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Spinal cord injury-induced cognitive impairment: a narrative review

Neural Regeneration Research 2022年第12期17卷 2649-2654页

作者： Oscar V.Alcántar-Garibay Diego Incontri-Abraham antonio ibarra Centro de Investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus NorteHuixquilucanEstado de MéxicoMéxico

Spinal cord injury is a serious damage to the spinal cord that can lead to life-long disability.Based on its etiology,spinal cord injury can be classified as traumatic or non-traumatic spinal cord injury.Furthermore,the pathology of spinal cord injury can be divided into two phases,a primary injury phase,and a secondary injury phase.The primary spinal cord injury phase involves the initial mechanical injury in which the physical force of impact is directly imparted to the spinal cord,disrupting blood vessels,axons,and neural cell membranes.After the primary injury,a cascade of secondary events begins,expanding the zone of neural tissue damage,and exacerbating neurological deficits.Secondary injury is a progressive condition characterized by pro-inflammatory cytokines,reactive oxygen species,oxidative damage,excitatory amino acids such as glutamate,loss of ionic homeostasis,mitochondrial dysfunction,and cell death.This secondary phase lasts for several weeks or months and can be further subdivided into acute,subacute,and chronic.One of the most frequent and devastating complications developed among the spinal cord injury population is cognitive impairment.The risk of cognitive decline after spinal cord injury has been reported to be 13 times higher than in healthy individuals.The exact etiology of this neurological complication remains unclear,however,many factors have been proposed as potential contributors to the development of this disorder,such as concomitant traumatic brain injury,hypoxia,anoxia,autonomic dysfunction,sleep disorders such as obstructive sleep apnea,body temperature dysregulation,alcohol abuse,and certain drugs.This review focuses on a deep understanding of the pathophysiology of spinal cord injury and its relationship to cognitive impairment.We highlight the main mechanisms that lead to the development of this neurological complication in patients with spinal cord injury.

关键词： autonomic dysfunction cognitive impairment spinal cord injury traumatic brain injury

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Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke

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Neural Regeneration Research 2015年第11期10卷 1733-1734页

作者： Yolanda Cruz Paola Suárez-Meade antonio ibarra Facultad de Ciencias de la Salud Universidad Anáhuac México Norte Av.Universidad Anáhuac No.46 Col.Lomas Anáhuac C.P.52786 Huixquilucan Edo.de México Proyecto CAMINA A.C. Tlalpan No.4430 Col.Toriello Guerra C.P.14050México City México

Cerebrovascular diseases are considered to be amongst the most serious public health issues,since they are the third leading cause of death（WHO,2014）and the most common cause of disability worldwide.Its monetary significance is evidenced by the economic burden imposed on health care systems,given that the cost of medical care for a patient that has suffered a stroke is around$25,741US dollars every 5 years（Luengo-Fernandez et al.,2012）.A stroke occurs as a result of a disturbance or interruption of cerebral blood flow that significantly reduces the supply of oxygen and glucose to the neural tissue. Consequently, several cell death mechanisms （secondary lesion mechanisms） such as necrosis, excitotoxicity, free radical production and inflammation are triggered （Castillo, 2000）.

关键词： Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke BDNF Figure

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Spinal cord injury： potential neuroprotective therapy based on neural-derived peptides

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Neural Regeneration Research 2016年第11期11卷 1762-1763页

作者： elisa garcía josé mondragón-caso antonio ibarra Facultad de Ciencias de la Salud Universidad Anahuac Mexico Estado de Mexico Mexico

Spinal cord injury （SCI） is a degenerative disease that causes an important neurological impairment, it is a medically complex and life-disrupting condition. SCI has a devastating impact on international health systems due to its irreversible consequences and lack of efficient treatment, affecting mostly young population within their productive years. Global SCI incidence in high-income countries is 40 to 80 new cases per million per year,

关键词： SCI Spinal cord injury GME

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Uremic Bleeding in 2 Patients with Dieulafoy’s Lesion: Case Report and Literature Review

