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Effects of progesterone on T-type-Ca^(2+)-channel expression in Purkinje cells

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Neural Regeneration Research 2022年第11期17卷 2465-2471页

作者： annika Eickhoff Jonas Tjaden Sarah Stahlke Matthias Vorgerd Verena Theis Veronika Matschke Carsten Theiss Department of Cytology Institute of AnatomyRuhr-University BochumBochumGermany Department of Neurology Neuromuscular Center RuhrgebietUniversity Hospital BergmannsheilRuhr-Universität BochumBochumGermany

Plasticity of cerebellar Purkinje cells(PC)is influenced by progeste rone via the classical progeste rone receptors PR-A and PR-B by stimulating dendritogenesis,spinogenesis,and synaptogenesis in these *** PC cultures were used to analyze progeste rone effects at a molecular level on the voltage-gated T-type-Ca^(2+)-channels Ca_(v)3.1,Ca_(v)3.2,and Ca_(v)3.3 as they helped determine neuronal plasticity by regulating Ca^(2+)-influx in neuronal *** results showed direct effects of progesterone on the mRNA expression of T-type-Ca^(2+)-channels,as well as on the protein kinases A and C being involved in downstream signaling pathways that play an important role in neuronal *** the mRNA expression studies of T-type-Ca^(2+)-channels and protein kinases of the signaling cascade,laser microdissection and purified PC cultures of diffe rent maturation stages were *** staining was also performed to characte rize the localization of T-type-Ca^(2+)-channels in *** rimental progesterone treatment was performed on the purified PC culture for 24 and 48 *** results show that progesterone increases the expression of Ca_(v)3.1 and Ca_(v)3.3 and associated protein kinases A and Cin PC at the mRNA level within 48 hours after treatment at *** effects extend the current knowledge of the function of progesterone in the central nervous system and provide an explanatory approach for its influence on neuronal plasticity.

关键词： Ca_(v)3.1 Ca_(v)3.2 Ca_(v)3.3 neuronal plasticity progesterone protein kinase A protein kinase C Purkinje cells rat cerebellum T-type-Ca^(2+)-channels

Optimization of residence time distribution in RCDG and an assessment of its applicability in continuous manufacturing

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Particuology 2021年第3期19卷 43-49页

作者： annika Wilms Peter Kleinebudde Heinrich Heine University Düsseldorf Institute of Pharmaceutics and BiopharmaceuticsUniversitätsstraße 140225 DüsseldorfGermany INVITE GmbH Drug Delivery Innovation Center(DDIC)Chempark Building W3251368 LeverkusenGermany

Knowledge of residence time is a critical aspect in developing control and material diversion strategies for continuous manufacturing processes in pharmaceutical *** granulation is a promising continuous granulation technique as it is fast and *** this study,a step-change method to determine residence time in roll compaction/dry granulation is *** factors roll speed and rotational speed of the impeller in the powder inlet unit of the compactor were evaluated using a central composite circumscribed statistical design of experiments in order to optimize the residence *** fill volume in the compactor was varied *** was found that high roll speed,low rotational speed of the impeller and low fill volume in the compactor are beneficial to generate fast transition through the *** impact of roll speed increase was *** can be concluded that despite fast residence time in the process,high roll speed and its subsequent high material throughput can generate a large amount of material that has to be discarded if material diversion is required.

关键词： Roll compaction/dry granulation Residence time distribution Continuous manufacturing Digital image analysis Response surface optimization

Creation of a Novel Piezoelectric Nanogenerator for Sensory Receptor Damage Treatments

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Journal of Materials Science and Chemical Engineering 2023年第7期11卷 73-90页

作者： annika Joshi Johns Creek High School Johns Creek GA USA

Every year, millions of people incur damage to sensory receptors that interact with the external environment. Two areas of concern are hearing loss (affecting around 430 million) and burns (affecting 11 million annually). Current treatments for burns involve skin grafts, which are expensive and prone to rejection by the body. Current treatments for hearing loss involve implants and hearing aids, which have limited sensitivity, need batteries and charging, are expensive, and are prone to infection. Thus, there is a need for a self-powered, flexible, biocompatible, antibacterial, and inexpensive solution that can respond to stimuli at a rate comparable to tissue. Piezoelectric materials convert mechanical energy into electricity, thus replicating touch and hearing by simulating nerve signals. In this study, piezoelectric membranes with varying ratios of polyvinylidene fluoride (PVDF) and zinc oxide (ZnO) were fabricated using electrospinning. These membranes were characterized with scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), stress-strain analysis, and piezoresponse testing. Results showed that increasing the amount of PVDF made the membrane more flexible but reduced its piezoelectric potential (decrease in PVDF β-phase). Increasing the amount of ZnO significantly increased piezoelectric potential (increase in PVDF β-phase) but degraded the flexibility and usability of the membrane. Therefore, a 1:1 w/w ratio of PVDF to ZnO is the optimum ratio for balancing both piezoelectric potential and flexibility. These results support the hypothesis that composites of PVDF and ZnO can help realize self-powered hearing rehab devices and wearable electronic skin.

