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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry

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Eye and Vision 2021年第6期8卷 374-384页

作者： Jorge L.Alio Francesco D’Oria Francesca Toto Joan Balgos antonio Palazon Francesco Versaci Jorge L.Alio del barrio Vissum Innovation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezVissum Miranzac/Cabañal103016 AlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly

Background:To study and compare the clinical optical image quality following implantation with different premium IOLs by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based ***:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 LENTIS Mplus LS-313 MF30;(d)33 LENTIS Mplus LS-313 MF15;(e)17 AkkoLens Lumina;(f)31 AT LISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis *** outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(LOA)and high-order aberration(HOA)RMS measured by PWS ***:AT LISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;P<0.05),followed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT LISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.004).Mplus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.002).Total RMS,LOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(P<0.001).Conclusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted *** LISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.

关键词： Cataract surgery Pyramidal aberrometry Multifocal IOL Extended depth of focus Accommodative IOL

A novel botnet attack detection for IoT networks based on communication graphs

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Cybersecurity 2024年第4期7卷 19-35页

作者： David Concejal Munoz antonio del-Corte Valiente Inetum Espana S.A. C/Maria de Portugal9-11Building 128050 MadridSpain Department of Computer Engineering Polytechnic SchoolUniversity of AlcalaMadrid-Barcelona Road Km 33.6.Alcala de Henares28871 MadridSpain

Intrusion detection systems have been proposed for the detection of botnet *** types of centralized or distributed cloud-based machine learning and deep learning models have been ***,the emergence of the Internet of Things(loT)has brought about a huge increase in connected devices,necessitating a different *** this paper,we propose to perform detection on IoT-edge *** suggested architecture includes an anomaly intrusion detection system in the application layer of IoT-edge devices,arranged in software-defined ***-edge devices request information from the software-defined networks controller about their own behaviour in the *** behaviour is represented by communication graphs and is novel for IoT *** representation better characterizes the behaviour of the device than the traditional analysis of network traffc,with a lower volume of *** attack scenarios are simulated with the IoT-23 *** results show that attacks are detected with high accuracy using a deep learning model with low device memory requirements and significant storage reduction for training.

关键词： Autoencoders Communication graphs Cyberattacks Internet of Things

MUF Resins Improved by Citric Acid as Adhesives for Wood Veneer Panels

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Journal of Renewable Materials 2023年第2期11卷 539-553页

作者： Claudio del Menezzi antonio Pizzi Siham Amirou Xuedong Xi Department of Forestry Engineering Faculty of TechnologyUniversity of BrasiliaBrasíliaBrazil LERMAB University of LorraineNancyFrance SeniorPost-Doctoral Internship LERMAB-ENSTIBUniversity of LorraineEpinalFrance Yunnan Key Laboratory of Wood Adhesives and Glue Products College of Material Science and EngineeringSouthwest Forestry UniversityKunmingChina International Joint Research Center for Biomass Materials Southwest Forestry UniversityKunmingChina

This article presents the first applied results of using citric acid in combinations with a melamine-urea-formal-dehyde(MUF)resin for bonding wood *** chemical reactions involved are shown based on a MALDI ToF analysis of the reaction of the MUF resin with citric *** preliminary results of the physical and mechanical properties of the LVL prepared are also *** from Populus sp were used to manufacture 5-layer laminated veneer lumber(LVL)of small *** combinations of the amount of citric acid,MUF spread rate and pressing parameters were *** bonded with 20%of citric acid+100 g/m^(2)of MUF,hot-pressed using a 3-step process with maximum 1.5 MPa of pressure yielded the board with better dimensional stability and mechanical *** could be concluded that citric acid in combination with MUF can be used for bonding wood veneer and the research should be continued to study further the parameters involved and to enhance the results.

关键词： LVL wood adhesives citric acid MUF resins MALDI ToF mechanical performance

Entry of hepatitis C virus into the cell: A therapeutic target

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World Journal of Gastroenterology 2012年第33期18卷 4481-4485页

作者： José antonio del Campo ngela Rojas Manuel Romero-Gómez Unit for Medical and Surgical Management of Digestive Diseases Center for Biomedical Research in Digestive and Liver Diseases Network (CIBERehd) Valme University Hospital University of Seville E-41014 Sevilla Spain

Several receptors have been identified as implicated on viral entry into the hepatocyte; and, this interaction between the virus and potential receptors could modulate infection, spontaneous viral clearance, persistence of the infection and the widespread of the virus as outbreak. Nevertheless, the playing role of each of them remains controversial. The NiemannPick type C1 like 1 gene (NPC1L1) receptor has been recently implicated on hepatitis C virus (HCV) entry into the cell and ezetimibe, an anti-cholesterol drug seems to block that, emerging the idea to control hepatitis C outbreak modulating lipid-related receptors. Hepatitis C infection seems to modulate lipid metabolism according to host genetic background. Indeed, it circulates like a lipoviroparticle. The main aim of this field of vision would be to discuss the role of hepatocyte receptors implicated on virus entry, especially NPC1L1 and the therapeutic options derived from the better knowledge about HCV-lipidsreceptors interaction.

