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Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis

World Journal of Clinical Oncology 2020年第3期11卷 121-135页

作者： Ivan Shabo Joar Svanvik annelie lindström Tanguy Lechertier Sara Trabulo James Hulit Tim Sparey John Pawelek Endocrine and Sarcoma Surgery Unit Department of Molecular Medicine and SurgeryKarolinska InstituteStockholm SE 17177Sweden Patient Area of Breast Cancer Sarcoma and Endocrine TumoursTheme CancerKarolinska University HospitalStockholm SE 17176Sweden The Transplant Institute Sahlgrenska University HospitalGothenburg SE 41345Sweden Division of Surgery Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58183Sweden Division of Cell Biology Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58185Sweden Novintum Bioscience Ltd London Bioscience Innovation CentreLondon NW10NHUnited Kingdom Department of Dermatology and the Yale Cancer Center Yale University School of MedicineNew HavenCT 06520United States

Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and *** cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid cells with new genetic and phenotypic properties at a rate exceeding that achievable by random *** that stimulate cell fusion are inflammation and *** of cancer cells with non-neoplastic cells facilitates several malignancy-related cell phenotypes,e.g.,reprogramming of somatic cell into induced pluripotent stem cells and epithelial to mesenchymal *** is now considerable in vitro,in vivo and clinical evidence that fusion of cancer cells with motile leucocytes such as macrophages plays a major role in cancer *** the many changes in cancer cells after hybridizing with leucocytes,it is notable that hybrids acquire resistance to chemo-and radiation *** phenomenon that has been largely overlooked yet plays a role in these processes is *** of the mechanism of polyploid cell formation,it happens in response to genotoxic stresses and enhances a cancer cell’s ability to *** we summarize the recent progress in research of cell fusion and with a focus on an important role for polyploid cells in cancer *** addition,we discuss the clinical evidence and the importance of cell fusion and polyploidization in solid tumors.

关键词： Cell fusion Hybrid formation Polyploidization macrophage Cancer progression Oncologic treatment resistance

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Hypoglycaemiac medicinal Plants Used by Diabetics at CNHU-HKm

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Journal of Diabetes mellitus 2024年第1期14卷 41-48页

作者： annelie Kerekou Hode Hubert Dedjan Léonce Gaba Department of Endocrinology metabolism Nutrition of CNHU-HKm Cotonou Bénin Department of medicine and medical Specialties of the CHUD-OP Porto-Novo Benin

Introduction: Diabetes is a major public health problem. medicinal plants are frequently used either combine with industrial treatment or exclusively, in Africa and particularly in Benin. Our study aims to identify the different medicinal plants used by diabetic patients at the CNHU-HKm. method: we carried out a descriptive and analytical cross-sectional study. It took place at the University Clinic of Endocrinology, metabolism and Nutrition of CNHU-HKm over a of 3 months period from 20th of June to 16th of September, 2022, over diabetic followed-up. Results: One hundred and seventy-three (173) patients were gathered using an anonymous inquiry form. In the study population, the age of the patients varied between 31 and 75 years with an average age of 59 +/− 1.43 years, women represented 59% with a sex ratio (male/female) of 0.69. Sixty-five (65) or 37.6% of the population had used medicinal plants. Among given reasons for using medicinal plants were, mainly the positiveness on a third party. Data analysis outcome twenty-nine species of plants belonging to twenty (20) botanical families, the most represented being the Annonaceae and Fabaceae. The most used species are Phyllanthus amarus (hlenwé in fon), mangifera indica (mangatin in fon), momordica charantia (gninsikin in fon), Combretum micranthum (kinkéliba in fon), and Picralima nitida (ayorkpè in fon). most used parts of the plants are the leaves. The recipes are prepared mainly by infusion and are administered exclusively by mouth. most of the patients who used the hypoglycaemic medicinal plants were satisfied and no adverse effects were reported by them. Conclusion: Hypoglycaemic medicinal plants could be subjected to pharmacognosy and marketed due to their richness in active components, after further toxicological studies.

