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Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review

World Journal of Gastroenterology 2017年第9期23卷 1697-1711页

作者： anne-Claire Desbois Patrice Cacoub Inflammation-Immunopathology-Biotherapy Department Sorbonne Universités UMR_S 959 French National Institute of Health and Medical Research FRE3632 The French National Center for Scientific Research Department of Internal Medicine and Clinical Immunology Groupe Hospitalier Pitié-Salpêtrière AP-HP

To summarise the literature data on hepatitis C virus (HCV)-infected patients concerning the prevalence of glucose abnormalities and associated *** conducted a PubMed search and selected all studies found with the key words 'HCV' or 'hepatitis C virus' and 'diabetes' or 'insulin resistance'. We included only comparative studies written in English or in French, published from January 2000 to April 2015. We collected the literature data on HCV-infected patients concerning the prevalence of glucose abnormalities [diabetes mellitus (DM) and insulin resistance (IR)] and associated risk [i.e., severe liver fibrosis, response to antivirals, and the occurrence of hepatocellular carcinoma (HCC)].RESULTSHCV infection is significantly associated with DM/IR compared with healthy volunteers and patients with hepatitis B virus infection. Glucose abnormalities were associated with advanced liver fibrosis, lack of sustained virologic response to interferon alfa-based treatment and with a higher risk of HCC development. As new antiviral therapies may offer a cure for HCV infection, such data should be taken into account, from a therapeutic and preventive point of view, for liver and non-liver consequences of HCV disease. The efficacy of antidiabetic treatment in improving the response to antiviral treatment and in decreasing the risk of HCC has been reported by some studies but not by others. Thus, the effects of glucose abnormalities correction in reducing liver events need further *** abnormalities are strongly associated with HCV infection and show a negative impact on the main liver related outcomes.

关键词： Hepatitis C virus Diabetes mellitus Insulin resistance Liver fibrosis Treatment

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Overview of clinical trials for nasopharyngeal carcinoma(in the English literature)

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Chinese Journal of Cancer 2010年第8期29卷 709-714页

作者： anne W.M.Lee Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital

Megavoltage radiation therapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). Treatment results have been steadily improving with rapid technological advances and better knowledge on optimization of dose fractionation. During the past decade, RT techniques have evolved from conventional 2-dimensional (2D) to 3-dimensional (3D) complex technique with multiple conformal fields and intensity-modulation. There is little controversy that intensity-modulated technique (IMRT) is recommended if resources permit, dosimetric studies show clear improvement in dose distribution, with conformity of high dose to concave tumor targets and sharp dose gradient for adequate tumor coverage and better protection of adjacent normal tissues.

关键词：鼻咽癌英文文献临床试验治疗方式技术进步强度调制 RT技术高剂量

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Value co-creation in service marketing: A critical (re)view

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International Journal of Innovation Studies 2019年第4期3卷 73-83页

作者： anne Vorre Hansen Department of Social Sciences and Business Roskilde University4000RoskildeDenmark

The present study critically explores and discusses the concept of value co-creation asrevealed and recognized in the research streams that have formed the conceptual basis forthe construct:service-dominant logic,service logic,and customer-dominant *** is positioned within critical hermeneutics;thus,a hermeneutic review strategy isapplied and the subsequent critical discussion is inspired by a Habermasian understandingof society as composed of a system and *** findings of the study are twofold;they reveal how different underlying assumptions frame the perception of the unit ofanalysis when focusing on value co-creation and how that the relocation of the locus ofvalue creation from the company to the customer sphere hides that value is an economicconcept in service marketing ***,the analysis reveals that in servicesmarket research,the concept of value co-creation in a company is applied to analyze thecustomer *** dimension has not received much academic attention despite thatthe existing concept might be applicable neither analytically nor *** on value co-creation acknowledges that the meaning of the concept is *** present study therefore contributes to literature with a refined conceptualunderstanding of how the underlying perceptions of the concept lead to differentanalytical foci in existing research and by identifying questions for further ***,the review and the discussion are based within a hermeneutic paradigm andcontribute as such with a rarely applied review methodology within the field of service marketing.

