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Methane Direct Conversion on Mo/ZSM-5 Catalysts Modified by Pd and Ru

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Journal of Natural Gas Chemistry 2006年第2期15卷 82-86页

作者： priscila dias Sily Fabio Bellot Noronha Fabio Barboza Passos Departamento de Engenharia Química Universidade Federal FluminenseRua Passo da Pátria156 Niterói -RJ CEP 24210-240Brazil Instituto Nacional de Tecnologia Av. Venezuela 82Rio de Janeiro -RJ CEP 20081-312Brazil Departamento de Engenharia Química Universidade Federal FluminenseRua Passo da Pátria156 Niterói-RJ CEP 24210-240Brazil

The effect of addition of Ru and Pd to Mo/HZSM-5 catalysts used in the dehydroaromatization of methane was investigated. Catalytic tests and temperature-programmed oxidation results showed that Pd-based catalysts were more selective to naphthalene and suffered strong deactivation. The presence of Ru improved the activity and stability, with a decrease in the carbonaceous deposit probably because of a mechanism of protection of the Mo2C surface.

关键词： methane Pd Ru Mo ZSM-5 dehydroaromatization

Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging

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World Journal of Gastroenterology 2019年第37期25卷 5687-5701页

作者： Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser priscila Mina Falsarella Rafael Noronha Cavalcante Marcio dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker Department of Interventional Radiology Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil Department of Liver Transplant Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil Department of Vascular Surgery Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil

BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus *** survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were *** TACE,only patients within Milan Criteria(MC)were *** patients underwent LT in bridging ***-year post-transplant overall survival,recurrence-free survival has no difference between the *** response was observed more frequently in bridging *** in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing *** To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs *** Prospective cohort study of 200 patients included from April 2011 through June *** group included patients within *** group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly *** survival and tumor recurrence rates were calculated by the Kaplan-Meier ***,eligibility for LT,time on the waiting list until LT and radiological response were *** After TACE,only patients within MC were *** patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant over

关键词： Hepatocellular carcinoma Down-staging Liver transplantation Localregional therapy Bridging

Diagnosis and management of hepatic artery in-stent restenosis after liver transplantation by optical coherence tomography:A case report

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World Journal of Hepatology 2020年第7期12卷 399-405页

作者： Francisco Leonardo Galastri Guilherme Moratti Gilberto Breno Boueri Affonso Leonardo Guedes Moreira Valle priscila Mina Falsarella Adriano Mendes Caixeta Camila Antunes Lima Marcela Juliano Silva Lucas Lembrança Pinheiro Conrado dias Pacheco Annicchino Baptistella Márcio dias de Almeida Rodrigo Gobbo Garcia Nelson Wolosker Felipe Nasser Hospital Israelita Albert Einstein Department of Interventional RadiologySão Paulo 05652900Brazil Hospital Israelita Albert Einstein Department of Interventional CardiologySão Paulo 0562900Brazil Hospital Israelita Albert Einstein Department of Liver TransplantSão Paulo 05652900Brazil Hospital Israelita Albert Einstein Department of Vascular SurgerySão Paulo 05652-000Brazil

BACKGROUNDPercutaneous transluminal angioplasty and stenting represent an effectivetreatment for hepatic artery stenosis after liver transplantation. In the first yearafter stenting, approximately 22% of patients experience in-stent restenosis,increasing the risk of artery thrombosis and related complications, and 50%experience liver failure. Although angiography is an important tool for diagnosisand the planning of therapeutic interventions, it may raise doubts, especially insmall-diameter arteries, and it provides low resolution rates compared withnewer intravascular imaging methods, such as optical coherence tomography(OCT).CASE SUMMARYA 64-year-old male developed hepatic artery stenosis one year after orthotropicliver transplantation and was successfully treated with percutaneous transluminalangioplasty with stenting. Five months later, the Doppler ultrasound resultsindicated restenosis. Visceral arteriography confirmed hepatic artery tortuositybut was doubtful for significant in-stent restenosis (ISR) and intrahepatic flowreduction. To confirm ISR, identify the etiology and guide treatment, OCT wasperformed. OCT showed severe stenosis due to four mechanisms: Focal andpartial stent fracture, late stent malapposition, in-stent neointimal hyperplasia,and *** diagnostic methods can be useful in evaluating cases in which initialangiography results are not sufficient to provide a proper diagnosis of significantstenosis, especially with regard to ISR. A wide range of diagnoses are provided byOCT, resulting in different treatment options. Interventional radiologists shouldconsider intravascular diagnostic methods as additional tools for evaluatingpatients when visceral angiography results are unclear.