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Open Journal of Gastroenterology 2024年第5期14卷 167-173页

作者： Gustavo Adolfo Hernández Valdez Diana Estefanía ibarra García Juan antonio Contreras Escamilla Janette Alejandra Gamiño Gutierrez Francisco Manuel Tonatiuh Carrillo Beltran Ulises Solis Gomez Jocelyn Nataly Quintero Meléndez Ivan Alejandro Medina Jimenez Marco antonio González Villar Jorge Rojas Morales Department of Internal Medicine ISSSTE APP General Hospital of Tepic Tepic Nayarit Mexico Hospital Civil de Guadalajara Fray antonio Alcalde Guadalajara Jalisco M&#233xico

Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage to this artery can cause severe and intermittent arterial bleeding from small vascular stumps that are difficult to visualize. Furthermore, these catastrophic bleeding episodes frequently result in hemodynamic instability and the need for transfusion of multiple blood products. Recently, uremic syndrome has been identified as a risk factor for gastric mucosal lesions. We present two clinical cases of acute digestive bleeding due to Dielafoy lesion with chronic kidney disease as the main cause, where two different therapies were performed endoscopically. We concluded with the results of our patients that the best therapy was the application of the hemostatic hemoclip on the injury vs the injection with adrenaline on the wound site. Uremia is identified as a risk factor for upper gastrointestinal bleeding in patients with pre-existing Dieulafoy’s lesion, as well as a higher incidence of new bleeding.

关键词： Dieulafoy’s Lesion Gastrointestinal Bleeding Endoscopy Endoscopy Hemostatic Clips Kidney Disease Adrenaline Thermal Coagulation Dieulafoy

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Neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1273-1280页

作者： Dulce Parra-Villamar Liliana Blancas-Espinoza Elisa Garcia-Vences Juan Herrera-García Adrian Flores-Romero Alberto Toscano-Zapien Jonathan Vilchis Villa Rodríguez Barrera-Roxana Soria Zavala Karla antonio ibarra Raúl Silva-García Unidad de Investigación Médica en Inmunología Hospital de PediatríaCentro Médico Nacional Siglo XXI/Instituto Mexicano del Seguro Social/Ciudad de MéxicoMéxico Centro de Investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac MéxicoCampus NorteHuixquilucanEdo de MéxicoMéxico Centro de Investigación del Proyecto Camina A.C Ciudad de MéxicoMéxico

Several therapies have shown obvious effects on structural conservation contributing to motor functional recovery after spinal cord injury(SCI).Nevertheless, neither strategy has achieved a convincing effect.We purposed a combined therapy of immunomodulatory peptides that individually have shown significant effects on motor functional recovery in rats with SCI.The objective of this study was to investigate the effects of the combined therapy of monocyte locomotion inhibitor factor(MLIF), A91 peptide, and glutathione monoethyl ester(GSH-MEE) on chronic-stage spinal cord injury.Female Sprague-Dawley rats underwent a laminectomy of the T9 vertebra and a moderate contusion.Six groups were included: sham, PBS, MLIF + A91, MLIF + GSH-MEE, A91 + GSH-MEE, and MLIF + A91 + GSH-MEE.Two months after injury, motor functional recovery was evaluated using the open field test.Parenchyma and white matter preservation was evaluated using hematoxylin & eosin staining and Luxol Fast Blue staining, respectively.The number of motoneurons in the ventral horn and the number of axonal fibers were determined using hematoxylin & eosin staining and immunohistochemistry, respectively.Collagen deposition was evaluated using Masson's trichrome staining.The combined therapy of MLIF, A91, and GSH-MEE greatly contributed to motor functional recovery and preservation of the medullary parenchyma, white matter, motoneurons, and axonal fibres, and reduced the deposition of collagen in the lesioned area.The combined therapy of MLIF, A91, and GSH-MEE preserved spinal cord tissue integrity and promoted motor functional recovery of rats after SCI.This study was approved by the National Commission for Scientific Research on Bioethics and Biosafety of the Instituto Mexicano del Seguro Social under registration number R-2015-785-116(approval date November 30, 2015) and R-2017-3603-33(approval date June 5, 2017).