关键词： value co-creation Service dominant logic Service logic Customer dominant logic Critical hermeneutics

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Neuroendocrine control of natural killer cell function through the checkpoint molecule PD-1

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Cellular & Molecular Immunology 2019年第2期16卷 109-111页

作者： Justine Devulder anne Tsicopoulos Catherine Duez Pulmonary Immunity Institut National de la SantéEt de la Recherche MédicaleU1019F-59019 LilleFrance Institut Pasteur de Lille Center for Infection and Immunity of LilleF-59019 LilleFrance CNRS UMR 8204 F-59000 LilleFrance Univ Lille Nord de France F-59000 LilleFrance Clinique des Maladies Respiratoires et Centre Hospitalier Régional et Universitaire de Lille 59037 LilleFrance

Host defense strategies encompass resistance to reduce pathogen burden,and disease tolerance to preserve host fitness.1 Immunedriven resistance mechanisms have inevitably a negative impact on host fitness and can lead to *** tolerance limit immunopathology and therefore disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen *** pathways cooperate to protect the *** pathways include metabolic and oxidative stress responses,2 and the interaction between neuroendocrine system and the immune system3 to favor resolution of inflammation and to prevent tissue damage.

关键词： damage killer inflammation

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Regulation of axonal remodeling following spinal cord injury

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Neural Regeneration Research 2015年第10期10卷 1555-1557页

作者： anne Jacobi Florence M.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universit?t München Munich Cluster of Systems Neurology (Sy Nergy)

Central nervous system injuries,such as spinal cord injury（SCI）,are a leading cause of disability in young *** generally have severe clinical consequences and often lead to loss of motor or sensory input below the s... 详细信息

关键词： Regulation of axonal remodeling following spinal cord injury STAT FGFR Figure CST

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Challenges in the conduct of randomised controlled trials in cardiogenic shock complicating acute myocardial infarction

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Journal of Geriatric Cardiology 2022年第2期19卷 125-129页

作者： anne Freund Steffen Desch Holger Thiele Department of Internal Medicine/Cardiology Heart Center Leipzig at the University of LeipzigLeipzigGermany German Center for Cardiovascular Research(DZHK) BerlinDeutschland

Cardiogenic shock(CS)following acute myocardial infarction(AMI)is a major challenge in cardiovascular *** remains high with 40%-50%after thirty *** controlled trials(RCTs)play a key role to generate evidence on optimal care in this ***,the number of completed or ongoing RCTs is still relatively low compared to the gaps in *** in the conduct of these trials are in particular the selection of patients and ethical issues in the informed consent *** determining eligibility criteria,special attention should be paid to the severity of CS,to the inclusion of patients with cardiac arrest and to potential age *** age of AMI-CS patients is *** limits are therefore controversial as it is important to include elderly patients in RCTs in order to make the results generalisable and to address the special needs of this *** patients with AMI-CS are in most cases unable to provide informed consent themselves,a step-wise approach with acute consent by a legal representative or independent physicians and later informed consent by the patient if possible might be established depending on regularities of the respective ethical review board and country *** studies should be sought to generate adequate power.

关键词： shock legal consent

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Climatic niche shift of an invasive shrub (Ulex europaeus): a global scale comparison in native and introduced regions

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Journal of Plant Ecology 2020年第1期13卷 42-50页

作者： Mathias Christina Fawziah Limbada anne Atlan UMR ISPA INRA71 Avenue Edouard Bourlaux33140 Villenave-d’ornonFrance UMR ECOBIO CNRS/UniversitéRennes 1Avenue du Général LeclercCampus de Beaulieu35042 RennesFrance UPR AIDA CIRAD40 Chemin Grand Canal97490 Sainte-ClotildeLa RéunionFrance UMR ESO CNRS/UniversitéRennes 2Place du Recteur Henri Le Moal35043 RennesFrance

