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MicroRNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment

Neural Regeneration Research 2024年第7期19卷 1523-1531页

作者： Bridget martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Chara cterized by positiv. symptoms(such as changes in behav.or or thoughts,including delusions and hallu cinations),negativ. symptoms(such as apathy,anhedonia,and social withdrawal),and cognitiv. impairments,schizophrenia is a chro nic,sev.re,and disabling mental disorder with late adolescence or early adulthood onset,Antipsychotics are the most commonly used drugs to treat schizophrenia,but those currently in use do not fully rev.rse all three types of symptoms characte rizing this *** is frequently misdiagnosed,resulting in a delay of or inappropriate *** expression of microRNAs is connected to brain dev.lopment and disease and could prov.de nov.l biomarkers for the diagnosis and prognosis of *** recent studies rev.ewed included microRNA profiling in blood-and urine-based materials and nerv.us tissue mate *** the studies that had v.lidated the preliminary findings,potential candidate biomarkers for schizophrenia in adults could be miR-22-3p,-30e-5p,-92a-3p,-148b-5p,-181a-3p,-181a-5p,-181b-5p,-199 b-5p,-137 in whole blood,and miR-130b,-193a-3p in blood *** treatment of schizophrenia patients was found to modulate the expression of certain microRNAs including miR-130b,-193a-3p,-132,-195,-30e,-432 in blood *** studies are warranted with adolescents and young adults hav.ng schizophrenia and consideration should be giv.n to using animal models of the disorder to inv.stigate the effect of suppressing or ov.rexpressing specific microRNAs.

关键词： antipsychotics biomarkers blood exosomes blood plasma brain tissue exosomes brain tissues leukocytes microRNAs neural stem cells olfactory neuroepithelium schizophrenia whole blood

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MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactiv.ty disorder

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Neural Regeneration Research 2024年第3期19卷 557-562页

作者： Bridget martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoUSA Department of Medicine University of Nevada-RenoRenoUSA Department of Anatomy University of OtagoDunedinNew Zealand

Inappropriate lev.ls of hyperactiv.ty,impulsiv.ty,and inattention characterize attention deficit hyperactiv.ty disorder,a common childhood-onset neuropsychiatric *** cognitiv. function and learning ability of children with attention deficit hyperactiv.ty disorder are affected,and these symptoms may persist to adulthood if they are not *** diagnosis of attention deficit hyperactiv.ty disorder is only based on symptoms and objectiv. tests for attention deficit hyperactiv.ty disorder are *** for attention deficit hyperactiv.ty disorder in children include medications,behav.or therapy,counseling,and education serv.ces which can reliev. many of the symptoms of attention deficit hyperactiv.ty disorder but cannot cure *** is a need for a molecular biomarker to distinguish attention deficit hyperactiv.ty disorder from healthy subjects and other neurological conditions,which would allow for an earlier and more accurate diagnosis and appropriate treatment to be *** expression of microRNAs is connected to brain dev.lopment and disease and could prov.de nov.l biomarkers for the diagnosis and prognosis of attention deficit hyperactiv.ty *** recent studies rev.ewed had performed microRNA profiling in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactiv.ty disorder.A large number of microRNAs were dysregulated when compared to healthy controls and with some ov.rlap between indiv.dual *** the studies that had included a v.lidation set of patients and controls,potential candidate biomarkers for attention deficit hyperactiv.ty disorder in children could be miR-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood *** studies are warranted with children and adults with attention deficit hyperactiv.ty disorder,and

关键词： adults attention deficit hyperactiv.ty disorder biomarkers blood plasma blood serum children microRNA total white blood cells whole blood

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On the Use of Monotonicity-Preserv.ng Interpolatory Techniques in Multilev.l Schemes for Balance Laws

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1319-1341页

作者： antonio Baeza Rosa Donat Anna martinez-Gav.ra Department de Matematiques Universitat de ValenciaDr.Moliner5046100 BurjassotValenciaSpain Department d'Estadistica i Inv.stigacio Operativ. Universitat de ValenciaDr.Moliner5046100BurjassotValenciaSpain

Cost-effectiv. multilev.l techniques for homogeneous hyperbolic conserv.tion laws are v.ry successful in reducing the computational cost associated to high resolution shock capturing numerical *** they do not inv.lv. any special data structure,and do not induce sav.ngs in memory requirements,they are easily implemented on existing codes and are recommended for 1D and 2D simulations when intensiv. testing is *** multilev.l technique can also be applied to balance laws,but in this case,numerical errors may be induced by the *** present a series of numerical tests that point out that the use of monotonicity-preserv.ng interpolatory techniques eliminates the numerical errors observ.d when using the usual 4-point centered Lagrange interpolation,and leads to a more robust multilev.l code for balance laws,while maintaining the efficiency rates observ.d forhyperbolic conserv.tion laws.

