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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Low-Cost Tiled Display System Architecture with Dynamic Web-Based Management

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China Communications 2022年第10期19卷 143-168页

作者： Daniel Marfil Fernando Boronat F.Javier Pastor anna vidal Communications Department Gandia CampusUniversitat Politecnica de ValenciaCalle Paraninfo146730Grao de GandiaValencia(Spain) Drawing Department Gandia CampusUniversitat Politecnica de ValenciaCalle Paraninfo146730Grao de GandiaValencia(Spain) Applied Mathematics Department Gandia CampusUniversitat Politecnica de ValenciaCalle Paraninfo146730Grao de GandiaValencia(Spain)

In this paper, a scalable hardware and software architecture for tiled display systems (a.k.a. videowalls), which can be implemented by using low-cost devices, together with a dynamic web-based management and configuration service are proposed. It has been designed to support both stored and live broadcast/broadband content, in mosaic or warp distributions. The displays and devices can be dynamically configured via web in different ways: the displays can create a single display of a larger size;or they can be configured in a customized way in order to playout different media contents in different display combinations. As display renderers, low-cost devices are proposed as the main hardware element to obtain affordable videowall systems. As a proof of concept, two prototypes have been implemented, including an accurate synchronization mechanism based on a Master/Slave control scheme and aggressive and smooth playout adjustment techniques. To evidence the good performance of the prototypes and configuration service, both objective and subjective evaluations have been conducted regarding synchronization accuracy and usability. On the one hand, the mean values of the asynchronies between the video playout processes in each display are kept below 25ms (i.e., frame accuracy). On the other hand, the obtained usability score in the System Usability Scale (SUS) test has been 88.65, which is considered as excellent.

关键词： AMP media synchronization multi-screen playout adjustment tiled displays videowall

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钼和钛对Fe—C—Cr—Nb的铸铁显微组织的影响

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钒钛 1990年第6期 55-59,76页

作者： lope.,CR

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Effect of glycerol on densification of agricultural biomass

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International Journal of Agricultural and Biological Engineering 2015年第1期8卷 64-73页

作者： Shahram Emami lope.G Tabil Phani Adapa Department of Plant Sciences University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8 Canada Department of Chemical and Biological Engineering College of EngineeringUniversity of Saskatchewan57 Campus DriveSaskatoonSK S7N 5A9 Canada Global Institute for Water Security University of SaskatchewanNational Hydrology Research Centre11 Innovation BoulevardSaskatoonSK S7N 3H5 Canada

Experiments were conducted to verify the effect of adding glycerol for pelleting of selected agricultural crop residues,namely,wheat,barley,oat and canola *** pelleting tests were conducted to study the effect of biomass type,hammer mill screen size,and crude glycerol content(co-product of biodiesel industry)on pellet quality(density and durability),ash content and gross heat of *** types of biomass were ground at three different hammer mill screen sizes of 6.4,3.2 and 1.6 *** biomass was mixed with three levels of glycerol of 2.5%,5.0%and 7.5% by *** were made at a pre-set load of 4400 N(138.9 MPa)using single-pelleting unit attached to an Instron testing *** of pellets was determined by measuring pellet density,relaxed density,durability(measured by pellet drop test)and specific energy required to make a *** gross heat of combustion and ash content of pellets were also determined and *** highest pellet density(988-1133 kg/m^(3))and relaxed density(992-1142 kg/m^(3))were obtained from biomass ground using a hammer mill screen size of 6.4 mm.A decrease in hammer mill screen size resulted in reduced *** highest durability of biomass obtained from hammer mill screen size of 6.4 mm ranged from 97%-100%.Addition of glycerol resulted in lower ash content in majority of *** highest gross heat of combustion was observed in pellets made from wheat straw with 7.5% glycerol content(38.3 MJ/kg).Addition of glycerol resulted in lower pellet densities,lower ash content,no change in durability and higher gross heating values.

关键词： biomass biofuels glycerol pelleting caloric value heating value

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Primary lateral sclerosis:more than just an upper motor neuron disease

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Neural Regeneration Research 2024年第9期19卷 1881-1882页

作者： Ee Ling Tan Jasmin lope.Peter Bede Computational Neuroimaging Group(CNG) School of MedicineTrinity College DublinIreland Department of Neurology St James’s HospitalDublinIreland

Advances in clinical care and recent research achievements:Primary lateral sclerosis(PLS)has traditionally been regarded as a pure upper motor neuron condition,a view perpetuated by most medical textbooks.

