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Branched chain amino acids in hepatic encephalopathy and sarcopenia in liver cirrhosis:Evidence and uncertainties

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World Journal of Gastroenterology 2023年第19期29卷 2905-2915页

作者： Giuseppe Marrone Amato Serra Luca Miele Marco Biolato antonio Liguori antonio Grieco antonio Gasbarrini Medical and Surgical Sciences Fondazione Policlinico Universitario A.Gemelli-IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy

Liver cirrhosis is commonly associated with nutritional alterations,reported in 20% of patients with compensated disease and over 60% of patients with decompensated *** disturbances are associated with a worse prognosis and increased risk of *** levels of branched-chain amino acids(BCAAs)are decreased in patients with liver *** imbalance of amino acids levels has been suggested to be associated with the development of complications,such as hepatic encephalopathy and sarcopenia,and to affect the clinical presentation and prognosis of these *** studies investigated the efficacy of BCAAs supplementation as a therapeutic option in liver cirrhosis,but uncertainties remain about the real efficacy,the best route of administration,and dosage.

关键词： Branched-chain amino acids Hepatic encephalopathy Sarcopenia Liver cirrhosis

Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

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World Journal of Gastroenterology 2021年第12期27卷 1161-1181页

作者： Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho luiz antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona luiz Augusto Carneiro D'Alburquerque Division of Anesthesiology Hospital das ClínicasUniversity of São Paulo School of MedicineSão Paulo 05403-000Brazil Department of Anesthesiology AC Camargo Cancer CenterSão Paulo 01509-010Brazil Department of Gastroenterology Discipline of Liver and Gastrointestinal TransplantationLaboratory of Medical Investigations LIM37 Hospital das ClinicasUniversity of São Paulo School of MedicineSão Paulo 05402-000Brazil Department of Liver Transplantation AC Camargo Cancer CenterSão Paulo 01525-901Brazil Department of Gastroenterology Division of Liver and Gastrointestinal TransplantHospital das ClinicasUniversity of São Paulo School of MedicineSão Paulo 05402-000Brazil

BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young *** and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver *** To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing *** We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative *** receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/***,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be *** High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up *** a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the *** a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection ***,Cox hazard regr

关键词： Liver transplantation Child Blood transfusion Outcome Liver cirrhosis Mortality

Oxidative reforming of methane for hydrogen and synthesis gas production:Thermodynamic equilibrium analysis

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Journal of Natural Gas Chemistry 2012年第5期21卷 571-580页

作者： antonio C.D.Freitas Reginaldo Guirardello School of Chemical Engineering University of Campinas (UNICAMP)Av.Albert Einstein 50013083-852Campinas-SPBrazil

A thermodynamic analysis of methane oxidative reforming was carried out by Gibbs energy minimization （at constant pressure and temperature） and entropy maximization （at constant pressure and enthalpy） methods,to determine the equilibrium compositions and equilibrium temperatures,*** cases were treated as optimization problems （non-linear programming formulation）.The GAMS 23.1 software and the CONOPT2 solver were used in the resolution of the proposed *** hydrogen and syngas production were favored at high temperatures and low pressures,and thus the oxygen to methane molar ratio （O 2 /CH 4） was the dominant factor to control the composition of the product *** O 2 /CH 4 molar ratios higher than 0.5,the oxidative reforming of methane presented autothermal behavior in the case of either utilizing O 2 or air as oxidant agent,but oxidation reaction with air possessed the advantage of avoiding peak temperatures in the system,due to change in the heat capacity of the system caused by the addition of *** calculated results were compared with previously published experimental and simulated data with a good agreement between them.

关键词： thermodynamic analysis methane oxidative reforming Gibbs energy minimization entropy maximization hydrogen and syngas production

Hydrogels from Chitosan and a Novel Copolymer Poly(N-Vinyl-2-Pyrrolidone-Co-Acrolein)

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Materials Sciences and Applications 2011年第8期2卷 1058-1069页

作者： Janaina Aline Galvao Barros antonio Jedson Caldeira Brant luiz Henrique Catalani Institute of Chemistry University of Sao PauloSao PauloBrazil

PVP, a synthetic polymer and chitosan, a natural polymer are biocompatible and have presented a great variety of interesting properties for cosmetic, biomedical, pharmaceutical and biotechnological applications, Many alternatives to improve the polymer propeties has been made as bleeding polymers, for example. In this work, two different techniques of hydrogel attainment were used: one from mixtures of acid aqueous cosolutions of chitosan and PVP, whose resultant films and solutions were irradiated, afterwards, by ultraviolet radiation (λ = 254 nm), another one from the reaction of poly (N-vinyl-2-pyrrolidone-co-acrolein)-a novel copolymer synthesized in our biomaterials laboratory-and chitosan. In the first one alternatives it was possible produce hydrogels directly from mixtures of aqueous acidic co-solutions of both polymers. In the second one, the attainment of hydrogels from Schiff base has proved to be an effective methodology for the production of hydrogels, showing good values of gel content and swelling.

