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Past,present and future of primary systemic treatment in breast cancer

World Journal of Obstetrics and Gynecology 2013年第2期2卷 21-33页

作者： JoséL Alonso-Romero antonio pinero-madrona Department of Oncology and Surgery "Virgen de la Arrixaca"University Hospital30120 MurciaSpain

Primary systemic treatment is a fundamental part of breast cancer therapy, and it is applied to non-surgical and locally advanced tumours as well as surgical tumours to increase the likelihood of conservative treatment. Its aim is to achieve the best possible survival with better cosmetic results and with the lowest number of treatment-related secondary effects. Before treatment is started, it is necessary to attain the best knowledge of the biological features and locoregional extension of the tumour. To do so, it is necessary to obtain a biopsy of the lesion with a wide bore needle,as well as good radiological knowledge of the ***, currently, the use of a dynamic magnetic resonance imaging(MRI) of the breast should be included in all cases. In addition, before it is started,especially in those tumours in which conservative treatment is considered, one or several radiopaque markers should be put into place to make it possible to locate the area to be treated if there is a considerable or complete response. Systemic treatment is mainly based on combined chemotherapy with anthracyclins and taxanes, in addition to some biological agents with demonstrated efficiency for increasing the likelihood of complete disease response(trastuzumab in patients with Her-2/neu overexpression). However, there is room for neoadjuvant hormone treatment, in patients with hormone receptor overexpression, especially in those cases in which chemotherapy is contraindicated as well as in elderly patients with a relatively short life expectancy. The assessment of preoperative treatment should be based on adequate radiological tests, and nowad these should include MRI before taking decisions about adequate surgical treatment. The objective of primary treatment is to be able to increase survival and improve the chances of local treatment in the case of locally advanced treatment, achieving results that are at least equal to those of adjuvant treatment in the case of surgical tumour

关键词： Breast cancer Breast carcinoma Primary systemic therapy Neoadjuvant chemotherapy Neoadjuvant therapy

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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

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Profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1046-1050页

作者： Jose antonio Trigueros David P pinero Mahmoud M Ismail Department of Financial Economic and Accounting Miguel Hernandez University Elche 03202 Alicante Spain Department of Optics Pharmacology and AnatomyUniversity of Alicante Crta San Vicente del RaspeigAlicante 03690 Spain Al-Azhar University Cairo 11651 Egypt

AIM：To define the financial and management conditions required to introduce a femtosecond laser system for cataract surgery in a clinic using a fuzzy logic ***：In the simulation performed in the current study,the costs associated to the acquisition and use of a commercially available femtosecond laser platform for cataract surgery（VICTUS,TECHNOLAS Perfect Vision GmbH,Bausch ＆ Lomb,Munich,Germany） during a period of 5y were considered.A sensitivity analysis was performed considering such costs and the countable amortization of the system during this 5y ***,a fuzzy logic analysis was used to obtain an estimation of the money income associated to each femtosecond laser-assisted cataract surgery（G）. RESULTS：According to the sensitivity analysis,the femtosecond laser system under evaluation can be profitable if 1400 cataract surgeries are performed per year and if each surgery can be invoiced more than $*** contrast,the fuzzy logic analysis confirmed that the patient had to pay more per surgery,between $661.8 and $667.4 per surgery,without considering the cost of the intraocular lens（IOL）.CONCLUSION：A profitability of femtosecond laser systems for cataract surgery can be obtained after a detailed financial analysis,especially in those centers with large volumes of *** cost of the surgery for patients should be adapted to the real flow of patients with the ability of paying a reasonable range of cost.

关键词： cataract surgery femtosecond laser fuzzy logic femto-cataract victus profitability analysis

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Evaluation of a new nomogram for Ferrara ring segment implantation in keratoconus

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1371-1383页

作者： Joaquín Fernández Cristina Peris-Martínez antonio Pérez-Rueda Sidi Mohamed Hamida Abdelkader María JoséRoig-Revert David P.pinero Department of Ophthalmology(Qvision) Vithas Virgen del Mar HospitalAlmeria 04120Spain Department of Ophthalmology Torrecardenas Hospital ComplexAlmeria 04009Spain Comea and External Diseases Unit FISABIO-Oftalmologia Medica(FOM)Valencia 46015Spain Avino Peris Eye Clinic Valencia 46001Spain Department of Surgery OphthalmologyUniversity of ValenciaValencia 46010Spain Department of Optics Pharmacologyand AnatomyUniversity of AlicanteAlicante 03690Spain