关键词： glutathione monoethyl ester monocyte locomotion inhibitor factor motor functional recovery neuroprotection neurorestoration peptides protective autoimmunity spinal cord injury

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Release of interleukin-10 and neurotrophic factors in the choroid plexus：possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia

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Neural Regeneration Research 2018年第10期13卷 1743-1752页

作者： Yolanda Cruz Edna E.García Jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-García Herlinda Bonilla-Jaime Julio Rojas-Castaneda antonio ibarra Centro de Investigación en Ciencias de la Salud (CICSA) FCSUniversidad Anáhuac México Norte Huixquilucan Estado de México México Lab. De Biologia de la reproducción UAMI. Ciudad de México México Hospital de Pediatría CMN Siglo XXI. Ciudad de México México Subdirección de Medicina Experimental Instituto Nacional de PediatríaCiudad de México México Doctorado en Ciencias Biológicas División de Ciencias Biológicas y de la SaludUniversidad Autónoma MetropolitanaUnidad Iztapalapa.Ciudad de México México

Copolymer-1（Cop-1） is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus（CP） is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors（brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3） and cytokines（tumor necrosis factor alpha, interferon-gamma, interleukin-4（IL-4）, IL-10 and IL-17）, in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and IL-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of IL-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and IL-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1.

关键词： choroid plexus growth factors immunomodulation protective autoimmunity Cop-1 Copaxone stroke glatiramer acetate t MCAo focal cerebral ischemia

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Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury

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Neural Regeneration Research 2019年第6期14卷 1060-1068页

作者： Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan antonio ibarra Centro de Investigación en Ciencias de la Salud (CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus Norte Centro de Investigación del Proyecto CAMINA A.C. Unidad de Investigación Médica en Enfermedades Neurologicas Hospital Especialidades CMN Siglo XXI Unidad de Rehabilitación Osteoarticular.Instituto Nacional de Rehabilitación. Luis Guillermo ibarra ibarra Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of Medicine

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016.

关键词： fibrin glue mesenchymal stem cells glial scar protective autoimmunity neural derived peptides neural regeneration

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Awake prone positioning for patients with COVID-19-induced acute hypoxemic respiratory failure

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Journal of Intensive Medicine 2022年第4期2卷 233-240页

作者： Yonatan Perez Jian Luo Miguel ibarra-Estrada Jie Li Stephan Ehrmann Médecine Intensive Réanimation Hôpital de HautepierreHôpitaux universitaires de StrasbourgStrasbourg 67000France Respiratory Medicine Unit and Oxford NIHR Biomedical Research Centre NDM Experimental MedicineUniversity of OxfordOxford OX39DUUK Unidad de Terapia Intensiva Hospital Civil Fray Antonio Alcalde.Universidad de Guadalajara.GuadalajaraJalisco 44280Mexico Department of Cardiopulmonary Sciences Division of Respiratory CareRush UniversityChicagoIL 60612USA Médecine Intensive Réanimation CIC 1415 INSERMCRICS-TriggerSep F-CRIN research networkCHRU de ToursTours France and Centre d’étude des pathologies respiratoires(CEPR)INSERM U1100Universitéde ToursTours 37000France

Whereas prone positioning of intubated patients suffering from acute respiratory distress syndrome represents the standard of care,proning non-intubated patients,so-called“awake prone positioning(APP),”has only recently gained popularity and undergone scientific evaluation.In this review,we summarize current evidence on physiological and clinical effects of APP on patients’centered outcomes,such as intubation and mortality,the safety of the technique,factors and predictors of success,practical issues for optimal implementation,and future areas of research.Current evidence supports using APP among patients suffering from acute hypoxemic respiratory failure due to COVID-19 and undergoing advanced respiratory support,such as high-flow nasal cannula,in an intensive care unit setting.Healthcare teams should aim to prone patients at least 8 h daily.Future research should focus on optimizing the tolerance of the technique and comprehensively evaluating benefits in other patient populations.

