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Towards an integrated risk analysis security framework according to a systematic analysis of existing proposals

Frontiers of Computer Science 2024年第3期18卷 199-216页

作者： antonio SANTOS-OLMO Luis Enrique SÁNCHEZ David G.ROSADO Manuel A.SERRANO Carlos BLANCO Haralambos MOURATIDIS eduardo FERNÁNDEZ-MEDINA GSyA Research Group University of Castilla-La ManchaCiudad Real 13071Spain Institute for Analytics and Data Science University of EssexColchester CO43SQUK Alarcos Research Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Research group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The information society depends increasingly on risk assessment and management systems as means to adequately protect its key information *** availability of these systems is now vital for the protection and evolution of ***,several factors have led to an increasing need for more accurate risk analysis *** are:the speed at which technologies evolve,their global impact and the growing requirement for companies to *** analysis processes must consequently adapt to these new circumstances and new technological *** objective of this paper is,therefore,to present the results of an exhaustive analysis of the techniques and methods offered by the scientific community with the aim of identifying their main weaknesses and providing a new risk assessment and management *** analysis was carried out using the systematic review protocol and found that these proposals do not fully meet these new *** paper also presents a summary of MARISMA,the risk analysis and management framework designed by our research *** basis of our framework is the main existing risk standards and proposals,and it seeks to address the weaknesses found in these *** is in a process of continuous improvement,as is being applied by customers in several European and American *** consists of a risk data management module,a methodology for its systematic application and a tool that automates the process.

关键词： information security management security system security risk assessment and management

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Analysing vaccine efficacy evaluated in phase 3 clinical trials carried out during outbreaks

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Infectious Disease Modelling 2024年第4期9卷 1027-1044页

作者： Francisco antonio Bezerra Coutinho Marcos Amaku Fernanda Castro Boulos Jose Alfredo de Sousa Moreira Joao Italo DiasFranca Julio antonio do Amaral Eliana Nogueira Castro de Barros Claudio Jose Struchiner Esper Jorge Kallas eduardo Massad School of Medicine University of Sao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil

In this paper we examine several definitions of vaccine efficacy(VE)that we found in the literature,for diseases that express themselves in outbreaks,that is,when the force of infection grows in time,reaches a maximum and then *** fact that the disease occurs in outbreaks results in several problems that we *** propose a mathematical model that allows the calculation of VE for several *** trials usually needs a large number of volunteers that must be ***,all volunteers should be enrolled in approximately the same time,but this is generally impossible for logistic reasons and they are enrolled in a fashion that can be replaced by a continuous density function(for example,a Gaussian function).The outbreak can also be replaced by a continuous density function,and the use of these density functions simplifies the ***,for example Gaussian functions,one of the problems one can immediately notice is that the peak of the two curves do not occur at the same *** model allows us to conclude:First,the calculated vaccine efficacy decreases when the force of infection increases;Second,the calculated vaccine efficacy decreases when the gap between the peak in the force of infection and the peak in the enrollment rate increases;Third,different trial protocols can be simulated with this model;different vaccine efficacy definitions can be calculated and in our simulations,all result are approximately the *** final,and perhaps most important conclusion of our model,is that vaccine efficacy calculated during outbreaks must be carefully examined and the best way we can suggest to overcome this problem is to stratify the enrolled volunteer's in a cohort-by-cohort basis and do the survival analysis for each cohort,or apply the Cox proportional hazards model for each cohort.

关键词： Vaccine efficacy Clinical trials Mathematical models Simulations Covid-19

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Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp.,Ehrlichia canis,and Anaplasma phagocytophilum

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Animal Diseases 2024年第3期4卷 224-230页

作者： Claire A.Vázquez‑Manzanilla María F.Cárdenas‑Marrufo eduardo Gutiérrez‑Blanco Matilde Jiménez‑Coello Nelly R.Pech‑Sosa antonio Ortega‑Pacheco Departamento de Salud Animal y Medicina Preventiva Facultad de Medicina Veterinaria y ZootecniaCampus de Ciencias Biológicas y AgropecuariasUniversidad Autónoma de YucatánMéridaYucatán 97100México Unidad Interinstitucional de Investigación Clínica y Epidemiológica Facultad de MedicinaUniversidad Autónoma de YucatánMéridaYucatán 97000México

Chronic kidney disease is commonly diagnosed in dogs,and clinical signs may be aggravated when infected agents are *** this case report,33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp.,Ehrlichia canis,and Anaplasma *** seroprevalence for Leptospira *** 39.4%.The most frequent serovars found were Pyrogenes,Canicola,Bratislava and Australis,with serological titers between 1:100 to 1:*** signs included fever,depression,decreased body condition,vomiting and hema‑*** laboratory fndings were anemia,leukocytosis,thrombocytopenia,increased liver enzymes,urea and creatinine,hyperbilirubinemia and *** leptospira seronegative dogs were positive for one or both monitored homoparasites(i.e.,*** and ***);only three leptospira seropositive dogs were positive for one or both *** also suggest that endemic hemoparasites of dogs should be moni‑tored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach.

