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Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition

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World Journal of Gastroenterology 2005年第39期11卷 6165-6169页

作者： Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa anne pompei Patrick Rampal Department of Hepato-Gastroenterology and Clinical Nutrition Archet University Hospital NiceFrance Bacteriology Laboratory Archet University Hospital NiceFrance Biostatistician Paris France Department of Hepato-Gastroenterology Princess Grace Hospital Monte-CarloMonaco

AIM： To assess the effects of Sb on fecal flora and shortchain fatty acids （SCFA） in patients on long-term TEN. METHODS： Ten patients （3 females, 7 males, 59±5.5 years）, on TEN for a median of 13 mo （1-125）, and 15 healthy volunteers （4 females, 11 males, 32±2.0 years） received Sb （0.5 g bid PO） for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification. Values （mean4-SE） were compared using sign tests and ANOVA. RESULTS： Fecal butyrate levels were lower in patients （10.1±2.9 mmol/kg） than in controls （19.2±3.9, P= 0.02）. Treatment with Sb increased total fecal SCFA levels in patients （150.2＋27.2 vs 107.5±18.2 mmol/kg, P= 0.02） but not in controls （129.0±28.6 vs 113.0±15.2 mmol/kg, NS）. At the end of treatment with Sb, patients had higher fecal butyrate（16.0±4.4 vs 10.1 [2.9] mmol/kg, P= 0.004）. Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls （2.4±2.3 vs 69.8±1.8, P= 0.003）. There were no significant changes in the fecal flora of TEN patients. CONCLUSION： Sb-induced increase of fecal SCFA concentrations （especially butyrate） may explain the preventive effects of this yeast on TEN-induced diarrhea.

关键词： Enteral nutrition Diarrhea Saccharomyces boulardii Short-chain fatty acids Intestinal microbiota

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Environmental parameters assessment of a new diffuser for air cooling/heating system:Measurements and numerical validation

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Building Simulation 2022年第6期15卷 1111-1132页

作者： Fabio Nardecchia Laura pompei Fabio Bisegna Department of Astronautic Electric and Energy EngineeringSapienza UniversityVia Eudossiana 18RomeItaly

Air distribution of HVAC systems is the most popular type used in the building sector,having a relevant impact on indoor air quality and occupant *** types of research developed optimal solutions for the HVAC system’s design,focusing on specific components of the distribution system,on the airflow and geometry of ducts,on the size of ducts,on the shape and position of air ***,few works in literature proposed a globally experimental and simulation analysis of an air distribution system with a variable mass flaw *** this line,the presented research investigates the potentialities of a new ceiling diffuser,installed in an exhibition *** system provides a variable mass flow rate thanks to its configuration,providing adequate thermal comfort.A warm wall is chosen as the heating *** tests are carried out,six for cooling and two for heating with different volumetric air rates and supply air temperature of the *** combination of two methods,the measurement campaigns and the computational fluid dynamics(CFD)technique represent a suitable approach to examine the thermal indoor *** general,results show a strong capability of this diffuser to provide a uniform temperature and velocity field inside the ***,experimental and numerical data are significantly comparable with an average deviation of 1%for the velocity and lower 1%for the temperature,guaranteeing an optimal distribution of the understudy environmental parameters on the vertical and horizontal planes.

关键词： environmental parameters CFD field measurements INDULINE HVAC systems thermal comfort

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Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats

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Biomedical and Environmental Sciences 2014年第2期27卷 85-96页

作者： Daniela-Saveta POPA pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN Department of Toxicology Faculty of Pharmacy Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca Department of Pathology Faculty of Veterinary MedicineUniversity of Agricultural Sciences and Veterinary Medicine Department of Biomedical Sciences Ross University School of Veterinary Medicine Department of Pharmaceutical Technology and Biopharmacy Faculty of Pharmacy ‘Iuliu Hatieganu'University of Medicine and Pharmacy Cluj-Napoca Department of Pharmaceutical Botany Faculty of Pharmacy ‘Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca

Objective To evaluate the influence of an extract of Genista tinctoria L. herba （GT） or methylparaben （MP） on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A （BPA）. Methods Adult female Wistar rats were orally exposed for 90 d to BPA （50 mg/kg）, BPA＋GT （35 mg isoflavones/kg） or BPA＋MP （250 mg/kg）. Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA＋MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA＋MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes.

关键词： Food contaminant Phytoestrogen Morphological effect Lipid peroxidation Hydroxylradical

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Chemical Characterization of PM10 Particulate Matter in the Ambient Air of a Region of Central Italy (Umbria)

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International Journal of Analytical Mass Spectrometry and Chromatography 2015年第3期3卷 47-53页

作者： Mara Galletti Silvia Castellini Andrea Pileri Caterina Austeri Marco pompei Monica Angelucci ARPA Umbria Perugia Italy Department of Chemistry Biology and Biotechnology University of Perugia Perugia Italy