关键词： Wearable Electronic Skin Hearing Rehab Piezoelectric Membranes Flexible Membranes Nanogenerator Self-Powered Nanogenerator

Crohn's disease in Stockholm County during 1990-2001:An epidemiological update

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World Journal of Gastroenterology 2006年第1期12卷 75-81页

作者： annika Lapidus Medical Department Centre of Gastrointestinal Disease.Ersta HospitalKarolinska Institnte at Karolinska University HospitalHuddingeStockhohnSweden

瞄准：进一步在 1990 年代期间在一张明确的人口 Crohn 的疾病(CD ) 的发生和本地化估计并且在 2002 年 1 月 1 日评估 CD 的流行。方法：在基于的一张回顾的人口学习，作为根据 Lennard Jone 在 1990 和 2001 之间的标准有 CD 诊断的... 详细信息

瞄准：进一步在 1990 年代期间在一张明确的人口 Crohn 的疾病(CD ) 的发生和本地化估计并且在 2002 年 1 月 1 日评估 CD 的流行。方法：在基于的一张回顾的人口学习，作为根据 Lennard Jone 在 1990 和 2001 之间的标准有 CD 诊断的斯德哥尔摩县的所有 16-90 岁公民被包括。盒子鉴定被使用计算机化的住院病人和门诊病人寄存器做。而且私人胃的肠学被要求可能的盒子。疾病的程度和肛门直肠的 fistulae 的频率是被决定是在诊断的年龄。进一步， CD 在上的流行(st ) 1 2002 年 1 月被估计。结果：所有 1 389 个病人， 689 个男人和 700 个女人，为 CD 完成了标准。为整个经期的吝啬的发生率每 10 是 8.3 (5 )(95%CI 7.9 -8.8) 。性之间没有差别。为颜色的整个学习经期的吝啬的年度发生表面的疾病和回盲肠疾病，是 4.4 (95%CI 4.0-4.7 ) 并且 2.4 (95%CI 2.1-2.6 ) 每 10 (5 ) 分别地。肛周疾病发生在 13.7%(95%CI 11.9-15.7 %) 病人。CD 的流行每 100,000 个居民是 213。结论：CD 的发生显著地在斯德哥尔摩县在最后十年期间增加了， 0.2% 人口受不了 CD。增加被归因于颜色的另外的增加表面的疾病，当回盲肠疾病的发生仍然保持稳定时。

关键词：结肠疾病炎症免疫学病理机制

A Transmission Electron Microscopy Study of Plate Martensite Formation in High-carbon Low Alloy Steels

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Journal of Materials Science & Technology 2013年第4期29卷 373-379页

作者： Albin Stormvinter Peter Hedstrm annika Borgenstam Department of Materials Science and Engineering School of Industrial Engineering and ManagementKTH Royal Institute of TechnologySE-100 44 StockholmSweden

The martensitic microstructures in two high-carbon low alloy steels have been investigated by classical and automated crystallographic analysis under a transmission electron microscope. It is found that the martensitic substructure changes from consisting mostly of transformation twins for 1.20 mass% carbon （C） steel to both transformation twins and planar defects on {101}M for 1.67 mass% C steel. In the 1.67 mass% C steel it is further found that small martensite units have a rather homogeneous substructure, while large martensite units are more inhomogeneous. In addition, the martensite units in both steels are frequently found to be of zigzag patterns and have distinct crystallographic relationships with neighboring martensite units, e.g. kink or wedge couplings. Based on the present findings the development of martensite in high-carbon low alloy steels is discussed and a schematic of the martensite formation is presented. Moreover, whether the schematic view can be applied to plate martensite formation in general, is discussed.

关键词： Transmission electron microscopy High-carbon low alloy steel Plate martensite

Smoking prevalence in the area of responsibility of the German Ministry of Defense——results of the employee survey in the context of occupational health management

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Military Medical Research 2020年第3期7卷 343-349页

作者： Stefan Sammito annika Claus Dirk-Matthias Rose Department I 3 Research&Development Air Force Centre of Aerospace MedicineCologneGermany Occupational Medicine Faculty of MedicineOtto-von-Guericke-University of MagdeburgMagdeburgGermany Institute for Teachers’Health Institute of OccupationalSocial and Environmental Medicine of the Johannes-Gutenberg University MainzMainzGermany

Background:Tobacco use,correlated with reduced physical fitness,is one of the leading causes of avoidable death *** increases the risk of dementia and can shorten the lifespan by 10 *** the German Armed Forces(Bundeswehr),figures on smoking behavior have not been comprehensively *** study analyzes current data in a large sample from this ***:Based on an employee survey as part of the Occupational Health Management System,data on smoking behavior from 13,326 participants were analyzed in relation to age,gender,professional status,education level and membership in military operational units versus other ***:Smoking behavior varied significantly(Polder),gender,professional status,military agency membership status,and education level(the lower the education level,the higher the smoking rates).With the exception of the downward trend in smoking behavior with increasing age among civilian employees,these results were all significant(P<0.005).Conclusions:This data analysis shows that smoking prevalence among personnel in the area of responsibility of the Federal Ministry of Defense is comparable to the current data from corresponding surveys of the German *** on gender,they generally show values that are slightly above those of the German *** well-known trend in the general population of decreasing smoking prevalence with increasing age is also seen in this ***,there are considerable differences in the smoking prevalence among individual subgroups(professional status,agency,gender,education level).The data show that particular young soldiers in the armed forces should be the target group for further preventive measures.