关键词： Anaplasma Chronic kidney disease Dog Ehrlichia Leptospira

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose antonio Lorente Fernando Vazquez-Alonso Luis Javier martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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NiO-CGO Composite for SOFC Anode： Synthesis and Characterization

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材料科学与工程（中英文版） 2010年第5期4卷 33-39页

作者： Beatriz Cela Daniel Araujo de Macedol Graziele Lopes de Souza Auristela Carla de Miranda antonio eduardo martine Rubens Maribondo do Nascimento Carlos Alberto Paskocimas PPGCEM CCET Federal University of Rio Grande do Norte 1524 - 59072-970 Natal RN Brazil Chemical Engineering Department CT Federal University of Rio Grande do Norte Natal 1524 - 59072-970 RN Brazil

In this work compounds of gadolinium-doped ceria, Ce0.9Gd0.1O1.95 (CGO) and NiO were synthesized by polymeric precursor method. NiO-Ce0.9Gd0.1O1.95 composite was attained by mixture of the powders of the both phases calcinated already. The precursor powders were characterized by simultaneous thermogravimetry-differential thermal analysis and the calcined materials were studied by X-ray diffraction, scanning electronic microscopy, Fourier transform infrared spectroscopy and dilatometry. The refinement of the diffraction data indicated that the powders were crystallized in the wanted phases. All the produced powders had nanometric and sub micrometric features. The produced composite showed good characteristics for the use as anode for SOFC.

关键词：固体氧化物燃料电池复合材料区政府 NIO 合成阳极聚合物前驱体法傅立叶变换红外光谱

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Ni-based catalysts obtained from perovskites oxides for ethanol steam reforming

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燃料化学学报 2018年第11期46卷 1332-1341页

作者： Fabiola Nerina Agüero Jose antonio Alonso Maria Teresa Fernández-Díaz Luis eduardo Cadus Instituto de Investigaciones en Tecnología Química(INTEQUI) UNSL-CONICETAlmirante Brown 14555700 San LuisArgentina Instituto de Ciencia de Materiales de Madrid Consejo Superior de Investigaciones CientíficasCantoblanco28049 MadridSpain Institut Laue-Langevin B.P.156F-38042 Grenoble Cedex 9France

Perovskites as host structures of cations were used in order to generate in situ active and stable catalysts for ethanol steam reforming. For this purpose,La_(1-x)Mg_xAl_(1-y)Ni_yO_3(x = 0.1; y = 0,0.1,0.2,0.3) perovskites were synthetized by the citrate *** segregation is evident for a substitution level higher than 0. 2. The segregation of Ni as NiO generated species interacts with different metal-support after the reduction step. The y = 0.1 catalyst presents the highest H_2 yield value about 85% during reaction time,with low mean values of CH_4 and CO selectivities of 3.4% and 11%,respectively and a low carbon formation. The better performance of y = 0.1 catalyst could be attributed to the minor proportion of segregated phases,thus a controlled expulsion of Ni is successfully reached.

关键词： perovskites catalyst design ethanol steam reforming

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Thermal and salinity effects on locomotor performance of Thoropa taophora tadpoles(Anura,Cycloramphidae)

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Integrative Zoology 2020年第1期15卷 40-54页

作者： antonio C.GALLO Cinthia ABRASILEIRO Fábio Cury DE BARROS Joséeduardo DE CARVALHO Department of Ecology and Evolutionary Biology Federal University of São PauloDiademaSão PauloBrazil

