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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

small dams/reservoirs site location analysis in a semi-arid region of Mozambique

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International soil and Water Conservation Research 2021年第3期9卷 381-393页

作者： antònio dos Anjos luís Pedro Cabral Department of GIs and Regional Planning Universidade Catdlica de MozambiqueBeiraSofalaMozambique NOVA Information Management school(NOVA IMs) Universidade Nova de Lisboa1070-312LisboaPortugal

The water crisis is one of the biggest human problems in developing countries,especially in semi-arid regions where it can form an obstacle to irrigation and cultivation,cattle raising and people's *** construction of small dams/reservoirs are a possible solution to remediate this *** infrastructures must be located in suitable areas to be *** study aimed to find the most suitable locations for small dams/reservoirs in the Tete province region,Mozambique,which has a pronounced water deficit A Geographical Information system(GIs)based approach was used to implement a multicriteria evaluation(MCE)analysis through an Analytic Hierarchical Process(AHP),which included local experts’*** main categories of suitability were identified:"Not suitable”(15%of total area),"Modestly suitable"(78%),and“suitable"(7%).We found that 35 of the 38(92%)abandoned small dams/reservoirs were in areas classified as“Modestly suitable”confirming the robustness of our *** also found that most of the dams/reservoirs currently operating(78%)and planned(73%)are in modestly suitable *** finding suggests that the decision to construct dams/reservoirs may not have considered the most critical suitability factors identified in this *** data and/or additional criteria are required for the full understanding of finding out why so many dams/reservoirs failed before building new ones to address the population’s water needs in the region.

关键词： Water scarcity Multi-criteria evaluation Geographic information systems Remote sensing Mozambique

Hydro-wind Optimal Operation for joint Bidding in Day-ahead Market: storage Efficiency and Impact of Wind Forecasting Uncertainty

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journal of Modern Power systems and Clean Energy 2020年第1期8卷 142-149页

作者： antónio Cerejo sílvio j.P.s.Mariano Pedro M.s.Carvalho Maria R.A.Calado Technical-scientific Unity of Electrical and Industrial Engineering Polytechnic Institute of Castelo BrancoAvenida do Empresário6000-767 Castelo BrancoPortugal Department of Electromechanical Engineering University of Beira Interior and Instituto de TelecomunicacoesCalcada Fonte do Lameiro6201-001 CovilhaPortugal Department of Electrical and Computer Engineering Instituto Superior Técnicoand INESC-IDUniversity of LisbonAv.Rovisco Pais1049-001 LisbonPortuga

Wind power production is *** imbalance between committed and delivered energy in pool markets leads to the increase of system costs,which must be incurred by defaulting producers,thereby decreasing their *** avoid this situation,wind producers can submit their bids together with hydro *** the mismatches between the predicted and supplied wind power can be used by hydro producers,turbining or pumping such differences when *** study formulates the problem of hydro-wind production optimization in operation contexts of pool *** problem is solved for a simple three-reservoir cascade case to discuss optimization *** results show a depreciation in optimal revenues from hydro power when wind forecasting is *** depreciation is caused by an asymmetry in optimal revenues from positive and negative wind power *** problem of neutralizing the effect of forecasting uncertainty is subsequently formulated and solved for the three-reservoir *** results are discussed to conclude the impacts of uncertainty on joint bidding in pool market contexts.

关键词： Optimization hydro power wind power uncertainty joint bidding pool market

Immunomodulation as a neuroprotective strategy after spinal cord injury

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Neural Regeneration Research 2018年第3期13卷 423-424页

作者： susana Monteiro antónio j. salgado Nuno A. silva life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de GualtarBragaPortugal ICVs/3B's-PT Government Associate laboratory Braga/GuimaraesPortugal

The initial trauma to the spinal cord is just the starting point for a cascade of endogenous events that will collectively determine the injury extension. These secondary events include, but are not limited to： glutamate excitoxicity, induction of apoptotic pathways, ionic imbalances and the development of a strong and dysfunctional inflammatory response. The secondary injury is associated to an aggravation of neuronal damage increasing the extent of neurological deficits （Ek et al., 2010）.

