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Precision medicine in gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 804-829页

作者： Patrizia Bonelli antonella Borrelli Franca Maria Tuccillo Lucrezia Silvestro Raffaele Palaia Franco Maria Buonaguro Molecular Biology and Viral Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Abdominal Medical Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Gastro-pancreatic Surgery Division Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy

Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic *** represents the second leading cause of cancer-related deaths *** onset is subtle,and the majority of patients are diagnosed once the cancer is already *** recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular *** to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic *** the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this *** phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic ***,the heterogeneity of this neoplasia makes the practical application of such approaches ***,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in *** continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate *** several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially ***,surgical resection with adjuvant or neoadjuvant radiotherapy and ch

关键词： Gastric cancer Molecular characterization Biomarkers Precision medicine Targeted therapy

Educational Practices in the Model of Music Learning Theory of E. Edwin Gordon： An Observational Research

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Journal of Literature and Art Studies 2013年第5期3卷 263-277页

作者： antonella Nuzzaci University of L'Aquila L'Aquila Italy

This paper analyzes the supervision activity, to which educators and teachers enrolled with AIGAM （Gordon Italian Association for the Musical Learning） are subject to every year and intends to verify the application of those principles expressed in the learning model of the MLT （Music Learning Theory） developed by educational psychologist E. Edwin Gordon （1989, 1999, 2000, 2001, 2007） and promoted internationally by various institutions and organizations specifically accredited. It describes the influence of the videotaped supervision on the process, functions of monitoring, and evaluation of educational practices, starting with an empirical model that has guided the interventions in a study of supervision on training aimed at consolidating and developing professional skills in music education in early childhood. This paper sought to understand： the kind of practices, interactions, communications developing during an educational actions, the existence of a consistent relationship between the principles expressed in the MLT and their application, the type and benefits of supervision performed by of video recording on stakeholders in terms of change in professional behavior, and finally whether the active supervision could be comparable with other kinds of approaches.

关键词： music education MLT (Music Learning Theory) empirical research in music education observational tool

Factors affecting the quality of bowel preparation for colonoscopy in hard-to-prepare patients:Evidence from the literature

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World Journal of Gastroenterology 2023年第11期29卷 1685-1707页

作者： Endrit Shahini Emanuele Sinagra Alessandro Vitello Rocco Ranaldo antonella Contaldo Antonio Facciorusso Marcello Maida Gastroenterology Unit National Institute of Gastroenterology-IRCCS“Saverio de Bellis”Castellana GrotteBari 70013Italy Gastroenterology and Endoscopy Unit Fondazione Istituto G.GiglioCefalù90015Italy Gastroenterology and Endoscopy Unit S.Elia-Raimondi HospitalCaltanissetta 93100Italy Department of Internal Medicine “Mazzolani-Vandini”HospitalDigestive EndoscopyFerrara 744011Italy Gastroenterology Unit National Institute of Gastroenterology“S de Bellis”Research HospitalBari 70013Italy Department of Medical Sciences University of FoggiaSection of GastroenterologyFoggia 71122Italy

Adequate bowel cleansing is critical for a high-quality colonoscopy because it affects diagnostic accuracy and adenoma ***,almost a quarter of procedures are still carried out with suboptimal preparation,resulting in longer procedure times,higher risk of complications,and higher likelihood of missing *** guidelines recommend high-volume or low-volume polyethylene glycol(PEG)/non-PEG-based split-dose *** patients who have had insufficient bowel cleansing,the colonoscopy should be repeated the same day or the next day with additional bowel cleansing as a salvage option.A strategy that includes a prolonged low-fiber diet,a split preparation regimen,and a colonoscopy within 5 h of the end of preparation may increase cleansing success rates in the ***,even though no specific product is specifically recommended in the other cases for difficult-to-prepare patients,clinical evidence suggests that 1-L PEG plus ascorbic acid preparation are associated with higher cleansing success in hospitalized and inflammatory bowel disease *** with severe renal insufficiency(creatinine clearance<30 mL/min)should be prepared with isotonic high volume PEG *** data on cirrhotic patients are currently available,and no trials have been conducted in this *** accurate characterization of procedural and patient variables may lead to a more personalized approach to bowel preparation,especially in patients undergoing resection of left colon lesions,where intestinal preparation has a poor *** purpose of this review was to summarize the evidence on the risk factors influencing the quality of bowel cleansing in difficult-to-prepare patients,as well as strategies to improve colonoscopy preparation in these patients.

