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Corneal neurotization: a narrative review of techniques, outcomes, and surgical considerations

Annals of Eye Science 2023年第2期8卷 1-13页

作者： Jessica Zhang anne barmettler Department of Ophthalmology and Visual Sciences Montefiore Medical CenterAlbert Einstein College of MedicineBronxNew YorkUSA

Background and Objective:Corneal neurotization is a novel surgical technique used to restore corneal sensation in patients with neurotrophic *** keratopathy is a disorder characterized by dysfunction of the ophthalmic division of the trigeminal nerve,which provides sensory innervation to the *** sensation,the cornea is at risk of infection,ulceration,perforation,and ultimately,vision *** neurotization has emerged as an innovative technique to reinnervate anesthetized corneas by transferring a healthy donor nerve to the affected eye around the corneoscleral *** the field of corneal neurotization rapidly grows,there is a need to synthesize the existing body of literature on corneal neurotization and identify important areas for further *** this review,we will discuss neurotrophic keratopathy and its current management strategies,followed by an overview of corneal neurotization techniques,outcomes,surgical considerations,and future ***:PubMed and Google Scholar searches were conducted to retrieve and analyze relevant original papers and reviews on neurotrophic keratopathy and corneal neurotization up until April *** Content and Findings:Currently,numerous techniques for corneal neurotization exist,including direct nerve transfers,as well as indirect neurotization via interposition nerve *** far,corneal neurotization has been shown to be highly successful in restoring corneal sensation,improving visual acuity,and improving corneal epithelial *** date,there have been no significant differences in outcomes between direct versus indirect neurotization techniques,different donor nerves,or autologous versus allogeneic interposition ***,there is some evidence that corneal neurotization procedures may be more successful in pediatric ***:Corneal neurotization shows great promise in treating neurotrophic corneas and represents the first management option to date tha

关键词： Corneal neurotization neurotrophic keratopathy corneal sensation neurotrophic cornea

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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ESTIMATION AND UNCERTAINTY QUANTIFICATION FOR PIECEWISE SMOOTH SIGNAL RECOVERY

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Journal of Computational Mathematics 2023年第2期41卷 246-262页

作者： Victor Churchill anne Gelb Department of Mathematics The Ohio State UniversityColumbusOHUSA Department of Mathematics Dartmouth CollegeHanoverNHUSA

This paper presents an application of the sparse Bayesian learning(SBL)algorithm to linear inverse problems with a high order total variation(HOTV)sparsity *** the problem of sparse signal recovery,SBL often produces more accurate estimates than maximum a posteriori estimates,including those that useℓ1 ***,rather than a single signal estimate,SBL yields a full posterior density estimate which can be used for uncertainty ***,SBL is only immediately applicable to problems having a direct sparsity prior,or to those that can be formed via *** paper demonstrates how a problem with an HOTV sparsity prior can be formulated via synthesis,and then utilizes *** expands the class of problems available to Bayesian learning to include,e.g.,inverse problems dealing with the recovery of piecewise smooth functions or signals from *** examples are provided to demonstrate how this new technique is effectively employed.

关键词： High order total variation regularization Sparse Bayesian learning Analysis and synthesis Piecewise smooth function recovery

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GREEN ROOFING IN INDIANA: CASE STUDIES AND DESIGN NOTES

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Journal of Green Building 2010年第3期5卷 50-68页

作者： anne Altor Tierra Verde Consulting

Green roof technology and implementation are taking root in North America at an accelerating *** recogni-tion of the benefits of green roofs and increasing interest in green infrastructure are leading to expansion of green roof tech-nologies that have been in use for decades in Europe and *** some regions have adopted the use of green roofs on a large scale,other areas are warming up to the concept more ***-scale implementation of green roofs has not yet occurred in Indiana,but a number of exemplary projects have been constructed,and there are signs that interest in the technology is increasing in the *** purpose of this article is to provide an overview of green roof technology,analyze selected green roofs in Indiana,explore trends in the state,and address issues for future development of green roof technol-ogy in the region.A variety of green roofs were investigated throughout the *** were held with individuals involved in each project to obtain technical and logistical details of green roof design,installation,and performance.

