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DNA and RNA oxidative dam.ge in hepatocellular carcinom. patients and m.rtality during the first year of liver transplantation

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World Journal of Hepatology 2022年第6期14卷 1182-1189页

作者： Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González m.ría m.m.rtín Alejandro Jim.nez Purificación Cerro Julián Portero m.nuel A Barrera Departm.nt ofIntensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Departm.nt of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Departm.nt of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Departm.nt of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Departm.nt of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain

BACKGROUND Oxidative dam.ge of DNA and RNA has been associated with m.rtality of patients with different ***,there is no published data on the potential use of DNA and RNA oxidative dam.ge to predict the prognosis of patients with hepatocellular carcinom.(HCC)undergoing liver transplantation(LT).AIm.To determ.ne whether patients with increased DNA and RNA oxidative dam.ge prior to LT for HCC have a poor LT *** Patients with HCC who underwent LT were included in this observational and retrospective *** levels of all three oxidized guanine species(OGS)were m.asured prior to LT since guanine is the nucleobase that form. DNA and RNA m.st prone to *** m.rtality at 1 year was the end-point *** Surviving patients(n=101)showed lower serum.OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum.OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression *** The m.in new finding was that high serum.OGS concentration prior to LT was associated with the m.rtality 1 year after LT in HCC patients.

关键词： DNA oxidative dam.ge Hepatocellular carcinom. Liver transplantation m.rtality Oxidized guanine species

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新疆石人子沟遗址出土家马的DNA研究

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第四纪研究 2014年第1期34卷 187-195页

作者：赵欣 antonia T Rodrigues 尤悦王建新马健任萌袁靖杨东亚中国社会科学院考古研究所北京100710 加拿大西蒙菲莎大学考古学系古DNA实验室首都师范大学历史学院北京100048 西北大学文化遗产学院西安710069

运用古DNA技术对新疆石人子沟遗址的墓葬中出土的古代家马样本进行遗传学分析。共选取5匹家马骨骼样本,从中提取DNA并对线粒体DNA控制区和毛色控制基因的核DNA进行PCR扩增。全部样本获得了线粒体DNA序列,在这5个序列中共检测出3个不同... 详细信息

运用古DNA技术对新疆石人子沟遗址的墓葬中出土的古代家马样本进行遗传学分析。共选取5匹家马骨骼样本,从中提取DNA并对线粒体DNA控制区和毛色控制基因的核DNA进行PCR扩增。全部样本获得了线粒体DNA序列,在这5个序列中共检测出3个不同的单倍型,可以归属到3个不同的谱系A,B和E。毛色控制基因的SNP检测结果显示石人子沟遗址古代家马有栗色(chestnut)、枣色(bay)和金黄色(palom.no)3种不同毛色。尽管样本量很小,但是线粒体DNA和毛色控制基因的核DNA研究均显示出石人子沟遗址的古代家马具有较高的遗传多样性。结合古代文献记载和新疆的特殊地理位置,支持新疆是家马引入中国的一个重要通道的观点。此外,金黄色马与墓主人同葬于墓室,可能是当时特殊的选择,表明马在古代人类社会中具有着重要的地位。

关键词：石人子沟遗址家马古 DNA毛色

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Endophytic m.cobiota Characterization of the Am.zonian m.stletoe Cladocolea m.crantha Hosted in Cashew Tree

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Am.rican Journal of Plant Sciences 2013年第4期4卷 917-921页

作者： Anderson C.Guim.raes Antonio C.Siani JoséL.Bezerra antonia Q.Lim. de Souza m.ria Inez m.Sarquis Instituto de Ciencias Exatas e Tecnologia de Itacoatiara Universidade Federal do AmazonasItacoatiaraBrazil Departam.nto de Produtos Naturais FarmanguinhosFiocruzRio de JaneiroBrazil Departam.nto de Ciencias Agronom.cas e Am.ientais Universidade Estadual de Santa CruzIlhéusBrazil Laboratório de Genética Escola Superior de Ciencias da SaúdeUniversidade Estadual do AmazonasManausBrazil Laboratório de Taxonom.a Bioquím.ca e Bioprospeccao de Fungos Instituto Oswaldo CruzFiocruzRio de JaneiroBrazil

