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International Journal of Sediment Research 2023年第3期38卷 303-315页

作者： Mario Misale Johan Augusto Bocanegra annalisa marchitto DIME-Department of Mechanics Energetics Management and Transportation Thermal Engineering and Environmental Conditioning Division University of Genoa

The stability of nanofluids is critical in engineering applications. The sedimentation of the nanoparticles in the base fluid limits the stability of the nanofluid. By measuring the absorbance of a visible laser through water aluminum oxide nanofluids it is possible to observe the evolution of the sedimentation process. A simple experimental setup consisting of a thin closed test cavity（0.8 mm or 1.5 mm thickness）filled with nanofluid and a set of laser diodes-photodiodes pairs was used in the experiments to determine the absorbance and the local volumetric concentration. The evolution of the local volumetric concentration of the nanofluid was measured at 13 height positions along the test cavity. Five initial volumetric concentrations of aluminum oxide（Al2O3; 0.5%, 1.0%, 1.5%, 2.0%, 3.0% and 4.0%） were considered. Data and digital photos were acquired for a total time lapse of 260 days. The results were independent of the container thickness. The same general trend was consistent for all the initial volumetric concentrations, i.e., the sedimentation rate decreases in time. The time evolution of the volumetric concentration was compared with results from a modified Mason-Weaver model. The comparison was possible by setting a variable sedimentation velocity in the model, suggesting that the sedimentation is affected by the dynamics of nanoparticle clusters with diverse sizes produced by agglomeration.

关键词： Pure nanofluid Aluminum oxide Nanoscale alumina particles Colloid sedimentation Nanoparticle settling Mason-Weaver model

How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Homocysteinemia and Depression in Community-Dwelling Older Adults: The Cohort Longitudinal Study “InveCeAb” (Brain Aging in Abbiategrasso)

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Health 2024年第1期16卷 22-36页

作者： Mauro Colombo annalisa Davin Elena Rolandi Michele Rossi Riccardo Ferrari Erica Spina Antonio Guaita Golgi Cenci Foundation Abbiategrasso Italy

Depression is a major health problem, especially for elderly people. According to the “homocysteine hypothesis of depression”, high homocysteine levels may cause depression of mood via cerebrovascular diseases. Whilst biologically plausible, such hypothesis needs yet confirmation. We aimed at: 1) studying the relationships between homocysteinemia (HCY) and depression in a community-dwelling cohort of people aged 70 to 75 years at baseline;2) investigating plasma levels of HCY and 3) comparing these levels between males and females, in the same population. We exploited the data from four waves (2010, 2012, 2014 and 2018) of the longitudinal study “InveCeAb”, with specific regard towards mood assessment, by Geriatric Depression Scale (GDS) scoring, and diagnosis of clinically relevant or subthreshold depression. HCY plasma levels were measured in the waves 2012, 2014 and 2018. Sample attrition was due mainly to death or overall worsening. No statistically significant differences were found in plasma homocysteine levels in each wave, according to depressive symptoms. No correlations were found between plasma HCY levels in each wave with their corresponding GDS scores, even after adjustment for folate and cobalamin blood concentrations. Dichotomized levels of HCY (≤15 vs >15 μM/l) were not associated with dichotomized GDS scores (≤4 vs higher), clinically relevant and subthreshold depression diagnosis and any antidepressive use, in any wave. First (2012) HCY levels increased with participants’ increasing age, cross-sectionally. Listwise HCY concentrations decreased along the 3 waves. HCY levels were always higher in males than in females. Our results may challenge the “homocysteine hypothesis” of depression, whilst supporting the role of high homocysteinemia as a marker of overall bad health.

关键词： Homocysteinemia Depression Aging Cohort

Nilotinib:from animal-based studies to clinical investigation in Alzheimer's disease patients

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Neural Regeneration Research 2023年第4期18卷 803-804页

作者： annalisa Nobili Marcello D’Amelio Maria Teresa Viscomi Department of Medicine and Surgery University Campus Bio-MedicoDepartment of Experimental NeuroscienceIRCCS Santa Lucia FoundationRomeItaly Department of Life Science and Public Health Section of Histology and Embryology UniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario“A.Gemelli”IRCCSRomeItaly

Since their first description in the brains of patients suffering from Alzheimer ’s disease(AD), more than 100 years ago, extracellular amyloid-β(Aβ) plaques and intracellular neurofibrillary tangles have been the principal focus of AD research. However, this focus has led to the failure of several long and promising clinical trials, and the efficacy of new Aβ-targeting drugs to slow down the disease progression is still controversial despite being successful in reducing the Aβ load.