It is well known that environmental temperature influences several biological functions of ectotherms,notably in *** high permeability of anuran skin,associated with the effect of elevated environmental temperature,potentiates the dehydration process and this combination may restrict locomotor ***pa taophora is an endemic species from the Atlantic Rainforest whose tadpoles are semiterrestrial and predominantly diurnal,and are found in rocky seashores where they are exposed to sea spray and high *** this study we investigated how temperature and salinity conditions affect the locomotor performance in Thoropa taophora *** also assessed how different osmotic concentrations affect the activity of the metabolic pathways that support muscle *** measured the sprint speed of tadpoles of various sizes at different temperatures and salinities in the *** also measured the activity of the enzymes pyruvate kinase(PK),lactate dehydrogenase(LDH)and citrate synthase(CS)in different temperatures and osmotic concentrations,and calculated the thermal sensitivity and the activity constants for each *** results showed that,in general,sprint speed decreased with increasing temperature and ***,whereas the effect of increased salinity was similar in smaller and larger tadpoles,increased temperature had a higher negative impact on sprint speed of larger tadpoles,thus indicating low thermal sensitivity of small *** and LDH thermal sensitivities and LDH constant of activity decreased as the osmolality *** conclusion,the locomotor capacity of tadpoles was decreased by temperature and salinity,which may be related to a decrease in anaerobic metabolism both in terms of sensitivity and total energy turnover through enzymatic *** discuss the ecological consequences,including the potential impacts on predator escape behavior promoted by changes in metabolism and locomotor performance

关键词： amphibians energy metabolism enzyme activity sprint speed

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Driving Factors for Forest Fire Occurrence in Durango State of Mexico:A Geospatial Perspective

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Chinese Geographical Science 2010年第6期20卷 491-497页

作者： Diana Avila-Flores Marin Pompa-Garcia Xanat antonio-Nemiga Dante A Rodriguez-Trejo eduardo Vargas-Perez Javier Santillan-Perez Forestry Division University of Chapingo Faculty of Forestry Juarez University of the State of DurangoRio Papaloapan and Durango Blvd Faculty of Geography Autonomous University of Mexico StateCerro de Coatepec s/nCiudad Universitaria

Forest fire is one of the major causes of forest loss and therefore one of the main constraints for sustainable forest management *** the driving factors and understanding the contribution of each factor are essential for the management of forest fire *** objective of this study is to identify variables that are spatially related to the occurrence and incidence of the forest fire in the State of Durango,*** this purpose,data from forest fire records for a five-year period were *** spatial correlations between forest fire occurrence and intensity of land use,susceptibility of vegetation,temperature,precipitation and slope were tested by Geographically Weighted Regression(GWR) method,under an Ordinary Least Square *** show that the spatial pattern of the forest fire in the study area is closely correlated with the intensity of land use,and land use change is one of the main explanatory *** addition,vegetation type and precipitation are also the main driving *** fitting model indicates obvious link between the *** fire was found to be the consequence of a particular combination of the environmental factors,and when these factors coexist with human activities,there is high probability of forest fire *** regulation of human activities is a key strategy for forest fire prevention.

关键词： forest fire Geographically Weighted Regression(GWR) land use forest management Durango State Mexico

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Management of hepatitis C in patients with chronic kidney disease

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World Journal of Gastroenterology 2015年第2期21卷 408-422页

作者： Roberto J Carvalho-Filho Ana Cristina CA Feldner antonio eduardo B Silva Maria Lucia G Ferraz Division of Gastroenterology Hepatology SectionFederal University of Sao PauloSao PauloSP 04023-900Brazil

Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus.

关键词： Hepatitis C virus Chronic kidney disease End-stage

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Comparison of Control Techniques in a Weight Lifting Exoskeleton

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Journal of Bionic Engineering 2019年第4期16卷 663-673页

作者： Irving Rosales-Diaz Jesus Ricardo Lopez-Gutierrez Angel eduardo Zamora Suarez Sergio Rosario Salazar antonio Osorio-Cordero Hipolito Aguilar-Sierra Rogelio Lozano CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico CONACYT-CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico Polytechnic University of Tulancingo St.Ingenierias 100Col.Huapalcalco43629TulancingoHidalgoMexico Centre de Recherches de Royalieu UTC-HEUDIASyCCompiegne60205France

The back pain is the most common injury in human activities where heavy objects must be lifted or must be suspended for a long time.A weight lifting exoskeleton also known as force augmentation exoskeleton is designed to reduce the strain on the back and the limbs and reduce the risk to suffer *** the other hand,different kinds of controllers have been implemented to achieve whit this goal,for example,a conventional PD Control,PD Control with Gravity Compensation,PD Control with Adaptive Desired Gravity Compensation and PD Control with Robust *** paper aims to evaluate and compare the performance from the previously cited controllers used to reduce the strain in the back,through the implementation of each controller in a three Degrees Of Freedom(DOF)exoskeleton powered by pneumatic muscle actuators;some numerical simulations as well as experimental trials have been conducted and three different performance indices were used in order to determine the effectiveness of each one with respect to the simple PD controller when the mass to be lifted is unknown.

关键词： augmenting force device exoskeleton robot pneumatic artificial muscles adaptive control robust control

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