Endophytic fungi were identified from.different parts of the m.dicinal parasitic m.stletoe Cladocolea m.crantha and from.its host Anacardium.occidentale, suggesting a strict host-parasite relationship. Eight fungal endophytes were isolated and m.rphologically characterized. The ascom.cete Guignardia m.ngiferae and strains of m.celia sterilia were prevalent in the isolations. The unequivocal identification of Guignardia m.ngiferae at a probabilistic degree close to 100% was carried out by DNA extraction followed by PCR analyses of the ITS-1 and ITS-2 regions and com.arison of the genetic sequence with the NCBI database.

关键词： Cladocolea m.crantha Endophytic m.cobiota Loranthaceae Guignardia m.ngiferae Anacardium.occidentale

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Fern extracts potentiate fluconazole activity and inhibit m.rphological changes in Candida species

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Asian Pacific Journal of Tropical Biom.dicine 2017年第11期7卷 1025-1030页

作者： m.ria A.Freitas antonia T.L.Santos Antonio J.T.m.chado Ana Raquel P.Silva Fábia F.Cam.ina m.ria S.Costa Gioconda m.A.B.m.rtins m.ria Flaviana B.m.rais-Braga Saulo R.Tintino Irwin R.A.m.nezes Jaim. Ribeiro-Filho Altevir P.m.deiros Adeliana S.Oliveira Patrício B.m.racajá Henrique D.m.Coutinho Universidade Regional do Cariri-URCA Universidade Federal Rural do Sem.-A′rido-UFERSA Universidade Federal do Rio Grande do Norte-UFRN Universidade Federal de Cam.ina Grande-UFCG

Objective: To investigate the antifungal activity of the fern species Lygodium.venustum.L. venustum. and Pityrogram.a calom.lanos(P. calom.lanos) against Candida albicans and Candida tropicalis ***: The m.crodilution m.thod was used to evaluate the antifungal activity, as well as the m.dulating effects of ethanolic extracts of these plants in com.ination with fluconazole. The m.nim.m.inhibitory concentration(m.C), m.nim.m.fungicide concentration and m.rphological changes were also ***: The extract obtained from.L. venustum.presented a m.C > 8 192 m./m.L, while the extract obtained from.and P. calom.lanos presented a m.C = 8 192 m./m.L, indicating that they present weak antifungal activity. However, com.ination of the extracts with Fluconazole potentiated the antifungal activity of this drug. At different experim.ntal conditions, such as concentration of the extract and type of strain, the extracts inhibited hyphae and pseudohyphae form.tion, indicating that these fern species can affect the m.rphology of the ***: The extracts obtained from.the fern species L. venustum.and P. calom.lanos dose not present significant antifungal activity. However, P. calom.lanos potentiates the activity of fluconazole and both extracts inhibits the m.rphological changes in Candida species, indicating that they have potential pharm.cological activity as m.dulators of fungal biology. Therefore, novel studies are required to characterize the interference of these extracts in the virulence and pathogenicity of Candida species as well as the potential of fern species to treat fungal infections.

关键词： Dim.rphism Candida species Ferns Lygodium.venustum Pityrogram.a calom.lanos

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Cervilla住宅

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城市环境设计 2010年第7期 67-69页

作者： Luis Izquierdo antonia Lehm.nn

这座房子选址在圣地亚哥东区的Lom.s de La Dehesa分区,在其开始施工的时候周围其他的建筑还未建成。这座房子所在的位置临街一面长36.76m.从街道入口向东,面向山脉,有一个略微向下的坡度。

关键词：客厅 La 入口房子圣地亚哥智利 Cervilla 露台园林建筑

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Antifungal activity of total and fractionated phenolic extracts from.two wild edible herbs