关键词： Colorectal cancer Colonoscopy Adenoma detection rate Bowel preparation Polyethylene glycol

Rawls and Catholicism: Towards Reconciliation?

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Cultural and Religious Studies 2019年第1期7卷 50-56页

作者： antonella Piccinin Pontifical Gregorian University RomeItaly

This paper takes up an ambivalence in Rawls’thought concerning the propriety of religious reason in public *** a general introduction,the second paragraph gives a basic description of the two sides of this *** the third paragraph,Joseph Ratzinger is introduced as a potential dialogue partner with Rawls,in as much as one side of Rawls’thought can be interpreted to be congenial to religious reasons that occur with his requirement for public *** aim of this paper is,eventually,to open the path towards a possible reconciliation between Rawls’positions and those of the Catholic tradition,as suggested by Joseph *** some dialectical tensions remain,engaging the Ratzingerian idea of a“mutual correction”might result into a fruitful encounter of different views.

关键词： public reason religious reasons religion in the public sphere catholic social thought

Irreversible electroporation for the management of pancreatic cancer: Current data and future directions

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World Journal of Gastroenterology 2023年第2期29卷 223-231页

作者： Stavros Spiliopoulos Lazaros Reppas Dimitrios Filippiadis antonella Delvecchio Maria Conticchio Riccar do Memeo Riccardo Inchingolo Second Department of Radiology School of MedicineNational and Kapodistrian University of AthensAthens 12461AttikiGreece Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalAcquaviva delle Fonti 70021BariItaly Interventional Radiology Unit “F.Miulli”Regional General HospitalAcquaviva delle Fonti 70021Italy

Pancreatic cancer is currently the seventh leading cause of cancer death(4.5%of all cancer deaths)while 80%-90%of the patients suffer from unresectable disease at the time of *** remains poor,with a mean survival up to 15 mo following systemic ***-regional thermal ablative techniques are rarely implemented due to the increased risk of thermal injury to the adjacent structures,which can lead to severe adverse *** electroporation,a promising novel non-thermal ablative modality,has been recently introduced in clinical practice for the management of inoperable pancreatic cancer as a safer and more effective loco-regional treatment *** and initial clinical data are *** review will focus on the basic principles of IRE technology,currently available data,and future directions.

关键词： Pancreatic cancer Interventional oncology Irreversible electroporation Ablation Loco-regional treatment Image-guided treatment

Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis： retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction

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Asian Journal of Andrology 2011年第6期13卷 819-827页

作者： Vittorio Magri Emanuele Montanari Visnja Skerk Alemka Markotic Emanuela Marras antonella Restelli Kurt G Naber Gianpaolo Perletti Urology and Sonography Secondary Care Clinic Azienda Ospedaliera Istituti Clinici di Perfezionamento Milano 20132 Italy Clinica Urologica III University of Milan/San Paolo Hospital Milano 20142 Italy University Hospital for Infectious Diseases Dr. Fran Mihaljevic Zagreb 10000 Croatia Laboratory of Toxicology and Pharmacology Department of Biomedical Informatic Environmental and Communication Sciences Universita degli Studi dell＇Insubria Busto A.Narese 21052 Italy Microbiology Unit Fondazione I RCCS Osp. Maggiore Policlinico Mangiagalli Regina Elena Milano 20122 Italy Technical University Munich 80333 Germany

We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category Ⅱ chronic bacterial prostatitis （CBP）. The aim of this study is to retrospectively compare the microbiological and clinical findings of two treatment schemes for CBP based on the combination of azithromycin （500 rag, thrice-weekly） with a once-daily 500- or 750-mg dose of ciprofloxacin （Cipro-500 or Cipro-750 cohort, respectively）. Combined administration of azithromycin （1500 mg week^-1） with ciprofloxacin at the rate of 750 mg day^- 1 for 4 weeks rather than at 500 mg day^- 1 for 6 weeks increased the eradication rates from 62.35% to 77.32% and the total bacteriological success from 71.76% to 85.57%. A significant decrease in pain and voiding signs/symptoms and a significant reduction in inflammatory leukocyte counts and serum prostate-specific antigen （PSA） were sustained throughout an 18-month follow-up period in both groups. Ejaculatory pain, haemospermia and premature ejaculation were significantly attenuated on microbiological eradication in both groups, but the latter subsided more promptly in the Cipro-750 cohort. In total, 59 Cipro-750 patients showed mild-to-severe erectile dysfunction （ED） at baseline, while 22 patients had no ED on microbiological eradication and throughout the follow-up period. In conclusion fluoroquinolone-macrolide therapy resulted in pathogen eradication and CBP symptom attenuation, including pain, voiding disturbances and sexual dysfunction. A once-daily 750-mg dose of ciprofloxacin for 4 weeks showed enhanced eradication rates and lower inflammatory white blood cell counts compared to the 500-mg dose for 6 weeks. Our results are open to further prospective validation.

