检索结果-南通市图书馆

维普期刊数据库

Machine learned interatomic potentials using random features

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 48-57页

作者： Gurjot Dhaliwal Prasanth b.nair Chandra Veer Singh Department of Mechanical and Industrial Engineering University of Toronto5 King’s College RdTorontoM5S 3G8ONCanada Institute for Aerospace Studies University of Toronto4925 Dufferin StTorontoM3H 5T6ONCanada Department of Materials Science and Engineering University of Toronto184 College StTorontoM5S 3E4ONCanada

We present a method to model interatomic interactions such as energy and forces in a computationally efficient *** proposed model approximates the energy/forces using a linear combination of random features,thereby enabling fast parameter estimation by solving a linear least-squares *** discuss how random features based on stationary and non-stationary kernels can be used for energy approximation and provide results for three classes of materials,namely two-dimensional materials,metals and *** and energy predictions made using the proposed method are in close agreement with density functional theory calculations,with training time that is 96%lower than standard kernel *** Dynamics calculations using random features based interatomic potentials are shown to agree well with experimental and density functional theory *** frequencies as computed by random features based interatomic potentials are within 0.1%of the density functional theory ***,the proposed random features-based potential addresses scalability issues encountered in this class of machine learning problems.

关键词： random stationary interatomic

Enhanced cavitation erosion resistance of a friction stir processed high entropy alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1353-1362页

作者： Rakesh b.nair H.S.Arora Harpreet Singh Grewal Surface Science and Tribology Lab Department of Mechanical EngineeringShiv Nadar UniversityGautam Buddha NagarUttar Pradesh 203207India

Friction stir processing of an Al0.1CoCrFeNi high entropy alloy(HEA)was performed at controlled cooling conditions(ambient and liquid submerged).Microstructural and mechanical characterization of the processed and as-cast HEAs was evaluated using electron backscatter diffraction,micro-hardness testing and *** under the submerged cooling condition showed elongated grains(10μm)with fine equiaxed grains(2μm)along the boundary compared to the coarser grain(~2 mm)of as-cast *** hardness showed remarkable improvements with four(submerged cooling condition)and three(ambient cooling condition)times that of as-cast HEA(HV^150).The enhanced hardness is attributed to the significant grain refinement in the processed *** erosion behavior was observed for samples using an ultrasonication *** of the HEAs showed better cavitation erosion resistance than the stainless steel *** sample processed under a submerged liquid condition showed approximately 20 and 2 times greater erosion resistance than stainless steel 316L and ascast HEA,*** enhanced erosion resistances of the processed HEAs correlate to their increased hardness,resistance to plasticity,and better yield strength than the as-cast *** surface of the tested samples showed nucleation and pit growth,and plastic deformation of the material followed by fatigue-controlled disintegration as the primary material removal mechanism.

关键词： cavitation erosion microstructure mechanical properties surface engineering

维普期刊数据库

Impact of nanoparticles on immune cells and their potential applications in cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

bIOCELL 2024年第11期48卷 1579-1602页

作者： JYOTHI b.nair ANU MARY JOSEPH SANOOP P MANU M.JOSEPH Leibniz Institute of Photonic Technology Albert-Einstein-Straße 9Jena07745Germany Serah Zines LLP SreeragamNaduvannor P.O.KozhikkodeKerala673614India Department of Chemistry Newman CollegeThodupuzhaKerala685585India Department of Chemistry Madanapalle Institute of Technology&Science(MITS)MadanapalleChittoorAndhra Pradesh517325India Department of Life Sciences CHRIST UniversityBengaluruKarnataka560029India

Nanoparticles represent a heterogeneous collection of materials,whether natural or synthetic,with dimensions aligning in the *** of their intense manifestation with the immune system,they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer *** review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages,dendritic cells,T lymphocytes,and natural killer(NK)*** also underscores the importance of knowing how nanoparticles inﬂuence immune cell functions,such as the production of cytokines and the presentation of antigens which are crucial for effective cancer *** overviews of bio-molecular mechanisms are *** can improve antigen presentation,boost T-cell responses,and overcome the immunosuppressive tumor *** regulatory mechanisms,signaling pathways,and nanoparticle characteristics are also presented for a comprehensive *** review the nanotechnology platform options and challenges in nanoparticlesbased immunotherapy,from an immunotherapy perspective including precise targeting,immune modulation,and potential toxicity,as well as personalized approaches based on individual patient and tumor *** development of emerging multifunctional nanoparticles and theranostic nanoparticles will provide new solutions for the precision and efﬁciency of cancer therapies in next-generation practice.

关键词： Nanotechnology Macrophages Dendritic cells Antigen presentation T lymphocytes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi N Jincy M.Jose Sreelata b.nair Prabha S.N Pappachan S Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline Super Specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGS;OMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical Notch Ligand 1(JAG1)gene(20p12.2)or in the Neurogenic locus notch homolog protein 2(NOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGS cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases Notch

Targeting LIF/LIFR signaling in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2022年第4期9卷 973-980页

作者： Suryavathi Viswanadhapalli Kalarickal V.Dileep Kam Y.J.Zhang Hareesh b.nair Ratna K.Vadlamudi Department of Obstetrics and Gynecology University of Texas Health San AntonioSan AntonioTX 78229USA Laboratory for Structural bioinformatics Center for Biosystems Dynamics ResearchRIKENYokohamaKanagawa 230-0045Japan Evestra Inc.San AntonioTX 78245USA Mays Cancer Center University of Texas Health San AntonioSan AntonioTX 78229USA

Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways including JAK/STAT3 as immediate effectors and MAPK, AKT, mTOR further downstream. LIF/LIFR signaling plays a key role in tumor growth, progression, metastasis, stemness and therapy resistance. Many solid cancers show overexpression of LIF and autocrine stimulation of the LIF/LIFR axis;these are associated with a poorer relapse-free survival. LIF/LIFR signaling also plays a role in modulating multiple immune cell types present in tumor micro environment (TME). Recently, two targeted agents that target LIF (humanized anti-LIF antibody, MSC-1) and LIFR inhibitor (EC359) were under development. both agents showed effectivity in preclinical models and clinical trials using MSC-1 antibody are in progress. This article reviews the significance of LIF/LIFR pathways and inhibitors that disrupt this process for the treatment of cancer.