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Natural Science 2013年第8期5卷 895-902页

作者： m.ria antonia Gatto Sim.na m.rianna Sanzani Piero Tardia Vito Linsalata m.riax Pieralice Lucrezia Sergio Donato Di Venere CNR-Institute of Sciences of Food Production (ISPA) Bari Italy Departm.nt of Pharm.cy—Drug Sciences—University of Bari “Aldo m.ro” Bari Italy Departm.nt of Soil Plant and Food Sciences (DiSSPA)—University of Bari “Aldo Moro” Bari Italy

The chem.cal characterization of phenolic extracts of salad burnet (Sanguisorba m.nor Scop. s.l.) and broom.ape (Orobanche crenata Forsk.) was perform.d. Active fractions were separated and characterized and, in the case of O. crenata, two phenolic com.ounds, verbascoside and is overbascoside, were quantitatively extracted, purified and characterized. These com.ounds proved to be effective in reducing the growth of som. im.ortant fungi responsible for the decay of fresh fruit and vegetables in postharvest. Verbascoside showed significant activity against Penicillium.italicum. fairly inhibited m.nilinia laxa, P. expansum. and Aspergillus carbonarius, and showed little activity against Botrytis cinerea, m. fructicola and P. digitatum. Isoverbascoside com.letely inhibited B. cinerea, P. digitatum. P. italicum. and P. expansum.it fairly inhibited m. laxa and A. carbonarius;while it showed to be less effective against m. fructicola. The obtained results support the possible use of som. wild edible plants as a source of phenolic substances for the postharvest biological control of fresh fruit and vegetable rots.

关键词： Antim.crobials Postharvest Rot Storage Phenols Verbascoside Isoverbascoside HPLC FLC

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Ultra-low-dose chest com.uted tom.graphy with m.del-based iterative reconstruction in the analysis of solid pulm.nary nodules:A prospective study

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World Journal of Radiology 2024年第11期16卷 668-677页

作者： Patrick W O'Regan antonia Harold-Barry Alexander T O'm.hony Claire Crowley Stella Joyce Niam. m.ore Owen J O'Connor m.chael T Henry David J Ryan m.chael m.m.her Departm.nt of Radiology School of MedicineUniversity College CorkCork T12 AK54Ireland Departm.nt of Radiology Cork University HospitalCork T12 DC4AIreland Departm.nt of Radiology Mercy University HospitalCork T12WE28Ireland Departm.nt of Respiratory m.dicine Cork University HospitalCork T12 DC4AIreland

BACKGROUND Incidental pulm.nary nodules are an increasingly com.on finding on com.uted tom.graphy(CT)scans of the thorax due to the exponential rise in CT exam.n-ations in everyday *** m.jority of incidental pulm.nary nodules are benign and correctly identifying the sm.ll num.er of m.lignant nodules is ***-low-dose CT(ULDCT)has been shown to be effective in diagnosis of respiratory pathology in com.arison with traditional standard dose *** hypothesis was that ULDCT chest com.ined with m.del-based iterative reconstruction(m.IR)is com.arable to standard dose CT(SDCT)chest in the analysis of pulm.nary nodules with significant reduction in radiation *** To prospectively com.are ULDCT chest com.ined with m.IR with SDCT chest in the analysis of solid pulm.nary *** A prospective cohort study was conducted on adult patients(n=30)attending a respiratory m.dicine outpatient clinic in a tertiary referral university hospital for surveillance of previously detected indeterm.nate pulm.nary nodules on SDCT *** study involved the acquisition of a reference SDCT chest followed im.ediately by an ULDCT *** identification,nodule characterisation,nodule m.asurem.nt,objective and subjective im.ge quality and radiation dose were com.ared between ULDCT with m.IR and SDCT *** One hundred solid nodules were detected on ULDCT chest and 98 on SDCT *** was no significant difference in the characteristics of correctly identified nodules when com.aring SDCT chest to ULDCT chest ***-to-noise ratio was significantly increased in the ULDCT chest in all areas except in the paraspinal m.scle at the m.xim.m.cardiac diam.ter level(Pm.an subjective im.ge quality score for overall diagnostic acceptability was 8.9/*** m.an dose length product,com.uted tom.graphy volum. dose index and effective dose for the ULDCT chest protocol were 5.592 ***,0.16 m.y and 0.08 m.v *** were sign

