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Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease

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World Journal of Diabetes 2022年第7期13卷 498-520页

作者： María M Adeva-Andany Natalia Carneiro-freire Nephrology Hospital Juan CardonaFerrol 15406Spain

In the glomeruli,mesangial cells produce mesangial matrix while podocytes wrap glomerular capillaries with cellular extensions named foot processes and tether the glomerular basement membrane(GBM).The turnover of the mature GBM and the ability of adult podocytes to repair injured GBM are *** actin cytoskeleton is a major cytoplasmic component of podocyte foot processes and links the cell to the *** components of the normal glomerular extracellular matrix(ECM)include glycosaminoglycans,proteoglycans,laminins,fibronectin-1,and several types of *** patients with diabetes,multiorgan composition of extracellular tissues is anomalous,including the kidney,so that the constitution and arrangement of glomerular ECM is profoundly *** patients with diabetic kidney disease(DKD),the global quantity of glomerular ECM is *** level of sulfated proteoglycans is reduced while hyaluronic acid is augmented,compared to control *** concentration of mesangial fibronectin-1 varies depending on the stage of *** type III collagen is abundant in patients with DKD,unlike normal *** amount of type V and type VI collagens is higher in DKD and increases with the progression of the *** GBM contains lower amount of type IV collagen in DKD compared to normal ***,genetic variants in theα3 chain of type IV collagen may modulate susceptibility to DKD and end-stage kidney *** cellular models of glomerular cells,analyses of human glomerular proteome,and improved microscopy procedures have been developed to investigate the molecular composition and organization of the human glomerular ECM.

关键词： Diabetes Kidney disease Glycosaminoglycans Factor H Sialic acid Laminin Collagen Fibronectin-1 Extracellular matrix

Lidocaine in fibromyalgia:A systematic review

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World Journal of Psychiatry 2022年第4期12卷 615-622页

作者： Jozélio freire de Carvalho Thelma L Skare Health Sciences Institute Federal University of BahiaSalvador 40231-300Brazil Rheumatology Unit Evangélico Mackenzie HospitalCuritiba 80730-420Brazil

BACKGROUND Fibromyalgia(FM)patients are treated with antidepressants,and in most cases,these drugs lose efficacy or present side *** lidocaine(IL)is an anesthetic drug used in some FM *** To systematically review the safety and efficacy of IL in FM *** To systematically search PubMed for articles in English,Spanish,and Japanese with English Abstracts on FM and lidocaine between 1966 and February *** study was registered at *** We found only ten articles published in this field,with a total of 461 *** predominated varying from 95%to 100%in the *** varied from 40.9 to 55 years *** duration varied from 1 mo to 6.4 *** dose varied from 2 to 7.5 mg/kg via intravenous ***-up period varied from 65.7 to 90 *** outcomes,most studies used the visual analogue scale(VAS)for pain;before short-term lidocaine administration,VAS was between 6.1 and 8.1 and after treatment was between 1.7 and 4.5 *** long term lidocaine,VAS varied from 30%to 35.4%after lidocaine *** effects were observed in 0%to 39.6%of cases,they were usually mild or *** This study demonstrates the short-term effectiveness and safety of intravenous lidocaine in FM ***,more studies,including long-term follow-up,are still needed.

关键词： Lidocaine Fibromyalgia Pain Intravenous infusions

Influence of the COVID-19 pandemic in the gastrointestinal oncology setting:An overview

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World Journal of Gastrointestinal Pathophysiology 2022年第5期13卷 157-169页

