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Microscopy Research 2020年第3期8卷 31-42页

作者： Lucia Proietti d’Empaire Félix Tejero Hector J. Finol Pedro M. Aso antonio roschman-gonzalez Centro de Biología Estructural Instituto Venezolano de Investigaciones Científicas Caracas Venezuela Instituto de Zoología y Ecología Tropical Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Centro de Microscopía Electrónica Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Departamento de Biología Celular Universidad Simón Bolívar Caracas Venezuela

A murine model is used to study qualitatively and quantitatively the splenic ultrastructural changes induced by two Trypanosoma evansi strains derived from naturally infected local equine hosts (Equusasinus and E. caballus);T. evansi causes ultrastructural modifications in the spleen of the infected mice. The modifications include tissular disorganization, fibrosis, mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection are quite similar, whereas the final phases differ qualitatively depending on the strain’s source. The ultrastructural quantitative changes were studied in the reticular splenocytes covering alterations in the area of the cytoplasm and nucleus. Analysis of the results shows the induction of various splenic alterations caused by local T. evansi strains. Also, it was documented that discriminative time modulation, as well as progressive tissular, cellular and subcellular changes, are more associated with derived infections from E. caballus strain.

关键词： Trypanosoma evansi Spleen Ultrastructure Mouse

New therapeutic strategy with extracorporeal membrane oxygenation for refractory hepatopulmonary syndrome after liver transplant: A case report

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World Journal of Transplantation 2024年第1期14卷 210-214页

作者： Belinda Sánchez Pérez María Pérez Reyes Jose Aranda Narvaez Julio Santoyo Villalba Jose antonio Perez Daga Claudia Sanchez-gonzalez Julio Santoyo-Santoyo Hepatobiliary and Trasplantation Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Department of General and Digestive Surgery Regional University Hospital of MalagaMalaga 29010Spain

BACKGROUND Due to the lack of published literature about treatment of refractory hepatopulmonary syndrome(HPS)after liver transplant(LT),this case adds information and experience on this issue along with a treatment with positive *** is a complication of end-stage liver disease,with a 10%-30%incidence in cirrhotic *** can reverse the physiopathology of this process and restore normal ***,in some cases,refractory hypoxemia persists,and extracorporeal membrane oxygenation(ECMO)can be used as a rescue therapy with good *** SUMMARY A 59-year-old patient with alcohol-related liver cirrhosis and portal hypertension was included in the LT waiting list for *** had good liver function(Model for End-Stage Liver Disease score 12,Child-Pugh class B7).He had pulmonary fibrosis and a mild restrictive respiratory pattern with a basal oxygen saturation of 82%.The macroaggregated albumin test result was>*** demonstrated a forced expiratory volume in one second(FEV1)of 78%,forced vital capacity(FVC)of 74%,FEV1/FVC ratio of 81%,diffusion capacity for carbon monoxide of 42%,and carbon monoxide transfer coefficient of 57%.He required domiciliary oxygen at 2 L/min(16 h/d).The patient was admitted to the intensive care unit(ICU)and extubated in the first 24 h,needing high-flow therapy and non-invasive ventilation and inhaled nitric oxide *** was needed after 72 *** to the non-response to supportive therapies,installation of ECMO was decided with progressive recovery after 9 *** was possible on the tenth day,maintaining a high-flow nasal cannula and de-escalating to conventional oxygen therapy after 48 *** was discharged from ICU on postoperative day(POD)20 with a 90%-92%oxygen *** recycling was needed twice for acute *** patient was discharged from hospital on POD 27 with no symptoms,with an 89%-90%oxygen *** Due to the favorable results observed,ECMO could bec

关键词： Liver transplantation Hepatopulmonary syndrome Refractory hypoxemia Treatment Extracorporeal membrane oxygenation Case report

Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Parking Availability Prediction with Coarse-Grained Human Mobility Data

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Computers, Materials & Continua 2022年第6期71卷 4355-4375页

作者： Aurora gonzalez-Vidal Fernando Terroso-Sáenz antonio Skarmeta University of Murcia Murcia30003Spain Universidad Católica de Murcia(UCAM) Murcia30107Spain

Nowadays,the anticipation of parking-space demand is an instrumental service in order to reduce traffic congestion levels in urban *** purpose of our work is to study,design and develop a parking-availability predictor that extracts the knowledge from human mobility data,based on the anonymized human displacements of an urban area,and also from weather *** of the existing solutions for this prediction take as contextual data the current road-traffic state defined at very high temporal or spatial ***,access to this type of fine-grained location data is usually quite limited due to several economic or privacy-related *** overcome this limitation,our proposal uses urban areas that are defined at very low spatial and temporal *** conducted several experiments using three Artificial Neural Networks:Multilayer Perceptron,Gated Recurrent Units and bidirectional Long Short Term Memory networks and we tested their suitability using different combinations of *** metrics are provided for the sake of comparison within our study and between other *** solution has been evaluated in a real-world testbed in the city of Murcia(Spain)integrating an open human-mobility dataset showing high accuracy.A MAPE between 4%and 10%was reported in horizons of 1 to 3 h.

关键词： Parking space human mobility mining recurrent neural networks prediction

A wood-wood joining system suitable for digital fabrication and its application in the design of a“wood-only”spatial modulea

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Frontiers of Architectural Research 2023年第3期12卷 523-540页

作者： antonio Jesús de-los-Aires-Solís Francisco gonzalez-Quintial Doctoral School.University of the Basque Country UPV/EHULeioa 48940Spain Department of Architecture.University of the Basque Country UPV/EHULeioa 48940Spain

This paper describes a wood-wood spatial joining system adapted to digital fabrication which has been designated the“Spatial Masterkey”.The wood stereotomy of the joints between the different pieces that make up this joining system is inspired by a three-dimensional puzzle called“snowflake”.The production process used in the masterkey system can be carried out using only a 3-axis CNC milling machine—a relatively affordable and easily accessible *** using digital manufacturing for the execution of wood-wood joints,several benefits are obtained including faster machining and greater cutting precision and uniformity in the products *** advantages make this joining system both economically competitive and environmentally ***,the versatility of this joining system means that its configuration can be adapted to a wide range of casuistry of encounters between members,which means that it can be used for a number of spatial *** includes,but is not limited to,the spatial module presented in this document.

关键词： Wood-wood joinery Digital fabrication 3-Axis CNC Spatial module Sustainability Burr puzzle

Fine‑tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book:the case of the Pura Raza Española horse

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Journal of Animal Science and Biotechnology 2023年第2期14卷 515-528页

作者： Davinia Isabel Perdomo‑gonzalez Nora Laseca Sebastian Demyda‑Peyras Mercedes Valera Isabel Cervantes antonio Molina Departamento Agronomia Escuela Tecnica Superior de Ingenieria AgromomicaUniversidad de SevillaCtra Utrera Km 141013 SevillaSpain Departamento de Genetica Universidad de CordobaCordobaSpain Facultad de Ciencias Veterinarias Universidad Nacional de La PlataLa PlataArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET) La PlataArgentina Departamento de Produccion Animal Facultad de VeterinariaUniversidad Complutense de MadridMadridSpain.