关键词： Chitosan Hydrogel Copolymer Crosslinking Schiff Base Poly(Vinyl-Pyrrolidone-Co-Acrolein)

Short-term effects of post-fire mulching with straw or wood chips on soil properties of semi-arid forests

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Journal of Forestry Research 2023年第6期34卷 1777-1790页

作者： Manuel Esteban Lucas Borja Demetrio antonio Zema Department of Agroforestry Technology Science and GeneticsSchool of Advanced Agricultural and Forestry EngineeringCampus Universitario s/nCastilla La Mancha UniversityE-02071 Castilla La ManchaAlbaceteSpain Department AGRARIA “Mediterranea”University of Reggio CalabriaLocalitàFeo di VitoI-89122 Reggio CalabriaItaly

Few studies have compared the variability of soil properties using different types of mulches in semi-arid *** study evaluated the changes in physico-chemical soil properties in a semi-arid forest of Central Eastern Spain,where straw and pine wood chips were distributed as mulch three months after a *** were sampled under burned and unmulched and burned and mulched plots three and nine months after the *** data was processed using Principal Component Analysis(PCA)and Analytical Hierarchical Cluster Analysis(AHCA).Mulching with straw or wood chips did not have any significant effects on the texture and chemical properties of burned sites few months after the *** contrast,significant changes are expected over time in organic matter,nutrients and many *** were no significant differences in soil properties between the two *** low changes were confirmed by PCA coupled with AHCA,which did not show a clear distinction among the three soil ***,a noticeable and significant variability of many of these properties over time was *** study shows that mulching does not degrade of soil properties in the short-term after a wildfire and after post-fire treatments,and thus helps protect semi-arid forest ecosystems against the negative impacts of high-severity fires.

关键词： Post-fire management High-severity fire Aridisols Erosion Vegetal residues incorporation Soil degradation

Dynamic necking of a near α titanium alloy at high strain rates:Experiments and modelling

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Defence Technology（防务技术） 2021年第4期17卷 1126-1134页

作者： Long-hui Zhang antonio Pellegrino Nik Petrinic Department of Engineering Science University of OxfordOxfordOX13PJUK

The tensile behaviour of near a Ti3Al2.5 V alloy,conceived for applications in aerospace and automotive engineering,is characterized from quasi-static to high strain *** material is found to present noticeable strain rate *** dynamic true strain rate in the necking cross-section reaches values up to ten times higher than the nominal strain *** is also observed that beyond necking the dynamic true stress-strain curves present limited rate *** experimental results at different strain rates are used to determine a suitable constitutive model for finite element simulations of the dynamic tensile *** model predicts the experimentally macroscopic force-time response,true stress-strain response and effective strain rate evolution with good agreement.

关键词： Nearαtitanium alloy High strain rate Locking effect Constitutive modeling Finite element simulation

Autophagy inhibition: a new therapeutic target in spinal muscular atrophy

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Neural Regeneration Research 2018年第5期13卷 813-814页

作者： antonio Piras Marina Boido Neuroscience Institute Cavalieri Ottolenghi (NICO) Dept. Neuroscience University of Torino

Spinal muscular atrophy（SMA）is a hereditary pediatric motor neuron（MN）disease：survival motor neuron 1（SMN1）gene mutation determines MN degeneration and,consequently,muscle atrophy,breathing and swallowing difficulties,and,in the most severe cases,premature death.A second unaffected gene（SMN2）is present,but it can only produce a limited amount of functional protein,modulating the disease severity and progression.

关键词： Figure SMN a new therapeutic target in spinal muscular atrophy SMA

A Proof of Wedderburn＇s Theorem

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Algebra Colloquium 2015年第4期22卷 603-606页

作者： José antonio Cuenca Mira Departamento de álgebra Geometría y Topología Facultad de Ciencias Universidad de Málaga 29071 Málaga Spain

In this note we first introduce the finite weak Herstein condition, which is a property that holds for every finite field. For a field F satisfying the finite weak Herstein condition, we then characterize whether all the finite-dimensional division F-algebras are commutative. This gives an alternate proof of Wedderburn＇s Theorem.

关键词： division algebra finite-dimensional algebra finite field Galois extension

New oral agents for erectile dysfunction: what is changing in our practice?

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Asian Journal of Andrology 2001年第3期3卷 175-179页

作者： antonio Aversa Andrea Fabbri AFaR-CRCC Fatebenefratelli-Isola Tiberina Hospital and Endocrinology Unit Department of Internal Medicine University of Rome 'Tor Vergata' 00133 Rome ItalyEndocrinology Unit Department of Internal Medicine University of Rome 'Tor Vergata' 00133 Rome Italy

Erectile dysfunction (ED) is a highly prevalent disorder affecting an estimated 152 million men worldwide and isassociated with a variety of behavioral risk factors, such as cigarette smoking and excessive alcohol consumption, aswell as numerous age - related medical conditions, notably type-2 diabetes mellitus and cardiovascular disease. A ratio-nal step - wise approach which includes comprehensive medical and sexual history, a focused physical examination andessential laboratory tests such as fasting glucose, lipid profile and testosterone assay is to be preferred. Current diagnos-tic work - up does not recommend any of the specialized tests which were previously considered mandatory-i. e. penilepharmacotesting, Duplex ultrasound and nocturnal penile tumescence. Hormonal replacement therapy is appropriate onlyin the hypogonadal male with ED. Prior to direct intervention, the physician should consider altering modifiable riskfactors or causes, although frequently insufficient to reverse ED completely. When indicated, oral therapy with newmolecules (phosphodiesterase inhibitors or apomorphine) is the first - line treatment for the majority of patients becauseof potential benefits and lack of invasiveness. (Asian J Androl 2001 Sep; 3: 175-179 )

关键词： erectile dysfunction oral medicine therapy phosphodiesterase inhibitors apomorphine nitric oxide