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Estimation of Burden of Kidney Dysfunction in HIV-Infected pediatrics and Adolescents by Use of Urinary Neutrophil Gelatinase-Associated Lipocalin: A Single Center Experience in Kenya

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Infectious Diseases & Immunity 2022年第1期2卷 9-14页

作者： anne p.lomole William M.Macharia Mary S.Limbe Doris W.Kinuthia Samuel K.Kabinga Aga Khan University Medical College East AfricaAga Khan University HospitalNairobiKenya University of Nairobi East African Kidney InstituteNairobiKenya

Background:About 75%of patients infected with human immunodeficiency virus(HIV)live in sub-Saharan *** Kenya,about 1.5 million Kenyans are living with HIV,of whom almost 100,000 are children and *** active antiretroviral therapy(HAART)has converted HIV infection to a chronic illness with its attendant *** disease is a common complication of HIV infection and its *** disease in HIV-infected persons can be asymptomatic,insidious onset and may lack specific clinical *** can only be detected on active *** urine albumin-to-creatinine ratio and estimated glomerular filtration rate(eGFR)using serum creatinine are not sensitive in identification of early kidney *** neutrophil gelatinase-associated lipocalin(uNGAL)has been used as marker of early kidney ***:This cross-sectional study used uNGAL and serum creatinine to determine the prevalence of kidney dysfunction in HIVinfected children and adolescents with HAART at Gertrude’s Children’s Hospital,Nairobi,Kenya,from March 2016 to February *** samples were assayed for uNGAL using the Bio porto®enzyme-linked immunosorbent *** creatinine was assayed using the Jaffe reaction in the Cobas®6000 biochemistry analyzer and eGFR calculated using the Schwartz *** plot of eGFR against log uNGAL levles was performed by Statistical package for Social Sciences and pearson correlation coefficeint between log uNGAL levles and eGFR was ***:Ninety-three patients were *** mean age was 11.8±3.6 years and the median duration on HAART was 72.6 *** were 47(50.5%).The prevalence of kidney dysfunction using uNGAL was 15.1%(95%CI 7.6%–22.5%)and 5.4%(95%CI 1.8%–12.1%)by *** mean eGFR was 131±25mL·min1·1.73m2 and median uNGAL was 10 ng/*** every one ng/mL increase in uNGAL value above the normal value,eGFR decreases by 4.8mL·min1·1.73m2(p=0.038).patients with elevated uNGAL were older when co

关键词： HIV Estimated glomerular filtration rate Highly active antiretroviral therapy Kidney disease Serum creatinine uNGAL

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo anne Stratton G.R.Wayne Moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Metal-organic frameworks (MOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

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Science China Chemistry 2025年

作者： Bo Han Erhai Hu Bei-Er Jia Ziyang Liu Shuen Tso Afriyanti Sumboja Ivandini T.Anggraningrum anne Zulfia Syahrial Qingyu Yan SCARCE Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University School of Materials Science and Engineering Nanyang Technological University Material Science and Engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of Chemistry University of Indonesia Metallurgical & Materials Engineering Department Fakultas Teknik Universitas Indonesia

Metal-organic frameworks (MOFs) represent a revolutionary class of materials in the field of energy storage,particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,MOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that MOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which MOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of MOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of MOFs are comprehensively ***,we explore the distinct advantages of MOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of MOFs for advanced energy storage solutions.

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Systemic inflammation in colorectal cancer: Underlying factors,effects, and prognostic significance

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World Journal of Gastroenterology 2019年第31期25卷 4383-4404页

作者： anne E Tuomisto Markus J Makinen Juha p Vayrynen Cancer and Translational Medicine Research Unit University of OuluOulu 90220Finland Department of pathology Oulu University Hospital and Medical Research Center OuluOulu 90220Finland Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical SchoolBostonMA 02115United States

Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40%of colorectal cancer *** hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the *** the low-level systemic inflammation is often clinically silent,its consequences are many and may ultimately lead to chronic cancer-associated wasting,*** this review,we discuss the pathogenesis of cancer-related systemic inflammation,explore the role of systemic inflammation in promoting cancer growth,escaping antitumor defense,and shifting metabolic pathways,and how these changes are related to less favorable outcome.