Aims Invasive species,which recently expanded,may help understand how climatic niche can shift at the time scale of the current global ***,we address the climatic niche shift of an invasive shrub(common gorse,Ulex europaeus)at the world and regional scales to assess how it could contribute to increasing *** Based on a 28187 occurrences database,we used a combination of 9 species distribution models(SDM)to assess regional climatic niche from both the native range(Western Europe)and the introduced range in different parts of the world(North-West America,South America,North Europe,Australia and New Zealand).Important Findings Despite being restricted to annual mean temperature between 4℃ and 22℃,as well as annual precipitation higher than 300 mm/year,the range of bioclimatic conditions suitable for gorse was very *** on a native versus introduced SDM comparison,we highlighted a niche expansion in North-West America,South America and to a lesser degree in Australia,while a niche displacement was assessed in North *** niche changes induced an increase in potential occupied areas by gorse by 49,111,202 and 283%in Australia,North Europe,North-West America and South America,*** the contrary,we found no evidence of niche change in New Zealand,which presents similar climatic condition to the native environment(Western Europe).This study highlights how niche expansion and displacement of gorse might increase invasibility at regional *** change in gorse niche toward new climatic conditions may result from adaptive plasticity or genetic evolution and may explain why it has such a high level of *** into account the possibility of a niche shift is crucial to improve invasive plants management and control.

关键词： plant invasion invasibility niche shift species distribution models ecological niche

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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(p<0.05).Light activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

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Success of three soil restoration techniques on seedling survival and growth of three plant species in the Sahel of Burkina Faso(West Africa)

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Journal of Forestry Research 2016年第2期27卷 313-320页

作者： Philippe Bayen anne Mette Lykke Adjima Thiombiano Laboratory of Plant Biology and Ecology University of Ouagadougou Department of Bioscience Aarhus University

In the Sahel of Africa, where 90 % of the population depends on natural resources for their liveli- hood, a large part of the soils are structurally unstable, prone to crusting and hard setting, and have low water holding capacity, which hamper vegetation establishment. The effect of soil restoration techniques on survival and growth of seedlings of Acacia nilotica, Acacia tortilis and Jatropha curcas was tested in completely barren, degraded land in a Sahelian ecosystem in Burkina Faso. A total of 522 seedlings （174 plants of each plant species） were planted in a randomized complete block design with three replicates combining three soil preparation techniques： half-moon, zai＂ and standard plantation. Survival and growth rates evaluated over 20 months were significantly higher using the half-moon technique compared with the other two techniques. Survival rates of plant species planted using half-moon technique were 62.5, 28.57 and 10.71% for A. nilotica, A. tortilis and J. curcas respec- tively, but in za＇i and standard planting, seedling survival was zero. The low survival rate of J. curcas using the half-moon technique may indicate that J. curcas is unsuit- able for barren and degraded land, whereas A. nilotica and A. tortilis appear to be promising tree species for rehabil- itation of degraded land.

关键词： Afforestation Bare soil Soil rehabilitation Species selection Water conservation

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Understanding future changes to fires in southern Europe and their impacts on the wildland-urban interface

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Journal of Safety Science and Resilience 2021年第1期2卷 20-29页

作者： anne Ganteaume Renaud Barbero Marielle Jappiot Eric Maillé INRAE RECOVERAix-en-ProvenceFrance

Southern Europe is a highly fire-prone region where extreme fires have often disastrous consequences on both structures and *** activities and fire weather conditions favouring ignitions and propagation have always been the drivers of such fires but anthropogenic climate change alongside the extension of wildland-urban interface(WUI)that concentrates both assets and fire ignitions have the compounding effect of exacerbating fire *** are currently not adequately prepared to sustain events whose frequency and intensity are foreseen to increase in the future as shown during the extreme fires that occurred recently in Euro-Mediterranean *** work presents the context of WUI fires in the Euro-Mediterranean region,their driving forces and their impacts on society,with insights from three recent catastrophic fires that drew much *** this context,we propose a conceptual framework for understanding the WUI issue assessing the implications for fire risk and providing some guidance to mitigate this risk,updated management strategies as well as comments about gaps in our current knowledge and how we might address this problem in the future.A successful approach to reduce fire risk in the future will require building resilient landscapes and communities better prepared to face these extreme fire events in which WUI population,forest managers,land planners,civil protection,and policy-makers need to work together to improve the safety and resilience of these fire-prone areas.

关键词： Wildland-urban interface Mediterranean region Fire risk Resilient community and landscape fire weather conditions Vulnerability

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