Atmospheric particulate matter is a critical factor for many regional urban areas of Umbria (Central Italy region). During 2013 the monitoring air quality network, managed by ARPA Umbria, has been upgraded to Legislative Decree of 13 August 2010, n.155 and an analytical study about chemical composition of PM10 (Particulate Matter with diameter of 10 micrometres or less) over all the region has been started. The PM10 filters have been analyzed for Benzo(α)Pyrene, Pb, Cr, Ni and Cd to check compliance with limits or target values defined in Italian regulation (Legislative Decree of 13 August 2010, n.155);other parameters, like US-EPA list Polycyclic Aromatic Hydrocarbons (PAHs), Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzo Furans (PCDD/ Fs), Polychlorinated Biphenyls (PCBs), Organic Carbon/Elemental Carbon (OC/EC) and Levoglucosan were analyzed because they are toxic or because they identify particular pollutant sources. The data obtained showed a large and diffusive biomass burning contribution, widely used in the Umbria Region both for domestic heating in traditional fireplaces and for combustion of pruning residues. In particular the urban sites of Terni and suburban site near Terni (Narni), both lying in the Terni basin called “Conca Ternana”, showed a chemical composition of PM10 that suggests a very large anthropization. This area is the principal industrial reality in the Central Italy because there is a steel production plant, a Municipal solid waste (MSW) burning plant and a chemical plant.

关键词： Particulate Matter Chemical Composition Biomass Burning

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Oral low-dose estradiol plus norethisterone acetate with or without simvastatin in dyslipidemic and symptomatic menopausal women: A randomized clinical trial

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Health 2013年第7期5卷 110-118页

作者： Marcelo Luis Steiner Luciano Melo pompei Rodolfo Strufaldi Everaldo Porto Cunha Cesar Eduardo Fernandes Postgraduate Student in Gynecology Obstetricsand MastologyUniversidade Estadual de Sao Paulo(Unesp)BotucatuSao PauloBrazil Assistant Physician Gynecological Endocrinologyand Menopause DivisionDepartment of Gynecology and ObstetricsFaculdade de Medicina do ABC(FMABC)Sao Bernardo do CampoSao PauloBrazil Assistant Professor Department of Gynecologyand ObstetricsFaculdade de Medicina do ABC(FMABC)Sao Bernardo do CampoSao PauloBrazil Head of the Gynecological Endocrinology and Menopause Division Department of Gynecology and ObstetricsFaculdade de Medi-cina do ABC(FMABC)Sao Bernardo do CampoSao PauloBrazil

Context and Objective: Cardiovascular diseases are the leading causes of death in postmenopausal women and dyslipidemia has important contributing factor. The objective of the study was to evaluate low-dose estrogen plus progestogen therapy (EPT) + simvastatin for vasomotor symptoms and lipid and lipoprotein profiles. Design and Setting: Clinical trial was conducted in a private clinical research center. Methods: Two hundred forty symptommatic postmenopausal women with dyslipidemia were randomized to one of three treatment groups: A) 1 mg estradiol/ 0.5 mg norethisterone acetate (E2/NETA) + 20 mg simvastatin;B) E2/NETA + placebo;or C) 20 mg simvastatin + placebo. Lipid and lipoprotein profiles and menopausal symptoms were evaluated after 16 weeks. Results: Total cholesterol, LDL cholesterol, non-HDL cholesterol decreased (P < 0.05) in all three groups, Apo-B/Apo-A1 and ApoB (P < 0.01) in groups A and C and TG and ApoA1 only in group A comparing baseline versus final. Comparing the groups, group B showed differences in relation to others in total cholesterol, non-HDL cholesterol, LDL cholesterol, Apo B and ApoB/Apoa1 (P Conclusions: Thus in postmenopausal women with dyslipidemia, the association of E2/ NETA low-dose with simvastatin relieved climacteric symptoms similar to that observed with isolated E2/NETA and improved lipid and lipoprotein profile similar to the isolated use of simvastatin. The use of E2/NETA alone decreased menopausal symptoms, but did not improve dyslipidemia.

关键词： Dyslipidemia Hormone Replacement Therapy Lipoproteins Simvastatin Cardiovascular Diseases

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Inflammation in irritable bowel syndrome:Myth or newtreatment target?

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世界胃肠病学杂志：英文版 2016年第7期22卷 2242-2255页

作者： Emanuele Sinagra Giancarlo pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo Gastroenterology and Endoscopy Unit Fondazione Istituto San Raffaele GiglioContrada Pietra Pollastra Pisciotto90015 CefalùItaly PhD Course in Surgical Biotechnology and Regenerative Medicine University of Palermo90100 PalermoItaly Euro-Mediterranean Institute of Science and Technology(IEMEST) 90100 PalermoItaly Pathology Unit Fondazione Istituto San Raffaele GiglioContrada Pietra Pollastra Pisciotto90015 CefalùItaly Department of Experimental Biomedicine and Clinical Neuroscience Section of Human AnatomyUniversity of Palermo90100 PalermoItaly Unit of Gastroenterology Ospedali Riuniti Villa Sofia-Vincenzo Cervello90100 PalermoItaly DICHIRONS Department of SurgicalOncological and Stomatological DisciplinesUniversity of Palermo90100 PalermoItaly Unit of Pathology Ospedali Riuniti Villa Sofia-Vincenzo Cervello90100 PalermoItaly

Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.

关键词： Inflammation Irritable bowel syndrome Mast cells Neuroendocrine cells Pathology

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