关键词： Colorectal cancer Inflammation prognosis Cytokine Chemokine C-reactive protein Glasgow prognostic score Cachexia Metastasis

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Combinatorial Complexity in a Transcriptionally Centered Signaling Hub in Arabidopsis

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Molecular plant 2014年第11期7卷 1598-1618页

作者： anne pfeiffer Department of plant and Microbial Biology University of California Berkeley CA 94720 USA United States Department of Agriculture Plant Gene Expression Center Albany CA 94710 USA

A subfamily of four phytochrome （phy）-Interacting bHLH transcription Factors （pIFs） collectively promote skotomorphogenic development in dark-grown seedlings. This activity is reversed upon exposure to light, by photoacti- vated phy molecules that induce degradation of the pIFs, thereby triggering the transcriptional changes that drive a tran- sition to photomorphogenesis. The pIFs function both redundantly and partially differentially at the morphogenic level in this process, To identify the direct targets of pIF transcriptional regulation genome-wide, we analyzed the DNA-binding sites for all four pIFs by Chlp-seq analysis, and defined the genes transcriptionally regulated by each pIF, using RNA-seq analysis of pif mutants. Despite the absence of detectable differences in DNA-binding-motif recognition between the pIFs, the data show a spectrum of regulatory patterns, ranging from single pIF dominance to equal contributions by all four. Similarly, a broad array of promoter architectures was found, ranging from single pIF-binding sites, containing single sequence motifs, through multiple pIF-binding sites, each containing one or more motifs, with each site occupied prefer- entially by one to multiple pIFs. Quantitative analysis of the promoter occupancy and expression level induced by each pIF revealed an intriguing pattern. Although there is no robust correlation broadly across the target-gene population, examination of individual genes that are shared targets of multiple pIFs shows a gradation in correlation from strongly positive, through uncorrelated, to negative. This finding suggests a dual-layered mechanism of transcriptional regulation, comprising both a continuum of binding-site occupancy by each pIF and a superimposed layer of local regulation that acts differentially on each pIF, to modulate its intrinsic transcriptional activation capacity at each site, in a quantitative pattern that varies between the individual pIFs from gene to gene. These findings pr

关键词： phytochromes light-signaling pIFs bHLH transcription factors promoter occupancy Arabidopsis transcrip-tional regulation Chlp-seq RNA-seq.

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Bacterial direct-fed microbials fail to reduce methane emissions in primiparous lactating dairy cows

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Journal of Animal Science and Biotechnology 2019年第3期10卷 802-810页

作者： Jeyamalar Jeyanathan Cecile Martin Maguy Eugene anne Ferlay Milka popova Diego p.Morgavi Universite Clermont Auvergne INRAVetAgro SupUMR 1213 HerbivoresF-63122 Saint-Genes-ChampanelleFrance Laboratory for Animal Nutrition and Animal product Quality Faculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000 GhentBelgium

Direct-fed microbials(DFM) are considered as a promising technique to improve animal productivity without affecting animal health or harming the *** potential of three bacterial DFM to reduce methane(CH4)emissions,modulate ruminal fermentation,milk production and composition of primiparous dairy cows was examined in this *** previous reports have shown that DFM respond differently to different diets,two contrasting diets were used in this *** lactating primiparous cows were randomly divided into two groups that were fed a corn silage-based,high-starch diet(HSD) or a grass silage-based,high-fiber diet(HFD).Cows in each dietary group were randomly assigned to four treatments in a 4 × 4 Latin square *** bacterial DFM used were selected for their proven CH4-reducing effect in *** included control(without DFM) and 3 DFM treatments: propionibacterium freudenreichii 53-W(2.9 × 10^10 colony forming units(CFU)/cow per day),Lactobacillus pentosus D31(3.6 × 10^11 CFU/cow per day) and Lactobacillus bulgaricus D1(4.6 × 10^10 CFU/cow per day).Each experimental period included 4 weeks of treatment and 1 week of wash-out,with measures performed in the fourth week of the treatment *** CH4 emissions were measured during 3 consecutive days using respiration *** samples were collected for ruminal fermentation parameters and quantitative microbial *** samples were collected for composition *** weight of cows were recorded at the end of each treatment *** of diet,no mitigating effect of DFM was observed on CH4 emissions in dairy *** contrast,propionibacterium increased CH4 intensity by 27%(g CH4/kg milk) in cows fed *** was no effect of DFM on other fermentation parameters and on bacterial,archaeal and protozoal ***,the effect of DFM on milk fatty acid composition was *** and *** DFM tended to increase body weight gain with ***

关键词： Bacterial direct-fed microbial Dairy cow Methane Milk fatty acid

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ESTIMATION AND UNCERTAINTY QUANTIFICATION FOR pIECEWISE SMOOTH SIGNAL RECOVERY

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Journal of Computational Mathematics 2023年第2期41卷 246-262页

作者： Victor Churchill anne Gelb Department of Mathematics The Ohio State UniversityColumbusOHUSA Department of Mathematics Dartmouth CollegeHanoverNHUSA