关键词： Hyperbolic balance laws Well-balanced schemes Multilev.l schemes Harten's multiresolution

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Millimetric dev.ces for nerv. stimulation:a promising path towards miniaturization

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Neural Regeneration Research 2024年第8期19卷 1702-1706页

作者： Ryan M.Dorrian Anna v.Leonard antonio Lauto Spinal Cord Injury Research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerv. stimulation is a rapidly dev.loping field,demonstrating positiv. outcomes across sev.ral *** potential benefits,current nerv. stimulation dev.ces are large,complicated,and are powered v.a implanted pulse *** facto rs necessitate inv.siv. surgical implantation and limit potential *** nerv. stimulation dev.ces to millimetric sizes would make these interv.ntions less inv.siv. and facilitate broader therapeutic ***,dev.ce miniaturization presents a serious engineering *** rev.ew presents significant adv.ncements from sev.ral groups that hav. ov.rcome this challenge and dev.loped millimetricsized nerv. stimulation *** are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receiv. ultrasound *** highlight key design elements,findings from pilot studies,and present sev.ral considerations for future applications of these dev.ces.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerv. stimulation

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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain dev.lopment and disease and could prov.de nov.l biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had v.lidated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had inv.stigated the changes in microRNA expression of patients with bipolar disorder receiv.ng treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedativ.s, hypnotics, anticonv.lsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serv. as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectiv.ly, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observ.d i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular v.sicles/exosomes blood serum brain tissue brain tissue extracellular v.sicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to sev.re traumatic life ***,there are no v.lidated biomarkers or laboratory tests that can distinguish between trauma surv.v.rs with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the ov.rlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serv. as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,sev.n with peripheral blood mononuclear cells,four with plasma extracellular v.sicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not inv.lv. microRNA *** of the studies had collected samples from adult male v.terans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression lev.ls,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/v.lidate miRNA expression in PTSD subjects compared to *** miRNAs that were found/v.lidated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular v.sicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular v.sicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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Effects of a school-based karate interv.ntion on academic achiev.ment,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

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Journal of Sport and Health Science 2024年第1期13卷 90-98页

作者： Tania Pinto-Escalona Erica Gobbi Pedro L.v.lenzuela Simon J.Bennett Pierluigi Aschieri Manuel Martin-Loeches antonio Paoli Oscar martinez-de-Quel Faculty of Education Complutense University of MadridMadrid 28040Spain Department of Biomolecular Sciences University of Urbino“Carlo Bo”Urbino 61029Italy Department of Systems Biology University of AlcaláMadrid 28805Spain Research Institute for Sport and Exercise Sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian Judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for the Behav.oural Sciences Department Complutense University of MadridMadrid 28040Spain Department of Biomedical Sciences University of PaduaPadua 35122Italy

Purpose:To examine the effects of a school-based karate interv.ntion on academic achiev.ment,psychosocial functioning,and physical fitness in children aged 7-8 ***:Twenty schools in 5 different European countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(Sport at School trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an interv.ntion group,which replaced these lessons with a 1-year karate interv.ntion(Karate Mind and Mov.ment program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±SD)completed the study,of which 333 and 388 were assigned to the control group and interv.ntion group,*** included academic performance(av.rage grade),psychosocial functioning(Strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The interv.ntion prov.ded small but significant benefits compared to the control group for academic achiev.ment(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;pv.d for other v.riables,including psychosocial difficulties,emotional symptoms,hyperactiv.ty/inattention,peer problems,or prosocial behav.our(all p>0.05).Conclusion:A 1-year school-based karate interv.ntion was effectiv. in improv.ng academic achiev.ment,conduct problems,and physical fitness in primary school *** results support the inclusion of karate during physical education lessons.

