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Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika m.Joshi Theresa Currier Thomas Nafisa m.Jadavji College of Osteopathic medicine Midwestern UniversityGlendaleCAUSA Department of Biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3

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Revisiting non-linear Thomson scattering with metamaterials

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National Science Review 2024年第1期11卷 71-72页

作者： Natalia m.Litchinitser Department of Electrical and Computer Engineering Duke University

Non-linear optics is a branch of optics that studies the intriguing and sometimes unexpected ways in which light and matter interact at high intensities, when the polarization density does not respond linearly to the electric field of the light. The pursuit of the perfect non-linear optical material has been ongoing ever since the pioneering experiment on second harmonic generation carried out by Franken in 1961 [1]. Indeed,

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Soils in extraterrestrial space: Need for studies under microgravity

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Pedosphere 2024年第1期34卷 13-14页

作者： m.B.KIRKHAm Department of Agronomy Kansas State UniversityManhattan KS 66506USA

With the increased interest of plants in space, gravity cannot be ignored when studying soil-plant-water relations. Therefore, it is important to understand the water relations of soils under zero gravity in space or under reduced gravity on the moon or mars. This paper outlines the problems of moving water in soils under zero gravity or microgravity, as well as growing plants in these soils. It is suggested that microgravity experiments could be done on Earth using both soils and plants. Results from such experiments could be used to grow plants when mankind establishes bases on the moon and mars.

关键词： soils soil bases

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Enhanced Wolf Pack Algorithm (EWPA) and Dense-kUNet Segmentation for Arterial Calcifications in mammograms

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Computers, materials & Continua 2024年第2期78卷 2207-2223页

作者： Afnan m.Alhassan College of Computing and Information Technology Shaqra UniversityShaqra11961Saudi Arabia

Breast Arterial Calcification(BAC)is a mammographic decision dissimilar to cancer and commonly observed in elderly *** identifying BAC could provide an expense,and be *** Deep Learning(DL)methods have been introduced for automatic BAC detection and quantification with increased ***,classification with deep learning had reached higher efficiency,but designing the structure of DL proved to be an extremely challenging task due to overfitting *** also is not able to capture the patterns and irregularities presented in the *** solve the overfitting problem,an optimal feature set has been formed by Enhanced Wolf Pack Algorithm(EWPA),and their irregularities are identified by Dense-kUNet *** this paper,Dense-kUNet for segmentation and optimal feature has been introduced for classification(severe,mild,light)that integrates DenseUNet and *** bound links exist among adjacent modules,allowing relatively rough data to be sent to the following component and assisting the system in finding higher *** major contribution of the work is to design the best features selected by Enhanced Wolf Pack Algorithm(EWPA),and modified Support Vector machine(mSVm)based learning for classification.k-Dense-UNet is introduced which combines the procedure of Dense-UNet and kU-Net for image *** bound associations occur among nearby sections,allowing relatively granular data to be sent to the next subsystem and benefiting the system in recognizing smaller *** proposed techniques and the performance are tested using several types of analysis techniques 826 filled digitized *** proposed method achieved the highest precision,recall,F-measure,and accuracy of 84.4333%,84.5333%,84.4833%,and 86.8667%when compared to other methods on the Digital Database for Screening mammography(DDSm).

关键词： Breast arterial calcification cardiovascular disease semantic segmentation transfer learning enhanced wolf pack algorithm and modified support vector machine

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^(4)He monolayer on graphene:a quantum monte Carlo study

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Communications in Theoretical Physics 2024年第9期76卷 149-157页

作者： S Yu m Boninsegni Department of Physics University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revisit the problem of adsorption of a single^(4)He layer on graphene,focusing on the commensurate(C_(1/3))crystalline phase,specifically on whether it may possess a nonzero superfluid response,and on the existence of superfluid phases,either(metastable)liquid or vacancy-doped *** make use of canonical quantum monte Carlo simulations at zero and finite temperature,based on a realistic microscopic model of the *** results confirm the absence of any superfluid response in the commensurate crystal,and that no thermodynamically stable uniform phase exists at lower *** evidence of a possibly long-lived,metastable superfluid phase at C_(1/3)coverage is ***,the results of ground-state projection methods and finite-temperature simulations are entirely consistent.