Background:Estimating inbreeding,which is omnipresent and inevitable in livestock populations,is a primary goal for management and animal breeding especially for those interested in mitigating the negative consequences of *** coefficients have been historically estimated by using pedigree information;however,over the last decade,genome-base inbreeding coefficients have come to the forefront in this *** Pura Raza Espanola(PRE)horse is an autochthonous Spanish horse breed which has been recognised since *** total PRE population(344,718 horses)was used to estimate Classical(F),Ballou’s ancestral,Kalinowski’s ancestral,Kalinowski’s new and the ancestral history coefficient *** addition,genotypic data from a selected population of 805 PRE individuals was used to determine the individual inbreeding coefficient using SNP-by-SNP-based techniques(methods of moments-FHOM-,the diagonal elements of the genomic-FG-,and hybrid matrixes-FH-)and ROH measures(FRZ).The analyse of both pedigree and genomic based inbreeding coefficients in a large and robust population such as the PRE horse,with proven parenteral information for the last 40 years and a high degree of completeness(over 90%for the last 70 years)will allow us to understand PRE genetic variability better and the correlations between the estimations will give the data greater ***:The mean values of the pedigree-based inbreeding coefficients ranged from 0.01(F for the last 3 generations-F3-)to 0.44(ancestral history coefficient)and the mean values of genomic-based inbreeding coefficients varied from 0.05(FRZ for three generations,FH and FHOM)to 0.11(FRZ for nine generations).Significant correlations were also found between pedigree and genomic inbreeding values,which ranged between 0.58(F3 with FHOM)and 0.79(F with FRZ).In addition,the correlations between FRZ estimated for the last 20 generations and the pedigree-based inbreeding highlight the fact that fewer generations of

关键词： Genomic inbreeding Horses Pedigree inbreeding

Modulation of cell physiology under hypoxia in pancreatic cancer

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World Journal of Gastroenterology 2021年第28期27卷 4582-4602页

作者： Matias Estaras antonio gonzalez Department of Physiology Institute of Molecular Pathology BiomarkersUniversity of ExtremaduraCaceres 10003Spain Department of Physiology Cell Biology and Communication Research GroupUniversity of ExtremaduraCaceres 10003Spain

In solid tumors,the development of vasculature is,to some extent,slower than the proliferation of the different types of cells that form the tissue,both cancer and stroma *** a consequence,the oxygen availability is compromised and the tissue evolves toward a condition of *** presence of hypoxia is variable depending on where the cells are localized,being less extreme at the periphery of the tumor and more severe in areas located deep within the tumor ***,the cells do not *** pathways that are critical for cell fate such as endoplasmic reticulum stress,apoptosis,autophagy,and others are all involved in cellular responses to the low oxygen availability and are orchestrated by hypoxia-inducible *** stress and inflammation are critical conditions that develop under *** with changes in cellular bioenergetics,all contribute to cell ***,cell-to-cell interaction is established within the tumor such that cancer cells and the microenvironment maintain a bidirectional ***,the release of extracellular vesicles,or exosomes,represents short and long loops that can convey important information regarding invasion and *** a result,the tumor grows and its malignancy ***,one of the most lethal tumors is pancreatic *** paper reviews the most recent advances in the knowledge of how cells grow in a pancreatic tumor by adapting to *** the physiological processes that help the tumor increase its size and their regulation will be of major relevance for the treatment of this deadly tumor.

关键词： Hypoxia Cancer Tumor Pancreas Proliferation Cell survival

Use of residual lignocellulosic biomass for energetic uses and environmental remediation through pyrolysis

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Energy Storage and Saving 2022年第3期1卷 129-135页

作者： Nezly Martelo Mirari Antxustegi Eriz Corro Marya Baloch Rosaria Volpe antonio Gagliano Alberto Fichera María gonzalez Alriols Biorefinery Processes Research Group(BioRP) Chemical and Environmental Engineering DepartmentUniversity of the Basque CountryUPV/EHUSan Sebastian20018Spain Department of Electrical Electronics and Computer EngineeringUniversity of CataniaCatania95125Italy

This study analyzes the potential of an agricultural residue,hazelnut shells,as raw material in a combined ther-mochemical process to obtain pyro-gas and biochar for environmental *** novelty of this study relies on the definition of a pyrolytic polygeneration process to simultaneously attain an energy-type product and abiochar to maximize the versatility of the products and their *** this aim,the heating value of the gas and its potential to feed a micro combined heat and power(micro-CHP)system was ***,the resulting biochar was chemically activated and tested as adsorbent for the removal of contaminants from an aqueous *** show that the pyro-gas from the shell-type residue was suitable to be used as feed stream in a micro-CHP unit,which was able to operate near the full-load(91.9%)with electrical and thermal efficiencies of 27.6%and 57.9%,*** the case of the biochar fraction,poor results were found for the char prior to ***,once it was activated with KOH,the resulting activated carbon presented high effectiveness as adsorbent and complete removal of the measured compound(methylene blue)was achieved.

