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Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan antonio lópez-Villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(Ols),glial cells that provide myelin sheaths to axons in the central nervous system(CNs),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,Ols provide trophic support to neurons and ***,Ol metabolism is important for Ol well-being and the proper accomplishment of their functions,and Ol metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado antonio Rodríguez-Fernández Javier luis lópez-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** sUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

具有Ruddlesden-Popper结构的杂化非本征铁电体(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)陶瓷的制备及其物理性能

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天津师范大学学报（自然科学版） 2024年第2期44卷 19-25页

作者： MARCO antonio lópez-Aguila 柳志旭王守宇黄聪刘卫芳天津大学理学院天津300350 天津师范大学物理与材料科学学院天津300387

为探究稀土离子掺杂对Ca_(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了sm^(3+)掺杂的(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPs、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、... 详细信息

为探究稀土离子掺杂对Ca_(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了sm^(3+)掺杂的(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPs、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、光学性能、电学性能和磁学性能进行分析.结果表明:随着sm^(3+)含量的增加,(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)的晶胞参数逐渐增大.sm^(3+)掺杂导致氧空位减少,因此样品的漏电流随着sm^(3+)掺杂量的增加而减小.同时,随着sm^(3+)掺杂量的增加,样品的光学带隙呈现增大趋势.此外,第一性原理研究表明,sm^(3+)掺杂可在体系中诱导出磁性能,进一步丰富了该材料的物理性能.

关键词： (Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)陶瓷铁电性氧空位光学带隙第一性原理

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala sara Pischedda Miriam Cebey-lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello sandra Viz-lasheras antonio Justicia-Grande Julian Montoto-louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres antonio salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-Es) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAs(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Catalytic feasibility of Ce-doped laCoO_(3) systems for chlorobenzene oxidation:An analysis of synthesis method

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Journal of Rare Earths 2022年第6期40卷 897-905,I0002页

作者： Héctor Acosta Pérez Carlos A.lópez luis E.Cadús Fabiola N.Agüero Chemical Technology Research Institute(INTEQUI) UNSL-CONICETFaculty of Biochemical Chemistry and Pharmacy(UNSL)Almirante Brown 14555700San LuisArgentina

A family of Ce-doped laCoO_(3) perovskites are presented as possible catalysts for Cl-VOCs *** materials with different contents of Ce were obtained through the citrate and the reactive grinding *** insertion of Ce in the original perovskite structure favours the presence of Co^(2+)/Co^(3+) and Ce^(3+)/Ce^(4+) redox pairs and a higher content of oxygen vacancies that enhances the catalytic performance in chlorobenzene combustion based on differential kinetics *** family obtained by the grinding method presents a performance as high as that synthesized by citrate ***,the reactive grinding is a feasible green chemistry alternative to obtain a catalyst with the same performance as that obtained from traditional ***,the stability of samples was evaluated under total combustion reaction conditions showing an excellent activity during 45 h time on stream.

关键词： Cl-VOCs Perovskites Chlorobenzene Cerium Cobalt Rare earths

Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum l.)as affected by carbonates and Fe oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： Ana M.GARCÍA-lÓpez Ramiro RECENA antonio DElGADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the effect of Zn sorbent surface on the use of complexed Zn by plants remains *** objective of this research was to elucidate how Zn complexation with humic substances(Hs)and phytate affects the uptake of Zn by wheat plants depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-Hs complex,Zn phytate,and ZnsO_(4).All sources were applied with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-Hs complex significantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnsO_(4).In the calcareous medium,Zn-Hs complex and Zn phytate resulted in significantly higher dry biomass yields of wheat than ZnsO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-Hs complex at the low rate and Zn phytate at both rates were not significantly different from those with ZnsO_(4) at the high *** harvest,approximately 50%of the Zn applied as Zn-Hs complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%for the other Zn ***,Zn-Hs complex and Zn phytate are sources of available Zn for plants,and they are more effective than ZnsO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surface.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn deficiency Zn sorbent surface Zn source

Twenty-four-hour movement guidelines during middle adolescence and their association with glucose outcomes and type 2 diabetes mellitus in adulthood

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Journal of sport and Health science 2023年第2期12卷 167-174页

作者： antonio García-Hermoso JoséFrancisco lópez-Gil Yasmin Ezzatvar Robinson Ramírez-Vélez Mikel Izquierdo Navarrabiomed Hospital Universitario de Navarra(HUN)Universidad Publica de Navarra(UPNA)IdiSNAPamplona 31008Spain Health and social Research Center Universidad de Castilla-La ManchaCuenca 16007Spain Department of Nursing Universitat de ValenciaValencia 46010Spain

Purpose:The aim of the present study was to determine the association between adherence to the 24-h movement guidelines during middle adolescence and glucose outcomes(glycated hemoglobin and fasting glucose)and type 2 diabetes mellitus(T2DM)in adulthood,14 and 22 years ***:We analyzed data from apparently healthy adolescents aged 12-18 years who participated in WavesⅠandⅡ(1994-1996,n=14,738),WaveⅣ(2008-2009,n=8913),and Wave V(2016-2018,n=3457)of the National longitudinal study of Adolescent to Adult Health(Add Health)in the United *** activity,screen time,and sleep duration were measured using questionnaires,and the 24-h guidelines were defined as:5 or more times moderate-to-vigorous physical activity per week,≤2 h per day of screen time,and 9-11 h of sleep for 12-13 years and 8-10 h for 14-17 *** and venous whole blood was collected and analyzed to determine glycated hemoglobin and fasting glucose for WavesⅣandⅤ,***:Only 2.1%of the adolescents met all the 3 guidelines,and 37.8%met none of *** both wavesⅣandⅤ,adolescents who met physical activity and screen time guidelines had lower odds of T2DM in adulthood than those who did not meet any of these guidelines(WaveⅣ;prevalence ratio(PR)=0.57,95%confidence interval(95%CI):0.21-0.89;Wave V:PR=0.43,95%CI:0.32-0.74).Only for Wave V did adolescents who met all 3 guidelines have lower odds of T2DM at follow-up compared with those who did not meet any of these guidelines(PR=0.47,95%CI:0.24-0.91).Also,for each increase in meeting one of the 24-h recommendations,the odds of T2DM decreased by 18%(PR=0.82,95%CI:0.61-0.99)and 15%(PR=0.85,95%CI:0.65-0.98)in adulthood for WavesⅣandⅤ,***:Promoting all 24-h movement guidelines in adolescence,especially physical activity and screen time,is important for lowering the potential risk of T2DM in adulthood.

关键词： Glucose metabolism Glycated hemoglobin Physical activity screen time sleep duration

The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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science China Materials 2022年第6期65卷 1662-1670页

作者： Eric Voltà-Durán Julieta M sánchez Hèctor-lópez-laguna Eloi Parladé laura sánchez-García Alejandro sánchez-Chardi Ario de Marco Ugutz Unzueta Esther Vázquez antonio Villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(CONICET-Universidad Nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina servei de Microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain laboratory for Environmental and life sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute sant Pau(IIB sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins EM1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

Recent Advances on Early-stage Fire-Warning systems: Mechanism, Performance, and Perspective

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Nano-Micro letters 2022年第12期14卷 106-136页

作者： Xiaolu li antonio Vazquez-lopez Jose sanchez del Rio saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.s.de Ingenieros de Caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWss)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWss has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWss,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWss are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWss and a guideline for the cutting-edge development direction of EFWss for readers.

关键词： smart thermosensitive fire sensors Working mechanism Response time signal conversion