AIM:To evaluate the short-term clinical outcomes of Ferrara rings in keratoconus using an optimized nomogram developed after several years of research and retrospective analysis of clinical ***:This prospective longitudinal non-comparative clinical trial evaluated 88 eyes of 88 patients(age 18-62 y)with keratoconus diagnosis from two Spanish *** ring segment(AJL Ophthalmic)implantation was performed in all cases,using the mechanical procedure in 25 eyes(28.4%)and a femtosecond laser-assisted procedure in 63 eyes(71.6%).The ring segments implanted in each case were selected using a new optimized nomogram that considered variables such as anterior corneal asphericity and astigmatism or the discrepancy among astigmatism and coma ***,refractive,corneal topographic,aberrometric,and pachymetric changes after surgery were evaluated during a 3-month ***:The implants induced a significant refractive change as well as an improvement in uncorrected(UDVA)and corrected distance visual acuity(CDVA;P<0.001).Postoperative CDVA of 0.10 log MAR or better was achieved in 28.4%and 46.5%of eyes,*** eyes(2.3%)lost two or more lines of CDVA whereas a total of 53.5%of eyes gained lines of CDVA.A significant central anterior and posterior corneal flattening was induced(P≤0.003),with a significant reduction of anterior(P<0.001)and posterior corneal astigmatisms(P=0.048),and a change in anterior asphericity(P<0.001).Total primary coma(6 mm pupil)change was also statistically significant(preoperative 3.66±3.04μm vs postoperative 2.33±2.26μm,P<0.001).No significant differences were found in the effect of ring segments between cases implanted using the mechanical and femtosecond techniques(P≥0.101).CONCLUSION:The implantation of Ferrara rings based on the nomogram evaluated is safe and effective for promoting a visual rehabilitation in keratoconus,with a relevant control of primary coma aberration.

关键词： intracorneal ring segment Ferrara ring segment femtosecond keratoconus coma aberration

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Quasi-freestanding graphene on Ni（110）： A graphene/ metal contact with suppressed interface states

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Nano Research 2016年第6期9卷 1795-1800页

作者： antonio Politano Department of Physics University of Calabria via Ponte Bucci 3 I/C 1-87036 Rende (CS) Italy

Graphene/Ni（110） has been studied by time-resolved X-ray photoelectron spectroscopy and near-edge X-ray absorption fine structure. The C ls core level shows a splitting typical of periodically rippled interfaces. The analysis of the C K-edge reveals that the interface states previously observed for graphene/Ni（111） are suppressed in graphene/Ni（110）. This suppression is due to the reduced hybridization of the Dirac-cone electrons in graphene with the d-bands of the （110）-oriented nickel contacts. Our results show that, contrary to commensurate growth of graphene on Ni（111）, epitaxially grown graphene on Ni（110） behaves as a quasi-freestanding sheet, as the lattice mismatch gives rise to a moir6 reconstruction.

关键词： graphene electronic properties synchrotron radiation X-ray photoelectronspectroscopy near-edge X-rayphotoelectron spectroscopy

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Interplay between the glass and the gel transition

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 45-50页

作者： Annalisa Fierro antonio de Candia antonio Coniglio CNR-SPIN c/o Complesso di Monte S.AngeloNapoli 80126Italy Dipartimento di Fisica"Pancini" Universita di Napoli"FedericoⅡ"Complesso di Monte S.AngeloNapoli 80126Italy

By changing the control parameters, many physical systems reach a slow dynamics regime followed by an arrested or a quasiarrested state. Examples, among others, are gels and glasses. In this paper, we discuss some experimental and theoretical results in polymer and colloidal systems, where gel and glass transitions interfere, and use models from Mode Coupling Theory（MCT）to illustrate the rich phenomenology observed. The continuous and the discontinuous transition lines, found in the MCT models,are considered suitable to describe respectively the gel and the glass transitions, so we suggest that the interplay between gel and glass may be interpreted in terms of the F13 MCT model, clarifying also the origin of logarithmic decays often observed in such systems. In particular, the theoretical predictions of the MCT in the F13 model are compared with Molecular Dynamics simulations in model systems for chemical gels and charged colloids.