关键词： Diabetes Hypoglycaemic medicinal Plants Glycemic Imbalance Chronic Complications Benin

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Pathological and Clinical Correlation European Union-Thyroid Imaging Reporting and Data System (EU-TIRADS) Classification of Thyroid Nodules in Two University Hospitals in Cotonou

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Open Journal of Endocrine and metabolic Diseases 2024年第2期14卷 15-25页

作者： annelie Kerekou Hode Hubert Dedjan Fréjus Alamou Department of Endocrinology metabolism Nutrition of National University Hospital Center-Hubert Koutoukou maga Cotonou Bénin Department of medicine and medical Specialties of the Departemental University Hospital Center of Ouémé/Plateau Porto-Novo Bénin

Introduction: Since its creation in 2017 by the European community, the EU-TIRADS classification has enjoyed an excellent reputation in several countries around the world. Indeed, several studies conducted in these countries testify to the effectiveness of this tool for the management of nodular thyroid pathology. However, in Benin, the contribution of this classification has not yet been evaluated. It is therefore to overcome this inadequacy that we undertook this study. Objective: Participate in improving the diagnostic and therapeutic management of thyroid nodules at the CNHU HKm in Cotonou and at the CHUZ in Suru-Léré. methods: This is a cross-sectional study with retrospective data collection spread over a period of 3 years 5 months, from January 2019 to may 2022 and carried out jointly in the Endocrinology metabolism Nutrition and ORL-CCF departments of the CNHU HKm of Cotonou and in the ORL-CCF department of the CHUZ of Suru-Léré. The study population consisted of patients who consulted the University Clinic of Endocrinology metabolism Nutrition, the University Clinic of ORL-CCF of the CNHU-HKm and the University Clinic of ORL-CCF of the CHUZ of Suru-Léré for thyroid nodule and who have had surgery. The study data was collected from patients hospitalization records using a survey form. Results: On ultrasound, according to the EU-TIRADS classification, 56.8% of nodules presented a low risk of malignancy (EU-TIRADS 3) compared to respectively 19.8%;23% and 2.5% of nodules with zero (EU-TIRADS 2), intermediate (EU-TIRADS 4) and high (EU-TIRADS 5) risk of malignancy. Regarding the performance of this classification, it is sensitive in 37.5% of cases and has a specificity of 78.5% with a PPV (Positive Predictive Value) and a NPV (Negative Predictive Value) respectively of 6.6 % and 91.6%. Furthermore, the bivariate correlations revealed that the size of the nodule was significantly associated with the malignancy of the nodule (p = 0.014) and the calculated value o

关键词： Thyroid Nodules EU-TIRADS Classification malignancy

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macroangiopathic Complications and Associated Factors in Type 2 Diabetics at CNHU-HKm

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Journal of Diabetes mellitus 2024年第1期14卷 13-19页

作者： annelie Kerekou Hode Hubert Dedjan Gaëtan Ayina Endocrinology Metabolism and Nutrition Department CNHU-HKM Cotonou Benin Department of medicine and medical Specialties CHUD-OP Porto-Novo Benin

Nowadays, chronic clinical manifestations of diabetemellitus constitute an important disease and a huge public health issue. Aim: Study the macroangiopathic complications in type 2 diabetics. method: It is a descriptive cross-sectional study with an analytical aim covering the period from January 2019 to December 31, 2021 in the Endocrinology, metabolism and Nutrition clinic of the National Teaching Hospital Hubert Koutoukou maga (CNHU-HKm) We thus identified 150 type 2 diabetic patients. Results: The prevalence of macroangiopathy was 60% with 11.3% for stroke, 28.6% for acute coronary syndrom, 4% for cervical macroangiopathy, and 46.97% ± 25.36% for obliterating arteriopathy of the lower limbs (OALL). The mean age of the patients was 57.69 ± 1.77 years with a sex ratio 1. The duration of diabetes progression was greater than 10 years for more than half of the patients 52.6%. The main associated cardiovascular risk factors were arterial high blood pressure (64.7%), family history of diabetes (33.7%), obesity with 20.0%. The death rate was 7.3%. Conclusion: macroangiopathy’s mortality rate of in type 2 diabetics is high. Prevention remains the best treatment and involves screening for factors associated with macroangiopathy.

关键词： Type 2 Diabetes macroangiopathy Coronary Artery Disease Stroke Peripheral Arterial Disease

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Prognostic Factors for Diabetic Foot at CNHU-HKm

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Journal of Diabetes mellitus 2024年第1期14卷 20-27页

作者： annelie Kerekou Hode Alihonou Hubert Dedjan Déo-Gratias Gnaho Centre National Hospitalier Universitaire Hubert Koutoukou maga Cotonou Benin Centre Hospitalier Universitaire Départemental-Ouémé/Plateau Porto-Novo Porto-Novo Benin