关键词： Alzheimer Aβ drugs

Autoimmune liver diseases and SARS-CoV-2

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World Journal of Gastroenterology 2023年第12期29卷 1838-1851页

作者： Costantino Sgamato Alba Rocco Debora Compare Stefano Minieri Stefano Andrea marchitto Simone Maurea Gerardo Nardone Department of Clinical Medicine and Surgery University of Naples Federico ⅡNaples 80131Italy Department of Advanced Biomedical Sciences University of Naples Federico ⅡNaples 80131Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing coronavirus disease 2019(COVID-19),can trigger autoimmunity in genetically predisposed individuals through hyperstimulation of immune response and molecular *** we summarise the current knowledge about autoimmune liver diseases(AILDs)and SARS-CoV-2,focusing on:(1)The risk of SARS-CoV-2 infection and the course of COVID-19 in patients affected by AILDs;(2)the role of SARS-CoV-2 in inducing liver damage and triggering AILDs;and(3)the ability of vaccines against SARS-CoV-2 to induce autoimmune responses in the *** derived from the literature suggest that patients with AILDs do not carry an increased risk of SARS-Cov-2 infection but may develop a more severe course of COVID-19 if on treatment with steroids or *** SARSCoV-2 infection can lead to the development of several autoimmune diseases,few reports correlate it to the appearance of de novo manifestation of immunemediated liver diseases such as autoimmune hepatitis(AIH),primary biliary cholangitis(PBC)or AIH/PBC overlap *** case series of an AIHlike syndrome with a good prognosis after SARS-CoV-2 vaccination have been *** the causal link between SARS-CoV-2 vaccines and AIH cannot be definitively established,these reports suggest that this association could be more than coincidental.

关键词： Autoimmune liver disease SARS-CoV-2 COVID-19 COVID-19 vaccine Autoimmune hepatitis

Dendritic cell subsets in cancer immunity and tumor antigen sensing

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Cellular & Molecular Immunology 2023年第5期20卷 432-447页

作者： annalisa Del Prete Valentina Salvil Alessandra Soriani Mattia Laffranchi Francesca Sozio Daniela Bosisio Silvano Sozzani Department of Molecular and Translational Medicine University of BresciaBresciaItaly Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti Department of Molecular Medicine Sapienza University of RomeRomeItaly

Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune *** to their ability to cross-present tumor cell-associated antigens to naïve T cells,DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell *** an immunosuppressive tumor microenvironment,DC antitumor functions can,however,be severely *** this review,we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions,taking advantage of recent studies showing the phenotype acquisition,transcriptional state and functional programs revealed by scRNA-seq *** therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed.

关键词： Dendritic cell subsets Tumor microenvironment Migration Innate immune sensing Immune cell death Tumor-derived extracellularvesicles

Impact of laser chirp on the polarization of terahertz from two-color plasma

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Photonics Research 2023年第6期11卷 978-985页

作者： SEN MOU LUCA TOMARCHIO annalisa D’ARCO MARTA DI FABRIZIO SALVATORE MACIS ALESSANDRO CURCIO LUIGI PALUMBO STEFANO LUPI MASSIMO PETRARCA INFN-Roma1 and Physics Department University of Rome“La Sapienza”00185 RomeItaly Physics Department University of Rome“La Sapienza”00185 RomeItaly SBAI Department of Basic and Applied Sciences for EngineeringUniversity of Rome“La Sapienza”00161 RomeItaly Centro de Laseres Pulsados(CLPU) 37185 VillamayorSalamancaSpain INFN-LNF 00044 FrascatiItaly

Two-color plasma,induced by two lasers of different colors,can radiate ultra-broadband and intense terahertz(THz)pulses,which is desirable in many technological and scientific *** was found that the polarization of the emitted THz depends on the phase difference between the fundamental laser wave and its second *** investigation suggests that chirp-induced change of pulse overlap plays an important role in the THz yield from two-color ***,the effect of laser chirp on THz polarization remains ***,we investigate the impact of laser chirp on THz *** is unveiled that the chirp-induced phase difference affects THz ***,positive and negative chirps have opposite effects on the variation of the THz polarization versus the phase *** polarization of THz generated by a positively chirped pump laser rotates clockwise with an increasing phase difference,while it rotates anticlockwise when generated by a negatively chirped pump laser.

关键词： polarization laser pump

Functional impacts of non-coding RNA processing on enhancer activity and target gene expression

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Journal of Molecular Cell Biology 2019年第10期11卷 868-879页

作者： Evgenia Ntini annalisa Marsico Max Planck Institute for Molecular Genetics 14195BerlinGermany Free University Berlin 14195BerlinGermany Institute of Computational Biology Helmholtz Zentrum MunchenMunchenGermany

Tight regulation of gene expression is orchestrated by *** recent research advancements,it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histone marks,but they rather display sign atures of active transcription,showingdistinct degrees oftranscription unit ***,a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential *** this review,we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers,as well as enhancer-produced long non-coding RNA transcripts,may modulate or define the functional regulatory potential ofthe cognate *** addition,we summarize supporting evidence that RNA processing ofthe enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity,which contributes to the control and final outcome of enhancer-targeted gene expression.

关键词： transcription enhancer RNA processing cotranscriptional RNA splicing chromatin long non-coding RNA(IncRNA)

On the Numerical Solution to a Nonlinear Wave Equation Associated with the First Painlev Equation:an Operator-Splitting Approach

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Chinese Annals of Mathematics,Series B 2013年第2期34卷 237-254页

作者： Roland GLOWINSKI annalisa QUAINI Department of Mathematics University of Houston4800 Calhoun RdHouston(TX) 77204USA Laboratoire Jacques-Louis Lions Universit Pierre et Marie Curie4Place Jussieu75252 Paris CEDEX 05France

The main goal of this article is to discuss the numerical solution to a nonlinear wave equation associated with the first of the celebrated Painlev'e transcendent ordinary differential *** order to solve numerically the above equation,whose solutions blow up in finite time,the authors advocate a numerical methodology based on the Strang's symmetrized operator-splitting *** this approach,one can decouple nonlinearity and differential operators,leading to the alternate solution at every time step of the equation as follows:(i) The first Painlevé ordinary differential equation,(ii) a linear wave equation with a constant *** that the space dimension is two,the authors consider a fully discrete variant of the above scheme,where the space-time discretization of the linear wave equation sub-steps is achieved via a Galerkin/finite element space approximation combined with a second order accurate centered time discretization *** handle the nonlinear sub-steps,a second order accurate centered explicit time discretization scheme with adaptively variable time step is used,in order to follow accurately the fast dynamic of the solution before it blows *** results of numerical experiments are presented for different coefficients and boundary *** show that the above methodology is robust and describes fairly accurately the evolution of a rather "violent" phenomenon.

关键词：非线性波动方程 Painlevé方程数值解法操作员 Galerkin 常微分方程分裂分离方法

Histone deacetylase inhibitors for treatment of hepatocellular carcinoma

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Acta Pharmacologica Sinica 2005年第9期26卷 1025-1033页

作者： Danila CORADINI annalisa SPERANZA UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy

Hepatocellular carcinoma(HCC)is one of the most common cancers in the *** resection has been considered the optimal treatment approach,but onlya small proportion of patients are suitable candidates for surgery,and the relapserate is *** to prevent recurrence,including chemoemboliza-tionbefore and adjuvant therapy after surgery,have proven to have a limited benefit;liver transplantation is successful in treating limited-stage HCC because only aminority of patients qualify for ***,new therapeutic strat-egies are urgently *** in addition to the classical genetic mecha-nisms of deletion or inactivating point mutations,epigenetic alterations,such ashyperacetylation of the chromatin-associated histones(responsible for genesilencing),are believed to be involved in the development and progression ofHCC,novel compounds endowed with a histone deacetylase(HDAC)inhibitoryactivity are an attractive therapeutic *** particular,pre-clinical resultsobtained using HA-But,an HDAC inhibitor in which butyric acid residues areesterified to a hyaluronic acid backbone and characterized by a high affinity forthe membrane receptor CD44,indicated that this class of compounds may repre-sent a promising approach for hepatocellular carcinoma treatment.

关键词： hepatocellular carcinoma histone deace-tylase inhibitors cancer therapy