Doilom AndreLuiz Cabral Monteiro de Azevedo Santiago Kanad Das Patinjareveettil Manimohan Tatiana B.Gibertoni Young Woon Lim anusha hasini ek.nayak. Benjarong Thongbai Hyang Burm Lee Jun-Bo Yang Paul M.Kirk Phongeun Sysouphanthong Sanjay K.Singh Saranyaphat Boonmee Wei Dong K.N.Anil Raj K.P.Deepna Latha Rungtiwa Phookamsak Chayanard Phukhamsakda Sirinapa Konta Subashini C.Jayasiri Chada Norphanphoun Danushka S.Tennakoon Junfu Li Monika C.Dayarathne Rekhani H.Perera Yuanpin Xiao Dhanushka N.Wanasinghe Indunil C.Senanayake Ishani D.Goonasekara N.Ide Silva Ausana Mapook Ruvishika S.Jayawardena Asha J.Dissanayake Ishara S.Manawasinghe K.W.Thilini Chethana Zong-Long Luo Kalani Kanchana Hapuarachchi Abhishek Baghela Adriene Mayra Soares Alfredo Vizzini Angelina Meiras-Ottoni Armin Mesic Arun Kumar Dutta Carlos Alberto Fragoso de Souza Christian Richter Chuan-Gen Lin Debasis Chakrabarty Dinushani A.Daranagama Diogo Xavier Lima Dyutiparna Chakraborty Enrico Ercole Fang Wu Giampaolo Simonini Gianrico Vasquez Gladstone Alves da Silva Helio Longoni Plautz Jr Hiran A.Ariyawansa Hyun Lee Ivana Kusan Jie Song Jingzu Sun Joydeep Karmakar Kaifeng Hu Kamal C.Semwal Kasun M.Thambugala Kerstin Voigt Krishnendu Acharya Kunhiraman C.Rajeshkumar Leif Ryvarden Margita Jadan MdIqbal Hosen Michal Miksık Milan C.Samarakoon Nalin N.Wijayawardene Nam Kyu Kim Neven Matocec Paras Nath Singh Qing Tian R.P.Bhatt Rafael JoseVilela de Oliveira Rodham E.Tulloss S.Aamir Saithong Kaewchai Sayali D.Marathe Sehroon Khan Sinang Hongsanan Sinchan Adhikari Tahir Mehmood Tapas Kumar Bandyopadhyay Tatyana YuSvetasheva Thi Thuong Thuong Nguyen Vladimır Antonın Wen-Jing Li Yong Wang Yuvraj Indoliya Zdenko Tkalcec Abdallah M.Elgorban Ali H.Bahkali Alvin M.C.Tang Hong-Yan Su Huang Zhang Itthayakorn Promputtha Jennifer Luangsa-ard Jianchu Xu Jiye Yan Kang Ji-Chuan Marc Stadler Pete Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani” Via Roma 18Forlı`Italy A.M.B.Circolo Micologico“Giovanni Carini” C.P.314BresciaItaly Societa`per gli Studi Naturalistici della Romagna C.P.144BagnacavalloRAItaly Formerly Department of Botany Goa UniversityTaleigaoGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa VelhaIndia 33 B St.Edwards Road Southsea Hants Hampshire PO53DHUK Landcare Research Manaaki Whenua Private Bag 92170AucklandNew Zealand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Division of Applied Science College of International EducationThe Hong Kong Baptist UniversityHong Kong SARChina PostGraduate Program in Biology of Fungi Department of MycologyFederal University of PernambucoAv.Nelson Chavess/nRecifePE 50670-420Brazil Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Environmental Microbiology Lab Division of Food TechnologyBiotechnology&AgrochemistryCollege of Agriculture and Life SciencesChonnam National UniversityYongbong-Dong 300Buk-GuGwangju 61186Korea Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China Yunnan Institute of Food Safety Kunming University of Science&TechnologyKunming 650500YunnanPeople’s Republic

This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ***ever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever *** on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans ***.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph *** new species are Amanita cornelii,***,Angustimassarina alni,***,***,***,***,Ascochyta italica,***,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,***,***,***,***,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,***,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,***,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,***nae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,***,***,Keissleriella cirsii,Lepiota cylindrocystidia,***,***,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,***tata,***,Panus subf

关键词： Agaricomycetes Ascomycota Basidiomycota Dacrymycetes Dothideomycetes Eurotiomycetes New combination Mucoromycotina New genus New records New species Pezizomycetes Phylogeny Sordariomycetes Taxonomy