Introduction: Predictions on the prevalence of diabetes mellitus, according to the International Diabetes Federation, indicated 9.3% in 2019 and nearly 10.9% of the general population in 2045. In Benin, the increase in this prevalence, according to the World Health Organization (WHO), is constantly increasing. Diabetic foot is one of its most common complications. The aim of this work was to study the prognostic factors of diabetic foot in the Department of Endocrinology, metabolism and Nutrition of the CNHU-HKm of Cotonou. Patients and method: This is a descriptive and analytical retrospective study of the prognostic factors of diabetic foot over a period of 3 years from January 2019 to December 2021 in patients who have been hospitalized or followed on an outpatient basis for diabetic foot in the Endocrinology, metabolism and Nutrition Department of the CNHU-HKm of Cotonou. Results: A total of 112 patients were included in this study. The average age of the patients was 59.70 ± 2.10 years. A male predominance was noted with a sex ratio (m/F) of 1.7. mixed gangrene and phlegmons were the most common lesions. According to the classification of diabetic feet according to the University of Texas, 59.1% of patients had a 100% risk of amputation. Ten patients died from sepsis (8.9%). The average blood glucose on admission was 2.74 ± 0.23 g/l, reflecting the glycemic imbalance in these patients. There is a statistically significant association between the duration of progression of diabetes, the type of lesion and amputation. Patients whose diabetes has lasted more than 30 years and patients who are not monitored have a greater risk of death. Conclusion: Diabetic patients most often consulted at a late stage, compromising conservative treatment. The duration of diabetes and the type of lesion on admission were the main factors leading to amputation, thus compromising the functional prognosis. As for death, it was mainly linked to irregular monitoring of diabetes and the

关键词： Diabetes Diabetic Foot Prognosis Blood Sugar Imbalence Benin

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mission Impossible?

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ChinAfrica 2016年第2期8卷 32-33页

作者： annelie Rozeboom

African opposition to the ICC threatens an important legal recourse available to the continent＇s victims of human rights violations

关键词： ICC mission Impossible

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Baird’s tapir density in high elevation forests of the Talamanca region of Costa Rica

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Integrative Zoology 2012年第4期7卷 381-388页

作者： JoséF.GONZÁLEZ-mAYA Jan SCHIPPER Beth POLIDORO annelie HOEPKER Diego ZÁRRATE-CHARRY Jerrold L.BELANT Sierra to Sea Institute ProCAT Internacional/ColombiaLas AlturasCoto BrusPuntarenasCosta Rica Instituto de Ecología Universidad Nacional Autónoma de México(IE-UNAM)Ciudad UniversitariaDFMexico Carnivore Ecology Laboratory Forest and Wildlife Research CenterMississippi State UniversityMississippiUSA Big Island Invasive Species Committee University of HawaiiHiloHawaiiUSA Old Dominion University NorfolkVirginiaUSA

Baird’s tapir(Tapirus bairdii)is currently endangered throughout its neotropical range with an expected popula--lished in Valle del Silencio within Parque Internacional La Amistad(PILA).Seventy-seven tapir pictures of 15 individuals comprising 25 capture-recapture events were analyzed using mark-recapture *** 100%minimum convex polygon of the sampled area was 5.7 km2 and the effective sampled area using half mean max-imum distances moved by tapirs was 7.16 *** estimated a tapir density of 2.93 individuals/km2 which rep-resents the highest density reported for this *** valleys can represent unique and important habitats for large mammal ***,the extent of isolation of this population,potentially constrained by steep slopes of the cordillera,remains *** genetic and movement studies are required to un-derstand meta-population dynamics and connectivity between lowland and highland areas for Baird’s tapir con-servation in Costa Rica.

关键词： camera trap capture Central America populations tapir

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Glycated Haemoglobin Determination in the Biological Follow-Up of Diabetic Subjects Admitted to the Endocrinology Department of the CNHU-HKm of Cotonou

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Journal of Diabetes mellitus 2023年第1期13卷 36-44页

作者： annelie Kerekou Hode Hubert Dedjan Nesme Aboudou Department of Endocrinology Metabolism and Nutrition CNHU-HKM Cotonou Benin

