Branched chain amino acids in hepatic encephalopathy and sarcopenia in liver cirrhosis:Evidence and uncertainties

作     者：Giuseppe Marrone Amato Serra Luca Miele Marco Biolato Antonio Liguori Antonio Grieco Antonio Gasbarrini 

作者机构：Medical and Surgical SciencesFondazione Policlinico Universitario A.Gemelli-IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第19期

页      面：2905-2915页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Branched-chain amino acids Hepatic encephalopathy Sarcopenia Liver cirrhosis 

摘      要：Liver cirrhosis is commonly associated with nutritional alterations,reported in 20% of patients with compensated disease and over 60% of patients with decompensated *** disturbances are associated with a worse prognosis and increased risk of *** levels of branched-chain amino acids(BCAAs)are decreased in patients with liver *** imbalance of amino acids levels has been suggested to be associated with the development of complications,such as hepatic encephalopathy and sarcopenia,and to affect the clinical presentation and prognosis of these *** studies investigated the efficacy of BCAAs supplementation as a therapeutic option in liver cirrhosis,but uncertainties remain about the real efficacy,the best route of administration,and dosage.