作者： Breno Bittencourt de Brito Hanna Santos Marques Filipe antônio França da Silva Maria Luísa Cordeiro Santos Glauber Rocha Lima Araújo Lara de Araujo Valente Fabrício freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45055-380BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been impacting healthcare in various ways worldwide and cancer patients are greatly affected by the coronavirus disease 2019(COVID-19)*** reorganization of the health facilities in order to supply the high demand resulting from the aforementioned infection as well as the social isolation measures led to impairments for the diagnosis and follow-up of patients with gastrointestinal cancers,which has had an impact on the prognosis of the oncologic *** that context,health authorities and organizations have elaborated new guidelines with specific recommendations for the management of individuals with gastrointestinal neoplasms during the *** note,oncologic populations seem to be more susceptible to unfavorable outcomes when exposed to SARS-CoV-2 infection and some interactions involving virus,tumor,host immune system and anticancer therapies are probably related to the poorer prognosis observed in those COVID-19 ***,vaccination stands out as the main prevention method against severe SARS-CoV-2 infection and some particularities have been observed regarding the seroconversion of vaccinated oncologic patients including those with gastrointestinal *** this minireview,we gather updated information regarding the influence of the pandemic in the diagnosis of gastrointestinal neoplasms,new recommendations for the management of gastrointestinal cancer patients,the occurrence of SARSCoV-2 infection in those individuals and the scenario of the vaccination against the virus in that population.

关键词： Gastrointestinal cancer COVID-19 Treatment Diagnosis Vaccination Pandemic

Mathematical simulation of radial heat transfer in packed beds by pseudohomogeneous modeling

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Particuology 2011年第2期9卷 107-113页

作者： Rodrigo Béttega Marcos Flávio Pinto Moreira Ronaldo Guimaraes Corrêa José Teixeira freire Federal University of Uberlandia/School of Chemical Engineering-Av.Jo o Naves ávila 2121 Uberlandia-MGCEP 38400-902Brazil Western Paraná State University-Rua da Faculdade 645 Jardim La SalleToledo-PRCEP 85903-000Brazil Federal University of S o Carlos/Department of Chemical Engineering-Rod.Washington Luiz km 235 S o Carlos-SPCEP 13565-905P.O.Box 676Brazil

Uniform flow regime and constant effective thermal conductivity inside packed beds are commonly accepted in the evaluation of the fluid dynamics and heat transfer in such systems. However, several authors have confirmed the presence of an oscillatory velocity profile caused by the effective contribu~ tion of porosity profile in the fluid dynamic behavior of packed beds, which directly influences the heat transfer inside the beds. This paper describes the application of a pseudo-homogeneous mathematical model for describing heat transfer in packed beds with oscillatory profiles of velocity and porosity, using a radius-dependent model for effective thermal conductivity kr. Several temperature profiles were obtained in a packed bed system with thermal source located on the wall. The simulated temperature and effective thermal conductivity obtained from simulations were compared with experimental data and calculation from a model based on uniform kr fitting. The results indicate that the proposed mathematical modeling was capable of better reDresenting the heat transfer in the packed bed.

关键词： Packed bedHeat transferPseudohomogeneous modeling

Ruthenium promotion of Co/SBA-15 catalysts for Fischer-Tropsch synthesis in slurry-phase reactors

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Journal of Natural Gas Chemistry 2012年第6期21卷 722-728页

作者： Jocielys Jovelino Rodrigues Gina Pecchi Fabiano AndrNarciso Fernandes Meiry Glucia freire Rodrigues Federal University of Campina Grande Academic Unit of Chemical Engineering Facultad de Ciencias Químicas Departamento de Físico-QuímicaUniversidad de Concepción Federal University of Ceara Department of Chemical Engineering

The aim of this work was to evaluate the catalytic properties of a Ru promoted Co/SBA-15 catalyst for Fischer-Tropsch synthesis （FTS）. The Ru promoted Co/SBA-15 catalyst was prepared by wet impregnation method and was characterized by X-ray diffraction, X-ray energy dispersion spectrophotometer, N2 adsorption-desorption, temperature-programmed reduction and transmission electron microscopy. The Fischer-Tropsch synthesis using the catalyst was carried out to evaluate the catalyst activity and its effect on FTS product distribution. The synthesis was carried out in a slurry reactor operating at 513 K, 20 atm, CO ： H2 molar ratio of 1 ： 1. X-ray diffraction showed that the calcined cobalt catalyst did not modify the structure of SBA-15, proving that Co was present in the form of Co3O4 in the catalyst. The addition of cobalt in SBA-15 decreased the specific superficial area of the molecular sieve. Fischer-Tropsch synthesis activity and C5＋ hydrocarbon selectivity increased with the addition of Ru. The increases in activity and selectivity were attributed to the increased number of active sites resulting from higher reducibility and the synergetic effect of Ru and Co. Ru/Co/SBA-15 catalysts showed moderate conversion （40%） and high selectivity towards the production of C5＋（80 wt%）.