关键词： sclerosis clinical traditionally

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Resveratrol as an inductor of autophagy: is there a unique pathway of activation?

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Neural Regeneration Research 2021年第1期16卷 101-103页

作者： Narayana Pineda-Ramírez Penélope.Aguilera Laboratorio de Patología Vascular Cerebral.Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Ciudad de MéxicoMéxico

Autophagy is a process of cellular degradation for the removal of damaged components and eventual recycling of the resulting molecules that help to the maintenance of cellular *** this pathway,proteins with relatively long half-life and whole organelles(e.g.,mitochondria,peroxisomes,and ribosomes)are degraded in the cytoplasm for the continuous turnover of cellular structures to facilitate their ***,the beneficial effect of autophagy goes beyond cellular“cleaning”and resides to a large extent on its ability to recycle cell components back into the ***,autophagy is a fundamental mechanism to regulate cellular functions,including DNA repair,proliferation,differentiation,embryonic development,and the immune response.

关键词： homeostasis activation autophagy

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The importance of the bite angle of metal(Ⅲ) salen catalysts in the sequestration of CO_(2) with epoxides in mild conditions

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Green Chemical Engineering 2022年第2期3卷 180-187页

作者： anna vidal-lope. Sergio Posada-Perez Miquel Sola Valerio D'Elia Albert Poater Institut de Quimica Computacional i Catalisi and Departament de Quimica Universitat de GironaC/Maria Aurelia Capmany6917003GironaCataloniaSpain Department of Chemistry Universitat Autonoma de BarcelonaCerdanyola del VallesCatalonia08193Spain Department of Materials Science and Engineering School of Molecular Science and EngineeringVidyasirimedhi Institute of Science and Technology(VISTEC)21210PayupnaiWang ChanThailand

Located in the middle of the fever to solve the problem of CO_(2)emissions in the environment,CO_(2)sequestration by reaction with epoxides is one of the key tools,as it not only fixes CO_(2),but also makes it functional by leading to cyclic ***,the results are focused specifically on the formation of cyclic organic carbonates catalyzed by metal-salen complexes,previously achieved with yttrium and scandium,that are compared with those of analogous complexes containing metals from the first transition series,such as cobalt or *** functional theory(DFT)calculations allow to determine whether this switch of metals will be feasible and provide the basis for instigating future experimental efforts in this *** calculations analyzing the structure and electronics of the catalysts allow us to give not only a clear picture of whether these catalysts will be efficient,but also allow us to assess which metal center is the most convenient and/or whether the catalytic reaction will occur under mild *** buried volume calculations with the SambVca packages shed light on the different catalytic pockets of monometallic first row transition metals *** III salen *** predictive catalysis results show that the bite O-M-O angle plays an essential role in the catalysis.

关键词： CO_(2)fixation Salen catalyst CO_(2)functionalization Cyclic carbonate DFT calculations Predictive catalysis

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Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke

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Neural Regeneration Research 2022年第4期17卷 783-784页

作者： Iván Alquisiras-Burgos Penélope.Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezInsurgentes Sur#3877Col.La FamaTlalpanCiudad de MéxicoMéxico

Cerebral ischemia and resultant energy collapse:The ischemic stroke is a complex neurological condition that can be devastating for patients and their *** disease is the second leading cause of death worldwide and is characterized by a sudden decrease in cerebral blood flow due to major blood vessel *** stroke generates two damaged zones with distinctive metabolic *** first is the ischemic core,the region directly irrigated by the occluded artery.A reduction to less than 20%of the baseline blood flow levels defines the area;therefore,depletion of glucose and adenosine triphosphate(ATP)cause an irreversible failure in the energy metabolism that leads to loss of ionic homeostasis,acidosis,and *** second is the region surrounding the ischemic core,called the penumbra,characterized by significantly depressed tissue perfusion that is barely sufficient to support basal oxygen,glucose,and ATP levels.

关键词： metabolism damage homeostasis

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肝移植后胆道并发症的处理

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国外学者来访报告 1992年第4期12卷 26-27页

作者： lope.,RR 项明

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小麦和面时发育和未发能面团的理化特性研究

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农业科技译丛（湛江） 1989年第2期3卷 54-60页

作者： lope.,OP 王中琪

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