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Crystal Structure of the Arabidopsis thaliana L1L/ NF-YC3 Histone-fold Dimer Reveals Specificities of the LECl Family of NF-Y Subunits in Plants

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Molecular Plant 2017年第4期10卷 645-648页

作者： Nerina Gnesutta Dana saad antonio Chaves-Sanjuan roberto Mantovani Marco Nardini Dipartimento di Bioscienze Università degli Studi di Milano Via Celoria 26 20133 Milan Italy

The NF-Y transcription factor is a heterotrimer formed by evolu- tionarily conserved subunits： NF-YA, NF-YB, and NF-YC. NF-YB and NF-YC harbor a histone fold domain （HFD）, structur- ally similar to that of nucleoso... 详细信息

关键词： NF-Y transcription factor heterotrimer evolutionarily conserved

Sagittal abdominal diameter as a marker of visceral obesity in older primary care patients

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Journal of Geriatric Cardiology 2020年第5期17卷 279-283页

作者： Maria Auxiliadora Nogueira saad antonio José Lagoeiro Jorge Diane Xavier deávila Wolney de Andrade Martins Márcia Maria Sales dos Santos Luciana Thurler Tedeschi Ismar Lima Cavalcanti Maria Luiza Garcia Rosa Rubens Antunes da Cruz Filho Fluminense Federal University NiteróiRio de Janeiro StateBrazil

Background Longevity,combined with a higher prevalence of obesity,particularly visceral obesity,has been associated with an increased risk of cardiovascular *** resistance(IR)is an important link between visceral obesity and cardiovascular *** important association has been found between sagittal abdominal diameter,visceral obesity and *** objective of this study is to evaluate sagittal abdominal diameter as a marker of visceral obesity and correlate it with IR in older primary health care *** A cross-sectional study was performed with 389 patients over 60 years of age(70.6±6.9),of whom 74%were *** clinical,anthropometric and metabolic profiles were assessed and their fasting serum insulin level was used to calculate the homeostasis model assessment insulin resistance(HOMA-IR).Sagittal abdominal diameter was measured in the supine position at the midpoint between the iliac crest and the last rib with abdominal *** Sagittal abdominal diameter was significantly correlated with anthropometric measures of general and visceral obesity and with HOMA-IR in both *** was no change in the association between sagittal abdominal diameter and HOMA-IR after adjusting for age,sex,diabetes and *** It is feasible to use sagittal abdominal diameter in older primary care patients as a tool to evaluate visceral obesity,which is an indicator of cardiovascular risk.

关键词： Cardiovascular risk Insulin resistance Primary health care Sagittal abdominal diameter

Process of Salinisation of a Lagoon and a Coastal Aquifer in Annaba Area （East Algerian）

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Journal of Agricultural Science and Technology(A) 2013年第12期3卷 973-981页

作者： Mekkakia Mokhtaria Larbi Djabri Chemseddine Fehdi Fethi Baali Azzedine Hani antonio Pulido Bosch saad Bouhsina Department of Hydrogeology University Badji Mokhtar Laboratory Ressource en Eau et Ddveloppement Durable (REDD)Annaba 23000 Algeria Department of Geology University of Tebessa Tebessa 12000 Algeria Department of Hydrogeology University of Almeria Edificio CITE II-B Almeria 04120 Spain University of Littoral Cote d 'Opale Dunkerque 59183 France

The study area is located in a Mediterranean region, so the effects of the climate variations are very important. The authors contribution to this subject is based on the compilation of many results obtained from dissertations and theses that are carried out under their supervision. The main tool used, in addition to other methods, is the water hydrochemistry as it is proved very useful in obtaining good results and helpful in getting objective interpretations regarding the presence and absence of salinity. Several factors are undertaken to show the presence of salts in waters in the plain, the lithology of the geological formations shows that they are composed of alluvium sediments where the permeability is quite high, and this enables hydraulic communication between the fresh water of the aquifer and saline water of the sea. The study of climate shows a decrease of precipitation which favors an important decrease of recharge rate to the aquifer, and hence a decrease of water resource. The strontium which is a good indicator for the origin of salinity shows a variation that indicates a variation in the distribution of the salinity, and therefore diverse origins of salinity all over the studied area. This can infer the presence of marine invasion in the down-stream part of the aquifer, whereas elsewhere salinity is caused by the presence of evaporitic formation, mainly by the argillaceous matrix in the bottom of the lake. in the up-stream part of the aquifer. In the lake, salinity is explained

关键词： Lake river sea marine invasion aquifer transmissivity evaporitic.