关键词： glass gel and sol colloid

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Cost-effective synthesis of giant molecule acceptors(GMAs)for stable polymer solar cells

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Science China Chemistry 2024年第4期67卷 1041-1043页

作者： antonio Facchetti Department of Chemistry and the Materials Research Center Northwestern University2145 Sheridan Road60208 EvanstonIllinoisUSA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive30332 AtlantaGeorgiaUSA

Polymer solar cells(PSCs)have emerged as a disruptive energy technology due to simple device architecture,earthabundant elemental composition,lightweight nature,and inherent mechanical flexibility[1,2].Via a strategic acceptordonor-acceptor(A-D-A)design of small-molecule acceptors(SMAs),device power conversion efficiency(PCE)has now increased>19%.

关键词： acceptor synthesis donor

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Impact of radiative cooling on the energy performance of courtyards in Mediterranean climate

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Building Simulation 2024年第9期17卷 1491-1513页

作者： Carlos-antonio Domínguez-Torres antonio Domínguez-Delgado Escuela Técnica Superior de Arquitectura Universidad de SevillaAv.de Reina Mercedes241012 SevillaSpain Department of Applied Mathematics 1 Escuela Técnica Superior de ArquitecturaUniversidad de SevillaAv.de Reina Mercedes241012 SevillaSpain

Radiative cooling has proven to be a useful tool to address the problems of lack of comfort and excessive energy consumption in situations of high temperatures,overheating and heat ***,incorporating courtyards in warm climate zones has been found to be highly beneficial in addressing similar ***,there is interest in analyzing the combined effects of both:radiative cooling and *** paper presents an analysis of the impact of the application of radiative cooling on a courtyard using a comprehensive simulation approach that includes a CFD model for the thermodynamic airflow in the adjacent roofs and inside the courtyard,equations for the transient heat conduction through roofs,walls and courtyard slabs,and a hybrid raytracing-radiosity model for the evaluation of the solar radiation reaching the building surfaces and its reflections,both of specular and diffuse origin,and for the calculation of the thermal radiation exchange,especially with the *** results show that in the hot season,the courtyard with radiative cooling always provides lower temperatures than the initial courtyard does,with a temperature range of 18.33℃to 33.78℃,compared to a range of 19.32℃to 38.00℃in the initial courtyard,and producing a greater difference with outdoor temperatures that can reach 12℃versus 8℃for the reference *** addition,it was found that the courtyard with radiative cooling is able to significantly reduce the observed nighttime overheating by providing lower temperatures than the outdoor temperatures in the 50%of the nights *** was also found that the thermal loads to achieve indoor thermal comfort in the spaces adjacent to the courtyard were reduced by 63.46%to 69.85%.

关键词： radiative cooling passive cooling CFD three-dimensional modeling energy saving thermal comfort

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Tannin-Based Biofoams-A Review

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Journal of Renewable Materials 2019年第5期7卷 477-492页

作者： antonio Pizzi LERMAB-ENSTIB University of Lorraine27 rue Philippe Seguin88000 EpinalFrance

This review details the development of tannin-based biofoams for fire resistance and acoustic insulation and details the different varieties of these foams that have been developed,from tannin-furanic self-blowing foa... 详细信息

关键词： Biofoams tannins tannin-furanic tannin-carbohydrates,nonisocyanate polyurethanes(NIPU)

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Molecular conformation-induced interfacial stress at the origin of the instability of organic transistors

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Science China Chemistry 2021年第9期64卷 1437-1438页

作者： antonio Facchetti Department of Chemistry and Materials Research Center Northwestern University2145 Sheridan RoadEvanstonIL60208USA Flexterra Corporation 8025 Lamon AvenueSkokieIL60077USA

As one of the most important organic electronic building block,organic field-effect transistors(OFETs)have broad application prospects in the fields of flexible displays,electronic skins,and wearable *** more than 30 years of development,the performance(e.g.,the carrier mobility)and processing technology of OFETs have made considerable progress^([1,2]).

关键词： transistors interfacial origin

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