This paper presents an application of the sparse Bayesian learning(SBL)algorithm to linear inverse problems with a high order total variation(HOTV)sparsity *** the problem of sparse signal recovery,SBL often produces more accurate estimates than maximum a posteriori estimates,including those that useℓ1 ***,rather than a single signal estimate,SBL yields a full posterior density estimate which can be used for uncertainty ***,SBL is only immediately applicable to problems having a direct sparsity prior,or to those that can be formed via *** paper demonstrates how a problem with an HOTV sparsity prior can be formulated via synthesis,and then utilizes *** expands the class of problems available to Bayesian learning to include,e.g.,inverse problems dealing with the recovery of piecewise smooth functions or signals from *** examples are provided to demonstrate how this new technique is effectively employed.

关键词： High order total variation regularization Sparse Bayesian learning Analysis and synthesis piecewise smooth function recovery

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Analysis of Lateritic Soil Reinforced with palm Kernel Shells for Use as a Sub-Base Layer for Low-Traffic Roads

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Fluid Dynamics & Materials processing 2022年第5期18卷 1469-1482页

作者： Joel Koti Crespin p.Yabi Mohamed Gibigaye anne Millien Christophe petit LEMA University of Abomey-CalaviCotonouBenin GC2D University of Limoges17 Bd Jacques DercheEgletonsFrance National University of Sciences TechnologiesEngineering and MathematicsAbomeyBenin

In tropical areas,palm oil production generates significant amounts of waste,including palm kernel *** use of this waste in the civil engineering sector,presents a very challenging *** the present study,the production of lateritic soil(A-2 in GTR classification and A-7-6(9)in HRB classification)reinforced with palm kernel shells is *** order to improve their performances,these materials are mixed using the Fuller’s parabolic ***,experimental tests are used to characterize the physical and mechanical geotechnical properties of the lateritic *** characterizing the matrix(i.e.,lateritic soil)and the inclusions(i.e.,palm kernel shells)in their natural state,it is found that Avrankou’s lateritic soil has a high level of fine particles(56.6%),high plasticity(pI=21%)and low lift(ICBR=17%);which makes it unusable in the pavement *** also prove that the mixture composed of 39%of lateritic soil volume and 61%of pKS with a CBR index equals to 30 and the mixture composed of 45%of lateritic soil,40%pKS and 15%of lagoon sand with a CBR index equals to 41 can be used as sub-base layer for roads for low and medium traffic,respectively.

关键词： palm kernel shell lateritic soil subbase layer low-traffic roads

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GREEN ROOFING IN INDIANA: CASE STUDIES AND DESIGN NOTES

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Journal of Green Building 2010年第3期5卷 50-68页

作者： anne Altor Tierra Verde Consulting

Green roof technology and implementation are taking root in North America at an accelerating *** recogni-tion of the benefits of green roofs and increasing interest in green infrastructure are leading to expansion of green roof tech-nologies that have been in use for decades in Europe and *** some regions have adopted the use of green roofs on a large scale,other areas are warming up to the concept more ***-scale implementation of green roofs has not yet occurred in Indiana,but a number of exemplary projects have been constructed,and there are signs that interest in the technology is increasing in the *** purpose of this article is to provide an overview of green roof technology,analyze selected green roofs in Indiana,explore trends in the state,and address issues for future development of green roof technol-ogy in the region.A variety of green roofs were investigated throughout the *** were held with individuals involved in each project to obtain technical and logistical details of green roof design,installation,and performance.

关键词： green roof technology green roof design and installation green roof maintenance and performance stormwater management modular versus loose laid systems energy efficiency

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Cellulose Synthases and Synthesis in Arabidopsis

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Molecular plant 2011年第2期4卷 199-211页

作者： anne Endler Staffan persson Max-planck-Institute for Molecular plant physiology Am M6hlenberg 1 14476 Potsdam Germany

plant cell walls are complex structures composed of high-molecular-weight polysaccharides, proteins, and lignins. Among the wall polysaccharides, cellulose, a hydrogen-bonded β-1,4-1inked glucan microfibril, is the main load-bearing wall component and a key precursor for industrial applications. Cellulose is synthesized by large multi-meric cellulose synthase （CesA） complexes, tracking along cortical microtubules at the plasma membrane. The only known components of these complexes are the cellulose synthase proteins. Recent studies have identified tentative interaction partners for the CesAs and shown that the migratory patterns of the CesA complexes depend on phosphorylation status. These advances may become good platforms for expanding our knowledge about cellulose synthesis in the near future. In addition, our current understanding of cellulose chain polymerization in the context of the CesA complex is discussed.

关键词： Cell expansion cell walls cytoskeleton-cell wall interactions Arabidopsis.

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