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Spectroscopic visualization of hydrogenation and hydrogen diffusion on a bimetallic interface with high spatial resolution

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Spectroscopic visualization of hydrogenation and hydrogen di...

Women on the liver transplantation waitlist are at increased risk of hospitalization compared to men

第二十届全国光散射学术会议（cNcLS20）

作者： Hao Yin Liqing Zheng Wei Fang Ying-hung Lai Nikolaus Porenta Guillaume Goubert Jeremy richardson Bin Ren Jianfeng Li Renato Zenobi Department of chemistry and Applied Biosciences ETH Zurich Department of chemistry Xiamen University

＜正＞catalytic hydrogenation has diverse important industrial *** frequently,industrial hydrogenation relies on heterogeneous catalysts especially novel metal hydrogenation catalysts such as palladium （Pd）,platinum （Pt）,ruthenium （Ru）.While a single metal catalyst is not enough to achieve both high efficiency and selectivity,researchers have developed several

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World Journal of Gastroenterology 2019年第8期25卷 980-988页

作者： Jessica B Rubin Marie Sinclair Robert S Rahimi Elliot B Tapper Jennifer c Lai Division of Gastroenterology and Hepatology Department of MedicineUniversity of California-San FranciscoSan FranciscoCA 94143 United States Department of Gastroenterology and Hepatology Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine the University of MelbourneMelbourne 3010VictoriaAustralia Division of Hepatology Annette C.and Harold C.Simmons Transplant InstituteBaylor University Medical CenterDallasTX 75346United States Division of Gastroenterology and Hepatology University of MichiganAnn ArborMI 48109United States

BAcKGROUND Hospital admissions are common among patients with cirrhosis,but patient factors associated with hospitalization have not been well *** recent data suggesting increased liver transplant waitlist dropout among women,we hypothesized that women on the liver transplant waitlist would have increased rates of hospitalization compared with *** To evaluate the role of gender on risk of hospitalization for patients on the liver transplant waitlist,in order to help explain gender disparities in waitlist *** Patients listed for liver transplant at a single center in the United States were prospectively enrolled in the Functional Assessment in Liver Transplantation *** included in this retrospective analysis included those enrolled between March 2012 and December 2014 with at least 12 mo of follow up and without hepatocellular *** primary and secondary outcomes were hospitalization and total inpatient days within 12 mo,*** and negative binomial regression associated baseline factors with *** Of the 392 patients,41%were female,with median(interquartile range)age 58 years(52-63)and model for end-stage liver disease 18(15-22).Within 12 mo,186(47%)patients were hospitalized≥1 time;48%were readmitted,with a median of 8(4-15)inpatient *** women than men were hospitalized(54%vs 43%;P=0.03).In univariable analysis,female sex was associated with an increased risk of hospitalization[odds ratios(OR)1.6,95%confidence interval(cI)1.0-2.4;P=0.03],which remained significant on adjusted multivariable analysis(OR 1.6,95%cI:1.1-2.6;P=0.03).Female gender was also associated with an increased number of inpatient days within 12 mo in both univariable and multivariable *** Women with cirrhosis on the liver transplant waitlist have more hospitalizations and inpatient days in one year compared with men,suggesting that the experience of cirrhosis differs between men and women,despite

关键词： Gender cirrhosis Liver transplantation waitlist Hospitalization Readmission Women

勃朗:《弗洛伊德与后期弗洛伊德学说》艾逊克:《变态心理学手册》

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现代外国哲学社会科学文摘 1961年第11期 32-33页

作者：理查逊方同源

输证精神分析时所遇到的最大困难,象弗洛伊德本人所指出的,是在于精神分析活动的过程中,本质上有它的主观性。除非你本人自己具有精神分析的经验,这就意味着具有相当广泛的不受拘束的联想实习经验,因而即使看来同当前活动无关的,细小

关键词：弗洛伊德勃朗逊克

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成功销售手册英汉对照

丛书名：职业成功必读书架

2006年

作者：（美）琳达·理查德森（Linda richardson）施淑芳译

本书介绍了6个销售计划，介绍了如何聆听并了解顾客的意见，如何成功地和精明顾客交易，以及如何针对顾客意见提出解决问题的销售建议。

ISBN: (纸本)7302123632

本书介绍了6个销售计划，介绍了如何聆听并了解顾客的意见，如何成功地和精明顾客交易，以及如何针对顾客意见提出解决问题的销售建议。

关键词：企业管理销售管理

来源：畅想之星图书光盘版（南... 评论

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猪细小病毒疫苗的效力试验

贵州畜牧兽医 1997年第4期21卷 41-43页

作者： K.R.Edwards M.A.Emmerson P.R.Luff D.E.Wells J.c.Muskett.A.E.Wrtahall c.richardson B.N.J.Parker D.H.Thornton 陈眷华

本次研究旨在调查和比较3种不同疫苗所提供的避免胎儿死亡的保护力,其中两种疫苗采用3个不同的剂量接种,以期能够获得不同的保护水平,以半数保护剂量(PD_(50))表示,由此获得的数据可以对其它疫苗作出评价。同时,对在已建立的细胞系上增... 详细信息

本次研究旨在调查和比较3种不同疫苗所提供的避免胎儿死亡的保护力,其中两种疫苗采用3个不同的剂量接种,以期能够获得不同的保护水平,以半数保护剂量(PD_(50))表示,由此获得的数据可以对其它疫苗作出评价。同时,对在已建立的细胞系上增殖病毒。

关键词：猪病细小病毒病疫苗免疫接种

Design,Synthesis,and Applications of Mesoporous covalent Organic Frameworks

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ccS chemistry 2024年第1期6卷 57-68页

