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Non-interventional management of resistant hypertension

World Journal of Cardiology 2014年第10期6卷 1080-1090页

作者： Michael Doumas Costas Tsioufis Charles Faselis antonios Lazaridis Haris Grassos Vasilios Papademetriou 2nd Propedeutic Department of Internal Medicine Aristotle University 54643 Thessaloniki Greecest 1st Cardiology Department Kapodestrian University 11527 Athens Greece Department of Internal Medicine Veterans Af-fairs Medical Center and George Washington University Department of Cardiology KAT Hospital 14561 Athens Greece Department of Cardiology Veterans Affairs Medical Center and Georgetown University

Hypertension is one of the most popular fields of re-search in modern medicine due to its high prevalence and its major impact on cardiovascular risk and con-sequently on global health. Indeed, about one third of individuals worldwide has hypertension and is under increased long-term risk of myocardial infarction, stroke or cardiovascular death. On the other hand, resistant hypertension, the "uncontrollable" part of arterial hy-pertension despite appropriate therapy, comprises a much greater menace since long-standing, high levels of blood pressure along with concomitant debilitating entities such as chronic kidney disease and diabetes mellitus create a prominent high cardiovascular risk milieu. However, despite the alarming consequences, resistant hypertension and its effective management still have not received proper scientific attention. As-pects like the exact prevalence and prognosis are yet tobe clarified. In an effort to manage patients with resis-tant hypertension appropriately, clinical doctors are still racking their brains in order to find the best therapeutic algorithm and surmount the substantial difficulties in controlling this clinical entity. This review aims to shed light on the effective management of resistant hyper-tension and provide practical recommendations for cli-nicians dealing with such patients.

关键词： Resistant hypertension Antihypertensive drugs Adherence White coat hypertension Secondary hypertension

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Prolonged hypernatremia triggered by hyperglycemic hyperosmolar state with coma: A case report

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World Journal of Nephrology 2015年第2期4卷 319-323页

作者： Darlene Vigil Kavitha Ganta Yijuan Sun RichardⅠDorin antonios H Tzamaloukas Karen S Servilla Nephrology Section Medicine ServiceRaymond G Murphy Veterans Affairs Medical Center Nephrology Division Department of MedicineUniversity of New Mexico School of Medicine Endocrinology Section Medicine ServiceRaymond G Murphy Veterans Affairs Medical Center Nephrology Section Medicine Service Raymond G Murphy Veterans Affairs Medical Center Nephrology Division Department of Medicine University of New Mexico School of Medicine

A man with past lithium use for more than 15 years, but off lithium for two years and not carrying the diagnosis of diabetes mellitus or nephrogenic diabetes insipidus(NDI), presented with coma and hyperglycemic hyperosmolar state(HHS). Following correction of HHS, he developed persistent hypernatremia accompanied by large volumes of urine with low osmolality and no response to desmopressin injections. Urine osmolality remained < 300 m Osm/kg after injection of vasopressin. Improvement in serum sodium concentration followed the intake of large volumes of water plus administration of amiloride and hydrochlorothiazide. Severe hyperglycemia may trigger symptomatic lithium-induced NDI years after cessation of lithium therapy. Patients with newonset diabetes mellitus who had been on prolonged lithium therapy in the past require monitoring of their serum sodium concentration after hyperglycemic episodes regardless of whether they do or do not carry the diagnosis of NDI.

关键词：糖尿病肾病血糖临床分析

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Catheter ablation of persistent atrial fibrillation:The importance of substrate modification

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World Journal of Cardiology 2015年第3期7卷 111-118页

作者： Konstantinos P Letsas Michael Efremidis Nikolaos P Sgouros Konstantinos Vlachos Dimitrios Asvestas antonios Sideris Second Department of Cardiology Laboratory of Cardiac ElectrophysiologyEvangelismos General Hospital of Athens

Accumulating data have shown that elimination of atrial fibrillation(AF) sources should be the goal in persistent AF ablation. Pulmonary vein isolation, linear lesions and complex fractionated atrial electrograms(CFAEs) ablation have shown limited efficacy in patients with persistent AF. A combined approach using voltage, CFAEs and dominant frequency(DF) mapping may be helpful for the identification of AF sources and subsequent focal substrate modification. The fibrillatory activity is maintained by intramural reentry centered on fibrotic patches. Voltage mapping may assist in the identification of fibrotic areas. Stable rotors display the higher DF and possibly drive AF. Furthermore, the single rotor is usually consistent with organized AF electrograms without fractionation. It is therefore quite possible that rotors are located at relatively "healthy islands" within the patchy fibrosis. This is supported by the fact that high DF sites have been negatively correlated to the amount of fibrosis. CFAEs are located in areas adjacent to high DF. In conclusion, patchy fibrotic areas displaying the maximum DF along with high organization index and the lower fractionation index are potential targets of ablation. Prospective studies are required to validate the efficacy of substrate modification in left atrial ablation outcomes.