关键词： green roof technology green roof design and installation green roof maintenance and performance stormwater management modular versus loose laid systems energy efficiency

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Isoform-and cell-state-specific APOE homeostasis and function

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Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： Karina Lindner anne-Claude Gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein E homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol

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INTEGRATED DESIGN FOR FLOOD RISK AND SPATIAL QUALITY-EXAMPLES FROM THE DUTCH DELTA PROGRAMME

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Journal of Green Building 2018年第1期13卷 159-184页

作者： anne Loes Nillesen DEFACTO Architecture and Urbanism

INTRODUCTION The Netherlands faces a significant flood risk task. In order to remain a safe place to live the Netherlands has to upgrade its extensive flood risk protection system. This results in an elevation and reinforcement task for many of the Netherlands water barriers. When those barriers are positioned in an open landscape, the technical rein-forcement is often easy to embed specially. However, many barriers have been built over the years making the reinforcement into a challenging spatial assignment. This article shows different case study examples of a research by design study (performed in the broader context of the Dutch Delta programme) that explores integral design solutions for flood risk and spatial (re)development. The Houston Galveston Bay case study demonstrates the international applicability of the research by design method.

关键词： research by design flood risk integral design Dutch Delta programme spatial design The Hague Rijnmond region(The Netherlands) Houston Galveston Bay(USA).

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Science Fiction as a Manifestation of Culture in America

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外国文学研究 2005年第6期27卷 41-47页

作者： Elizabeth anne Hull William Rainey Harper College USA

Culture is broadly viewed as all the human activities that define us as a species. ″Sturgeon’s Law″ (that 90% of everything is inferior) is introduced to defend the study of fiction, and science fiction in particular, in higher education as a way of understanding ourselves better, and perhaps improving the world through the increased understanding of tomorrow’s leaders. Several ways of reading particular works of science fiction are examined, like providing historical contexts for readers, close reading and structural analysis, and application of theories based on particular ideologies or from other disciplines in the social and political sciences (such as feminist theory, Marxist theory, psychological theory, etc.). A conclusion is drawn that for literary analysis, a hybrid methodology, one devised individually for each text, works best.

关键词：科学小说美国文学研究文化背景

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Extended Evolutionary Fast Learn-to-Walk Approach for Four-Legged Robots

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Journal of Bionic Engineering 2007年第4期4卷 255-263页

作者： Muh. Anshar Mary-anne Williams Innovation and Technology Research Laboratory Faculty of Information Technology University of Technology Sydney City Campus 15 Broadway Ultimo NSW 2007 Australia

Robot locomotion is an active research area. In this paper we focus on the locomotion of quadruped robots. An effective walking gait of quadruped robots is mainly concerned with two key aspects, namely speed and stability. The large search space of potential parameter settings for leg joints means that hand tuning is not feasible in general. As a result walking parameters are typically determined using machine learning techniques. A major shortcoming of using machine learning techniques is the significant wear and tear of robots since many parameter combinations need to be evaluated before an optimal solution is found. This paper proposes a direct walking gait learning approach, which is specifically designed to reduce wear and tear of robot motors, joints and other hardware. In essence we provide an effective learning mechanism that leads to a solution in a faster convergence time than previous algorithms. The results demonstrate that the new learning algorithm obtains a faster convergence to the best solutions in a short run. This approach is significant in obtaining faster walking gaits which will be useful for a wide range of applications where speed and stability are important. Future work will extend our methods so that the faster convergence algorithm can be applied to a two legged humanoid and lead to less wear and tear whilst still developing a fast and stable gait.

关键词： legged-robots locomotion learning genetic convergence walking gaits

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Matrix Roots and Embedding Conditions for Three-State Discrete-Time Markov Chains with Complex Eigenvalues

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Communications in Mathematics and Statistics 2022年第3期10卷 435-450页

作者： Marie-anne Guerry Department of Business Technology and Operations Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

The present paper examines matrix root properties and embedding conditions for discrete-time Markov chains with three states and a transition matrix having complex *** as well as sufficient conditions for the existence of an m-th stochastic root of the transition matrix are *** roots are expressed in analytical form based on the spectral decomposition of the transition matrix,and properties of these matrix roots are proved.

关键词： Markov chain Embedding problem Matrix root Complex eigenvalues

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Semen analysis： a new manual and its application to the understanding of semen and its pathology

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Asian Journal of Andrology 2010年第1期12卷 11-13页

作者： anne M. Jequier PIVET Medical Centre Leederville Western Australia 6007 Australia

This article reviews the latest edition of the World Health Organization＇s manual on seme instructional guide. The methodology used in the assessment of the usual variables in semen many of the less common, but very valuable, sperm function tests. Seminal fluid preparatio such as in vitro fertilization and intrauterine insemination are also outlined in the manual. useful techniques for the assessment of seminal fluid. It will be a very useful manual for an analyses of seminal fluid.

关键词： laboratory practice male infertility semen analysis

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