关键词： Ultra-low dose com.uted tom.graphy Solid pulm.nary nodules Com.uted tom.graphy m.thods Radiation dosage Adult hum.n

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Elevated soluble fas blood concentrations in patients dying from.spontaneous intracerebral hem.rrhage

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World Journal of Critical Care m.dicine 2023年第2期12卷 63-70页

作者： Leonardo Lorente m.ría m.m.rtín antonia Pérez-Cejas Luis Ram.s-Góm.z Jordi Solé-Violan Juan J Cáceres Alejandro Jim.nez Agustín F González-Rivero Departm.nt of Intensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Departm.nt of Intensive Care Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010TenerifeSpain Departm.nt of Laboratory Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Departm.nt of Intensive Care Hospital Universitario de La PalmaBreña Alta 38713Spain Departm.nt of Critical Care Hospital Universitario de Gran Canaria Dr NegrinLas Palmas de Gran Canaria 35010Spain Departm.nt of Critical Care Universidad Fernando Pessoa CanariasLas Palmas de Gran Canaria 35450Spain Departm.nt of Intensive Care Hospital InsularLas Palmas de Gran Canaria 35016Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain

BACKGROUND Several studies of spontaneous intracerebral hem.rrhage(SICH)patients have shown apoptotic changes in brain sam.les after hem.tom. ***,there have been no data on the association between blood concentrations of soluble fas(sFas)(the m.in surface death receptor of the extrinsic apoptosis pathway)and the prognosis of spontaneous intracranial hypotension(SIH)*** To determ.ne whether there is an association between blood sFas concentrations and SICH patient *** We included patients with severe and supratentorial *** was defined as having Glasgow Com. Scalem.ned serum.sFas concentrations at the tim. of severe SICH *** We found that non-surviving patients(n=36)com.ared to surviving patients(n=39)had higher ICH score(P=0.001),higher m.dline shift(P=0.004),higher serum.sFas concentrations(Pm.tom. evacuation(P=0.04).m.ltiple logistic regression analysis showed an association between serum.sFas concentrations and 30-d m.rtality(odds ratio=1.070;95%confidence interval=1.014-1.129;P=0.01)controlling for ICH score,m.dline shift,and early hem.tom. *** The association of blood sFas concentrations and SICH patient m.rtality is a novel finding in our study.

关键词： Spontaneous intracerebral hem.rrhage Soluble fas Apoptosis Patients m.rtality

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动态^(18)F-FDG PET定量分析用于骨病变鉴别诊断

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中华核医学杂志 2002年第2期22卷 77-79,I002页

作者：吴华 antonia Dim.trakopoulou-Strauss Thom.s O-Heichel Burkhard Lehner Ludger Bernd Volker Ewerbeck Cyrill Burger Ludwig G Strauss 华中科技大学同济医学院附属同济医院核医学科武汉430030 Division of Oncological Diagnostics and Therapy Medical PET-GroupGerman Cancer Research Center Orthopedic Clinics University of Heidelberg Departm.nt of Nuclear m.dicine University of Zuerich

目的　评价18F 脱氧葡萄糖 (FDG)PET在骨骼病变中的诊断价值。方法　研究对象为40例原发性骨骼病变患者。所有患者在注射示踪剂后立即开始动态PET采集 ,持续 6 0m.n。对动态PET图像进行半定量分析 ,分别计算平均和最大标准摄取值 (SUVa... 详细信息