关键词： Ablation Atrial fibrillation Persistent Substrate Dominant frequency

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肠促胰岛素类药物与2型糖尿病患者胆管癌的风险:基于人群的队列研究

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英国医学杂志中文版 2019年第7期22卷 371-371页

作者： Devin Abrahami antonios Douros Hui Yin Oriana HY Yu Jean-Luc Faillie Francois Montastruc Robert W Platt Nathaniel Bouganim Laurent Azoulay 张弘哲(译) 吴东(校) 不详中国医学科学院北京协和医学院北京协和医院消化科

目的确定二肽基肽酶-4 (DPP-4)抑制剂和胰高血糖素样肽-KGLP-1)受体激动剂的使用是否与成人2型糖尿病患者胆管癌风险的增加有关。设计基于人群的队列研究。背景向英国临床实践研究数据链提供数据的全科医学机构。参与者在2007年1月1日至... 详细信息

目的确定二肽基肽酶-4 (DPP-4)抑制剂和胰高血糖素样肽-KGLP-1)受体激动剂的使用是否与成人2型糖尿病患者胆管癌风险的增加有关。设计基于人群的队列研究。背景向英国临床实践研究数据链提供数据的全科医学机构。参与者在2007年1月1日至2017年3月31日期间接受过抗糖尿病药物治疗的154162名成年患者,并随访至2018年3月31日。主要结局测量将DPP-4抑制剂和GLP-1受体激动剂的使用设立为时间相关变量.并与使用其他二、三线抗糖尿病药物进行比较。所有的暴露都推后一年,以校正癌症的潜伏期并最大限度地减少逆向因果关系。Cox比例风险模型用于估计DPP-4抑制剂和GLP-1受体激动剂相关性胆管癌事件的风险比(HR)和95%可信区间(C/)。采用世界卫生组织的全球个案安全报告数据库VigiBase开展了一项事后药物警戒分析,以评估胆管癌的报告比值比。结果在对614 274人年的随访期间,发生105例胆管癌事件(发生率17.1/10万人年)。使用DPP-4抑制剂胆管癌风险增加77%(HR1.77,95%CI 1.04-3.01),GLP-1 受体激动剂的使用与风险增加相关,具有较宽的可信区间(HR1.97,95%C/0.83-4.66).在药物警戒分析中,与磺脉类或噬醴烷二酮类药物相比,使用DPP-4抑制剂和GLP-1受体激动剂均与胆管癌的报告比值比增加相关(分别为1.63, 95%CI 1.00-2.66;4.73,95%CI 2.95-7.58)。结论与其他二、三线抗糖尿病药物相比,使用DPP-4抑制剂和GLP-1受体激动剂可能与成人2型糖尿病患者患胆管癌的风险增加有关。

关键词： 2型糖尿病成年患者队列研究胆管癌风险比类药物肠促胰岛素人群

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用于纳米网络的软件定义超材料设计与开发

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通信对抗 2016年第2期35卷 47-56页

作者： Christos Liaskos Ageliki Tsioliaridou Andreas Pitsillides lan F.Akyildiz Nikolaos V.Kantartzis antonios X.Lalas Xenofontas Dimitropoulos Sotiris loannidis Maria Kafesaki C.M.Soukoulis 陈玲璐陈鼎鼎

介绍了一类可通过软件来控制电磁特性的可编程超材料。这种软件定义超材料(SDM)源于超材料与纳米网络的结合。超材料是一种人工结构,具有特殊的材料特性,在自然界中无法找到这类材料。自超材料出现以来,近几年许多研究领域都取得了突破... 详细信息

介绍了一类可通过软件来控制电磁特性的可编程超材料。这种软件定义超材料(SDM)源于超材料与纳米网络的结合。超材料是一种人工结构,具有特殊的材料特性,在自然界中无法找到这类材料。自超材料出现以来,近几年许多研究领域都取得了突破性进展,例如电磁隐身(隐身衣)、辐射吸收、声波光波过滤,以及可应用于传感器和植入式通信设备的高效能天线等。然而,现有的超材料结构是"僵化"的,即,它们不具备可重构功能。这一缺陷使超材料只有少数具有精密设备的实验室才能制造,这阻碍了该领域的发展与创新,尤其是限制了超材料的应用范围,使得它只能在静态结构中应用。文章所提出的软件定义超材料类似于"可塑的"(可重构)超材料,其特性可以通过计算机接口来编程控制。这种控制是通过在超材料结构并入纳米机器网络来实现的。纳米机器可以接收来自用户的指令并对超材料外轮廓做出简单的几何调整,以达到调整超材料电磁特性的目的。文章讨论了软件定义超材料的结构、预期特性和实现方面的问题,并通过对预期性能的仿真讨论了合适的纳米组网模型,概括总结了在软件定义超材料的分析、设计、样机研究、制造和初始应用场景等方面所存在的研究难点。