关键词： LIF LIFR LIFR inhibitor STAT3 Targeted therapy

Optical parameters induced by phase transformation in RF magnetron sputtered TiO2 nanostructured thin films

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2014年第3期24卷 218-225页

作者： Prabitha b.nair V.b.Justinvictor Georgi P.Daniel K.Joy K.C.James Raju David Devraj Kumar P.V.Thomas Thin Film Lab Post Graduate and Research Department of Physics Mar Ivanios College School of Physics University of Hyderabad Central University P. O. College of Education Florida Atlantic University

Pure TiO2 thin films were deposited onto quartz substrates using a ceramic TiO2 target at an elevated substrate temperature of 573 K by RF magnetron sputtering, and an analysis of structural, optical and photoluminescence characteristics of the films upon phase transformation is reported in this paper. Structural investigations using X-ray diffraction revealed that the as-deposited film was amorphous in nature. Thermal annealing for 2 h at 873 K in air resulted in the formation of anatase phase, and a phase transformation to rutile was observed at 1073 *** increase in grain size and an improvement in crystallinity were also observed on annealing. Rod- like rutile crystallites were observed in the SEM images of the film annealed at 1273 K. As-deposited films and films annealed up to 1073 K were highly transparent in the visible region with a transparency 480%. Optical band gap of the films decreased upon thermal annealing which is attributed to phase transformation from amorphous to anatase and then to rutile. Optical parameters such as refractive index, optical conductivity and optical dielectric constant increased with increase in annealing temperature. Since rutile is the optically active phase, the superior refractive index of the film annealed at 1073 K along with its high transparency in visible region suggests the application of this film in antireflective coatings. Photoluminescence emission of maximum intensity was observed for the film annealed at 873 K, which exhibits anatase phase. Intense blue emission observed in this film makes it suitable for use in optoelectronic display devices.

关键词： RF magnetron sputtering TiO2thin films Dislocation density Optical conductivity Photoluminescence

Neuroinflammation revisited through the microglial lens

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

维普期刊数据库

Identification of slot discharges in rotating machine insulation system using variable frequency PD measurement

在线全文

学校读者我要写书评

暂无评论

High Voltage 2018年第3期3卷 179-186页

作者： Ramesh P.nair Sumangala b.Vishwanath Nageshwar b.Rao Cables and Diagnostics Division Central Power Research InstituteBengaluruIndia Dr.Ambedkar Institute of Technology BengaluruIndia

Slot discharge studies are very important from the insulation diagnosis *** in practice,testing of rotating machines with power frequency requires sources which are quite bulky and *** if the diagnosis is carried out at lower frequencies(be reduced ***,it is important to know whether the study at low frequencies can be considered equivalent to study at power ***,in this study,a slot discharge phenomenon occurring in a rotating machine insulation system was investigated experimentally at different frequencies(50,10,1 and 0.1 Hz).Slot discharges are known to have a distinct phase resolved partial discharge pattern for power frequency(50/60 Hz)*** distinct patterns are useful in identifying the presence of slot discharge activity in rotating *** discharges were created on a 6.6 kV mica-epoxy stator coil and the slot discharge characteristics measured at different frequencies are *** discharge measurements were repeated by varying the air gap between the insulation surface and grounded steel *** changes in slot discharge characteristics due to the increase in air gap were found similar at all *** comparison suggests that the identification of slot discharge is also possible from the partial discharge(PD)measurement at low frequencies.

关键词： steel rotating insulation

A Deep Convolutional Architectural Framework for Radiograph Image Processing at bit Plane Level for Gender&Age Assessment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2020年第2期62卷 679-694页

作者： N.Shobha Rani M.Chandrajith b.R.Pushpa b.J.bipin nair Department of Computer Science Amrita School of Arts and SciencesMysuruAmrita Vishwa VidyapeethamIndia Maharaja Institute of Technology MysuruIndia

Assessing the age of an individual via bones serves as a fool proof method in true determination of individual *** attempts are reported in the past for assessment of chronological age of an individual based on variety of discriminative features found in wrist radiograph *** permutation and combination of these features realized satisfactory accuracies for a set of limited *** this paper,assessment of gender for individuals of chronological age between 1-17 years is performed using left hand wrist radiograph images.A fully automated approach is proposed for removal of noise persisted due to non-uniform illumination during the process of radiograph acquisition *** to this a computational technique for extraction of wrist region is proposed using operations on specific bit planes of image.A framework called GeNet of deep convolutional neural network is applied for classification of extracted wrist regions into male and *** experimentations are conducted on the datasets of Radiological Society of North America(RSNA)of about 12442 *** of preprocessing and segmentation techniques resulted into a correlation of about 99.09%.Performance of GeNet is evaluated on the extracted wrist regions resulting into an accuracy of 82.18%.

关键词： bit plane processing automated segmentation deep convolutional network