关键词： Liver transplantation Hepatic artery restenosis Tomography Optical coherence Case report Endovascular procedures Angiography

Association between Frailty Syndrome and Anemia in Community-Dwelling Elderly

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Advances in Aging Research 2019年第5期8卷 75-87页

作者： Elisa priscila Sousa de Assis Barbara Gazolla de Macêdo Thais Almeida Marques da Silva Poliana de Paula dias Rezende érica Leandro Marciano Vieira Antonio Lucio Teixeira Junior Carlos Maurício de Figueiredo Antunes Laboratório de Epidemiologia Programa de Pós-gradua&#231 o Stricto Sensu em Medicina e Biomedicina Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte Belo Horizonte Brasil Fundaç o Hospitalar do Estado de Minas Gerais (FHEMIG) Hospital Regional de Barbacena Fisioterapia Respiratória Barbacena Brasil Departamento de Fisioterapia Instituto da Previdência dos Servidores do Estado de Minas Gerais (IPSEMG) Belo Horizonte Brasil Laboratório Interdisciplinar de Investigaç o Médica Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brasil Centre of Addiction and Mental Health (CAMH) Toronto Canada

Frailty is an important and complex phenomenon in the fields of geriatrics and gerontology and a highly relevant topic. Frailty syndrome (FS) is a multidimensional clinical condition characterized by loss of physiological and cognitive reserves across multiple organ systems. The Fried frailty phenotype is the main model used to categorize FS. Recent studies have shown an association between anemia, low hemoglobin concentration and frailty. This study aimed to assess the association between FS and anemia in community-dwelling elderly. An observational cross-sectional design was used, with 308 elderly subjects. Most participants were women (78.2%) between 60 and 69 years old (50.6%). The average schooling level was 9.7 years. Anemia was detected in 9.7% of participants. The frequency of frailty, pre-frailty and non-frailty was 8.2, 74.0 and 17.8%, respectively. The multivariate ordinal logistic regression model identified low levels of brain-derived neurotrophic factor (BDNF) (OR = 0.9, 95% CI = 0.9;0.9) as risk factor associated with FS. No significant association was found between frailty and anemia. Moreover, FS may be influenced by low schooling levels, despite the non-significant result obtained in the statistical model. These findings contribute to elucidating other factors associated with FS, especially in community-dwelling elderly.

关键词： Anemia Frailty Elderly

Novel Immunogenic Epitopes in the NaPi-IIb Protein: Production of Monospecific Antibodies Using Synthetic Peptides Outlined on Isoform Specific Regions of the Type IIb Sodium-Dependent Phosphate Transporter (NaPi-IIb)

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Journal of Cancer Therapy 2016年第2期7卷 129-151页

作者： Ângela Alice Amadeu Megale Jorge Mário da Costa Ferreira Júnior Letícia Batista Azevedo Rangel Maria Del Pilar Estevez Diz Max Senna Mano Paulo Marcelo Gehm Hoff priscila Hess Lopes Roberto Jun Arai Wilmar dias da Silva Laboratório de Imunoquímica Instituto Butantan S&atildeo Paulo Brazil Departamento de Ciências Farmacêuticas Universidade Federal do Espírito Santo Espírito Santo Brazil Departamento de Pesquisa Clínica Instituto do C&acircncer do Estado de S&atildeo Paulo S&atildeo Paulo Brazil

NaPi-IIb is a multiple passage protein membrane which is primarily responsible for phosphate uptake in the kidney and in the small intestine. Beyond its physiological functions, their involvement with carcinogenesis was initially described in mid-2003, due to its distinct level of expression in normal and tumor cells of the ovary. Although less common than cervical cancer, epithelial ovarian cancer is considered the most lethal gynecologic malignancy, which is mainly due to diagnosis in the advanced stages as a result of the absence of symptoms during the onset of the disease and the lack of tools for early detection. Here, we produce antibodies that are anti-synthetic peptides that are derived from the regions of second extracellular loop of NaPi-IIb, which is a non-overlapping portion of MX35 epitope. These two 15 distinct amino acid residue peptides, designated as Let#1 and Let#2, are engineered in a very thorough way to detect specific sites only in this isoform, thus excluding cross-reactivity with other carriers of the same family. The lack of immunogenicity of small peptides is surpassed by the conjugation with carrier proteins. Using immunochemical methods, we demonstrate that polyclonal antibodies that are mono-specific for the Let#1 and Let#2 peptides recognize proteins that express similar amino acid sequences during blood circulation. Additionally, using flow cytometry, we identify NaPi-IIb in NIH:OVCAR-3 cells. The clear identification of two shorter peptides on the extracellular loop of NaPi-IIb, which are far from the monoclonal antibody MX35-recognizing epitopes, adds new promising tools for ovarian cancer follow-up and staging.