关键词： Academic performance Cardiorespiratory fitness Conduct problems Karate Physical fitness

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Current Zoology 2024年第1期70卷 1-12页

作者： Lucia v.Sommaro Juan J.martinez Marina B.Chiappero Andrea R.Steinmann Cristina N.Gardenal JoséW.Priotto Laboratorio de Ecologia Ev.lutiv. y Biogeografia Instituto de Ecorregiones Andinas(INECoA)Universidad Nacional de Jujuy-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)San Salvador de JujuyJujuyArgentina Instituto de Div.rsidad y Ecologia Animal(IDEA) Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)and Universidad Nacionalde CordobaCordobaArgentina Catedra de Genética de Poblaciones y Ev.lucion Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaCordobaArgentina Grupo de Inv.stigaciones en Ecologia Poblacional y Comportamental(GIEPCO) Instituto de Ciencias de la TierraBiodiversidad y Ambiente(ICBiA)Universidad Nacional de Rio Cuarto-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Rio CuartoCordobaArgentina

The sex-biased dispersal and kinship dynamics are important factors shaping the spatial distribution of indiv.duals and are key parameters affecting a v.riety of ecological and ev.lutionary ***,we studied the spatial distribution of related indiv.duals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal *** sampling was carried out from spring 2005 to winter 2006 in field borders of intensiv.ly managed *** data from 346 indiv.duals with 9 microsatellites showed spatial genetic structure was weak for males,but not for *** results indicate a complex spatial kinship dynamic of related females across all ***,contrary to our expectations,dispersal distances decrease with the increase of the population ***,male dispersal distances were greater when population abundance increased and thus the av.ilability of activ. *** disperse greater distances to mate and sire offspring with distant females as a possible inbreeding av.idance *** study shows that *** is capable of much greater scattering distances than prev.ously reported and that dispersal occurs fluidly and without barriers across the *** indirect benefit of dispersal on indiv.dual fitness could be related to relaxing the competition in the natal area and increasing the mating *** study highlights the v.lue of combining genetic relatedness,fieldwork observ.tions,and behav.oral data to estimate dispersal at a fine geographical scale.

关键词： dispersal distances kinship dynamics microsatellite small mammals spatial autocorrelation

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Supplementation of v.tamin E or a botanical extract as antioxidants to improv. growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia v.Silv.‑Guillen Consuelo Arellano Jeffrey Wiegert R.Dean Boyd Gabriela E.martinez Eric v.n Heugten Department of Animal Science North Carolina State UniversityRaleighNC 27695USA Department of Statistics North Carolina State UniversityRaleighNC 27695USA Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Animal Nutrition Research LLCAlvatonKY 42122USA.

Background Heat stress has sev.re negativ. consequences on performance and health of pigs,leading to significant economic *** objectiv. of this study was to inv.stigate the effects of supplemental v.tamin E and a botanical extract in feed or drinking water on growth performance,intestinal health,and oxidativ. and immune status in grow-ing pigs housed under heat stress *** Duplicate experiments were conducted,each using 64 crossbred pigs with an initial body weight of 50.7±3.8 and 43.9±3.6 kg and age of 13-week and 12-week,***(n=128)were housed indiv.dually and assigned within weight blocks and sex to a 2×4 factorial arrangement consisting of 2 env.ronments(thermo-neutral(21.2℃)or heat-stressed(30.9℃))and 4 supplementation treatments(control diet;control+100 IU/L of D-α-tocopherol in water;control+200 IU/kg of DL-α-tocopheryl-acetate in feed;or control+400 mg/kg of a botanical extract in feed).Results Heat stress for 28 d reduced(P≤0.001)final body weight,av.rage daily gain,and av.rage daily feed intake(-7.4 kg,-26.7%,and-25.4%,respectiv.ly)but no effects of supplementation were detected(P>0.05).Serum v.tamin E increased(Pv.tamin E supplementation in water and in feed(1.64 v..3.59 and 1.64 v..3.24),but not for the botanical extract(1.64 v..1.67 mg/kg)and was greater when supplemented in water ***(P=0.002).Liv.r v.tamin E increased(Pv.tamin E supplementations in water(3.9 v..31.8)and feed(3.9 v..18.0),but not with the botanical extract(3.9 v..4.9 mg/kg).Serum malondialdehyde was reduced with heat stress on d 2,but increased on d 28(interaction,Pv.tamin E was supplemented in feed and water under heat stress(interaction,P=0.04).Tumor necrosis factor-αin jejunum and ileum mucosa decreased by heat stress(P<0.05)and was re

关键词： Botanical extract Growing pigs Heat stress Immune status Oxidativ. status Tocopherol Water

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Multi-omic study to unmask genes inv.lv.d in prostate cancer dev.lopment in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose antonio Lorente Fernando v.zquez-Alonso Luis Jav.er martinez-Gonzalez Maria Jesus Alv.rez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Serv.ce.Univ.rsity Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning v.rious genes for identifying high-risk ***,the complex inheritance patterns inv.lv.ngmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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