关键词： SBA-15 cobalt ruthenium heterogeneous catalyst slurry reactor Fischer-Tropsch synthesis

Body Composition,Aerobic Fitness,Isokinetic Profile,and Vertical Jump Ability in Elite Male and Female Volleyball and Beach Volleyball Players

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Journal of Science in Sport and Exercise 2023年第4期5卷 385-395页

作者： Raul freire Matheus Hausen Glauber Pereira Alex Itaborahy Olympic Laboratory Brazil Olympic CommitteeRio de JaneiroBrazil Laboratory of Biomechanics and Motor Behavior Institute of Physical Education and SportsRio de Janeiro State UniversityRio de JaneiroBrazil

Purpose This study aimed to compare the physical attributes of male and female Volleyball and Beach Volleyball *** Fifty-five athletes from Volleyball(Male,n=19,age 27.3±6.1 years,body mass 93.2±9.9 kg,and height 196.8±7.4 cm and Female,n=16,age 28.0±5.6 years,body mass 76.9±8.8 kg,and height 179.9±5.8 cm)and Beach Volleyball(Male,n=10,age 26.8±3.4 years,body mass 92.9±9.9 kg,and height 195.3±7.9 cm and Female,n=10,age 31.1±6.2 years,body mass 74.6±8.5 kg,and height 180.9±6.0 cm)participated in the *** tests were performed in a single visit to the laboratory in the following order:body composition,vertical jump(squat and countermovement jump),isokinetic(knees and shoulders),and cardiopulmonary exercise *** variables were analyzed using a two-way ANOVA(Sex and Sport factors)for independent *** Beach Volleyball athletes presented lower body fat(P=0.03;ES=0.32)and higher maximal cardiorespiratory variables(VO2,HR,and vVO2max).Only flexion bilateral difference(knee)at 60°/s was affected by sex(P=0.002;ES=0.63).For shoulders,only dominant external/internal rotation ratio presented a significant interaction for sport and sex(P=0.05;ES=0.28).Regarding vertical jumps,Volleyball male players presented a greater elastic index than BV male players(P=0.002,ES=0.67).Conclusion Beach Volleyball players are thinner and have better cardiorespiratory fitness than Volleyball ***,they presented less use of elastic properties for vertical jumping and have a greater muscle imbalance in the hamstrings than Volleyball players.

关键词： Athlete profile Court VO2max Neuromuscular Sex Sport

Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Hanna Santos Marques Ronaldo Teixeira da Silva Júnior Lorena Sousa de Carvalho Samuel de Sousa Cruz Gabriel Reis Rocha Gabriel Lima Correa Santos Kathlen Coutinho de Souza Rebeca Gabrielle Almeida Maciel Daiana Silva Lopes Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

SARS-CoV-2 infection in liver transplant recipients:A complex relationship

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World Journal of Gastroenterology 2021年第44期27卷 7734-7738页

作者： Ricardo Wesley Alberca Gil Benard Gabriela Gama freire Alberca Maria Notomi Sato Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de Dermatologia e Institute de Medicina TropicalFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

The recent manuscript reviewed investigations involving liver damage in coronavirus disease 2019(COVID-19)patients,and COVID-19 in patients with previous chronic hepatological diseases,such as patients with liver *** literature presents several conflicting results concerning the anti-SARS-CoV-2 response in patients with solid organ transplants,in liver transplant ***,we would like to humbly state a few points for consideration involving liver transplant recipients and COVID-19,such as the time since transplantation,comorbidities,and immunosuppressive regimens.

关键词： COVID-19 SARS-CoV-2 Liver transplant Immunosuppression Infection Comorbidities

Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão freire Natália Marchesan Bexiga Marco antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging