检索结果-南通市图书馆

Aberrant expression of CD56 by circulating Sézary syndrome malignant T lymphocytes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Immunology 2013年第3期3卷 68-71页

作者： Nicolas Thonnart Caroline Ram-Wolff Martine Bagot Armand Bensussan anne marie-cardine INSERM U976 Saint Louis Hospital 75010 Paris France University Paris Diderot Sorbonne Paris Cité 75013 Paris France AP-HP Department of Dermatology Saint Louis Hospital 75010 Paris France

Sézary syndrome(SS) is an aggressive variant of cutaneous T cell lymphoma characterized by the presence of malignant T cells in the skin, peripheral blood and lymph nodes. The tumoral population typically displays a CD3+ CD4+ CD45RO+ memory T cell phenotype. We report a case of SS with an aberrant CD56+ immunophenotype. This patient presented with a generalized erythroderma and palpable small axillary lymph ***(stage IVA) was diagnosed on histological criteria and by the detection of a major T cell clone in skin and blood, an elevated CD4/CD8 T cell ratio and Sézary cells count > 1000/mm3. Beside the Sézary cell marker KIR3DL2, immunostainings revealed that two third of the malignant cells expressed CD56 but no other natural killer(NK) cell marker such as CD16, CD160 or NKp46. This atypical expression was not linked to an activation-dependent process and remained stable during the time course of the disease. No loss of the panT-cell markers CD2, CD3 or CD4 was detected while a complete down-modulation of CD26 was observed. Despite several lines of treatment, no durable amelioration was observed and patient died after 10 mo of follow-up. Because this CD4+ CD56+ SS case is the only one reported so far, the functional significance of CD56 expression remained difficult to assess in terms of aggressiveness and prognosis.

关键词： Cutaneous T cell lymphomas Sézary syndrome CD56

Optimization Management of Industrial Organizations Based on Performance Indicators

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Engineering and Technology 2024年第1期12卷 185-199页

作者： anne marie Chana Bernabé Batchakui Blaise Ndangang Department of Computer Engineering National Advanced School of Engineering Yaoundé Cameroon

This paper proposes an intelligent management system (IMS) to help managers in their delicate and tedious task of exploiting the plethora of data (indicators) contained in management dashboards. This system is based on intelligent agents, ontologies and data mining. It is implemented by PASSI (Process for Agent Societies Specification and Implementation) methods for agent design and implementation, the Methodology for Knowledge Modeling and Hot-Winters for data prediction. Intelligent agents not only track indicators but also store the knowledge of managers within the company. Ontologies are used to manage the representation and presentation aspects of knowledge. Data mining makes it possible to: make the most of all available data;model the industrial process of data selection, exploration and modeling;and transform behaviors into predictive indicators. An instance of the IMS named SYGISS, currently in operation within a large brewery organization, allows us to observe very interesting results: the extraction of indicators is done in less than 5 minutes whereas manual extraction used to take 14 days;the generation of dashboards is instantaneous whereas it used to take 12 hours;the interpretation of indicators is instantaneous whereas it used to take a day;forecasts are possible and are done in less than 5 minutes whereas they did not exist with the old management. These important contributions help to optimize the management of this organization.

关键词： Performance Indicator Intelligent Agent Data Mining Intelligent Management System Enterprise Management

Isoform-and cell-state-specific APOE homeostasis and function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： Karina Lindner anne-Claude Gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein E homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol

Digital Twin-Assisted Semi-Federated Learning Framework for Industrial Edge Intelligence

在线全文

学校读者我要写书评

暂无评论

China Communications 2024年第5期21卷 314-329页

作者： Wu Xiongyue Tang Jianhua marie Siew Shien-Ming Wu School of Intelligent Engineering South China University of TechnologyGuangzhou 511442China Electrical and Computer Engineering Department Carnegie Mellon UniversityPittsburghPA 15213United States

The rapid development of emerging technologies,such as edge intelligence and digital twins,have added momentum towards the development of the Industrial Internet of Things(IIo T).However,the massive amount of data generated by the IIo T,coupled with heterogeneous computation capacity across IIo T devices,and users’data privacy concerns,have posed challenges towards achieving industrial edge intelligence(IEI).To achieve IEI,in this paper,we propose a semi-federated learning framework where a portion of the data with higher privacy is kept locally and a portion of the less private data can be potentially uploaded to the edge *** addition,we leverage digital twins to overcome the problem of computation capacity heterogeneity of IIo T devices through the mapping of physical *** formulate a synchronization latency minimization problem which jointly optimizes edge association and the proportion of uploaded nonprivate *** the joint problem is NP-hard and combinatorial and taking into account the reality of largescale device training,we develop a multi-agent hybrid action deep reinforcement learning(DRL)algorithm to find the optimal *** results show that our proposed DRL algorithm can reduce latency and have a better convergence performance for semi-federated learning compared to benchmark algorithms.