关键词： Hepatitis C virus entry Niemann-Pick type C1 like 1 gene Lipid metabolism Ezetimibe

Transformation of leather waste into microwave-activated and N-doped carbon for Li-S batteries

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新型炭材料(中英文) 2025年

作者： Carolina Pano-Azucena Roberto Rosas-Rangel Miguel Olvera-Sosa David Salvador González-González Rene Rangel-Mendez Luis Felipe Chazaro-Ruiz Miguel Avalos-Borja Javier antonio Arcibar-Orozco CIATEC.Center for Applied Innovation in Competitive Technologies Tecnologico de Monterrey School of Engineering and Sciences Instituto Potosino de Investigación Científica y Tecnológica Universidad Autónoma de Coahuila Facultad de SistemasCiudad Universitaria

The use of carbon from waste biomass has the potential to buffer the drawbacks of Li-S batteries and improve their overall performance. Chrome-Tanned-LeatherShavings(CTLS) are undesirable wastes, highly available for transformation into porous carbon. Microwave activation is an efficient state-of-the-art procedure to obtain unique porous structures and nitrogen incorporation can improve the performance of porous carbons. This study proposes the transformation of CTLS into a microwave activated porous carbon, and then was modified to introduce nitrogen. A microporous activated carbon with a specific surface area of 556 m2g-1 with honeycomb-like structure was obtained. Both urea thermal decomposition and ethanolamine impregnation improves the nitrogen and amine presence of surface groups. However,the results indicated that only urea treatment was effective in improving the initial capacity of the cell(1363 mAhg-1), which is probably linked with the sorption of long-chain polysulfides. This investigation confirms that it is possible to obtain carbon materials from CTLS, for use as sulfur-host cathodes in Li-S batteries, and improve their performance with urea thermal decomposition. Furthermore, a Radial basis function neural network was fitted to provide statistical support to the experimental results. The trained model corroborated the importance of nitrogen content of the carbons in the discharge capacity of the cells.

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Recent Advances on Early-Stage Fire-Warning Systems: Mechanism, Performance, and Perspective

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Nano-Micro Letters 2022年第12期14卷 106-136页

作者： Xiaolu Li antonio Vazquez-Lopez Jose Sanchez del Rio Saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.S.de Ingenieros de Caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWSs)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWSs has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWSs,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWSs are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWSs and a guideline for the cutting-edge development direction of EFWSs for readers.

关键词： Smart thermosensitive fire sensors Working mechanism Response time Signal conversion

Selective suspension of single layer graphene mechanochemically exfoliated from carbon nanofibres

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Nano Research 2014年第7期7卷 963-972页

作者： antonio Esau del Rio-CastilloI Cesar Merino Enrique Diez-Barra Ester Vazquez Departamento de Quimica Orgdnica Facultad de Ciencias y Tecnologfas Qufmicas-IRICA Universidad de Castilla-La Mancha 13071 Ciudad Real Spain Grupo Antolin Ingenieria S.A. Burgos E09007 Spain

This paper presents the first report of the successful ball-milling exfoliation of graphitic filaments （GANF~ carbon nanofibres） into single layer graphene. The addition of small amounts of solvent during the milling process makes it possible to enhance the intercalation of the exfoliating agent （melamine） between the graphene layers, thus promoting exceptional exfoliation. Advantage has also been taken of the fact that the Hansen solubility parameters of graphene are different from those of carbon fibres, which allows single and few-layer graphene to be suspended in a particular solvent, thus discriminating them from poorly exfoliated carbon nanofibres.

关键词： carbon fibre graphene ball-milling exfoliation Hansen solubilityparameters

Potential of RP-UHPLC-DAD-MS for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： María del Mar Contreras Aránzazu Morales-Soto antonio Segura-Carretero Javier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation < 5%). The detection and quantification limits were 0.07 μg/mL and 0.36 μg/mL, ***, the use of high-resolution MS enabled us to ensure the specificity, check impurities and better sensitivity. Therefore, this methodology promises to be suitable not only for the routine analysis of sofosbuvir in pharmaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC Sofosbuvir