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Additive manufacturing of biodegradable porous orthopaedic screw

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Bioactive Materials 2020年第3期5卷 458-467页

作者： Ramya Dhandapani Priya Dharshini Krishnan Allen Zennifer Vishal Kannan Amrutha Manigandan Michael R.Arul Devina Jaiswal anuradha subramanian Sangamesh Gurappa Kumbar Swaminathan Sethuraman Centre for Nanotechnology&Advanced Biomaterials SASTRA Deemed UniversityThanjavur613401India Department of Orthopaedics UConn HealthFarmingtonCT06030USA Department of Biomedical Engineering Western New England UniversitySpringfieldMA01119USA

Advent of additive manufacturing in biomedical field has nurtured fabrication of complex,customizable and reproducible orthopaedic ***-by-layer deposition of biodegradable polymer employed in development of porous orthopaedic screws promises gradual dissolution and complete metabolic resorption thereby overcoming the limitations of conventional metallic *** the present study,screws with different pore sizes(916×918μm to 254×146μm)were 3D printed at 200μm layer height by varying printing parameters such as print speed,fill density and travel speed to augment the bone ***-CT analysis and scanning electron micrographs of screws with 45%fill density confirmed porous interconnections(40.1%)and optimal pore size(259×207×200μm)without compromising the mechanical strength(24.58±1.36 MPa).Due to the open pore structure,the 3D printed screws showed increased weight gain due to the deposition of calcium when incubated in simulated body ***-like cells attached on screw and infiltrated into the pores over 14 days of in vitro ***,the screws also supported greater human mesenchymal stem cell adhesion,proliferation and mineralized matrix synthesis over a period of 21 days in vitro culture as compared to non-porous *** porous screws showed significantly increased vascularization in a rat subcutaneous implantation as compared to control *** screws produced by additive manufacturing may promote better osteointegration due to enhanced mineralization and vascularization.

关键词： 3D printing Orthopaedic screws Biodegradable Porous screws

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

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Neural Regeneration Research 2025年第10期20卷 2862-2871页

作者： Prajakta Deshpande anuradha Venkatakrishnan Chimata Amit Singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and *** acetylation is a common post-translational modification pivotal to basic cellular *** to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and *** this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in ***,we have focused on N-acetyltransferase 9 and its role in microtubule *** have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative *** have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

关键词： acetyl-coenzyme A Alzheimer’s disease animal models cell death drosophila eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 neurodegeneration

OKRA (HIBISCUS ESCULENTUS) AND FENUGREEK (TRIGONELLA FOENUM GRACEUM) MUCILAGE:CHARACTERIZATION AND APPLICATION AS FLOCCULANTS FOR TEXTILE EFFLUENT TREATMENTS

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Chinese Journal of Polymer Science 2008年第6期26卷 679-687页

作者： Rajani Srinivasan anuradha Mishra Blackland Research and Extension Centre Texas A&M University System720East Blackland RoadTempleTX76502USA Department of Chemistry University Institute of Engineering and TechnologyCSJM UniversityKanpur-208 024India

The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was *** polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic *** of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...

关键词： Fenugreek Okra Natural polysaccharides Flocculation Wastewater treatment Textile effluent Bridging Hibiscus esculentus Trigonella foenum graceum.

Anticancer Activity of Rice Callus Suspension Cultures from Aromatic Varieties and Metabolites Regulated in Treated Cancer Cell Lines

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Rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： anuradha KUMARI Wusirika RAMAKRISHNA Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. Rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite

Asymptotic and Partial Asymptotic Hankel Operators on H^2(D^n)

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Acta Mathematica Sinica,English Series 2019年第11期35卷 1729-1740页

作者： anuradha GUPTA Bhawna GUPTA Department of Mathematics Delhi College of Arts and CommerceNetaji NagarUniversity of DelhiDelhiIndia Department of Mathematics University of DelhiDelhiIndia

In this paper,we generalize the concept of asymptotic Hankel operators on H2(D)to the Hardy space H2(Dn)(over polydisk)in terms of asymptotic Hankel and partial asymptotic Hankel operators and investigate some properties in case of its weak and strong ***,we introduce ith-partial Hankel operators on H2(Dn)and obtain a characterization of its compactness for n>*** main results include the containment of Toeplitz algebra in the collection of all strong partial asymptotic Hankel operators on H2(Dn).It is also shown that a Toeplitz operator with symbolφis asymptotic Hankel if and only if φ is holomorphic function in L∞(Tn).

关键词： Hankel operator Asymptotic Hankel operator partial asymptotic Hankel operator i(th)-partial Hankel operator i(th)-partial big Hankel operator

Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis

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Chinese Journal of Integrative Medicine 2023年第9期29卷 818-824页

作者： Sahar Idris anuradha Mishra Mohammad Khushtar Faculty of Pharmacy Integral UniversityDasauliLucknow226026Uttar PradeshIndia Amity Institute of Pharmacy LucknowAmity University Uttar PradeshNoida201313India