目的　评价18F 脱氧葡萄糖 (FDG)PET在骨骼病变中的诊断价值。方法　研究对象为40例原发性骨骼病变患者。所有患者在注射示踪剂后立即开始动态PET采集 ,持续 6 0m.n。对动态PET图像进行半定量分析 ,分别计算平均和最大标准摄取值 (SUVaver和SUVm.x) ,病灶SUV/肌肉SUV比值 (T/m. ,病灶 6 0m.nSUV/ 30m.nSUV比值 (SUVaver 60 /3 0m.n和SUVm.x 60 /3 0m.n)等。采用Patlak作图分析法对动态图像数据进行拟合计算 ,得出摄入常数 (Ki) ,计算FDG代谢率 (m.FDG)。根据接受器工作特性曲线 (ROC)确定各定量指标的诊断阈值 ,并比较其鉴别良恶性病变的灵敏度和特异性。结果　经病理检查证实恶性病变 2 1例 ,良性病变 19例。恶性病变的m.FDG和SUV值高于良性病变 ,但各种指标的数值分布均存在交叉重叠。SUVaver与m.FDG呈正相关 (r=0 6 7)。以SUV值≥ 1 8作为阈值时 ,鉴别良恶性病变的灵敏度和特异性分别为 85 0 %和 82 4% ,以m.FDG(1 1)为阈值时的灵敏度 (82 4% )与SUV相近 ,而特异性 (92 9% )较高。同时采用SUV(1 8)和SUVaver 60 /3 0m.n(1 1)作为鉴别标准时 ,较之单独采用SUV特异性可改善为 93 3% ,灵敏度略有降低 (81 3% )。结论　骨骼良恶性病变之间存在葡萄糖代谢率差异。单用静态FDGPET获取SUV值不能很好鉴?

关键词：动态^18F-FDG PET定量分析鉴别诊断骨疾病骨肿瘤良恶性病变 ^18F-脱氧葡萄糖 ^18F-FDG

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Digestibility,Antioxidant and Anti-Inflam.atory Activities of Pecan Nutshell(Carya illioinensis)Extracts

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Journal of Renewable m.terials 2022年第10期10卷 2569-2580页

作者： m.ría Janeth Rodríguez-Roque Carm.n Lizette Del-Toro-Sánchez Janet m.deline Chávez-Ayala Ricardo Iván González-Vega Liliana m.ribel Pérez-Pérez Esteban Sánchez-Chávez Nora AideéSalas-Salazar Juan m.nuel Soto-Parra Rey David Iturralde-García m.ría antonia Flores-Córdova Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Universidad de Sonora Rosales y Niños Héroes S/NHermosilloSonMéxico Centro de Investigación en Alim.ntación y Desarrollo A.C.Unidad DeliciasDeliciasChihuahuaMéxico

Phenolic com.ounds are related to high biological activity,avoiding oxidation in food and hum.n *** are by-products derived from.the pecan nut processing that contain im.ortant am.unts of phenols which biological activity m.st be *** research aim.d to evaluate the antioxidant(DPPH,ABTS,FRAP and hem.lysis)and anti-inflam.atory activities of shell extracts from.pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic com.ounds,including *** showed that extracts from.the crop production cycle 2018 obtained the highest yield,while those from.2019 contained the highest concentration of phenolic com.ounds,flavonoids and antioxidant capacity determ.ned by DPPH(22.96 m.ol ET),ABTS(91.55 m.ol ET)and inhibition of hem.lysis(92.12%).The anti-inflam.atory activity exhibited an inhibition of the elastase enzym. up to 50 m.n and the bioaccessibility of phenolic com.ounds reached up to 32%.These results showed that pecan nutshell extracts are an im.ortant source of biologically active com.ounds,thus,they are suitable to be used as com.odities in different fields such as agricultural,food and pharm.ceutical *** studies m.st be carried out in order to elucidate the activity of nutshell extracts within in vivo system..

关键词： Anti-inflam.atory activity antioxidants digestibility shell phenolic com.ounds

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