Introduction: One of the biological markers for monitoring glycaemic control in diabetic patients is glycated protein. The definition of a reference method to improve the accuracy of measurement tools is necessary. The aim of our study was to assess the glycemic control of diabetic patients based on glycated hemoglobin. Patients and method: This is a descriptive cross-sectional study conducted in April 2021 at the national university hospital center (CNHU-HKm) of Cotonou. All patients who consulted during the period and who gave their consent were included. After collecting the blood samples according to the classical standards of the pre-analytical phase, we measured the blood glucose level and the HbA1c. Results: The mean blood glucose level of the patients was 1.52 ± 0.16 g/L with extremes of 0.80 g/L and 3.5 g/L. The mean HbA1c proportion was 8.39% ± 0.60% with a minimum and maximum value of 5.40% and 16% respectively. We also noted that the mean body mass index (BmI) of the patients was 28.61 ± 1.46 Kg/m2 with extremes of 17.50 Kg/m2 and 46.02 Kg/m2. Oral anti diabetic and hygienic-dietary measures were used by 44 patients (80%) and hygienic-dietary measures (HDm) only used by 9.09%. A frequency of 87.53% of patients had at least one degenerative complication. Retinopathy was the most observed degenerative disease (36.36%) followed by cardiovascular disease (25.45%). Conclusion: This study showed that there is a poor correlation between fasting blood glucose and glycated haemoglobin levels, which could be due to several biological and clinical reasons. It also showed that despite the respect of hygienic dietary measures and a well conducted treatment, it is difficult to obtain a satisfactory glycemic balance in obese patients.

关键词： Glycemia Glycated Haemoglobin Diabetes Benin

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microalbuminuria and Associated Factors in Diabetics at the CNHU-HKm of Cotonou

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Journal of Diabetes mellitus 2023年第1期13卷 1-11页

作者： annelie Kerekou Hode Hubert Dedjan Doucelyne d’Almeida Endocrinology Teaching Unit Faculty of Health Sciences of the University of Abomey-Calavi Abomey-Calavi Benin

Diabetes mellitus is a disease of great frequency and is a major public health problem. Several complications can occur during the course of diabetes such as diabetic nephropathy, which starts with microalbuminuria in diabetic patients. This was a cross-sectional and analytical study which took place from 23 September to 23 December 2021 in the Endocrinology-metabolism-Nutrition Department of the CNHU-HKm of Cotonou, Benin. We carried out an exhaustive census of the patients. Type 2 diabetic patients were included in the study, and 24-hour microalbumunuria, fundus examination and assessment of complications were performed. We identified 145 type 2 diabetic patients of whom 44 had positive microalbuminuria, i.e. a prevalence of 30.3%. There were 61 men and 84 women with a sex ratio of 0.72. The mean age was 59 years with extremes of 26 and 85 years. The complications identified in diabetics with positive microalbuminuria were Neuropathy (43.2%), Nephropathy (22.7%) and Retinopathy (20.5%). Factors associated with microalbuminuria in diabetics were: age, occupation, hypertension, diabetes imbalance, erectile dysfunction. Conclusion: microalbuminuria is common in type 2 diabetes. It should be managed early to slow the progression of kidney disease to the end stage.

关键词： Diabetes microalbuminuria Associated Factors Benin

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Peripheral Neuropathy and Associated Factors in Diabetics at the CNHU-HKm of Cotonou in 2021

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Journal of Diabetes mellitus 2023年第1期13卷 12-22页

作者： annelie Kerekou Hode Hubert Dedjan Fidodé martine Sondjo Endocrinology Teaching Unit Faculty of Health Sciences of the University of Abomey-Calavi Abomey-Calavi Benin

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes. The main objective of the study was to determine the prevalence of diabetic peripheral neuropathy and associated factors in diabetics in the University Clinic of Endocrinology metabolism Nutrition of the CNHU-HKm, Cotonou, Benin 2021. This was a cross-sectional, analytical study that ran from 23 September to 23 December 2021. Admitted diabetic patients seen in consultation during the study period were included. The DN4 tool was used as the basis for data collection. Data analysis was performed using R software version 3.6.1. multivariate analysis was used to identify factors associated with DPN. Out of 155 diabetics, 54 patients had diabetic peripheral neuropathy, a prevalence of 34.8%. The average age of our patients was 56.8 years and 56.8% were female. Of the patients, 54.7% had unbalanced diabetes. An association between DPN and gender (p = 0.022), occupation (p = 0.004), education (p = 0.011), hypertension (p = 0.017), smoking (p = 0.031), diabetic imbalance (p = 0.001), diabetic retinopathy (p = 0.020) and dyslipidaemia (p = 0.015) was observed. DPN was also associated with erectile dysfunction in men (p = 0.001). Conclusion: Diabetic peripheral neuropathy is common (34.8). Its occurrence is indicative of the presence of associated factors.

关键词： Diabetes Diabetic Peripheral Neuropathy DN4 Questionnaire Associated Factors Benin

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