关键词： Respiratory distress syndrome Intensive care units Prone position Intubation

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The influence of elevation on soil properties and forest litter in the Siliceous Moncayo Massif,SW Europe

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Journal of Mountain Science 2016年第12期13卷 2155-2169页

作者： BADIA David RUIZ Alberto GIRONA antonio MARTI Clara CASANOVA Jose ibarra Paloma ZUFIAURRE Raquel Department of Agricultural and Environmental Sciences Technic School of Agricultural Engineering and Environmental SciencesUniversidad de Zaragoza Department of Geography and Land Management University of Zaragoza Department of Analytical Chemistry Technic School of Agricultural Engineering and Environmental SciencesUniversity of Zaragoza

Understanding the effects of elevation and related factors(climate,vegetation) on the physical and chemical soil properties can help to predict changes in response to future climate or afforestation forcings.This work aims to contribute to the knowledge of soil evolution and the classification of forest soils in relation to elevation in the montane stage,with special attention to podzolization and humus forms.The northern flank of the Moncayo Massif(Iberian Range,SW Europe) provides a unique opportunity to study a forest soils catena within a consistent quartzitic parent material over a relatively steep elevation gradient.With increasing elevation,pH,base saturation,exchangeable potassium,and fine silt-sized particles decrease significantly,while organic matter,the C/N ratio,soil aggregate stability,water repellency and coarse sand-sized particles increase significantly.The soil profiles shared a set of properties in all horizons:loamy-skeletal particle-size,extreme acidity(pH-H_2O<5.6) and low base saturation(<50%).The most prevalent soil forming processes in the catena include topsoil organic matter accumulation and even podzolization,which increases with elevation.From the upper to lower landscape positions of wooded montane stage of the Moncayo Massif,mull-moder-mor humus and an UmbrisolCambisol-Podzol soil unit sequences were found.

关键词：森林凋落物土壤特性西南部高程欧洲盐基饱和度有机质积累海拔梯度

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Laser Wavelength Estimation Method Based on a High-Birefringence Fiber Loop Mirror

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Photonic Sensors 2019年第1期9卷 89-96页

作者： Ricardo I.ALVAREZ-TAMAYO Patricia PRIETO-CORTES Manuel DURAN-SANCHEZ Baldemar ibarra-ESCAMILLA antonio BARCELATA-PINZON Evgeny A.KUZIN Faculty of Physical-Mathematical Sciences CONACYT-Universidad Autonoma de Nuevo LeonSan Nicolas de los Garza 66451Mexico Faculty of Physical-Mathematical Sciences Universidad Autonoma de Nuevo LednSan Nicolas de los Garza 66451 Mexico Optics department CONA CYT-Instituto Nacional de AstrofisieaOptica y EleetronieaTonantzintla 72480Mexico Optics department Instituto Nacional de AstrofisicaOptica y ElectronicaTonantzintla 72480Mexico Mechatronics division Universidad Tecnologica de PueblaPuebla 72300Mexico

A simple method for the estimation of the wavelength of a fiber laser system is proposed. The method is based on the use of a high-birefringence-fiber loop mirror(HBFLM).The HBFLM exhibits a periodic transmission/reflection spectrum whose spectral characteristics are determined by the length and temperature of the high-birefringence fiber(HBF).Then,by the previous characterization of the HBFLM spectral transmission response,the central wavelength of the generated laser line can be estimated.By using a photodetector,the wav.elength of the laser line is estimated during an HBF temperature scanning by measuring the temperature at which the maximum transmitted power of the HBFLM is reached.The proposed method is demonstrated in a linear cavity tunable Er/Yb fiber laser.This method is a reliable and low-cost alternative for laser wavelength determination in short wavelength ranges without the use of specialized and expensive equipment.

关键词： Wavelength meter fiber lasers fiber optical loop mirror high-birefringence fiber

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