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patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations

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World Journal of Clinical Cases 2023年第8期11卷 1753-1760页

作者： Leonardo Lorente Sergio T Rodriguez pablo Sanz Agustín F González-Rivero antonia pérez-cejas Javier padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez purificación Cerro Julián portero Manuel A Barrera Intensive Care Unit Hospital Universitario de CanariasLa Laguna 38320Spain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain Department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Department of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain Department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain

BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis *** expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was *** To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample *** patients underwent LT due to HCC were included in this retrospective *** sFasL levels prior to LT were measured and one-year LT mortality was *** Non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;ppatients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;p=0.001)independently of age of LT donor in the logistic regression *** We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.

关键词： sFasL Hepatocellular carcinoma Liver transplantation Mortality Outcome

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DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation

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World Journal of Hepatology 2022年第6期14卷 1182-1189页

作者： Leonardo Lorente Sergio T Rodriguez pablo Sanz Agustín F González-Rivero antonia pérez-cejas Javier padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez purificación Cerro Julián portero Manuel A Barrera Department ofIntensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Department of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain

BACKGROUND Oxidative damage of DNA and RNA has been associated with mortality of patients with different ***,there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT *** patients with HCC who underwent LT were included in this observational and retrospective *** levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to *** mortality at 1 year was the end-point *** Surviving patients(n=101)showed lower serum OGS levels(p=0.01)and lower age of the liver donor(p=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;p=0.001)was found in the logistic regression *** The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.

关键词： DNA oxidative damage Hepatocellular carcinoma Liver transplantation Mortality Oxidized guanine species

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Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage

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World Journal of Critical Care Medicine 2023年第2期12卷 63-70页

作者： Leonardo Lorente María M Martín antonia pérez-cejas Luis Ramos-Gómez Jordi Solé-Violan Juan J Cáceres Alejandro Jiménez Agustín F González-Rivero Department of Intensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Department of Intensive Care Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010TenerifeSpain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Department of Intensive Care Hospital Universitario de La PalmaBreña Alta 38713Spain Department of Critical Care Hospital Universitario de Gran Canaria Dr NegrinLas Palmas de Gran Canaria 35010Spain Department of Critical Care Universidad Fernando Pessoa CanariasLas Palmas de Gran Canaria 35450Spain Department of Intensive Care Hospital InsularLas Palmas de Gran Canaria 35016Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain

BACKGROUND Several studies of spontaneous intracerebral hemorrhage(SICH)patients have shown apoptotic changes in brain samples after hematoma ***,there have been no data on the association between blood concentrations of soluble fas(sFas)(the main surface death receptor of the extrinsic apoptosis pathway)and the prognosis of spontaneous intracranial hypotension(SIH)*** To determine whether there is an association between blood sFas concentrations and SICH patient *** We included patients with severe and supratentorial *** was defined as having Glasgow Coma Scalepatients(n=36)compared to surviving patients(n=39)had higher ICH score(p=0.001),higher midline shift(p=0.004),higher serum sFas concentrations(pp=0.04).Multiple logistic regression analysis showed an association between serum sFas concentrations and 30-d mortality(odds ratio=1.070;95%confidence interval=1.014-1.129;p=0.01)controlling for ICH score,midline shift,and early hematoma *** The association of blood sFas concentrations and SICH patient mortality is a novel finding in our study.

关键词： Spontaneous intracerebral hemorrhage Soluble fas Apoptosis patients Mortality

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