作者： Niyati Arora cassandra Flores Milinda c.Senarathna christina M.Thompson Ronald A.Smaldone Department of chemistry and Biochemistry University of TexasDallasRichardsonTexas 75080

covalent organic frameworks(cOFs)are highly ordered and permanently porous organic polymers that can be classified as two-dimensional or *** tunable design and crystalline order endow a range of pore sizes,shapes,functions,and applications that differentiate them from other *** cOF pore sizes and shapes rely on the geometry of the monomers and dynamic covalent chemistry,while the stacking of the sheets relies on noncovalent *** tunability allows for post-modification or the incorporation of additional functional groups for the reinforcement by various noncovalent *** limits of mesoporous cOFs are still being investigated,with the design rules continuing to *** we report a comprehensive review of mesoporous cOFs,explore strategies for large pore reinforcement,highlight structural design and features,elucidate their various functions and applications,discuss fundamental challenges faced that need to be addressed,and predict future directions.

关键词： covalent organic frameworks mesoporous supramolecular chemistry polymers pore size

A phaseⅡprospective trial of photobiomodulation therapy in limiting oral mucositis in the treatment of locally advanced head and neck cancer patients

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第4期8卷 345-354页

作者： Janielle K.-A.Taylor Leila J.Mady Khalil Baddour Uzoma K.Iheagwara Shuyan Zhai James P.Ohr Daniel P.Zandber Vikram c.Gorantla Robert L.Ferris Seungwon Kim Umamaheswar Duvvuri Mark W.Kubik Shaum Sridharan Jonas T.Johnson Karen D.Holeva annette E.Quinn David A.clump School of Medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Otorhinolaryngology—Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Otolaryngology—Head and Neck Surgery UPMCPittsburghPennsylvaniaUSA UPMc Department of Radiation Oncology UPMCPittsburghPennsylvaniaUSA Biostatistics UPMC Hillman Cancer CenterPittsburghPennsylvaniaUSA Department of Medicine Division of Hematology/OncologyUPMC Hillman Cancer CenterPittsburghPennsylvaniaUSA Department of Immunology UPMCPittsburghPennsylvaniaUSA Department of Plastic and Reconstructive Surgery University of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA

Objective:This study aimed to compare the historical incidence rate of severe oral mucositis(OM)in head and neck cancer patients undergoing definitive concurrent chemoradiation therapy(cRT)versus a prospective cohort of patients with locally advanced head and neck squamous cell carcinoma(HNScc)treated with prophylactic photobiomodulation therapy(PBMT).Methods:This US-based,institutional,single-arm,phaseⅡprospective clinical trial was initiated in 50 patients(age≥18 years,Karnofsky Performance Scale Index>60,with locally advanced HNScc(excluding oral cavity)receiving definitive or adjuvant radiation therapy(RT)with concurrent platinum-based chemotherapy(cT).PBMT was delivered three times per week throughout RT utilizing both an intraoral as well extraoral delivery *** outcome measure was incidence of severe OM utilizing both the National cancer Institute common Toxicity criteria,version 4.0(NcI-cTcAE)Grade≥3 and the World Health Organization Mucositis Grading Scale(WHO)Grade≥3 versus historical controls;secondary outcome measures included time to onset of severe OM following therapy ***:At baseline,all patients included in final analysis(N=47)had OM Grade *** RT and cT dose was(66.3±5.1)Gy and(486.1±106.8)mg/m ^(2),*** OM was observed in 11 of 47 patients(23%,confidence interval:12,38).OM toxicity grade trended upward during treatment,reaching a maximum at 7 weeks(WHO:1.8 ***-cTcAE:1.7).Subsequently,OM grade returned to baseline 3 months following completion of *** mean time to onset of severe OM was(35±12)*** mean time to resolution of severe OM was(37±37)***:compared to historical outcomes,PBMT aides in decreasing severe OM in patients with locally advanced *** represents a minimally invasive,prophylactic intervention to decrease OM as a major treatment-related side effect.

关键词： chemoradiotherapy oral mucositis photobiomodulation therapy squamous cell carcinoma of head and neck

帕博利珠单抗治疗伴脑转移NScLc患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析

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中国肺癌杂志 2021年第9期24卷 I0007-I0016页

作者： Sarah B GOLDBERG Kurt A ScHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne c cHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L cHANG Harriet M KLUGER 董晓荣(翻译/校对) Department of Medicine(Medical Oncology) Yale School of MedicineNew HavenCTUSA Department of Pathology Yale School of MedicineNew HavenCTUSA Department of Radiology Yale School of MedicineNew HavenCTUSA Department of Neurosurgery Yale School of MedicineNew HavenCTUSA Department of Therapeutic Radiology Yale School of MedicineNew HavenCTUSA Interdepartmental Program in computational Biology and Bioinformatics Yale School of MedicineNew HavenCTUSA Department of Biostatistics Yale School of Public HealthNew HavenCTUSA 华中科技大学同济医学院附属协和医院胸部肿瘤科

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NScLc)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(ce... 详细信息

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NScLc)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,cNS)中的疗效。中期结果已发表,现报道对NScLc队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NScLc并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern cooperative Oncology Group,EcOG)cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1cT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%cI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NScLc伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NScLc合并cNS转移。

关键词：非小细胞肺癌脑转移免疫治疗帕博利珠单抗

Large-Eddy Simulation of Flows over Idealized Urban Roughness in Unstable Thermal Stratification

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Large-Eddy Simulation of Flows over Idealized Urban Roughnes...