关键词： NaPi2b Peptides Antibodies Ovarian Cancer

Yield and Characterization of the Centesimal Composition of Amazonian Estuarine Fish

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Journal of Agricultural Science and Technology(B) 2019年第3期9卷 175-183页

作者： Arllon José dos Santos dias Nyelle priscila Brito Facanha Ed Marcos Homobono da Silva Evlen Tamille Silva do Carmo Charles dos Santos Barros Gabriel Araujo da Silva Laboratory of Organic Chemistry and Biochemistry Amapá State University Macapá Amapá 68900-070 Brazil

Fish, as one of the fishery resources, is an important constituent of the diet of the Amazon population, as it is the source of several nutritional components. The present work aimed to characterize the centesimal composition of Plagioscion squamosissimus fillet (n = 10) and Macrobrachium amazonicum meat (n = 82), species acquired in the estuarine region of the state of Amapá, Brazil. Carcass yield, as well as protein, water content, lipids and ashes was determined according to the methodologies proposed by the Adolf Lutz Institute, as well as carbohydrate and caloric determinations. The analyses were performed in triplicate per sample. After comparing with the literature, it was possible to conclude that P. squamosissimus presented a fillet yield of 31.11%± 0.61%, high protein content (15.99 ± 1.26 g/100 g) and humidity (79.40 ± 1.10 g/100 g), moderate contents of mineral residues (1.10 ± 0.07 g/100 g) and carbohydrates (0.96 ± 0.90 g/100 g), low lipid contents (2.29 ± 0.65 g/100 g), as well as low caloric values (385,018.12 J/100 g) and M. amazonicum a meat yield of 44.12%± 8.34%, high levels of protein (22.81 ± 1.72 g/100 g), carbohydrates (1.92 ± 1.61 g/100 g) and mineral residues (1.76 ± 0.78 g/100 g), moderate water content (73.38 ± 0.78 g/100 g), low lipid levels (0.43 ± 0.08 g/100 g), as well as low caloric values (440,786.3 J/100 g). The results obtained in this work can serve as a subsidy in nutritional diets for humans, thus allowing an adequate dietary use of these species.

关键词： Nutritional assessment bromatological variables nutritional value chemical parameters of food

Clinical Outcomes of Positive Newborns for COVID-19 in Rio de Janeiro, Brazil

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Open Journal of Obstetrics and Gynecology 2021年第12期11卷 1851-1861页

作者： Karina Martins-Cardoso Luana Ferreira Martins de Toledo Juliana Aparecida Souza Paz Andressa Rangel de Oliveira Lima Thaís Chrispim de Souza Giangiarulo Jéssica da Silva Oliveira IPB COVID Workgroup Carla Carolina Teixeira Jones Zitenfeld Cardia Neto Giovanna Geórgia Pires Carrilho Vallim Shana priscila Coutinho Barroso Laboratório de Biologia Molecular Instituto de Pesquisas Biomédicas Hospital Naval Marcílio Dias Rio de Janeiro Brasil Instituto de Bioquímica Médica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil UTI neonatal Clínica de Pediatria Hospital Naval Marcílio Dias Rio de Janeiro Brasil Serviç o de Patologia Hospital Naval Marcílio Dias Rio de Janeiro Brasil

The disease caused by the SARS-CoV-2 virus has spread very rapidly throughout the world, causing various clinical manifestations and affecting several organs and systems. However, the possibility of vertical transmission of COVID-19 in symptomatic pregnant women has been questioned. The aim of this work was to report cases of possible vertical transmission in pregnant women affected by the SARS-CoV-2 virus, as well as its clinical repercussions on the newborn. In this paper, we conducted a cross-sectional retrospective study by analyzing medical records of pregnant women admitted at the military hospital, in Rio de Janeiro, Brazil, diagnosed with COVID-19 and who had positive newborns. To evaluate epidemiological data, clinical manifestations, laboratorial and histopathological changes were related to such vertical transmission. Only six tested newborns were positive for COVID-19. The mothers had no respiratory symptoms, and the gestational age was at term, except for one newborn born prematurely due to detection of pericadial effusion. Three neonates had respiratory symptoms, requiring ventilatory support. None of the mothers or newborns died. During the pandemic, possible vertical transmission cases of infected pregnant women in the third trimester of pregnancy were observed. According to the case reports published in the literature, they illustrate phenotypes of neonatal involvement with varied clinical manifestations and severity;however, further scientific studies are needed to prove the effective vertical transmission of SARS-CoV-2 in positive pregnant women.

关键词： SARS-CoV-2 Infection Neonatal Outcomes Vertical Transmission