关键词： Prevention Smoking Military Health promotion

Optimal plot design in a multipurpose forest inventory

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Forest Ecosystems 2016年第1期3卷 37-50页

作者： Helena M.Henttonen annika Kangas Natural Resources Institute Finland(Luke) Economics and Society unit

Background： We explore the factors affecting the optimal plot design （size and type as well as the subsample tree selection strategies within a plot） and their relative importance in defining the optimal plot design in amultipurpose forest inventory. The factors include time used to lay out the plot and to make the tree measurements within the plot, the between-plot variation of each of the variables of interest in the area, and the measurement and model errors for the different variables. Methods： We simulate different plot types and sizes and subsample tree selection strategies on measuredtest areas from North Lapland. The plot types used are fixed-radius, concentric and relascope plots. Weselect the optimal type and size first at plot level using a cost-plus-loss approach and then at cluster level byminimizing the weighted standard error with fixed budget. Results： As relascope plots are ve~/efficient at the plot level for volume and basal area, and fixed-radius plots for stems per ha, the optimal plot type strongly depends on the relative importance of these variables. The concentric plot seems to be a good compromise between these two in many cases. The subsample tree selection strategy was more important in selecting optimal plot than many other factors. In cluster level, the most important factor is the transfer time between plots. Conclusions： While the optimal radius of plots and other parameters were sensitive to the measurement times and other cost factors, the concentric plot type was optimal in almost all studied cases. Subsample tree measurement strategies need further studies, as they were an important cost factor. However, their importance to the precision was not as clear.

关键词： Sample Plot Forest inventory Measurement Cost Loss

Benefits of past inventory data as prior information for the current inventory

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Forest Ecosystems 2020年第2期7卷 263-273页

作者： annika Kangas Terje Gobakken Erik Næsset Bioeconomy and Environment Natural Resources Institute Luke(Finland)Yliopistokatu 680100 JoensuuFinland Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway.

Background:When auxiliary information in the form of airborne laser scanning(ALS)is used to assist in estimating the population parameters of interest,the benefits of prior information from previous inventories are not *** a simulation study,we compared three different approaches:1)using only current data,2)using nonupdated old data and current data in a composite estimator and 3)using updated old data and current data with a Kalman *** also tested three different estimators,namely i)Horwitz-Thompson for a case of no auxiliary information,ii)model-assisted estimation and iii)model-based *** compared these methods in terms of bias,precision and accuracy,as estimators utilizing prior information are not guaranteed to be ***:The largest standard errors were obtained when neither prior information nor auxiliary information were *** a growth model was not applied to update the old data,the resulting composite estimators were *** RMSEs were obtained using non-updated prior information in a composite *** the ALS data as auxiliary information produced smaller RMSE than using prior information from the old *** smallest RMSEs were obtained when both the auxiliary data and updated old data were *** growth updating the bias can be substantially reduced,although design-unbiasedness of the estimator cannot be ***:Prior information from old inventory data can be useful also when combined with highly accurate auxiliary information,when both data sources are efficiently *** benefits obtained from using the old data will increase if the past harvests can be detected without errors from changes in the auxiliary data instead of being predicted with models.

关键词： Data fusion Kalman filtering

Predicting stand age in managed forests using National Forest Inventory field data and airborne laser scanning

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Forest Ecosystems 2020年第3期7卷 579-589页

作者： Matti Maltamo Hermanni Kinnunen annika Kangas Lauri Korhonen University of Eastern Finland School of Forest SciencesP.O.Box 11180101JoensuuFinland Natural Resources Institute Finland Bioeconomy and EnvironmentP.O.Box 6880100JoensuuFinland

Background: The aim of this study was to construct a nationwide stand age model by using National Forest Inventory(NFI) data and nationwide airborne laser scanning(ALS) data. In plantation forestry, age is usually *** this is not the case in boreal managed forests, age is still seldom predicted in forest management *** age accurately in situ is also very laborious. On the other hand, tree age is one of the accurately measured sample tree attributes in NFI field data. Many countries also have a nationwide coverage of airborne laser scanning(ALS) data. In this study, we merged these data sources and constructed a nationwide, area-based model for stand ***: While constructing the model, we omitted old forests from the data, since the correlation between ALS height metrics and stand age diminished at stands with age > 100 years. Additionally, the effect of growth conditions was considerable, so we also utilized different geographical and NFI variables such as site fertility and soil type in the modeling. The resultant nationwide model for the stand age of managed forests yielded a root mean square error(RMSE) of about 14 years. The model could be improved further by additional forest structure variables, but such information may not be available in ***: The results showed that the prediction of stand age by ALS, geographical and NFI information was challenging, but stil possible with moderate success. This study is an example of the joint use of NFI and nationwide ALS data and re-use of NFI data in research.

关键词： Forest stock age LiDAR NFI Nationwide model Growth conditions