Objective To quantify phytochemicals using liquid chromatography and mass spectroscopy(LCMS)analysis and explore the therapeutic effect of Aesculus hippocastanum L.(AH)seeds ethanolic extract against gastric ulcers in *** Preliminary phytochemical testing and LCMS analysis were performed according to standard *** treatment,the animals were divided into 7 groups including normal control,ulcer control,self-healing,AH seeds low and high doses,ranitidine and per se *** were orally administered with 10 mg/kg of indomethacin,excluding the normal control group(which received 1%carboxy methyl cellulose)and the per se group(received 200 mg/kg AH seeds extract).The test group rats were then given 2 doses of AH seeds extract(100 and 200 mg/kg,respectively),while the standard group was given ranitidine(50 mg/kg).On the 11th day,rats in all groups were sacrificed,and their stomach was isolated to calculate the ulcer index,and other parameters such as blood prostaglandin(PGE2),tissue superoxide dismutase(SOD),catalase(CAT),malonyldialdehyde(MDA),and glutathione(GSH).All isolated stomach tissues were analyzed for histopathological *** The phytochemical examination shows that the AH seeds contain alkaloids,flavonoids,saponins,phenolic components,and *** analysis confirms the presence of quercetin and *** AH seeds extract showed significant improvement in gastric mucosa conditions after indomethacin-induced gastric lesions(P<0.01).Further marked improvement in blood PGE2 and antioxidant enzymes,SOD,CAT,MDA and GSH,were observed compared with self-healing and untreated ulcer-induced groups(P<0.01).Histopathology results confirmed that AH seeds extract improved the mucosal layer and gastric epithelial membrane in treated groups compared to untreated ulcer-induced *** LCMS report confirms the presence of quercetin and rutin in AH seeds ethanolic *** therapeutic effect of AH seeds extract against indomethacin

关键词： Aesculus hippocastanum L. pharmacological action phytochemical physicochemical analysis liquid chromatography and mass spectroscopy analysis gastro-protective activity

Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma

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BIOCELL 2012年第2期36卷 63-71页

作者： anuradha SEHRAWAT VIJAY KUMAR Virology Group International Centre for Genetic Engineering and BiotechnologyAruna Asaf Ali MargNew Delhi 110067India

The flower of Butea monosperma(Lam.)(Fabaceae)has been used in traditional Indian medicine in the treatment of many ailments including liver *** understand the pharmacological basis of its beneficial effects,the extracts of dried flowers in water,methanol,butanol,ethyl acetate and acetone were evaluated for free radical scavenging and pro-apoptotic activities in cell cultures(human hepatoma Huh-7 cell line and immortalized AML-12 mouse hepatocytes).Butrin and butein-the active constituents of flower extracts-were used as reference *** levels of cell injury markers like lactate dehydrogenase,glutathione and lipid peroxidation and primary antioxidant enzymes glutathione S-transferase and catalase were also *** aqueous and butanolic extracts exhibited better 2,2-diphenyl-1-picrylhydrazyl scavenging and cytotoxic activities in hepatoma cells than in immortalized ***,butein inhibited 2,2-diphenyl-1-picrylhydrazyl radical better than *** aqueous and butanolic extracts were further investigated for hepatoprotection against carbon tertrachloride-induced biochemical changes and cell *** extracts,just as butrin and butein,significantly reversed the cellular glutathione levels and lipid peroxidation,and glutathione–S-transferase *** dehydrogenase leakage and cell death were also ***,only butein revived the catalase ***,the butein content of Butea monosperma flower extracts is important for free radical scavenging activity,apoptotic cell death and protection against oxidative injury in hepatic cells.

关键词： butrin cytotoxicity hepatoprotection methanol extract free radical scavenging

Performance analysis of an improved dynamic power management model in wireless sensor node

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Digital Communications and Networks 2017年第1期3卷 19-29页

作者： anuradha Pughat Vidushi Sharma School of Information and Communication Technology Gautam Buddha University Greater Noida India

The energy consumption in the wireless sensor networks is a very critical issue which attracts immediate attention for the sake of the growing demand of the billion dollar market in future. The Dynamic Power Management （DPM） technique is a way of controlling and saving the energy usage in a sensor node. Previously, researchers have proposed lifetime improving stochastic models for wireless sensor networks and limited work has been done focusing on the wireless sensor node. This paper proposes an analyser based Semi-Markov model for DPM in the event-driven sensor node. The power consumption comparison with previously proposed models without this analyser shows the analyser significant contributes to lifetime improvement. The improved model is more power efficient, presents how the DPM model observes the input event arrival and power states of the sensor node components, and then dynamically manages the power consumption of the overall system. Further, to observe the effect of event arrival, missed events, waiting time, processor utilization on the power consumption and lifetime, the proposed DPM system with the single server queuing model is developed.

关键词： Dynamic power managementStochastic modelLifetime improvementEvent drivenPower consumptionWireless sensor nodeAnalyser basedEvent arrivalSimulation modelPower analysis

Impact of increased renewables on natural gas markets in eastern United States

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Journal of Modern Power Systems and Clean Energy 2017年第3期5卷 424-438页

作者： Neha NANDAKUMAR anuradha M.ANNASWAMY Institute for Data Systemsand SocietyMassachusetts Institute of TechnologyCambridgeMAUSA Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

This paper explores the market structures of natural gas and electricity as well as the interdependence of natural gas prices and bids with increasing reliance on natural gas as the penetration of renewable energy resources increases in order to complement their intermittencies. In particular, the paper will attempt to answer the following two questions: What could the generation mix look like in 2030 with a renewable-rich generation landscape and how could this impact gas prices? How do gasfired generator(GFG) generation volatility, their prices,and their bids for gas change between 2015 and 2030 with increased penetration of renewables? In order to answer these questions, computational models are derived using forecasting and regression analysis tools and an auction model.

关键词： Natural gas markets Gas-fired generators Regression analysis Optimal auction model Volatility Gas prices