关键词： Residual lignocellulosic biomass Bioenergy Pollutants removal Micro-CHP Biogas Biochar

Tailoring Resorption Rates and Osteogenic Response in Xeno-Hybrid Bone Grafts: The Effect of Added Gelatins

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Engineering 2022年第6期8卷 197-208页

作者： Hao Zhu Havard Jostein Haugen Giuseppe Perale Janne Elin Reseland Liebert Parreiras Nogueira antonio gonzalez Cantalapiedra Fernando Maria Guzon Munoz Maria Permuy Mendana Felice Betge Stale Petter Lyngstadaas Jun Xiao Department of Orthopedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Biomaterials Institute of Clinical DentistryUniversity of OsloOslo 0317Norway Industrie Biomediche Insubri SA Mezzovico-Vira 6805Switzerland Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Vienna 1200Austria Faculty of Biomedical Sciences University of Southern SwitzerlandLugano 6900Switzerland Faculty of Veterinary University of Santiago de CompostelaLugo 27002Spain

Bone defects resulting from trauma,surgery,congenital malformations,and other factors are among the most common health problems *** current strategies such as autografts and allografts are recognized as the most successful treatments for stimulating bone regeneration,limitations such as graft source and complications still ***?is a xeno-hybrid bone graft(made from bovine bone matrix,poly(L-lactic-co-e-caprolactone),and gelatin)with a positive clinical record for bone *** this study,the formulation for designing xeno-hybrid bone grafts using gelatins from different sources(bovine-and porcine-derived gelatin,with bone grafts named SBN and SPK,respectively)was investigated,and the biological responses were evaluated in vitro and in *** results demonstrate that gelatins from both bovine and porcine sources can be loaded onto SmartBone?successfully and safely,withstanding the aggressive manufacturing *** bone cell responses were observed in *** was found to enhance osteocalcin secretion while SPK was found to upregulate osteopontin from human *** vivo,both bone grafts promoted osteogenesis,but SPK degraded earlier than *** findings suggest that SBN and SPK provide different yet comparable solutions for optimizing the bone resorption and regeneration *** xeno-hybrid bone grafts possess ideal potential for bone defect repairing.

关键词： Bone graft Xeno-hybrid Gelatin source Resorption Bone regeneration

Multi-camera systems for rehabilitation therapies:a study of the precision of Microsoft Kinect sensors

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 348-364页

作者： Miguel OLIVER Francisco MONTERO Jose Pascual MOLINA Pascual gonzalez antonio FERNANDEZ-CABALLERO Instituto de Investigacidn en Informdtica de Albacete Universidad de Castilla-La ManchaAlbacete 02071Spain Departamento de Sistemas Informaticos Universidad de Castilla-La ManchaAlbacete 02071Spain

This paper seeks to determine how the overlap of several infrared beams affects the tracked position of the user, depending on the angle of incidence of light, distance to the target, distance between sensors, and the number of capture devices used. We also try to show that under ideal conditions using several Kinect sensors increases the precision of the data collected. The results obtained can be used in the design of telerehabilitation environments in which several RGB-D cameras are needed to improve precision or increase the tracking range. A numerical analysis of the results is included and comparisons are made with the results of other studies. Finally, we describe a system that implements intelligent methods for the rehabilitation of patients based on the results of the tests carried out.

关键词： Kinect sensor Rehabilitation system Capture precision Multi-camera system