关键词：材料设计软件定义纳米机器网络电磁特性材料结构开发编程控制

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Respiratory failure in diabetic ketoacidosis

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World Journal of Diabetes 2015年第8期6卷 1009-1023页

作者： Nikifor K Konstantinov Mark Rohrscheib Emmanuel I Agaba Richard I Dorin Glen H Murata antonios H Tzamaloukas University of New Mexico School of Medicine Albuquerque Division of Nephrology Department of Medicine University of New Mexico School of Medicine Division of Nephrology Department of Medicine University of Jos Medical School Section of Endocrinology Medicine Service Raymond G. Murphy Veterans Affairs Medical Center Department of Medicine University of New Mexico School of Medicine Section of Informatics Medicine Service Raymond G. Murphy Veterans Affairs Medical Center Section of Nephrology Medicine Service Raymond G. Murphy Veterans Affairs Medical Center

Respiratory failure complicating the course of diabetic ketoacidosis(DKA)is a source of increased morbidity and *** of respiratory failure in DKA requires focused clinical monitoring,careful interpretation of arterial blood gases,and investigation for conditions that can affect adversely the *** that compromise respiratory function caused by DKA can be detected at presentation but are usually more prevalent during *** conditions include deficits of potassium,magnesium and phosphate and hydrostatic or non-hydrostatic pulmonary *** not caused by DKA that can worsen respiratory function under the added stress of DKA include infections of the respiratory system,pre-existing respiratory or neuromuscular disease and miscellaneous other *** recognition and management of the conditions that can lead to respiratory failure in DKA may prevent respiratory failure and improve mortality from DKA.

关键词： Diabetic ketoacidosis Respiratory failure Hypokalemia Hypomagnesemia Hypophosphatemia Pulmonary edema Adult respiratory distress syndrome Pneumonia Neuromuscular disease

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Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence

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World Journal of Cardiology 2015年第10期7卷 665-670页

作者： Eleftherios Spartalis Periklis Tomos Demetrios Moris antonios Athanasiou Charalampos Markakis Michael D Spartalis Theodore Troupis Dimitrios Dimitroulis Despina Perrea Second Department of Propedeutic Surgery Athens University Medical School "Laiko" Hospital Department of Cardiology Onassis Cardiac Surgery Center Department of Anatomy Medical School University of Athens Laboratory of Experimental Surgery and Surgical Research "N.S.Christeas" Medical School University of Athens

Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Plateletrich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application.

关键词： Platelet-rich plasma Ischemic heart disease Myocar

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Prediction of atrial fibrillation development and progression:current perspectives

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World Journal of Cardiology 2016年第3期8卷 267-276页

作者： Konstantinos Vlachos Konstantinos P Letsas Panagiotis Korantzopoulos Tong Liu Stamatis Georgopoulos Athanasios Bakalakos Nikolaos Karamichalakis Sotirios Xydonas Michael Efremidis antonios Sideris Second Department of Cardiology Laboratory of Cardiac Electrophysiology"Evangelismos" General Hospital of Athens First Department of Cardiology University Hospital of Ioannina Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical University

Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF.

关键词： Atrial fibrillation Development Progression Risk factors inflammation Fibrosis

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Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease

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World Journal of Nephrology 2014年第4期3卷 122-142页

作者： Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie antonios H Tzamaloukas Department of Surgery University of New Mexico School of Medicine Renal Section Raymond G Murphy Veterans Affairs (VA) Medical Center and Department of MedicineUniversity of New Mexico School of Medicine Division of Nephrology Department of MedicineUniversity of New Mexico School of Medicine Rheumatology Section Raymond G Murphy VA Medical Center and Department of MedicineUniversity of New Mexico School of Medicine Department of Pathology University of New Mexico School of Medicine Radiology Service Raymond G Murphy VA Medical Center and Department of RadiologyUniversity of New Mexico School of Medicine Pathology Section Raymond G Murphy VA Medical Center and Department of PathologyUniversity of New Mexico School of Medicine

Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and *** nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary *** of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these *** addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal *** preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies.

关键词：高草酸血症肾结石治疗方法临床分析

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Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

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