关键词： Immunomodulation as a neuroprotective strategy after spinal cord injury sCI

Peripheral refraction of myopic eyes with spectacle lenses correction and lens free emmetropes during accommodation

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Eye and Vision 2021年第1期8卷 454-461页

作者： antónio Queirós Alejandro Cerviño joséManuel González‑Méijome Clinical&Experimental Optometry Research lab(CEORlab) Center of Physics(Optometry)University of MinhoCampus de Gualtar4710‑057 BragaPortugal Optometry Research Group Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValenciaSpain

Purpose:To measure axial and off-axis refraction patterns in myopic eyes with spectacle lenses correction and lens free emmetropes in young healthy subjects at different target distances from 2.00 m(0.50 D)to 0.20 m(5.00 D)in terms of sphere,astigmatism,and spherical equivalent ***:Refraction was measured at the center,20 and 40 degrees from the line of sight both nasally and temporally in 15 emmetropic and 25 myopic young healthy subjects with an open field,binocular,infrared autorefractor(Grand seiko WAM-5500,Hiroshima,japan).Fixation target was a Maltese cross set at 2.00,0.50,0.33 and 0.20 m from the corneal *** in off-axis refraction with accommodation level were normalized with respect to distance axial values and compared between myopic eyes with spectacle lenses correction and lens free ***:Off-axis refraction in myopic eyes with spectacle lenses correction was significantly more myopic in the temporal retina compared to lens free emmetropes except for the closest target *** off-axis refractive error changed significantly with accommodation when compared to axial refraction particularly in the myopic *** change in the negative direction was due to changes in the spherical component of refraction that became more myopic relative to the center at the 0.20 m distance as the j0 component of astigmatism was significantly reduced in both emmetropes and myopes for the closest ***:Accommodation to very near targets(up to 0.20 m)makes the off-axis refraction of myopes wearing their spectacle correction similar to that of lens free emmetropes.A significant reduction in off-axis astigmatism was also observed for the 0.20 m distance.

关键词： Off-axis refraction Refractive error Accommodation Myopia progression

Effect of pier shape and pier alignment on the equilibrium scour depth at single piers

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International journal of sediment Research 2016年第3期31卷 244-250页

作者： Cristina Fael Rui lana antónio Cardoso Faculdade de Engenharia Universidade da Beira InteriorEdificio Ⅱ das EngenhariasCalcada Fonte da Lameiro Instituto superior de Engenharia/Universidade do Algarve Instituto superior Tecnico Universidade de Lisboa

The equilibrium scour depth at uniform single bridge piers depends on a large number of variables,including the pier horizontal cross-section shape and its alignment angle towards the flow *** influence of these variables has been studied by only a few researchers,mostly,on the basis of tests that were far from approaching *** experimental study aims at revisiting the influence of piers’ shape and alignment on local scouring for length-width ratios smaller than or equal to 4,by increasing the experimental *** five long-duration laboratory tests were run under steady,clear-water flow,close to the threshold for initiation of sediment *** pier shapes were considered:circular,rectangular square-nosed,rectangular round-nosed,oblong,and zero-spacing(packed) pile-groups;the tested skew-angles were 0°,30°,45°,60°,and 90°.It was concluded that i) the shape factor can be taken as 1.0,for rectangular round-nosed and oblong cross-section piers,and as 1.2,for rectangular squarenosed and packed pile-group cross-section piers,ii) the shape factor does not vary significantly with the duration of tests,this way confirming the robustness of the shape factors reported to date,iii) the effect of shape is present at skewed piers although the associated coefficients remain in the narrow range of1.0-1.2,and iv) for length-width ratios smaller than 4,the shape factor is of the same order of magnitude as the skew angle factor and should not be neglected.

关键词： scour Pier shape Pier alignment

Combinatorial therapies for spinal cord injury: strategies to induce regeneration

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Neural Regeneration Research 2019年第1期14卷 69-71页

作者： Eduardo D.Gomes Nuno A.silva antónio j. salgado life and Health sciences Research Institute (ICVs) School of Medicine University of Minho Campus de Gualtar ICVs/3B’s–PT Government Associate laboratory

spinal cord injury(sCI)is a condition without treatment,mainly characterized by the loss of motor and sensory function below the level of *** is accompanied by several complications such as cardiac and respiratory compromise,and often patients present psychological ailments associated with the drastic alteration of their normal *** pathophysiology derives from a massive damage to the spinal cord tissue,which is propagated

关键词：损害绳索新生治疗感觉功能生活方式星形细胞并发症