Paraneoplastic syndromes in cholangiocarcinoma

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World Journal of Hepatology 2020年第11期12卷 897-907页

作者： saad Ur Rahman Muhammad Khawar Sana Zabreen Tahir Aamir Ali Pir Ahmad Shah Department of Medicine King Edward Medical UniversityLahore 54000PunjabPakistan Department of Neurology Brigham and Women’s HospitalBostonMA 02115United States Department of Radiology Beth Israel Deaconess Medical CenterBostonMA 02215United States Department of Medicine University of Texas Health Science CenterSan AntonioTX 78229United States

Paraneoplastic syndromes are the symptoms or signs which result from damage to tissues that are distant from the site of malignancy,due to complex interactions between the body’s immune system and malignant ***(CCA)is an aggressive epithelial malignancy of hepatobiliary tree and it is found to be associated with various paraneoplastic *** syndromes can present as dermatological,neurological,renal,hematological,or multi-systemic *** suspicion and timely recognition of these syndromes can lead to early diagnosis of covert malignancies like *** management plan remains the removal of the underlying cause which in this case is CCA.

关键词： Cholangiocarcinoma Paraneoplastic syndrome Malignancy Immune system Biliary tree Multi-organ

Insights on Blood Cytokines Production under Different <i>In Vitro</i>Mycobacterial Antigens in Tuberculosis Intestinal Parasites Co Infected Patients

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Advances in Microbiology 2018年第3期8卷 161-174页

作者： Renan Jeremias da Silva Fernanda C. Q. Mello Janaína A. Leung antonio Henrique Almeida de Moraes Neto Leila de Souza Fonseca Helio Ribeiro de Siqueira Health Care Victor Vala and CSEGSF Team Maria Helena Féres saad Laboratory of Cellular Microbiology Oswaldo Cruz Institute (IOC) Fiocruz Rio de Janeiro Brazil Federal University of Rio de Janeiro Clementino Fraga Filho Hospital Rio de Janeiro RJ Brazil Laboratory of Innovations in Therapies Teaching and Bioproducts Oswaldo Cruz Institute (IOC) Fiocruz Rio de Janeiro Brazil Rio de Janeiro State University Pedro Ernesto Hospital Rio de Janeiro Brazil Victor Vala Family Clinic and Health Care-School Germano Silval Farias (CSEGSF) ENSP/Fiocruz Rio de Janeiro Brazil

Background: The concomitant presence of intestinal parasite infections (IP) and tuberculosis (TB) has relevance. M. tuberculosis immune response is associated with type 1 T helper cell (Th1) while IP is associated with type Th2 cell. However, there are several contradictory reports on cytokine production under coinfection and this could be in association to the mycobacterial antigens used in the studies. Aim: To get insight into the effects of different M. tuberculosis-specific antigens (ESAT-6/CFP-10 and 38 kDa/CFP-10) in generating of appropriate cytokines on peripheral blood mononuclear cells of IPTB co infected patients. Method: ELISA assessed IFN-γ and other 16 cytokines production and plasm IgE. In 18 months, we documented demographic, economic, clinical characteristics and IP frequency in individuals from Brazil. Results: An overall 10/35 (28.5%) were IPTB co infected and 40/76 (52.6%;p = 0.024) asymptomatic intestinal parasite infected community controls (IPCC). Endo-limax nana (40%) and Entamoeba coli (22%), were the most nonpathogenic protozoan identified and Entamoeba histolytica, Giardia intestinalis, Ascaris lumbricoides and Strongyloides stercoralis were the pathogenic species (40%). IgE was higher in IPCC (p = 0.036). Cytokine profiles were significantly biased toward a Th2 type IL-5 (p = 0.001) and IL-13 (p = 0.033), pro-inflammatory GM-CSF (p = 0.019) and borderline lower IL-1β in IPTB, all associated with ESAT-6/CFP-10, while IL-7 was borderline lower, but 38 kDa/CFP-10 associated;as well as IL-8 higher (p < 0.049) vs CC/IPCC. The TB/IPTB IFN-γ levels were similar to both antigens stimuli (p ≥ 0.208). Conclusion: Therefore, coin-cident IPTB coinfection did not exert a significant inhibitory effect in IFN-γ production in response to either of the two antigens, but the partial discrepancy in Th1/Th2 response, is associated with the antigen priming cells.

关键词： Mycobacterium tuberculosis Intestinal Parasites Mycobacterial Antigens IgE Cytokines