关键词： digital twin edge association industrial edge intelligence(IEI) semi-federated learning

Chrononutrition in traditional European medicine-Ideal meal timing for cardiometabolic health promotion

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第2期22卷 115-125页

作者： Nora Selena Eberli Ludivine Colas anne Gimalac Department of Traditional European Medicine Navi Institute of Research in Integrative HealthEcole Professionnelle Superieure de NaturopathieCentre Andre Henzelin1066 EpalingesSwitzerland

Meal timing plays a crucial role for cardiometabolic health,given the circadian regulation of cardiometabolic ***,to the best of our knowledge,no concept of meal timing exists in traditional European medicine(TEM).Therefore,in this narrative review,we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further *** reviewing literature published between 2002 and 2022,we found that optimal timing for energy intake may be between 06:00 and 09:00,12:00 and 14:00,and between 15:00 and18:00,with high energy breakfast,medium energy lunch and low energy dinner and possibly further adjustments according to one’s chronotype and ***,timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction,a concept describing digestion and metabolism in TEM.

关键词： Circadian rhythm Chrononutrition Naturopathy Traditional European medicine Metabolic syndrome Meal timing

A numerical model to simulate the transient frictional viscoelastic sliding contact

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第2期12卷 319-339页

作者： Dongze WANG Gregory de BOER anne NEVILLE Ali GHANBARZADEH School of Mechanical Engineering University of LeedsLeeds LS29JTUK

Sliding motion has always been one of the major concerns when it comes to the analysis of viscoelastic contact problems.A new model simulating the transient sliding contact of smooth viscoelastic surfaces is developed in this *** taking the dry contact friction and the coupling between shear tractions and normal pressure into account,the effect of the early partial slip period,which is often neglected in the study of viscoelastic sliding contact problems,is investigated *** with solutions based on the frictionless assumption,the steady-state pressure profile is found to be slightly different under the effect of the partial slip regime,including a lower peak pressure and the shift of the contacting region in the direction opposite to the sliding ***,the time required for the viscoelastic contact to reach its steady state is delayed owing to the partial slip period preceding the global sliding motion.

关键词： contact mechanics frictional sliding viscoelasticity viscoelastic friction

Photovoltaic waste management in sub-Saharan Africa:current practices in Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Waste Disposal and Sustainable Energy 2024年第2期6卷 271-282页

作者： Kodami Badza Yrebegnan Moussa Soro marie Sawadogo Laboratoire Energies Renouvelables et EfficacitéEnergétique Institut International d'Ingenierie de I'Eau et de I'Environnement(2iE)01 BP 594 OuagadougouBurkina Faso

Sub-Saharan Africa is witnessing a proliferation of photovoltaic(PV)waste due to the increasing number of solar PV power *** waste(panels,batteries,electrical cables,mounting structures,and inverters)consists of elements such as mercury,cadmium,chromium,lead,copper,aluminum,fluorinated compounds,and plastics that are toxic to human health and the environment if a proper management system is not *** many studies worldwide have focused on PV waste management,very few have been conducted in sub-Saharan *** study aims to investigate the current PV waste management system in Burkina Faso,determine stakeholder profiles,and propose strategies to enhance the existing *** research,interviews,questionnaires,and field visits were used in the *** survey showed that young people,mainly under 30 years of age and with a primary education,dominate(70%)in terms of PV waste collection and repair activities,while the more technical recycling and export activities are carried out mainly(88%)by stakeholders older than 40 years and with a secondary education(60%).Among the older stakeholders,100%are aware of the hazardous nature of PV waste,whereas 36%are young *** an environmental perspective,the main source of contamination observed is the release of lead-rich sulfuric acids into water and soil during the collection and repair *** the recycling of batteries and electrical cables,toxic fumes are emitted into the air,and recycling residues rich in toxic substances are *** reduce risks to human health and the environment when managing PV waste,the introduction of legislation,the multiplication of collection points and appropriate infrastructures,the training and awareness-raising of stakeholders,and the extended responsibility of manufacturers are *** on the economic feasibility of setting up formal management structures are needed to complete this work.

关键词： Photovoltaic waste Sub-Saharan Africa Waste management Recycling Batteries Incineration

Templated synthesis of transition metal phosphide electrocatalysts for oxygen and hydrogen evolution reactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： Rose anne Acedera Alicia Theresse Dumlao DJ Donn Matienzo Maricor Divinagracia Julie anne del Rosario Paraggua Po-Ya Abel Chuang Joey Ocon Laboratory of Electrochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Transition metal phosphides(TMPs)have been regarded as alternative hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts owing to their comparable activity to those of noble metal-based *** have been produced in various morphologies,including hollow and porous nanostructures,which are features deemed desirable for electrocatalytic *** synthesis routes are often responsible for such *** paper reviews the latest advances and existing challenges in the synthesis of TMP-based OER and HER catalysts through templated methods.A comprehensive review of the structure-property-performance of TMP-based HER and OER catalysts prepared using different templates is *** discussion proceeds according to application,first by HER and further divided among the types of templates used-from hard templates,sacrificial templates,and soft templates to the emerging dynamic hydrogen bubble *** catalysts are then reviewed and grouped according to their ***,prospective research directions for the synthesis of hollow and porous TMP-based catalysts,such as improvements on both activity and stability of TMPs,design of environmentally benign templates and processes,and analysis of the reaction mechanism through advanced material characterization techniques and theoretical calculations,are suggested.

关键词： OER HER Transition metal phosphide Templated synthesis Electrocatalysts

Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel Fleury Imane Boukhatem marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance Service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia