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Infectious Disease Modelling 2021年第1期6卷 46-55页

作者： Marcos Amaku Dimas Tadeu Covas Francisco Antonio Bezerra Coutinho Raymundo Soares Azevedo Neto Claudio Struchiner annelies Wilder-Smith Eduardo Massad School of Medicine University of Sao Paulo and LIM01-HCFMUSPSao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil School of Veterinary Medicine University of Sao PauloSao PauloBrazil Department Public Health and Clinical Heidelberg Institute of Global HealthUniversity of HeidelbergGermany Medicine Epidemiology and Global HealthUmeåUniversitySE-90185UmeåSweden Department of Disease Control London School of Hygiene and TropicalMedicineUK

Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of *** this paper we modelled and simulated a test-trace-andquarantine strategy to control the COVID-19 outbreak in the State of São Paulo,*** State of São Paulo failed to adopt an effective social distancing strategy,reaching at most 59%in late March and started to relax the measures in late June,dropping to 41%in 08 ***,São Paulo relies heavily on a massive testing strategy in the attempt to control the *** alternative strategies combined with economic evaluations were *** strategy included indiscriminately testing the entire population of the State,reaching more than 40 million people at a maximum cost of 2.25 billion USD,that would reduce the total number of cases by the end of 2020 by 90%.The second strategy investigated testing only symptomatic cases and their immediate contacts e this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%.The conclusion is that if the State of São Paulo had decided to adopt the simulated strategy on April the 1st,it would have been possible to reduce the total number of cases by 90%at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.

关键词： COVID-19 SARS-CoV-2 Testing Cost-analysis Modelling

For the Greater Good?—A Critical Reflection on Assessing Indirect Economic Effects Caused by Large Transport Projects

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Open Journal of Civil Engineering 2019年第2期9卷 135-156页

作者： Delphine Patrick Witte Thomas Hartmann Tejo Spit annelies Zoomers Department of Human Geography and Planning Utrecht University Utrecht The Netherlands Faculty of Environmental Sciences Wageningen University and Research Wageningen The Netherlands

Investing in large transport projects affects the (potential) economic development of metropolitan areas. Yet, very little critical research has been performed to understand how to assess these effects. The relationship between infrastructure investments and regional economic development is complex and indirect, and many theoretical and methodological difficulties remain. On the one hand, the assumption that investing in infrastructure is important to sustain economic growth is sometimes doubted. On the other hand, it is argued that investments in infrastructure enhance the accessibility of urban regions and that in the slipstream of such investments, social problems in urban regions can be tackled as well. Despite these contrasting views, there is at least a consensus that transport infrastructure development depends on economic development and vice versa. Yet, in many cases, the method of assessing economic impacts highly affects the results. Therefore, this paper focuses on a critical reflection of methods for estimating economic effects of infrastructure investments. A critical evaluation is made based on Indonesian and Japanese cases. After conducting in-depth desk research on both cases, we found that the broader effects on affected group of people tend to be overlooked due to the problems of time and space dimensions, the chain reaction of effects, and inappropriate data practices. The assessment on the appraisal processes tends to overlook the broader economic implication due to narrow focus and the concept of efficiency of economic theory.

关键词： Large Infrastructure Projects High-Speed Railways Economic Effects Transport Investment Economic Assessment

Estimating the size of Aedes aegypti populations from dengue incidence data: Implications for the risk of yellow fever outbreaks

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Infectious Disease Modelling 2017年第4期2卷 441-454页

作者： Eduardo Massad Marcos Amaku Francisco Antonio Bezerra Coutinho Claudio JoséStruchiner Luis Fernandez Lopez annelies Wilder-Smith Marcelo Nascimento Burattini School of Medicine University of Sao PauloBrazil London School of Hygiene and Tropical Medicine UK College of Life and Natural Sciences The University of DerbyUK Programme of Scientific Computation Fundação Oswaldo CruzRio de JaneiroBrazil Li Ka Shing Knowledge Institute St Michael's HospitalTorontoCanada Institute of Public Health University of HeidelbergGermany Department Public Health and Clinical Medicine Epidemiology and Global HealthUmeåUniversitySE-90185 UmeåSweden Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore Hospital São Paulo Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloSPBrazil

In this paper we present a model to estimate the density of aedes mosquitoes in a community affected by *** method consists in fitting a continuous function to the incidence of dengue infections,from which the density of infected mosquitoes is derived *** derivations allow the calculation of the latent and susceptible mosquitoes'densities,the sum of the three equals the total mosquitoes'*** method is illustrated with the case of the risk of urban yellow fever resurgence in dengue infested areas but the same procedures apply for other aedes-transmitted infections like Zika and chikungunya viruses.

关键词： Aedes aegypti Mosquitoes'densities Dengue Zika virus Yellow fever

“Ski”-Shaped Microneedle Facilitates Suturing in a Deep Narrow Surgical Field

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Open Journal of Modern Neurosurgery 2020年第3期10卷 364-370页

作者： Laura Celis annelies Mondelaers Andras Csokay Vincent Van Rompaey Tomas Menovsky Depatment of Ear Nose and Throat (ENT) St-Vincentius Hospital Antwerp Belgium NeuroVascular Center Antwerp Antwerp University Hospital Edegem Belgium Department of Translational Neurosciences University of Antwerp Antwerp Belgium Department of Neurosurgery Honved Military Hospital Budapest Hungary Department of Ear Nose and Throat (ENT) Antwerp University Hospital Antwerp Belgium Department of Neurosurgery Antwerp University Hospital Edegem Belgium

Background: Microsurgical suturing requires high level of dexterity and practice. Suturing in a deep and narrow operative field poses additional difficulties mainly due to the long microsurgical instruments and the difficulty of manipulating a curved needle. Objective: In this technical note, we describe a simple modification of a classical curved suture needle into a “ski”-shaped needle. Methods: A classical curved needle is stretched using a needle holder. Only the tip of the needle is left slightly bent, imitating a ski. Once the needle is bent into the ski shape, it can be grasped virtually in any position with the needle holder. Results: We have used the ski needle technique suturing in several patients in which the operative field was deep and limited such as dura repair in spinal surgery in obese patients, facial nerve grafting in the internal acoustic meatus and posterior inferior cerebellar artery suturing between the caudal cranial nerves. Conclusion: This modification facilitates free positioning of the needle in the needle holder and as a consequence results in easy and faster microsuturing in a deep and narrow operative field. The ski needle technique was felt to be superior to the classical curved needle technique.

关键词： Microneedle Facial Nerve Grafting Microsurgery Deep Surgical Field Ski

Selection Vector for Direct Cloning of Proof Reading Polymerase Chain Reaction Products Based on the Lethal <i>ccdB</i>Gene in <i>Escherichia coli </i>

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Advances in Microbiology 2013年第1期3卷 14-20页

作者： Pascal Weibel Miriam Ender Jerzy Madon annelies S. Zinkernagel Reto A. Schuepbach Clinic of Infectious Diseases and Hospital Hygiene University Hospital Zurich University of Zurich Zurich Switzerland Surgical Intensive Care Medicine University Hospital Zurich University of Zurich Zurich Switzerland

Introducing PCR products into plasmids vectors is key for molecular techniques. Ideally cloning vectors are easy to construct, modify and propagate, neither require advanced techniques nor special equipment or reagents and efficiently incorporate PCR products at close to zero empty vector background. We provide an easy to engineer self-made cloning vector, neither requiring sophisticated tools or techniques nor advanced cloning knowledge. Through recombination we obtained the pUC18ccdB vector, carrying the ccdB suicide gene within the pUC18 backbone. When SmaI cleaved (within the ccdB) vector was T4 ligated with small (0.2 kbp) and intermediate (1.3 to 2.2 kbp) blunt end PCR-products and transformed into E. coli, the amount of clones with incorporated PCR product was comparable to commercial PCR-cloning kits and at a close to zero PCR product negative background. In conclusion we present a simple, versatile and cheap approach to an efficient “home made” PCR-cloning vector that allows integration of crude blunt end PCR products at close to zero background.

关键词： PCR-Cloning Vector Blunt End ccdB Toxic Gene

New insights in the treatment of acromioclavicular separation

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World Journal of Orthopedics 2017年第12期8卷 861-873页

作者： Christiaan J A van Bergen annelies F van Bemmel Tjarco D W Alta Arthur van Noort Department of Orthopaedic Surgery Amphia Hospital Department of Orthopaedic Surgery Spaarne GasthuisHoofddorp 2134 TM

A direct force on the superior aspect of the shoulder may cause acromioclavicular(AC) dislocation or separation. Severe dislocations can lead to chronic impairment, especially in the athlete and high-demand manual laborer. The dislocation is classified according to Rockwood. Types Ⅰ?and Ⅱ are treated nonoperatively, while types Ⅳ, Ⅴ and Ⅵ are generally treated operatively. Controversy exists regarding the optimal treatment of type Ⅲ dislocations in the high-demand patient. Recent evidence suggests that these should be treated nonoperatively initially. Classic surgical techniques were associated with high complication rates, including recurrent dislocations and hardware breakage. In recent years, many new techniques have been introduced in order to improve the outcomes. Arthroscopic reconstruction or repair techniques have promising short-term results. This article aims to provide a current concepts review on the treatment of AC dislocations with emphasis on recent developments.

关键词： Acromioclavicular dislocation Rockwood classification Coracoclavicular ligament reconstruction Hookplate Arthroscopically assisted acromioclavicular reconstruction Weaver and Dunn procedure Conoid and trapezoid ligaments

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结构主义

结构主义

作者： J.M.·布洛克曼(J.M. broekman)

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婴儿能量消耗量与生长发育的研究

婴儿能量消耗量与生长发育的研究

中国营养学会第五届妇幼营养学术会议

作者：蒋卓勤阎勤苏宜香 Kevin J Acheson annelies Thelin Christelle Piguet-Welsch 何志谦中山大学公共卫生学院营养学系 Nestle Research Center Switzerland

目的:为了了解我国婴儿的能量消耗量,为能量参考摄入量的修订提供实验依据。方法:采用国际原子能机构(IAEA)和国际膳食与能量专家组(IDECG)推荐的双标记水法(Doubly labeledwater,DLW)直接测定自由活动条件下36名婴儿的总能量消耗量。结... 详细信息

目的:为了了解我国婴儿的能量消耗量,为能量参考摄入量的修订提供实验依据。方法:采用国际原子能机构(IAEA)和国际膳食与能量专家组(IDECG)推荐的双标记水法(Doubly labeledwater,DLW)直接测定自由活动条件下36名婴儿的总能量消耗量。结果:母乳喂养儿总能量消耗量(4月龄组2664±62 kJ/kg.d,6月龄组325±69 kJ/kg.d)比人工喂养儿(4月龄组325±70 kJ/kg.d,6月龄组3464±98 kJ/kg.d)低的趋势,而母乳喂养儿的体重、身高与人工喂养儿一致。随着年龄的增长,婴儿每kg体重消耗的能量呈增高趋向,可能与婴儿的活动量随年龄而增加有关。4月龄婴

关键词：能量消耗婴儿生长发育

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双标记水法测定婴儿机体构成的研究

双标记水法测定婴儿机体构成的研究