关键词： superfluidity low-dimensional systems quantum monte Carlo helium supersolids

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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(mC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Dermatofibrosarcoma Protuberans of the Breast: A Rare Localization

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Advances in Breast Cancer Research 2024年第3期13卷 36-42页

作者： Foba mamadou Lassana Bathily Yaye Coumba Teuw El Hadj Daour Sankale anne Aurore Fann Hospital Cheikh Anta Diop University Dakar Senegal Department of Gynecology and Obstetrics Grand Yoff Gnral Hospital Dakar Senegal Department of Plastic Surgery Fann Hospital Dakar Senegal

The dermatofibrosarcoma protuberans (DFP) is a rare skin tumor. It represents 0.1% of the malignant skin tumor. Surgery is its only treatment. The breast involvement is exceptional. We report our cases, 13 years old p... 详细信息

关键词： Breast Dermatofibrosarcoma Surgery

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Implementation of the Flood Risk management Directive in Selected European Countries

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International Journal of Disaster Risk Science 2013年第3期4卷 115-125页

作者： Uwe müller Saxon State Agency for Environment Agriculture and GeologyDresdenSaxony 01109Germany

Flood events are a recurrent threat to economic developments and can jeopardize human existence. In order to reduce the flood risks in Europe on a sustainable basis, the European Union adopted the Flood Risk management Directive in 2007. The implementation of the directive in the national laws of all member states has laid the foundation for intergovernmental integrated flood risk management on an European scale. The following article is intended to compare and briefly assess the implementation process on inland waters at the technical level in selected European countries in the middle of the process. It covers the different basic structural, methodological, and data conditions for preparing the preliminary flood risk assessment, the flood hazard maps, the flood risk maps, and the flood risk management plans as a result of two EU projects. The technical differences in the various European countries need to be reduced in the next cycles of implementation of the Flood Risk management Directive.

关键词： flood inland preparing

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Study of the Conversion of Postconsumer Polystyrene on CeO₂/HZSm-5 Type materials

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Journal of materials Science and Chemical Engineering 2024年第4期12卷 29-41页

作者： mirna Oliveira Sant’Ana anne michelle Garrido Pedrosa marcelo José Barros de Souza Graduate Program in Chemical Engineering at UFS Federal University of Sergipe (UFS) S&#227o Crist&#243v&#227o Brazil Department of Chemistry Federal University of Sergipe S&#227o Crist&#243v&#227o Brazil

The catalytic conversion of polystyrene (PS) was studied in the presence of the materials type HZSm-5, CeO2, 10% CeO2/HZSm-5 and 20% CeO2/HZSm-5, which were characterized by scanning electron microscopy (SEm), X-ray diffraction (XRD) and nitrogen adsorption at 77K. The catalytic tests were performed via thermogravimetric analysis (TG) at heating rates of 5, 10 and 20˚C min−1 in a temperature range from 30˚C to 900˚C. For the tests, a ratio of 30% by mass of each catalytic material mixed with PS was used and the activation energy of the degradation process was determined by the Vyazovkin method. The obtained results showed that the addition of the catalyst to the PS in general reduced its degradation temperature. The 10% CeO2/HZSm-5 catalyst showed greater efficiency, as it resulted in lower activation energy for PS degradation. Thus, the combination of CeO2 with HZSm-5 resulted in materials with potential for application in the catalytic degradation of polystyrene and the results indicate that the production of a composite material can be a good strategy to generate an increase in catalytic activity and a decrease in energy process activation.

关键词： HZSm-5 Zeolite Cerium Oxide Polystyrene Pyrolysis

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Effects of Andrade and Burgers rheologies on glacial isostatic adjustment modeling in Antarctica

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Geodesy and Geodynamics 2024年第5期15卷 429-440页

作者： Alexandre Boughanemi Anthony mémin UniversitéCôte d'Azur CNRSObservatoire de la Côte d'AzurIRDGéoazur250 rue Albert EinsteinSophia Antipolis 06560 ValbonneFrance

Variations in ice mass deform the Earth and modify its gravity field,a process known as Glacial Isostatic Adjustment(GIA).GIA in Antarctica remains poorly constrained due to the cumulative effect of past and present ice-mass changes,the unknown history of the past ice-mass change,and the uncertainties on the mechanical properties of the *** paper investigates the effect of using Andrade and Burgers viscoelastic rheologies,rather than the commonly used maxwell rheology,to model GIA-induced deformation in *** Love number and Green's function formalism are used to compute the radial surface displacements and the gravity changes induced by the past and present ice-mass *** consider an Earth model whose elastic properties and radial structure are averaged from the Preliminary Reference Earth model and two viscosity profiles to account for the recently published results on the present ice-mass *** the three rheological laws affects the temporal response of the Earth differently,leading to smaller discrepancies than those induced by the two viscosity *** differences are the largest between maxwell and Burgers rheologies during the 100-1000 years following the beginning of the surface-mass *** show that using the Andrade and Burgers rheologies allows the Earth to respond on decennial to centennial time scales,up to 10 m more than *** only the recent ice-mass changes,the deformation rates derived from Burgers and Andrade rheologies are several times larger than those estimated by maxwell rheology.

关键词： GIA Antarctica modeling Rheology Displacement Viscosity GNSS

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