关键词： azithromycin chronic bacterial prostatitis chronic pelvic pain syndrome ciprofloxacin erectile dysfunction InternationalIndex of Erectile Function (IIEF) National Institutes of Health Chronic Prostatitis Symptom Index (NiH-CPSI)

Notes for developing a molecular test for the full characterization of circulating tumor cells

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Chinese Journal of Cancer Research 2015年第5期27卷 471-478页

作者： Elisabetta Rossi antonella Facchinetti Rita Zamarchi Department of Surgery Oncology and GastroenterologyOncology SectionUniversity of Padova IOV-IRCCS

The proved association between the circulating tumor cell （CTC） levels and the patients＇ survival parameters has been growing interest to investigate the molecular profile of these neoplastic cells among which hide out precursors capable of initiating a new distant metastatic lesion. The full characterization of the tumor cells in peripheral blood of cancer patients is expected to be of help for understanding and （prospectively） for counteracting the metastatic process. The major hitch that is hampering the successful gaining of this result is the lack of a consensus onto standard operating procedures （SOPs） for performing what we generally define as the ＂liquid biopsy＂. Here we review the more recent acquisitions in the analysis of CTCs and tumor related nucleic acids, looking to the main open questions that are hampering their definitive employ in the routine clinical practice.

关键词： Circulating tumor cells (CTCs) single-cell analysis liquid biopsy

DACC Research 2012-2018:Reconnecting Culture and Competences

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Journal of Civil Engineering and Architecture 2019年第2期13卷 I0003-I0005页

作者： antonella Cecchi Director of the Department of Architecture Construction Conservation(2015-2018) Iuav University of Venice(Italy)

The most marked characteristic of a department dedicated to Architecture in the sense of Construction and Conservation is that it places Architecture as a constructed reality at the center of its teaching and research;or better,the indissoluble connection between a knowledge of form and a knowledge of construction.A connection that constitutes a category of awareness of architecture as designed in the past and a category of operational practices running across the entire process of projection from the analytical phase of the first moment of planning,to the identification of the materials and systems of construction to be used;a connection that overrides and informs the activity of construction on the building-site and which reveals it's quality when tested over time.

关键词： Reconnecting Culture Competences Construction

Inhibin B:are modified ranges needed for orchiectomised testicular cancer patients?

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Asian Journal of Andrology 2019年第4期21卷 332-336页

作者： Alessandra Petrozzi Francesco Pallotti Marianna Pelloni antonella Anzuini Antonio Francesco Radicioni Andrea Lenzi Donatella Paoli Francesco Lombardo Laboratory of Seminology Sperm Bank "Loredana Gandini" Department of Experimental Medicine Medical Pathophysiology Section"Sapienza" University of Rome Rome 00161 Italy Hormone Laboratory Department of Experimental Medicine Medical Pathophysiology Section"Sapienza" University of Rome Rome 00161 Italy

Inhibin B is a gon adal horm one that down regulates the pituitary production of follicle-stimulati ng horm one (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. This retrospective study evaluates horm onal and semen parameters of 290 no rmozoospermic patie nts atte nding the Laboratory of Semi no logy - Sperm Bank "Loredana Gandini"(Rome, Italy) for cryopreservation of seminal fluid following a diagnosis of testicular cancer (TC group) and 117 healthy, normozoospermic men as a control group (CTR group). The percentile distribution of gonadotropin and inhibin B values in the TC and CTR groups was analyzed. There was a statistically significant differenee between the two groups in the levels of all hormones (P ≤ 0.001) and in all semen parameters (P 95^th percentile of CTR group. Orchiectomised patients for testicular cancer presented inhibin B levels lower than healthy patients, despite normozoospermia. Our study revealed the poor sensitivity of the current inhibin B reference range when applied to monorchidic patients, suggesting the need to establish more representative ranges to enable more appropriate counseling in relation to the patienfs new endocrine condition.

关键词： inhibin B orchiectomy referenee range testicular cancer