Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease

作     者：Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie Antonios H Tzamaloukas 

作者机构：Department of SurgeryUniversity of New Mexico School of Medicine Renal SectionRaymond G Murphy Veterans Affairs (VA) Medical Center and Department of MedicineUniversity of New Mexico School of Medicine Division of NephrologyDepartment of MedicineUniversity of New Mexico School of Medicine Rheumatology SectionRaymond G Murphy VA Medical Center and Department of MedicineUniversity of New Mexico School of Medicine Department of PathologyUniversity of New Mexico School of Medicine Radiology ServiceRaymond G Murphy VA Medical Center and Department of RadiologyUniversity of New Mexico School of Medicine Pathology SectionRaymond G Murphy VA Medical Center and Department of PathologyUniversity of New Mexico School of Medicine 

出 版 物：《World Journal of Nephrology》 (世界肾病学杂志（英文版）)

年 卷 期：2014年第3卷第4期

页      面：122-142页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：高草酸血症 肾结石 治疗方法 临床分析 

摘      要：Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and *** nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary *** of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these *** addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal *** preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies.